HAP2-GCS1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Generative cell specific 1 protein, putative

Species:

Leishmania mexicana

UniProt:

E9B5T2_LEIMU

TriTrypDb:

LmxM.34.0460

Length:

917

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	7
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9B5T2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5T2

Function

Biological processes
Term	Name	Level	Count
GO:0007338	single fertilization	3	7
GO:0009566	fertilization	2	7
GO:0022414	reproductive process	1	7

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0008289	lipid binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	720	724	PF00656	0.607
CLV_NRD_NRD_1	100	102	PF00675	0.472
CLV_NRD_NRD_1	61	63	PF00675	0.312
CLV_NRD_NRD_1	654	656	PF00675	0.523
CLV_NRD_NRD_1	718	720	PF00675	0.563
CLV_NRD_NRD_1	732	734	PF00675	0.449
CLV_NRD_NRD_1	905	907	PF00675	0.558
CLV_PCSK_KEX2_1	100	102	PF00082	0.472
CLV_PCSK_KEX2_1	653	655	PF00082	0.519
CLV_PCSK_KEX2_1	717	719	PF00082	0.563
CLV_PCSK_KEX2_1	905	907	PF00082	0.558
CLV_PCSK_PC1ET2_1	717	719	PF00082	0.549
CLV_PCSK_SKI1_1	101	105	PF00082	0.347
CLV_PCSK_SKI1_1	127	131	PF00082	0.702
CLV_PCSK_SKI1_1	373	377	PF00082	0.592
CLV_PCSK_SKI1_1	90	94	PF00082	0.484
DEG_APCC_DBOX_1	203	211	PF00400	0.392
DEG_SCF_FBW7_1	872	878	PF00400	0.811
DEG_SCF_TRCP1_1	141	146	PF00400	0.283
DOC_CKS1_1	748	753	PF01111	0.609
DOC_CKS1_1	762	767	PF01111	0.632
DOC_CKS1_1	872	877	PF01111	0.811
DOC_CYCLIN_RxL_1	87	96	PF00134	0.559
DOC_CYCLIN_yCln2_LP_2	122	128	PF00134	0.657
DOC_CYCLIN_yCln2_LP_2	375	381	PF00134	0.320
DOC_CYCLIN_yCln2_LP_2	808	811	PF00134	0.707
DOC_MAPK_gen_1	148	157	PF00069	0.322
DOC_MAPK_gen_1	62	70	PF00069	0.420
DOC_MAPK_gen_1	653	662	PF00069	0.422
DOC_MAPK_HePTP_8	652	664	PF00069	0.437
DOC_MAPK_MEF2A_6	148	157	PF00069	0.322
DOC_MAPK_MEF2A_6	62	71	PF00069	0.404
DOC_MAPK_MEF2A_6	655	664	PF00069	0.337
DOC_MAPK_RevD_3	49	63	PF00069	0.195
DOC_PP1_RVXF_1	601	608	PF00149	0.320
DOC_PP2B_LxvP_1	375	378	PF13499	0.320
DOC_PP2B_LxvP_1	395	398	PF13499	0.156
DOC_PP2B_LxvP_1	796	799	PF13499	0.722
DOC_PP2B_LxvP_1	808	811	PF13499	0.744
DOC_PP4_FxxP_1	789	792	PF00568	0.722
DOC_PP4_FxxP_1	846	849	PF00568	0.727
DOC_PP4_MxPP_1	809	812	PF00568	0.736
DOC_USP7_MATH_1	129	133	PF00917	0.493
DOC_USP7_MATH_1	418	422	PF00917	0.320
DOC_USP7_MATH_1	638	642	PF00917	0.237
DOC_USP7_MATH_1	774	778	PF00917	0.757
DOC_USP7_MATH_1	785	789	PF00917	0.711
DOC_USP7_MATH_1	800	804	PF00917	0.607
DOC_USP7_MATH_1	837	841	PF00917	0.700
DOC_USP7_MATH_1	875	879	PF00917	0.816
DOC_WW_Pin1_4	187	192	PF00397	0.320
DOC_WW_Pin1_4	336	341	PF00397	0.320
DOC_WW_Pin1_4	471	476	PF00397	0.320
DOC_WW_Pin1_4	480	485	PF00397	0.320
DOC_WW_Pin1_4	747	752	PF00397	0.788
DOC_WW_Pin1_4	761	766	PF00397	0.698
DOC_WW_Pin1_4	781	786	PF00397	0.698
DOC_WW_Pin1_4	787	792	PF00397	0.768
DOC_WW_Pin1_4	868	873	PF00397	0.806
DOC_WW_Pin1_4	880	885	PF00397	0.673
DOC_WW_Pin1_4	889	894	PF00397	0.692
DOC_WW_Pin1_4	900	905	PF00397	0.566
DOC_WW_Pin1_4	906	911	PF00397	0.708
DOC_WW_Pin1_4	93	98	PF00397	0.761
LIG_14-3-3_CanoR_1	193	201	PF00244	0.392
LIG_14-3-3_CanoR_1	320	325	PF00244	0.256
LIG_14-3-3_CanoR_1	38	42	PF00244	0.537
LIG_14-3-3_CanoR_1	603	608	PF00244	0.346
LIG_14-3-3_CanoR_1	877	885	PF00244	0.792
LIG_14-3-3_CanoR_1	898	904	PF00244	0.755
LIG_BIR_III_4	246	250	PF00653	0.392
LIG_BRCT_BRCA1_1	168	172	PF00533	0.392
LIG_BRCT_BRCA1_1	254	258	PF00533	0.320
LIG_BRCT_BRCA1_1	610	614	PF00533	0.372
LIG_BRCT_BRCA1_1	842	846	PF00533	0.780
LIG_Clathr_ClatBox_1	401	405	PF01394	0.320
LIG_Clathr_ClatBox_1	659	663	PF01394	0.363
LIG_CtBP_PxDLS_1	367	371	PF00389	0.320
LIG_EVH1_1	796	800	PF00568	0.803
LIG_FHA_1	154	160	PF00498	0.392
LIG_FHA_1	238	244	PF00498	0.320
LIG_FHA_1	265	271	PF00498	0.392
LIG_FHA_1	311	317	PF00498	0.320
LIG_FHA_1	397	403	PF00498	0.354
LIG_FHA_1	441	447	PF00498	0.320
LIG_FHA_1	499	505	PF00498	0.339
LIG_FHA_1	50	56	PF00498	0.399
LIG_FHA_1	522	528	PF00498	0.326
LIG_FHA_1	533	539	PF00498	0.380
LIG_FHA_1	570	576	PF00498	0.385
LIG_FHA_1	587	593	PF00498	0.196
LIG_FHA_1	788	794	PF00498	0.814
LIG_FHA_2	178	184	PF00498	0.184
LIG_FHA_2	344	350	PF00498	0.323
LIG_LIR_Apic_2	788	792	PF02991	0.711
LIG_LIR_Apic_2	843	849	PF02991	0.727
LIG_LIR_Gen_1	349	358	PF02991	0.392
LIG_LIR_Gen_1	393	402	PF02991	0.320
LIG_LIR_Gen_1	415	420	PF02991	0.320
LIG_LIR_Gen_1	663	673	PF02991	0.382
LIG_LIR_LC3C_4	539	544	PF02991	0.304
LIG_LIR_Nem_3	310	314	PF02991	0.320
LIG_LIR_Nem_3	393	397	PF02991	0.320
LIG_LIR_Nem_3	415	419	PF02991	0.320
LIG_LIR_Nem_3	460	465	PF02991	0.320
LIG_LIR_Nem_3	473	479	PF02991	0.322
LIG_LIR_Nem_3	572	576	PF02991	0.279
LIG_LIR_Nem_3	663	668	PF02991	0.382
LIG_LYPXL_yS_3	852	855	PF13949	0.566
LIG_NRBOX	65	71	PF00104	0.423
LIG_PCNA_PIPBox_1	658	667	PF02747	0.337
LIG_PCNA_yPIPBox_3	653	665	PF02747	0.337
LIG_Pex14_1	299	303	PF04695	0.320
LIG_Pex14_2	295	299	PF04695	0.320
LIG_Pex14_2	680	684	PF04695	0.456
LIG_Pex14_2	896	900	PF04695	0.807
LIG_REV1ctd_RIR_1	677	686	PF16727	0.409
LIG_SH2_CRK	203	207	PF00017	0.320
LIG_SH2_CRK	74	78	PF00017	0.369
LIG_SH2_NCK_1	245	249	PF00017	0.337
LIG_SH2_NCK_1	287	291	PF00017	0.320
LIG_SH2_NCK_1	361	365	PF00017	0.337
LIG_SH2_NCK_1	768	772	PF00017	0.719
LIG_SH2_SRC	361	364	PF00017	0.392
LIG_SH2_STAP1	218	222	PF00017	0.320
LIG_SH2_STAP1	312	316	PF00017	0.392
LIG_SH2_STAP1	416	420	PF00017	0.320
LIG_SH2_STAT5	138	141	PF00017	0.378
LIG_SH2_STAT5	209	212	PF00017	0.320
LIG_SH2_STAT5	287	290	PF00017	0.320
LIG_SH2_STAT5	303	306	PF00017	0.320
LIG_SH2_STAT5	312	315	PF00017	0.320
LIG_SH2_STAT5	476	479	PF00017	0.320
LIG_SH2_STAT5	500	503	PF00017	0.320
LIG_SH2_STAT5	667	670	PF00017	0.381
LIG_SH2_STAT5	689	692	PF00017	0.660
LIG_SH2_STAT5	761	764	PF00017	0.707
LIG_SH3_2	872	877	PF14604	0.811
LIG_SH3_3	361	367	PF00018	0.366
LIG_SH3_3	375	381	PF00018	0.273
LIG_SH3_3	745	751	PF00018	0.734
LIG_SH3_3	759	765	PF00018	0.684
LIG_SH3_3	794	800	PF00018	0.740
LIG_SH3_3	847	853	PF00018	0.634
LIG_SH3_3	869	875	PF00018	0.742
LIG_SH3_3	901	907	PF00018	0.791
LIG_SH3_3	909	915	PF00018	0.743
LIG_SUMO_SIM_anti_2	36	44	PF11976	0.537
LIG_SUMO_SIM_anti_2	52	58	PF11976	0.207
LIG_SUMO_SIM_par_1	153	158	PF11976	0.320
LIG_SUMO_SIM_par_1	365	372	PF11976	0.322
LIG_SUMO_SIM_par_1	399	405	PF11976	0.320
LIG_SUMO_SIM_par_1	487	492	PF11976	0.281
LIG_SUMO_SIM_par_1	658	663	PF11976	0.337
LIG_TRAF2_1	165	168	PF00917	0.320
LIG_TRAF2_1	631	634	PF00917	0.304
LIG_TRAF2_1	878	881	PF00917	0.819
LIG_WRC_WIRS_1	841	846	PF05994	0.634
LIG_WW_1	849	852	PF00397	0.440
LIG_WW_3	810	814	PF00397	0.694
MOD_CDC14_SPxK_1	190	193	PF00782	0.487
MOD_CDK_SPK_2	889	894	PF00069	0.771
MOD_CDK_SPK_2	900	905	PF00069	0.595
MOD_CDK_SPxK_1	187	193	PF00069	0.487
MOD_CDK_SPxK_1	871	877	PF00069	0.793
MOD_CDK_SPxK_1	900	906	PF00069	0.588
MOD_CDK_SPxxK_3	93	100	PF00069	0.620
MOD_CK1_1	134	140	PF00069	0.480
MOD_CK1_1	301	307	PF00069	0.385
MOD_CK1_1	37	43	PF00069	0.422
MOD_CK1_1	432	438	PF00069	0.385
MOD_CK1_1	569	575	PF00069	0.352
MOD_CK1_1	580	586	PF00069	0.424
MOD_CK1_1	636	642	PF00069	0.385
MOD_CK1_1	722	728	PF00069	0.728
MOD_CK1_1	736	742	PF00069	0.710
MOD_CK1_1	840	846	PF00069	0.531
MOD_CK1_1	866	872	PF00069	0.715
MOD_CK1_1	876	882	PF00069	0.663
MOD_CK1_1	899	905	PF00069	0.780
MOD_CK2_1	139	145	PF00069	0.606
MOD_CK2_1	343	349	PF00069	0.374
MOD_CK2_1	433	439	PF00069	0.385
MOD_CK2_1	628	634	PF00069	0.367
MOD_CK2_1	875	881	PF00069	0.788
MOD_DYRK1A_RPxSP_1	906	910	PF00069	0.714
MOD_GlcNHglycan	141	144	PF01048	0.611
MOD_GlcNHglycan	174	177	PF01048	0.385
MOD_GlcNHglycan	198	201	PF01048	0.385
MOD_GlcNHglycan	30	33	PF01048	0.671
MOD_GlcNHglycan	300	303	PF01048	0.385
MOD_GlcNHglycan	324	327	PF01048	0.403
MOD_GlcNHglycan	493	496	PF01048	0.427
MOD_GlcNHglycan	505	508	PF01048	0.268
MOD_GlcNHglycan	510	513	PF01048	0.156
MOD_GlcNHglycan	568	571	PF01048	0.489
MOD_GlcNHglycan	582	585	PF01048	0.322
MOD_GlcNHglycan	621	624	PF01048	0.489
MOD_GlcNHglycan	626	629	PF01048	0.334
MOD_GlcNHglycan	633	638	PF01048	0.342
MOD_GlcNHglycan	735	738	PF01048	0.676
MOD_GlcNHglycan	776	779	PF01048	0.699
MOD_GSK3_1	130	137	PF00069	0.525
MOD_GSK3_1	139	146	PF00069	0.540
MOD_GSK3_1	192	199	PF00069	0.475
MOD_GSK3_1	260	267	PF00069	0.385
MOD_GSK3_1	310	317	PF00069	0.385
MOD_GSK3_1	318	325	PF00069	0.385
MOD_GSK3_1	33	40	PF00069	0.626
MOD_GSK3_1	396	403	PF00069	0.385
MOD_GSK3_1	429	436	PF00069	0.385
MOD_GSK3_1	471	478	PF00069	0.385
MOD_GSK3_1	480	487	PF00069	0.378
MOD_GSK3_1	532	539	PF00069	0.486
MOD_GSK3_1	543	550	PF00069	0.323
MOD_GSK3_1	580	587	PF00069	0.372
MOD_GSK3_1	603	610	PF00069	0.368
MOD_GSK3_1	615	622	PF00069	0.265
MOD_GSK3_1	624	631	PF00069	0.235
MOD_GSK3_1	632	639	PF00069	0.352
MOD_GSK3_1	724	731	PF00069	0.701
MOD_GSK3_1	781	788	PF00069	0.709
MOD_GSK3_1	836	843	PF00069	0.644
MOD_GSK3_1	871	878	PF00069	0.735
MOD_GSK3_1	896	903	PF00069	0.689
MOD_LATS_1	20	26	PF00433	0.778
MOD_N-GLC_1	314	319	PF02516	0.385
MOD_N-GLC_1	547	552	PF02516	0.409
MOD_N-GLC_1	615	620	PF02516	0.385
MOD_N-GLC_1	725	730	PF02516	0.521
MOD_N-GLC_2	228	230	PF02516	0.385
MOD_N-GLC_2	424	426	PF02516	0.385
MOD_NEK2_1	114	119	PF00069	0.410
MOD_NEK2_1	130	135	PF00069	0.598
MOD_NEK2_1	153	158	PF00069	0.412
MOD_NEK2_1	172	177	PF00069	0.385
MOD_NEK2_1	192	197	PF00069	0.409
MOD_NEK2_1	264	269	PF00069	0.385
MOD_NEK2_1	316	321	PF00069	0.393
MOD_NEK2_1	368	373	PF00069	0.439
MOD_NEK2_1	41	46	PF00069	0.350
MOD_NEK2_1	458	463	PF00069	0.445
MOD_NEK2_1	49	54	PF00069	0.379
MOD_NEK2_1	498	503	PF00069	0.452
MOD_NEK2_1	55	60	PF00069	0.389
MOD_NEK2_1	577	582	PF00069	0.244
MOD_NEK2_1	896	901	PF00069	0.795
MOD_NEK2_2	143	148	PF00069	0.346
MOD_NEK2_2	218	223	PF00069	0.385
MOD_OFUCOSY	426	433	PF10250	0.385
MOD_PIKK_1	252	258	PF00454	0.385
MOD_PIKK_1	418	424	PF00454	0.385
MOD_PIKK_1	433	439	PF00454	0.385
MOD_PIKK_1	615	621	PF00454	0.381
MOD_PIKK_1	876	882	PF00454	0.809
MOD_PK_1	320	326	PF00069	0.273
MOD_PKA_1	733	739	PF00069	0.507
MOD_PKA_2	192	198	PF00069	0.487
MOD_PKA_2	33	39	PF00069	0.646
MOD_PKA_2	532	538	PF00069	0.409
MOD_PKA_2	728	734	PF00069	0.807
MOD_PKA_2	77	83	PF00069	0.503
MOD_PKA_2	876	882	PF00069	0.809
MOD_Plk_1	143	149	PF00069	0.195
MOD_Plk_1	166	172	PF00069	0.385
MOD_Plk_1	177	183	PF00069	0.385
MOD_Plk_1	218	224	PF00069	0.385
MOD_Plk_1	260	266	PF00069	0.385
MOD_Plk_1	314	320	PF00069	0.385
MOD_Plk_1	498	504	PF00069	0.487
MOD_Plk_4	114	120	PF00069	0.426
MOD_Plk_4	131	137	PF00069	0.581
MOD_Plk_4	166	172	PF00069	0.385
MOD_Plk_4	182	188	PF00069	0.385
MOD_Plk_4	307	313	PF00069	0.385
MOD_Plk_4	37	43	PF00069	0.409
MOD_Plk_4	484	490	PF00069	0.487
MOD_Plk_4	526	532	PF00069	0.385
MOD_Plk_4	586	592	PF00069	0.322
MOD_ProDKin_1	187	193	PF00069	0.385
MOD_ProDKin_1	336	342	PF00069	0.385
MOD_ProDKin_1	471	477	PF00069	0.385
MOD_ProDKin_1	480	486	PF00069	0.385
MOD_ProDKin_1	747	753	PF00069	0.757
MOD_ProDKin_1	761	767	PF00069	0.636
MOD_ProDKin_1	781	787	PF00069	0.636
MOD_ProDKin_1	868	874	PF00069	0.788
MOD_ProDKin_1	880	886	PF00069	0.598
MOD_ProDKin_1	889	895	PF00069	0.625
MOD_ProDKin_1	900	906	PF00069	0.452
MOD_ProDKin_1	93	99	PF00069	0.719
MOD_SUMO_rev_2	144	154	PF00179	0.257
MOD_SUMO_rev_2	727	736	PF00179	0.717
TRG_DiLeu_BaEn_3	167	173	PF01217	0.487
TRG_ENDOCYTIC_2	205	208	PF00928	0.385
TRG_ENDOCYTIC_2	361	364	PF00928	0.487
TRG_ENDOCYTIC_2	416	419	PF00928	0.385
TRG_ENDOCYTIC_2	667	670	PF00928	0.381
TRG_ENDOCYTIC_2	74	77	PF00928	0.369
TRG_ENDOCYTIC_2	852	855	PF00928	0.450
TRG_ER_diArg_1	652	655	PF00400	0.363
TRG_ER_diArg_1	693	696	PF00400	0.437
TRG_ER_diArg_1	904	906	PF00400	0.774
TRG_ER_diArg_1	99	101	PF00400	0.602
TRG_NES_CRM1_1	456	470	PF08389	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P372	Leptomonas seymouri	50%	94%
A0A3S7X8Q7	Leishmania donovani	90%	100%
A4GRC6	Chlamydomonas reinhardtii	26%	81%
A4HM81	Leishmania braziliensis	71%	98%
A4IAU5	Leishmania infantum	90%	100%
E9AEM3	Leishmania major	88%	100%