Arrestin_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Arrestin (or S-antigen), N-terminal domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B5T0_LEIMU

TriTrypDb:

LmxM.34.0440

Length:

638

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B5T0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5T0

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.341
CLV_MEL_PAP_1	376	382	PF00089	0.511
CLV_NRD_NRD_1	280	282	PF00675	0.674
CLV_NRD_NRD_1	307	309	PF00675	0.632
CLV_NRD_NRD_1	334	336	PF00675	0.570
CLV_NRD_NRD_1	571	573	PF00675	0.560
CLV_PCSK_FUR_1	569	573	PF00082	0.557
CLV_PCSK_KEX2_1	278	280	PF00082	0.675
CLV_PCSK_KEX2_1	282	284	PF00082	0.669
CLV_PCSK_KEX2_1	307	309	PF00082	0.621
CLV_PCSK_KEX2_1	334	336	PF00082	0.570
CLV_PCSK_KEX2_1	571	573	PF00082	0.560
CLV_PCSK_PC1ET2_1	278	280	PF00082	0.708
CLV_PCSK_PC1ET2_1	282	284	PF00082	0.688
CLV_PCSK_SKI1_1	253	257	PF00082	0.558
CLV_PCSK_SKI1_1	307	311	PF00082	0.664
CLV_PCSK_SKI1_1	443	447	PF00082	0.535
CLV_PCSK_SKI1_1	46	50	PF00082	0.397
CLV_PCSK_SKI1_1	530	534	PF00082	0.586
CLV_PCSK_SKI1_1	80	84	PF00082	0.479
DEG_APCC_DBOX_1	518	526	PF00400	0.482
DEG_SIAH_1	112	120	PF03145	0.553
DOC_CKS1_1	491	496	PF01111	0.630
DOC_CKS1_1	532	537	PF01111	0.531
DOC_CYCLIN_yCln2_LP_2	470	476	PF00134	0.666
DOC_CYCLIN_yCln2_LP_2	580	583	PF00134	0.578
DOC_CYCLIN_yCln2_LP_2	631	637	PF00134	0.575
DOC_MAPK_gen_1	304	314	PF00069	0.584
DOC_MAPK_MEF2A_6	25	32	PF00069	0.305
DOC_MAPK_MEF2A_6	5	13	PF00069	0.415
DOC_MAPK_MEF2A_6	519	528	PF00069	0.488
DOC_MAPK_MEF2A_6	592	601	PF00069	0.348
DOC_MAPK_MEF2A_6	627	635	PF00069	0.464
DOC_PP1_RVXF_1	44	50	PF00149	0.378
DOC_PP2B_LxvP_1	475	478	PF13499	0.590
DOC_PP2B_LxvP_1	580	583	PF13499	0.577
DOC_PP2B_LxvP_1	631	634	PF13499	0.573
DOC_PP4_FxxP_1	208	211	PF00568	0.307
DOC_USP7_MATH_1	183	187	PF00917	0.327
DOC_USP7_MATH_1	363	367	PF00917	0.712
DOC_USP7_UBL2_3	264	268	PF12436	0.513
DOC_USP7_UBL2_3	278	282	PF12436	0.671
DOC_WW_Pin1_4	109	114	PF00397	0.564
DOC_WW_Pin1_4	464	469	PF00397	0.644
DOC_WW_Pin1_4	480	485	PF00397	0.662
DOC_WW_Pin1_4	490	495	PF00397	0.479
DOC_WW_Pin1_4	531	536	PF00397	0.534
DOC_WW_Pin1_4	564	569	PF00397	0.493
LIG_14-3-3_CanoR_1	307	313	PF00244	0.667
LIG_14-3-3_CanoR_1	5	10	PF00244	0.388
LIG_14-3-3_CanoR_1	592	597	PF00244	0.375
LIG_14-3-3_CanoR_1	80	85	PF00244	0.460
LIG_14-3-3_CterR_2	636	638	PF00244	0.585
LIG_BRCT_BRCA1_1	245	249	PF00533	0.630
LIG_BRCT_BRCA1_1	592	596	PF00533	0.482
LIG_CSL_BTD_1	212	215	PF09270	0.307
LIG_DLG_GKlike_1	5	13	PF00625	0.382
LIG_eIF4E_1	130	136	PF01652	0.518
LIG_eIF4E_1	42	48	PF01652	0.394
LIG_FHA_1	257	263	PF00498	0.488
LIG_FHA_1	319	325	PF00498	0.448
LIG_FHA_1	344	350	PF00498	0.605
LIG_FHA_1	442	448	PF00498	0.534
LIG_FHA_1	499	505	PF00498	0.523
LIG_FHA_1	510	516	PF00498	0.437
LIG_FHA_1	547	553	PF00498	0.426
LIG_FHA_1	612	618	PF00498	0.496
LIG_FHA_1	621	627	PF00498	0.617
LIG_FHA_1	95	101	PF00498	0.541
LIG_FHA_2	129	135	PF00498	0.606
LIG_FHA_2	188	194	PF00498	0.329
LIG_FHA_2	573	579	PF00498	0.558
LIG_FHA_2	604	610	PF00498	0.520
LIG_FHA_2	87	93	PF00498	0.516
LIG_IRF3_LxIS_1	7	12	PF10401	0.407
LIG_LIR_Apic_2	545	551	PF02991	0.439
LIG_LIR_Gen_1	112	122	PF02991	0.560
LIG_LIR_Gen_1	217	225	PF02991	0.286
LIG_LIR_Gen_1	410	421	PF02991	0.502
LIG_LIR_Gen_1	542	551	PF02991	0.444
LIG_LIR_Gen_1	593	604	PF02991	0.448
LIG_LIR_Gen_1	63	71	PF02991	0.518
LIG_LIR_LC3C_4	436	440	PF02991	0.525
LIG_LIR_Nem_3	112	117	PF02991	0.550
LIG_LIR_Nem_3	125	130	PF02991	0.567
LIG_LIR_Nem_3	201	207	PF02991	0.205
LIG_LIR_Nem_3	217	223	PF02991	0.239
LIG_LIR_Nem_3	246	251	PF02991	0.591
LIG_LIR_Nem_3	410	416	PF02991	0.517
LIG_LIR_Nem_3	527	532	PF02991	0.501
LIG_LIR_Nem_3	537	541	PF02991	0.502
LIG_LIR_Nem_3	542	546	PF02991	0.454
LIG_LIR_Nem_3	593	599	PF02991	0.450
LIG_LIR_Nem_3	63	67	PF02991	0.509
LIG_MYND_1	195	199	PF01753	0.307
LIG_MYND_1	212	216	PF01753	0.307
LIG_Pex14_2	204	208	PF04695	0.307
LIG_Pex14_2	218	222	PF04695	0.307
LIG_Pex14_2	416	420	PF04695	0.515
LIG_SH2_CRK	114	118	PF00017	0.560
LIG_SH2_CRK	220	224	PF00017	0.438
LIG_SH2_CRK	548	552	PF00017	0.424
LIG_SH2_NCK_1	114	118	PF00017	0.560
LIG_SH2_STAP1	114	118	PF00017	0.549
LIG_SH2_STAP1	231	235	PF00017	0.307
LIG_SH2_STAT5	130	133	PF00017	0.567
LIG_SH2_STAT5	148	151	PF00017	0.202
LIG_SH2_STAT5	509	512	PF00017	0.469
LIG_SH2_STAT5	548	551	PF00017	0.435
LIG_SH2_STAT5	605	608	PF00017	0.524
LIG_SH2_STAT5	71	74	PF00017	0.563
LIG_SH2_STAT5	77	80	PF00017	0.496
LIG_SH3_1	209	215	PF00018	0.307
LIG_SH3_1	548	554	PF00018	0.424
LIG_SH3_2	119	124	PF14604	0.598
LIG_SH3_2	353	358	PF14604	0.543
LIG_SH3_3	116	122	PF00018	0.636
LIG_SH3_3	172	178	PF00018	0.350
LIG_SH3_3	189	195	PF00018	0.319
LIG_SH3_3	209	215	PF00018	0.325
LIG_SH3_3	311	317	PF00018	0.599
LIG_SH3_3	350	356	PF00018	0.550
LIG_SH3_3	456	462	PF00018	0.615
LIG_SH3_3	478	484	PF00018	0.609
LIG_SH3_3	485	491	PF00018	0.607
LIG_SH3_3	548	554	PF00018	0.442
LIG_SH3_3	596	602	PF00018	0.426
LIG_SUMO_SIM_anti_2	327	333	PF11976	0.487
LIG_SUMO_SIM_anti_2	436	441	PF11976	0.470
LIG_SUMO_SIM_par_1	291	298	PF11976	0.639
LIG_SUMO_SIM_par_1	443	450	PF11976	0.580
LIG_TRAF2_1	131	134	PF00917	0.521
LIG_TRAF2_2	171	176	PF00917	0.262
LIG_TRFH_1	208	212	PF08558	0.307
LIG_TYR_ITIM	40	45	PF00017	0.405
LIG_TYR_ITSM	110	117	PF00017	0.559
LIG_UBA3_1	528	533	PF00899	0.609
LIG_WRC_WIRS_1	219	224	PF05994	0.307
LIG_WRC_WIRS_1	413	418	PF05994	0.487
LIG_WRC_WIRS_1	543	548	PF05994	0.439
LIG_WW_3	355	359	PF00397	0.547
MOD_CDK_SPK_2	564	569	PF00069	0.409
MOD_CDK_SPxxK_3	564	571	PF00069	0.417
MOD_CK1_1	318	324	PF00069	0.393
MOD_CK1_1	366	372	PF00069	0.586
MOD_CK1_1	392	398	PF00069	0.650
MOD_CK1_1	531	537	PF00069	0.571
MOD_CK1_1	542	548	PF00069	0.476
MOD_CK2_1	128	134	PF00069	0.551
MOD_CK2_1	187	193	PF00069	0.320
MOD_CK2_1	572	578	PF00069	0.580
MOD_CK2_1	603	609	PF00069	0.512
MOD_CK2_1	86	92	PF00069	0.511
MOD_Cter_Amidation	276	279	PF01082	0.605
MOD_GlcNHglycan	109	112	PF01048	0.487
MOD_GlcNHglycan	185	188	PF01048	0.457
MOD_GlcNHglycan	231	234	PF01048	0.317
MOD_GlcNHglycan	275	278	PF01048	0.699
MOD_GlcNHglycan	288	291	PF01048	0.648
MOD_GlcNHglycan	391	394	PF01048	0.631
MOD_GlcNHglycan	409	412	PF01048	0.464
MOD_GSK3_1	1	8	PF00069	0.457
MOD_GSK3_1	142	149	PF00069	0.324
MOD_GSK3_1	183	190	PF00069	0.252
MOD_GSK3_1	214	221	PF00069	0.431
MOD_GSK3_1	229	236	PF00069	0.352
MOD_GSK3_1	315	322	PF00069	0.646
MOD_GSK3_1	542	549	PF00069	0.446
MOD_GSK3_1	572	579	PF00069	0.583
MOD_GSK3_1	82	89	PF00069	0.514
MOD_N-GLC_1	363	368	PF02516	0.602
MOD_N-GLC_2	163	165	PF02516	0.329
MOD_N-GLC_2	423	425	PF02516	0.528
MOD_N-GLC_2	508	510	PF02516	0.409
MOD_NEK2_1	107	112	PF00069	0.507
MOD_NEK2_1	142	147	PF00069	0.361
MOD_NEK2_1	218	223	PF00069	0.307
MOD_NEK2_1	229	234	PF00069	0.307
MOD_NEK2_1	407	412	PF00069	0.543
MOD_NEK2_1	546	551	PF00069	0.435
MOD_NEK2_1	597	602	PF00069	0.490
MOD_NEK2_1	620	625	PF00069	0.487
MOD_NEK2_1	9	14	PF00069	0.416
MOD_NEK2_2	498	503	PF00069	0.527
MOD_PIKK_1	165	171	PF00454	0.402
MOD_PIKK_1	86	92	PF00454	0.568
MOD_PKA_1	281	287	PF00069	0.541
MOD_PKA_1	307	313	PF00069	0.627
MOD_PKA_2	307	313	PF00069	0.627
MOD_PKA_2	351	357	PF00069	0.815
MOD_PKB_1	279	287	PF00069	0.543
MOD_Plk_1	402	408	PF00069	0.645
MOD_Plk_1	52	58	PF00069	0.470
MOD_Plk_1	546	552	PF00069	0.495
MOD_Plk_4	214	220	PF00069	0.307
MOD_Plk_4	233	239	PF00069	0.307
MOD_Plk_4	243	249	PF00069	0.559
MOD_Plk_4	327	333	PF00069	0.511
MOD_Plk_4	576	582	PF00069	0.581
MOD_Plk_4	592	598	PF00069	0.630
MOD_Plk_4	603	609	PF00069	0.512
MOD_ProDKin_1	109	115	PF00069	0.561
MOD_ProDKin_1	464	470	PF00069	0.646
MOD_ProDKin_1	480	486	PF00069	0.658
MOD_ProDKin_1	490	496	PF00069	0.508
MOD_ProDKin_1	531	537	PF00069	0.531
MOD_ProDKin_1	564	570	PF00069	0.496
MOD_SUMO_for_1	626	629	PF00179	0.446
MOD_SUMO_rev_2	276	284	PF00179	0.614
MOD_SUMO_rev_2	383	392	PF00179	0.618
MOD_SUMO_rev_2	516	525	PF00179	0.436
MOD_SUMO_rev_2	609	617	PF00179	0.551
TRG_DiLeu_BaEn_1	193	198	PF01217	0.375
TRG_DiLeu_BaEn_1	43	48	PF01217	0.394
TRG_DiLeu_BaEn_1	434	439	PF01217	0.446
TRG_DiLeu_BaEn_1	63	68	PF01217	0.384
TRG_DiLeu_BaEn_2	101	107	PF01217	0.639
TRG_DiLeu_BaEn_4	102	108	PF01217	0.640
TRG_ENDOCYTIC_2	114	117	PF00928	0.546
TRG_ENDOCYTIC_2	219	222	PF00928	0.307
TRG_ENDOCYTIC_2	341	344	PF00928	0.565
TRG_ENDOCYTIC_2	413	416	PF00928	0.493
TRG_ENDOCYTIC_2	42	45	PF00928	0.423
TRG_ENDOCYTIC_2	543	546	PF00928	0.464
TRG_ENDOCYTIC_2	605	608	PF00928	0.515
TRG_ER_diArg_1	307	309	PF00400	0.630
TRG_ER_diArg_1	333	335	PF00400	0.572
TRG_ER_diArg_1	376	379	PF00400	0.634
TRG_ER_diArg_1	502	505	PF00400	0.449
TRG_ER_diArg_1	570	572	PF00400	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSS5	Leptomonas seymouri	61%	96%
A0A3S5H7Y4	Leishmania donovani	91%	100%
A4HM80	Leishmania braziliensis	77%	99%
A4IAU3	Leishmania infantum	91%	100%
E9AEM1	Leishmania major	91%	100%