Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B5S7_LEIMU

TriTrypDb:

LmxM.34.0390

Length:

547

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B5S7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5S7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.623
CLV_C14_Caspase3-7	161	165	PF00656	0.621
CLV_C14_Caspase3-7	186	190	PF00656	0.686
CLV_C14_Caspase3-7	336	340	PF00656	0.472
CLV_NRD_NRD_1	118	120	PF00675	0.530
CLV_NRD_NRD_1	174	176	PF00675	0.755
CLV_NRD_NRD_1	406	408	PF00675	0.465
CLV_NRD_NRD_1	480	482	PF00675	0.761
CLV_NRD_NRD_1	487	489	PF00675	0.668
CLV_PCSK_KEX2_1	118	120	PF00082	0.500
CLV_PCSK_KEX2_1	172	174	PF00082	0.631
CLV_PCSK_PC1ET2_1	172	174	PF00082	0.631
CLV_PCSK_SKI1_1	325	329	PF00082	0.686
CLV_PCSK_SKI1_1	411	415	PF00082	0.528
CLV_PCSK_SKI1_1	458	462	PF00082	0.713
CLV_PCSK_SKI1_1	466	470	PF00082	0.640
DEG_SCF_FBW7_1	123	129	PF00400	0.445
DEG_SPOP_SBC_1	126	130	PF00917	0.713
DOC_ANK_TNKS_1	44	51	PF00023	0.707
DOC_CDC14_PxL_1	363	371	PF14671	0.665
DOC_CKS1_1	123	128	PF01111	0.553
DOC_CKS1_1	191	196	PF01111	0.599
DOC_USP7_MATH_1	108	112	PF00917	0.532
DOC_USP7_MATH_1	215	219	PF00917	0.637
DOC_USP7_MATH_1	22	26	PF00917	0.541
DOC_USP7_MATH_1	310	314	PF00917	0.559
DOC_USP7_MATH_1	33	37	PF00917	0.427
DOC_USP7_MATH_1	71	75	PF00917	0.772
DOC_WW_Pin1_4	101	106	PF00397	0.685
DOC_WW_Pin1_4	122	127	PF00397	0.566
DOC_WW_Pin1_4	190	195	PF00397	0.608
DOC_WW_Pin1_4	273	278	PF00397	0.523
DOC_WW_Pin1_4	279	284	PF00397	0.398
DOC_WW_Pin1_4	350	355	PF00397	0.780
DOC_WW_Pin1_4	73	78	PF00397	0.708
LIG_14-3-3_CanoR_1	197	203	PF00244	0.666
LIG_14-3-3_CanoR_1	208	216	PF00244	0.539
LIG_14-3-3_CanoR_1	264	268	PF00244	0.601
LIG_14-3-3_CanoR_1	269	277	PF00244	0.616
LIG_14-3-3_CanoR_1	373	379	PF00244	0.554
LIG_14-3-3_CanoR_1	411	421	PF00244	0.455
LIG_14-3-3_CanoR_1	508	514	PF00244	0.673
LIG_14-3-3_CanoR_1	95	99	PF00244	0.489
LIG_Actin_WH2_2	405	422	PF00022	0.558
LIG_APCC_ABBA_1	96	101	PF00400	0.579
LIG_APCC_ABBAyCdc20_2	95	101	PF00400	0.549
LIG_BIR_II_1	1	5	PF00653	0.676
LIG_BRCT_BRCA1_1	1	5	PF00533	0.595
LIG_BRCT_BRCA1_1	216	220	PF00533	0.713
LIG_CSL_BTD_1	123	126	PF09270	0.627
LIG_CSL_BTD_1	191	194	PF09270	0.615
LIG_EH_1	388	392	PF12763	0.554
LIG_eIF4E_1	254	260	PF01652	0.559
LIG_FHA_1	150	156	PF00498	0.533
LIG_FHA_1	276	282	PF00498	0.510
LIG_FHA_1	373	379	PF00498	0.572
LIG_FHA_2	128	134	PF00498	0.736
LIG_FHA_2	299	305	PF00498	0.461
LIG_FHA_2	61	67	PF00498	0.783
LIG_Integrin_RGD_1	47	49	PF01839	0.670
LIG_LIR_Apic_2	97	102	PF02991	0.651
LIG_LIR_Gen_1	2	13	PF02991	0.558
LIG_LIR_Gen_1	252	262	PF02991	0.535
LIG_LIR_Nem_3	189	195	PF02991	0.515
LIG_LIR_Nem_3	2	8	PF02991	0.554
LIG_LIR_Nem_3	252	257	PF02991	0.482
LIG_MAD2	119	127	PF02301	0.622
LIG_MYND_1	367	371	PF01753	0.701
LIG_NRBOX	81	87	PF00104	0.580
LIG_PCNA_PIPBox_1	117	126	PF02747	0.615
LIG_Pex14_2	156	160	PF04695	0.543
LIG_Pex14_2	409	413	PF04695	0.561
LIG_Rb_pABgroove_1	297	305	PF01858	0.476
LIG_SH2_NCK_1	99	103	PF00017	0.660
LIG_SH2_SRC	421	424	PF00017	0.445
LIG_SH2_STAP1	241	245	PF00017	0.353
LIG_SH2_STAP1	318	322	PF00017	0.615
LIG_SH2_STAT3	318	321	PF00017	0.614
LIG_SH2_STAT5	20	23	PF00017	0.587
LIG_SH2_STAT5	421	424	PF00017	0.536
LIG_SH3_1	99	105	PF00018	0.670
LIG_SH3_2	368	373	PF14604	0.684
LIG_SH3_3	188	194	PF00018	0.623
LIG_SH3_3	277	283	PF00018	0.572
LIG_SH3_3	302	308	PF00018	0.522
LIG_SH3_3	362	368	PF00018	0.733
LIG_SH3_3	99	105	PF00018	0.641
LIG_SUMO_SIM_par_1	119	125	PF11976	0.398
LIG_SUMO_SIM_par_1	246	252	PF11976	0.419
LIG_SUMO_SIM_par_1	291	296	PF11976	0.543
LIG_SUMO_SIM_par_1	309	316	PF11976	0.571
LIG_UBA3_1	446	452	PF00899	0.643
LIG_Vh1_VBS_1	449	467	PF01044	0.713
MOD_CDK_SPxxK_3	190	197	PF00069	0.531
MOD_CK1_1	149	155	PF00069	0.544
MOD_CK1_1	200	206	PF00069	0.677
MOD_CK1_1	211	217	PF00069	0.586
MOD_CK1_1	4	10	PF00069	0.533
MOD_CK1_1	425	431	PF00069	0.560
MOD_CK1_1	514	520	PF00069	0.628
MOD_CK2_1	162	168	PF00069	0.592
MOD_CK2_1	246	252	PF00069	0.497
MOD_CK2_1	310	316	PF00069	0.585
MOD_CK2_1	317	323	PF00069	0.595
MOD_CK2_1	338	344	PF00069	0.711
MOD_CK2_1	60	66	PF00069	0.788
MOD_CK2_1	73	79	PF00069	0.695
MOD_GlcNHglycan	110	113	PF01048	0.545
MOD_GlcNHglycan	130	133	PF01048	0.412
MOD_GlcNHglycan	160	163	PF01048	0.635
MOD_GlcNHglycan	213	216	PF01048	0.631
MOD_GlcNHglycan	241	244	PF01048	0.640
MOD_GlcNHglycan	308	311	PF01048	0.556
MOD_GlcNHglycan	31	34	PF01048	0.621
MOD_GlcNHglycan	339	343	PF01048	0.591
MOD_GlcNHglycan	357	360	PF01048	0.717
MOD_GlcNHglycan	73	76	PF01048	0.685
MOD_GlcNHglycan	8	11	PF01048	0.503
MOD_GlcNHglycan	91	94	PF01048	0.595
MOD_GSK3_1	122	129	PF00069	0.570
MOD_GSK3_1	158	165	PF00069	0.506
MOD_GSK3_1	173	180	PF00069	0.697
MOD_GSK3_1	197	204	PF00069	0.580
MOD_GSK3_1	211	218	PF00069	0.584
MOD_GSK3_1	235	242	PF00069	0.611
MOD_GSK3_1	263	270	PF00069	0.610
MOD_GSK3_1	271	278	PF00069	0.440
MOD_GSK3_1	29	36	PF00069	0.590
MOD_GSK3_1	306	313	PF00069	0.588
MOD_GSK3_1	450	457	PF00069	0.663
MOD_GSK3_1	504	511	PF00069	0.638
MOD_GSK3_1	71	78	PF00069	0.767
MOD_GSK3_1	85	92	PF00069	0.525
MOD_GSK3_1	97	104	PF00069	0.510
MOD_LATS_1	450	456	PF00433	0.636
MOD_N-GLC_2	139	141	PF02516	0.574
MOD_NEK2_1	1	6	PF00069	0.571
MOD_NEK2_1	220	225	PF00069	0.621
MOD_NEK2_1	235	240	PF00069	0.585
MOD_NEK2_1	29	34	PF00069	0.567
MOD_NEK2_1	374	379	PF00069	0.593
MOD_NEK2_1	412	417	PF00069	0.502
MOD_NEK2_1	509	514	PF00069	0.697
MOD_NEK2_2	215	220	PF00069	0.656
MOD_NEK2_2	298	303	PF00069	0.423
MOD_NEK2_2	501	506	PF00069	0.668
MOD_PIKK_1	113	119	PF00454	0.539
MOD_PIKK_1	13	19	PF00454	0.525
MOD_PIKK_1	317	323	PF00454	0.595
MOD_PIKK_1	466	472	PF00454	0.734
MOD_PIKK_1	482	488	PF00454	0.557
MOD_PKA_1	173	179	PF00069	0.709
MOD_PKA_2	173	179	PF00069	0.784
MOD_PKA_2	22	28	PF00069	0.610
MOD_PKA_2	263	269	PF00069	0.573
MOD_PKA_2	372	378	PF00069	0.562
MOD_PKA_2	480	486	PF00069	0.542
MOD_PKA_2	507	513	PF00069	0.673
MOD_PKA_2	57	63	PF00069	0.760
MOD_PKA_2	94	100	PF00069	0.523
MOD_PKB_1	506	514	PF00069	0.626
MOD_Plk_4	215	221	PF00069	0.678
MOD_Plk_4	263	269	PF00069	0.479
MOD_Plk_4	298	304	PF00069	0.378
MOD_Plk_4	414	420	PF00069	0.502
MOD_Plk_4	94	100	PF00069	0.582
MOD_ProDKin_1	101	107	PF00069	0.686
MOD_ProDKin_1	122	128	PF00069	0.572
MOD_ProDKin_1	190	196	PF00069	0.602
MOD_ProDKin_1	273	279	PF00069	0.518
MOD_ProDKin_1	350	356	PF00069	0.779
MOD_ProDKin_1	73	79	PF00069	0.699
MOD_SUMO_rev_2	483	491	PF00179	0.703
TRG_DiLeu_BaLyEn_6	255	260	PF01217	0.485
TRG_DiLeu_BaLyEn_6	365	370	PF01217	0.745
TRG_DiLeu_BaLyEn_6	442	447	PF01217	0.612
TRG_ENDOCYTIC_2	254	257	PF00928	0.540
TRG_ER_diArg_1	118	120	PF00400	0.530
TRG_ER_diArg_1	173	175	PF00400	0.749
TRG_ER_diArg_1	505	508	PF00400	0.602
TRG_NLS_MonoExtC_3	473	479	PF00514	0.753
TRG_Pf-PMV_PEXEL_1	182	186	PF00026	0.702

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II05	Leptomonas seymouri	55%	96%
A0A0S4JU63	Bodo saltans	26%	100%
A0A1X0NIV1	Trypanosomatidae	30%	100%
A0A3S7X8R0	Leishmania donovani	92%	100%
A4HM76	Leishmania braziliensis	79%	100%
A4IAT9	Leishmania infantum	92%	100%
D0A2B2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AEL6	Leishmania major	92%	100%
V5BNA1	Trypanosoma cruzi	30%	100%