Thioredoxin domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

thioredoxin, putative

Species:

Leishmania mexicana

UniProt:

E9B5S6_LEIMU

TriTrypDb:

LmxM.34.0380

Length:

608

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B5S6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5S6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	246	250	PF00656	0.682
CLV_NRD_NRD_1	255	257	PF00675	0.569
CLV_PCSK_FUR_1	253	257	PF00082	0.615
CLV_PCSK_KEX2_1	16	18	PF00082	0.629
CLV_PCSK_KEX2_1	237	239	PF00082	0.688
CLV_PCSK_KEX2_1	255	257	PF00082	0.715
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.629
CLV_PCSK_PC1ET2_1	237	239	PF00082	0.660
CLV_PCSK_SKI1_1	13	17	PF00082	0.717
CLV_PCSK_SKI1_1	217	221	PF00082	0.400
CLV_PCSK_SKI1_1	429	433	PF00082	0.394
CLV_PCSK_SKI1_1	444	448	PF00082	0.309
CLV_PCSK_SKI1_1	474	478	PF00082	0.380
CLV_Separin_Metazoa	493	497	PF03568	0.236
DEG_Nend_Nbox_1	1	3	PF02207	0.653
DEG_SCF_FBW7_1	122	129	PF00400	0.624
DEG_SCF_FBW7_1	53	60	PF00400	0.491
DEG_SCF_SKP2-CKS1_1	230	237	PF00560	0.436
DEG_SPOP_SBC_1	292	296	PF00917	0.594
DOC_CKS1_1	408	413	PF01111	0.630
DOC_CKS1_1	54	59	PF01111	0.687
DOC_CYCLIN_yCln2_LP_2	277	283	PF00134	0.673
DOC_CYCLIN_yCln2_LP_2	377	383	PF00134	0.351
DOC_MAPK_gen_1	176	185	PF00069	0.508
DOC_MAPK_gen_1	373	379	PF00069	0.489
DOC_MAPK_gen_1	472	479	PF00069	0.432
DOC_MAPK_HePTP_8	183	195	PF00069	0.387
DOC_MAPK_MEF2A_6	176	185	PF00069	0.502
DOC_MAPK_MEF2A_6	186	195	PF00069	0.317
DOC_USP7_MATH_1	126	130	PF00917	0.612
DOC_USP7_MATH_1	156	160	PF00917	0.259
DOC_USP7_MATH_1	23	27	PF00917	0.693
DOC_USP7_MATH_1	248	252	PF00917	0.731
DOC_USP7_MATH_1	292	296	PF00917	0.694
DOC_USP7_MATH_1	304	308	PF00917	0.687
DOC_USP7_MATH_1	320	324	PF00917	0.400
DOC_USP7_MATH_1	352	356	PF00917	0.669
DOC_USP7_MATH_1	49	53	PF00917	0.604
DOC_USP7_MATH_1	554	558	PF00917	0.597
DOC_USP7_MATH_1	562	566	PF00917	0.603
DOC_USP7_MATH_1	80	84	PF00917	0.681
DOC_USP7_MATH_2	411	417	PF00917	0.468
DOC_WW_Pin1_4	122	127	PF00397	0.626
DOC_WW_Pin1_4	19	24	PF00397	0.652
DOC_WW_Pin1_4	231	236	PF00397	0.464
DOC_WW_Pin1_4	244	249	PF00397	0.750
DOC_WW_Pin1_4	407	412	PF00397	0.609
DOC_WW_Pin1_4	53	58	PF00397	0.625
DOC_WW_Pin1_4	62	67	PF00397	0.589
DOC_WW_Pin1_4	72	77	PF00397	0.585
LIG_14-3-3_CanoR_1	217	222	PF00244	0.495
LIG_14-3-3_CanoR_1	305	314	PF00244	0.601
LIG_14-3-3_CanoR_1	418	426	PF00244	0.489
LIG_14-3-3_CanoR_1	444	450	PF00244	0.430
LIG_APCC_ABBA_1	193	198	PF00400	0.462
LIG_CAP-Gly_1	605	608	PF01302	0.501
LIG_Clathr_ClatBox_1	194	198	PF01394	0.465
LIG_EVH1_1	395	399	PF00568	0.544
LIG_FHA_1	132	138	PF00498	0.696
LIG_FHA_1	188	194	PF00498	0.366
LIG_FHA_1	208	214	PF00498	0.272
LIG_FHA_1	218	224	PF00498	0.468
LIG_FHA_1	292	298	PF00498	0.639
LIG_FHA_1	529	535	PF00498	0.310
LIG_FHA_1	54	60	PF00498	0.671
LIG_FHA_1	66	72	PF00498	0.648
LIG_FHA_2	263	269	PF00498	0.743
LIG_FHA_2	294	300	PF00498	0.603
LIG_FHA_2	408	414	PF00498	0.603
LIG_FHA_2	430	436	PF00498	0.361
LIG_FHA_2	5	11	PF00498	0.726
LIG_GBD_Chelix_1	111	119	PF00786	0.455
LIG_GBD_Chelix_1	506	514	PF00786	0.382
LIG_LIR_Apic_2	482	486	PF02991	0.340
LIG_LIR_Gen_1	531	540	PF02991	0.354
LIG_LIR_Nem_3	441	446	PF02991	0.350
LIG_LIR_Nem_3	450	456	PF02991	0.373
LIG_LIR_Nem_3	522	526	PF02991	0.342
LIG_LIR_Nem_3	531	535	PF02991	0.308
LIG_MYND_1	376	380	PF01753	0.502
LIG_PDZ_Class_3	603	608	PF00595	0.489
LIG_Pex14_2	443	447	PF04695	0.373
LIG_Pex14_2	604	608	PF04695	0.495
LIG_SH2_NCK_1	544	548	PF00017	0.315
LIG_SH2_STAP1	567	571	PF00017	0.428
LIG_SH2_STAT3	403	406	PF00017	0.649
LIG_SH2_STAT5	478	481	PF00017	0.300
LIG_SH2_STAT5	523	526	PF00017	0.438
LIG_SH3_3	141	147	PF00018	0.687
LIG_SH3_3	17	23	PF00018	0.678
LIG_SH3_3	393	399	PF00018	0.552
LIG_SH3_3	405	411	PF00018	0.632
LIG_SH3_5	227	231	PF00018	0.537
LIG_SH3_5	519	523	PF00018	0.440
LIG_SUMO_SIM_anti_2	189	195	PF11976	0.341
LIG_SUMO_SIM_par_1	282	288	PF11976	0.522
LIG_SUMO_SIM_par_1	342	348	PF11976	0.536
LIG_SUMO_SIM_par_1	424	430	PF11976	0.423
LIG_TRAF2_1	391	394	PF00917	0.470
LIG_TRAF2_1	570	573	PF00917	0.422
LIG_TRAF2_1	9	12	PF00917	0.768
LIG_WRC_WIRS_1	529	534	PF05994	0.286
LIG_WRC_WIRS_1	591	596	PF05994	0.396
LIG_WW_2	144	147	PF00397	0.372
LIG_WW_3	302	306	PF00397	0.476
MOD_CDK_SPxK_1	231	237	PF00069	0.451
MOD_CDK_SPxxK_3	231	238	PF00069	0.461
MOD_CK1_1	129	135	PF00069	0.667
MOD_CK1_1	169	175	PF00069	0.598
MOD_CK1_1	201	207	PF00069	0.540
MOD_CK1_1	306	312	PF00069	0.753
MOD_CK1_1	323	329	PF00069	0.450
MOD_CK1_1	36	42	PF00069	0.706
MOD_CK1_1	553	559	PF00069	0.535
MOD_CK1_1	596	602	PF00069	0.500
MOD_CK1_1	83	89	PF00069	0.723
MOD_CK2_1	266	272	PF00069	0.712
MOD_CK2_1	293	299	PF00069	0.598
MOD_CK2_1	4	10	PF00069	0.718
MOD_CK2_1	407	413	PF00069	0.613
MOD_CK2_1	573	579	PF00069	0.453
MOD_CK2_1	600	606	PF00069	0.511
MOD_Cter_Amidation	371	374	PF01082	0.598
MOD_GlcNHglycan	115	118	PF01048	0.542
MOD_GlcNHglycan	128	131	PF01048	0.630
MOD_GlcNHglycan	173	176	PF01048	0.555
MOD_GlcNHglycan	23	26	PF01048	0.639
MOD_GlcNHglycan	239	242	PF01048	0.675
MOD_GlcNHglycan	325	328	PF01048	0.597
MOD_GlcNHglycan	362	365	PF01048	0.680
MOD_GlcNHglycan	419	422	PF01048	0.485
MOD_GlcNHglycan	552	555	PF01048	0.604
MOD_GlcNHglycan	556	559	PF01048	0.674
MOD_GSK3_1	120	127	PF00069	0.724
MOD_GSK3_1	152	159	PF00069	0.385
MOD_GSK3_1	162	169	PF00069	0.394
MOD_GSK3_1	19	26	PF00069	0.555
MOD_GSK3_1	197	204	PF00069	0.430
MOD_GSK3_1	2	9	PF00069	0.690
MOD_GSK3_1	207	214	PF00069	0.329
MOD_GSK3_1	244	251	PF00069	0.669
MOD_GSK3_1	262	269	PF00069	0.652
MOD_GSK3_1	303	310	PF00069	0.679
MOD_GSK3_1	330	337	PF00069	0.546
MOD_GSK3_1	402	409	PF00069	0.587
MOD_GSK3_1	413	420	PF00069	0.434
MOD_GSK3_1	452	459	PF00069	0.370
MOD_GSK3_1	466	473	PF00069	0.363
MOD_GSK3_1	49	56	PF00069	0.685
MOD_GSK3_1	502	509	PF00069	0.456
MOD_GSK3_1	549	556	PF00069	0.434
MOD_GSK3_1	589	596	PF00069	0.423
MOD_GSK3_1	72	79	PF00069	0.726
MOD_GSK3_1	83	90	PF00069	0.681
MOD_N-GLC_1	170	175	PF02516	0.540
MOD_N-GLC_1	81	86	PF02516	0.739
MOD_N-GLC_2	35	37	PF02516	0.575
MOD_NEK2_1	166	171	PF00069	0.476
MOD_NEK2_1	197	202	PF00069	0.393
MOD_NEK2_1	2	7	PF00069	0.636
MOD_NEK2_1	452	457	PF00069	0.310
MOD_NEK2_1	479	484	PF00069	0.338
MOD_NEK2_1	583	588	PF00069	0.439
MOD_NEK2_1	590	595	PF00069	0.393
MOD_PIKK_1	211	217	PF00454	0.454
MOD_PIKK_1	352	358	PF00454	0.606
MOD_PIKK_1	402	408	PF00454	0.650
MOD_PIKK_1	560	566	PF00454	0.488
MOD_PIKK_1	596	602	PF00454	0.440
MOD_PKA_1	237	243	PF00069	0.625
MOD_PKA_2	237	243	PF00069	0.625
MOD_PKA_2	304	310	PF00069	0.679
MOD_PKA_2	417	423	PF00069	0.509
MOD_PKA_2	466	472	PF00069	0.489
MOD_PKA_2	86	92	PF00069	0.729
MOD_PKB_1	85	93	PF00069	0.651
MOD_Plk_1	11	17	PF00069	0.605
MOD_Plk_1	197	203	PF00069	0.497
MOD_Plk_1	211	217	PF00069	0.467
MOD_Plk_4	162	168	PF00069	0.411
MOD_Plk_4	187	193	PF00069	0.354
MOD_Plk_4	345	351	PF00069	0.481
MOD_Plk_4	36	42	PF00069	0.502
MOD_Plk_4	438	444	PF00069	0.313
MOD_Plk_4	502	508	PF00069	0.423
MOD_Plk_4	528	534	PF00069	0.296
MOD_Plk_4	590	596	PF00069	0.460
MOD_ProDKin_1	122	128	PF00069	0.626
MOD_ProDKin_1	19	25	PF00069	0.652
MOD_ProDKin_1	231	237	PF00069	0.474
MOD_ProDKin_1	244	250	PF00069	0.750
MOD_ProDKin_1	407	413	PF00069	0.609
MOD_ProDKin_1	53	59	PF00069	0.627
MOD_ProDKin_1	62	68	PF00069	0.591
MOD_ProDKin_1	72	78	PF00069	0.586
MOD_SUMO_for_1	524	527	PF00179	0.455
MOD_SUMO_rev_2	92	102	PF00179	0.575
TRG_DiLeu_BaEn_1	189	194	PF01217	0.456
TRG_DiLeu_BaEn_2	492	498	PF01217	0.291
TRG_DiLeu_BaLyEn_6	373	378	PF01217	0.557
TRG_ENDOCYTIC_2	521	524	PF00928	0.432
TRG_ENDOCYTIC_2	544	547	PF00928	0.482
TRG_ER_diArg_1	253	256	PF00400	0.592
TRG_ER_diArg_1	85	88	PF00400	0.539
TRG_NES_CRM1_1	334	347	PF08389	0.469
TRG_NES_CRM1_1	515	527	PF08389	0.357
TRG_NLS_MonoExtC_3	15	21	PF00514	0.613
TRG_NLS_MonoExtN_4	13	20	PF00514	0.653
TRG_Pf-PMV_PEXEL_1	113	118	PF00026	0.455
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.397
TRG_Pf-PMV_PEXEL_1	496	500	PF00026	0.253
TRG_Pf-PMV_PEXEL_1	569	573	PF00026	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA84	Leptomonas seymouri	58%	97%
A0A1X0NIY2	Trypanosomatidae	34%	100%
A0A3R7NI96	Trypanosoma rangeli	33%	100%
A0A3S7X8S7	Leishmania donovani	93%	99%
A4HM75	Leishmania braziliensis	76%	100%
A4IAT8	Leishmania infantum	93%	99%
E9AEL5	Leishmania major	90%	100%
V5BSU4	Trypanosoma cruzi	33%	100%