LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B5S3_LEIMU
TriTrypDb:
LmxM.34.0350
Length:
703

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B5S3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5S3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 175 179 PF00656 0.521
CLV_C14_Caspase3-7 457 461 PF00656 0.726
CLV_C14_Caspase3-7 68 72 PF00656 0.356
CLV_NRD_NRD_1 258 260 PF00675 0.551
CLV_NRD_NRD_1 335 337 PF00675 0.344
CLV_NRD_NRD_1 650 652 PF00675 0.453
CLV_NRD_NRD_1 669 671 PF00675 0.426
CLV_PCSK_FUR_1 648 652 PF00082 0.471
CLV_PCSK_KEX2_1 149 151 PF00082 0.510
CLV_PCSK_KEX2_1 258 260 PF00082 0.607
CLV_PCSK_KEX2_1 335 337 PF00082 0.361
CLV_PCSK_KEX2_1 650 652 PF00082 0.456
CLV_PCSK_KEX2_1 669 671 PF00082 0.425
CLV_PCSK_PC1ET2_1 149 151 PF00082 0.464
CLV_PCSK_PC1ET2_1 669 671 PF00082 0.425
CLV_PCSK_SKI1_1 240 244 PF00082 0.322
CLV_PCSK_SKI1_1 296 300 PF00082 0.489
CLV_PCSK_SKI1_1 413 417 PF00082 0.447
CLV_PCSK_SKI1_1 558 562 PF00082 0.363
CLV_PCSK_SKI1_1 586 590 PF00082 0.443
CLV_PCSK_SKI1_1 698 702 PF00082 0.283
DEG_APCC_DBOX_1 239 247 PF00400 0.331
DEG_APCC_DBOX_1 262 270 PF00400 0.335
DEG_MDM2_SWIB_1 627 635 PF02201 0.442
DOC_ANK_TNKS_1 155 162 PF00023 0.440
DOC_ANK_TNKS_1 287 294 PF00023 0.411
DOC_ANK_TNKS_1 604 611 PF00023 0.301
DOC_ANK_TNKS_1 649 656 PF00023 0.533
DOC_CYCLIN_yCln2_LP_2 98 104 PF00134 0.465
DOC_MAPK_DCC_7 118 126 PF00069 0.416
DOC_MAPK_FxFP_2 551 554 PF00069 0.315
DOC_MAPK_gen_1 258 266 PF00069 0.397
DOC_MAPK_gen_1 479 488 PF00069 0.533
DOC_MAPK_gen_1 669 681 PF00069 0.350
DOC_MAPK_MEF2A_6 118 126 PF00069 0.416
DOC_MAPK_MEF2A_6 258 266 PF00069 0.397
DOC_MAPK_MEF2A_6 629 637 PF00069 0.309
DOC_MAPK_MEF2A_6 674 681 PF00069 0.321
DOC_MAPK_NFAT4_5 259 267 PF00069 0.374
DOC_PP2B_LxvP_1 98 101 PF13499 0.451
DOC_PP4_FxxP_1 235 238 PF00568 0.434
DOC_PP4_FxxP_1 551 554 PF00568 0.322
DOC_USP7_MATH_1 10 14 PF00917 0.418
DOC_USP7_MATH_1 109 113 PF00917 0.472
DOC_USP7_MATH_1 188 192 PF00917 0.585
DOC_USP7_MATH_1 358 362 PF00917 0.570
DOC_USP7_MATH_1 516 520 PF00917 0.645
DOC_USP7_MATH_1 653 657 PF00917 0.413
DOC_WW_Pin1_4 105 110 PF00397 0.392
DOC_WW_Pin1_4 113 118 PF00397 0.432
DOC_WW_Pin1_4 179 184 PF00397 0.595
DOC_WW_Pin1_4 470 475 PF00397 0.628
LIG_14-3-3_CanoR_1 261 267 PF00244 0.461
LIG_14-3-3_CanoR_1 9 17 PF00244 0.369
LIG_Actin_WH2_2 250 265 PF00022 0.415
LIG_Actin_WH2_2 674 689 PF00022 0.396
LIG_APCC_ABBA_1 677 682 PF00400 0.305
LIG_BIR_II_1 1 5 PF00653 0.388
LIG_BIR_III_4 223 227 PF00653 0.390
LIG_BRCT_BRCA1_1 111 115 PF00533 0.459
LIG_BRCT_BRCA1_1 140 144 PF00533 0.500
LIG_BRCT_BRCA1_1 309 313 PF00533 0.389
LIG_BRCT_BRCA1_1 535 539 PF00533 0.341
LIG_CaM_IQ_9 148 164 PF13499 0.496
LIG_Clathr_ClatBox_1 123 127 PF01394 0.416
LIG_Clathr_ClatBox_1 33 37 PF01394 0.297
LIG_deltaCOP1_diTrp_1 362 368 PF00928 0.418
LIG_FHA_1 114 120 PF00498 0.600
LIG_FHA_1 354 360 PF00498 0.430
LIG_FHA_1 471 477 PF00498 0.489
LIG_FHA_1 526 532 PF00498 0.331
LIG_FHA_1 545 551 PF00498 0.342
LIG_FHA_1 567 573 PF00498 0.374
LIG_FHA_1 695 701 PF00498 0.379
LIG_FHA_1 76 82 PF00498 0.692
LIG_FHA_2 378 384 PF00498 0.642
LIG_FHA_2 385 391 PF00498 0.527
LIG_FHA_2 623 629 PF00498 0.319
LIG_FHA_2 82 88 PF00498 0.654
LIG_IBAR_NPY_1 612 614 PF08397 0.446
LIG_LIR_Apic_2 549 554 PF02991 0.316
LIG_LIR_Gen_1 133 139 PF02991 0.453
LIG_LIR_Gen_1 14 25 PF02991 0.243
LIG_LIR_Gen_1 191 198 PF02991 0.508
LIG_LIR_Gen_1 200 209 PF02991 0.455
LIG_LIR_Gen_1 362 373 PF02991 0.464
LIG_LIR_Gen_1 484 491 PF02991 0.487
LIG_LIR_Gen_1 49 58 PF02991 0.445
LIG_LIR_Gen_1 587 595 PF02991 0.425
LIG_LIR_Nem_3 14 20 PF02991 0.291
LIG_LIR_Nem_3 191 196 PF02991 0.527
LIG_LIR_Nem_3 200 205 PF02991 0.446
LIG_LIR_Nem_3 362 368 PF02991 0.386
LIG_LIR_Nem_3 484 488 PF02991 0.512
LIG_LIR_Nem_3 49 54 PF02991 0.437
LIG_LIR_Nem_3 555 560 PF02991 0.460
LIG_LIR_Nem_3 587 591 PF02991 0.433
LIG_LIR_Nem_3 97 102 PF02991 0.462
LIG_LYPXL_yS_3 553 556 PF13949 0.350
LIG_MYND_1 207 211 PF01753 0.382
LIG_PCNA_yPIPBox_3 685 698 PF02747 0.462
LIG_Pex14_1 193 197 PF04695 0.398
LIG_Pex14_1 231 235 PF04695 0.444
LIG_Pex14_2 198 202 PF04695 0.403
LIG_Pex14_2 627 631 PF04695 0.315
LIG_Pex14_2 692 696 PF04695 0.308
LIG_PTB_Apo_2 424 431 PF02174 0.324
LIG_PTB_Phospho_1 424 430 PF10480 0.323
LIG_REV1ctd_RIR_1 152 160 PF16727 0.477
LIG_SH2_NCK_1 431 435 PF00017 0.443
LIG_SH2_NCK_1 453 457 PF00017 0.569
LIG_SH2_PTP2 614 617 PF00017 0.473
LIG_SH2_STAP1 134 138 PF00017 0.276
LIG_SH2_STAP1 431 435 PF00017 0.443
LIG_SH2_STAT5 197 200 PF00017 0.369
LIG_SH2_STAT5 485 488 PF00017 0.482
LIG_SH2_STAT5 51 54 PF00017 0.329
LIG_SH2_STAT5 603 606 PF00017 0.306
LIG_SH2_STAT5 614 617 PF00017 0.341
LIG_SH2_STAT5 65 68 PF00017 0.435
LIG_SH3_3 116 122 PF00018 0.385
LIG_SH3_3 123 129 PF00018 0.677
LIG_SH3_3 180 186 PF00018 0.646
LIG_SH3_3 397 403 PF00018 0.355
LIG_SH3_3 493 499 PF00018 0.650
LIG_SH3_3 660 666 PF00018 0.388
LIG_SH3_3 98 104 PF00018 0.465
LIG_SUMO_SIM_anti_2 484 490 PF11976 0.512
LIG_SUMO_SIM_anti_2 587 593 PF11976 0.293
LIG_SUMO_SIM_par_1 122 127 PF11976 0.416
LIG_SUMO_SIM_par_1 31 37 PF11976 0.315
LIG_TRAF2_1 392 395 PF00917 0.313
LIG_TRAF2_1 504 507 PF00917 0.663
LIG_UBA3_1 208 216 PF00899 0.457
LIG_WRC_WIRS_1 624 629 PF05994 0.427
LIG_WW_3 237 241 PF00397 0.472
MOD_CDK_SPK_2 113 118 PF00069 0.459
MOD_CK1_1 191 197 PF00069 0.530
MOD_CK1_1 454 460 PF00069 0.611
MOD_CK1_1 519 525 PF00069 0.600
MOD_CK1_1 542 548 PF00069 0.464
MOD_CK1_1 622 628 PF00069 0.321
MOD_CK1_1 656 662 PF00069 0.432
MOD_CK1_1 69 75 PF00069 0.602
MOD_CK1_1 90 96 PF00069 0.658
MOD_CK2_1 212 218 PF00069 0.487
MOD_CK2_1 377 383 PF00069 0.473
MOD_CK2_1 384 390 PF00069 0.513
MOD_CK2_1 622 628 PF00069 0.321
MOD_GlcNHglycan 1 4 PF01048 0.403
MOD_GlcNHglycan 109 112 PF01048 0.460
MOD_GlcNHglycan 173 177 PF01048 0.661
MOD_GlcNHglycan 336 339 PF01048 0.427
MOD_GlcNHglycan 369 372 PF01048 0.476
MOD_GlcNHglycan 377 380 PF01048 0.504
MOD_GlcNHglycan 455 459 PF01048 0.595
MOD_GlcNHglycan 544 547 PF01048 0.464
MOD_GSK3_1 105 112 PF00069 0.419
MOD_GSK3_1 113 120 PF00069 0.462
MOD_GSK3_1 184 191 PF00069 0.715
MOD_GSK3_1 303 310 PF00069 0.448
MOD_GSK3_1 330 337 PF00069 0.450
MOD_GSK3_1 363 370 PF00069 0.439
MOD_GSK3_1 507 514 PF00069 0.621
MOD_GSK3_1 521 528 PF00069 0.424
MOD_GSK3_1 535 542 PF00069 0.357
MOD_GSK3_1 619 626 PF00069 0.400
MOD_GSK3_1 65 72 PF00069 0.549
MOD_GSK3_1 694 701 PF00069 0.259
MOD_N-GLC_2 374 376 PF02516 0.574
MOD_NEK2_1 1 6 PF00069 0.441
MOD_NEK2_1 132 137 PF00069 0.452
MOD_NEK2_1 16 21 PF00069 0.236
MOD_NEK2_1 212 217 PF00069 0.517
MOD_NEK2_1 262 267 PF00069 0.447
MOD_NEK2_1 425 430 PF00069 0.363
MOD_NEK2_1 539 544 PF00069 0.325
MOD_PIKK_1 280 286 PF00454 0.413
MOD_PIKK_1 539 545 PF00454 0.460
MOD_PKA_1 558 564 PF00069 0.398
MOD_PKA_2 262 268 PF00069 0.453
MOD_PKA_2 334 340 PF00069 0.496
MOD_PKA_2 69 75 PF00069 0.394
MOD_PKA_2 87 93 PF00069 0.625
MOD_PKB_1 446 454 PF00069 0.546
MOD_Plk_1 539 545 PF00069 0.460
MOD_Plk_1 622 628 PF00069 0.321
MOD_Plk_2-3 460 466 PF00069 0.741
MOD_Plk_2-3 623 629 PF00069 0.426
MOD_Plk_4 11 17 PF00069 0.315
MOD_Plk_4 132 138 PF00069 0.399
MOD_Plk_4 188 194 PF00069 0.661
MOD_Plk_4 262 268 PF00069 0.453
MOD_Plk_4 590 596 PF00069 0.342
MOD_Plk_4 69 75 PF00069 0.557
MOD_ProDKin_1 105 111 PF00069 0.389
MOD_ProDKin_1 113 119 PF00069 0.442
MOD_ProDKin_1 179 185 PF00069 0.594
MOD_ProDKin_1 470 476 PF00069 0.626
MOD_SUMO_for_1 198 201 PF00179 0.359
TRG_DiLeu_BaEn_1 587 592 PF01217 0.278
TRG_DiLeu_BaEn_4 200 206 PF01217 0.473
TRG_DiLeu_BaLyEn_6 204 209 PF01217 0.392
TRG_DiLeu_BaLyEn_6 400 405 PF01217 0.421
TRG_ENDOCYTIC_2 134 137 PF00928 0.336
TRG_ENDOCYTIC_2 485 488 PF00928 0.482
TRG_ENDOCYTIC_2 51 54 PF00928 0.442
TRG_ENDOCYTIC_2 553 556 PF00928 0.350
TRG_ER_diArg_1 257 259 PF00400 0.462
TRG_ER_diArg_1 260 263 PF00400 0.385
TRG_ER_diArg_1 334 336 PF00400 0.448
TRG_NLS_MonoExtN_4 666 673 PF00514 0.383

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HV24 Leptomonas seymouri 63% 95%
A0A1X0NJK7 Trypanosomatidae 41% 91%
A0A3Q8IHZ3 Leishmania donovani 91% 100%
A0A3R7L3P1 Trypanosoma rangeli 46% 100%
A4HM73 Leishmania braziliensis 82% 100%
A4IAT6 Leishmania infantum 91% 100%
D0A2C2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 100%
E9AEL2 Leishmania major 90% 100%
V5BSU8 Trypanosoma cruzi 45% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS