LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B5S2_LEIMU
TriTrypDb:
LmxM.34.0340
Length:
497

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 10
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 3
GO:0110165 cellular anatomical entity 1 3

Expansion

Sequence features

E9B5S2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5S2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 131 135 PF00656 0.672
CLV_C14_Caspase3-7 167 171 PF00656 0.574
CLV_MEL_PAP_1 311 317 PF00089 0.548
CLV_NRD_NRD_1 37 39 PF00675 0.584
CLV_NRD_NRD_1 471 473 PF00675 0.413
CLV_NRD_NRD_1 97 99 PF00675 0.635
CLV_PCSK_FUR_1 35 39 PF00082 0.592
CLV_PCSK_FUR_1 95 99 PF00082 0.600
CLV_PCSK_KEX2_1 368 370 PF00082 0.508
CLV_PCSK_KEX2_1 37 39 PF00082 0.581
CLV_PCSK_KEX2_1 418 420 PF00082 0.512
CLV_PCSK_KEX2_1 471 473 PF00082 0.400
CLV_PCSK_KEX2_1 97 99 PF00082 0.594
CLV_PCSK_PC1ET2_1 368 370 PF00082 0.586
CLV_PCSK_PC1ET2_1 418 420 PF00082 0.487
CLV_PCSK_PC7_1 467 473 PF00082 0.409
CLV_PCSK_SKI1_1 130 134 PF00082 0.724
CLV_PCSK_SKI1_1 180 184 PF00082 0.616
CLV_PCSK_SKI1_1 222 226 PF00082 0.339
CLV_PCSK_SKI1_1 285 289 PF00082 0.571
CLV_PCSK_SKI1_1 467 471 PF00082 0.496
DEG_APCC_DBOX_1 179 187 PF00400 0.539
DEG_APCC_DBOX_1 200 208 PF00400 0.558
DOC_ANK_TNKS_1 183 190 PF00023 0.656
DOC_CDC14_PxL_1 215 223 PF14671 0.374
DOC_CDC14_PxL_1 5 13 PF14671 0.690
DOC_CKS1_1 356 361 PF01111 0.666
DOC_CYCLIN_RxL_1 219 226 PF00134 0.410
DOC_CYCLIN_RxL_1 368 379 PF00134 0.540
DOC_MAPK_gen_1 261 270 PF00069 0.431
DOC_MAPK_gen_1 35 43 PF00069 0.550
DOC_MAPK_gen_1 368 378 PF00069 0.419
DOC_MAPK_gen_1 62 70 PF00069 0.528
DOC_MAPK_MEF2A_6 368 377 PF00069 0.426
DOC_PP1_RVXF_1 465 471 PF00149 0.477
DOC_PP2B_LxvP_1 216 219 PF13499 0.382
DOC_PP2B_LxvP_1 229 232 PF13499 0.330
DOC_PP4_FxxP_1 411 414 PF00568 0.372
DOC_PP4_FxxP_1 6 9 PF00568 0.616
DOC_PP4_FxxP_1 73 76 PF00568 0.403
DOC_USP7_MATH_1 121 125 PF00917 0.696
DOC_USP7_MATH_1 132 136 PF00917 0.659
DOC_USP7_MATH_1 151 155 PF00917 0.422
DOC_USP7_MATH_1 176 180 PF00917 0.688
DOC_USP7_MATH_1 208 212 PF00917 0.415
DOC_USP7_MATH_1 333 337 PF00917 0.451
DOC_USP7_MATH_1 363 367 PF00917 0.461
DOC_USP7_MATH_1 389 393 PF00917 0.405
DOC_USP7_MATH_1 439 443 PF00917 0.541
DOC_USP7_MATH_1 452 456 PF00917 0.584
DOC_WW_Pin1_4 345 350 PF00397 0.568
DOC_WW_Pin1_4 355 360 PF00397 0.468
DOC_WW_Pin1_4 82 87 PF00397 0.402
LIG_14-3-3_CanoR_1 166 170 PF00244 0.387
LIG_14-3-3_CanoR_1 201 205 PF00244 0.535
LIG_14-3-3_CanoR_1 222 232 PF00244 0.356
LIG_14-3-3_CanoR_1 400 406 PF00244 0.399
LIG_AP2alpha_1 377 381 PF02296 0.371
LIG_AP2alpha_1 99 103 PF02296 0.392
LIG_BRCT_BRCA1_1 391 395 PF00533 0.378
LIG_BRCT_BRCA1_1 424 428 PF00533 0.233
LIG_BRCT_BRCA1_1 99 103 PF00533 0.678
LIG_Clathr_ClatBox_1 375 379 PF01394 0.438
LIG_FHA_1 105 111 PF00498 0.651
LIG_FHA_1 139 145 PF00498 0.593
LIG_FHA_1 21 27 PF00498 0.505
LIG_FHA_1 288 294 PF00498 0.553
LIG_FHA_2 165 171 PF00498 0.557
LIG_FHA_2 389 395 PF00498 0.501
LIG_LIR_Apic_2 3 9 PF02991 0.647
LIG_LIR_Apic_2 431 437 PF02991 0.253
LIG_LIR_Apic_2 477 483 PF02991 0.519
LIG_LIR_Apic_2 72 76 PF02991 0.397
LIG_LIR_Gen_1 153 163 PF02991 0.410
LIG_LIR_Gen_1 226 235 PF02991 0.404
LIG_LIR_Gen_1 266 275 PF02991 0.216
LIG_LIR_Gen_1 374 382 PF02991 0.380
LIG_LIR_Gen_1 392 403 PF02991 0.385
LIG_LIR_LC3C_4 124 129 PF02991 0.557
LIG_LIR_Nem_3 153 159 PF02991 0.498
LIG_LIR_Nem_3 226 231 PF02991 0.376
LIG_LIR_Nem_3 266 270 PF02991 0.217
LIG_LIR_Nem_3 3 8 PF02991 0.623
LIG_LIR_Nem_3 374 380 PF02991 0.363
LIG_LIR_Nem_3 392 398 PF02991 0.390
LIG_LIR_Nem_3 72 77 PF02991 0.464
LIG_NRBOX 220 226 PF00104 0.377
LIG_PCNA_yPIPBox_3 276 288 PF02747 0.536
LIG_Pex14_2 377 381 PF04695 0.371
LIG_Pex14_2 99 103 PF04695 0.489
LIG_REV1ctd_RIR_1 3 8 PF16727 0.584
LIG_SH2_CRK 156 160 PF00017 0.504
LIG_SH2_CRK 434 438 PF00017 0.476
LIG_SH2_CRK 480 484 PF00017 0.475
LIG_SH2_NCK_1 484 488 PF00017 0.419
LIG_SH2_SRC 74 77 PF00017 0.528
LIG_SH2_STAP1 156 160 PF00017 0.504
LIG_SH2_STAT5 215 218 PF00017 0.365
LIG_SH2_STAT5 220 223 PF00017 0.342
LIG_SH2_STAT5 257 260 PF00017 0.445
LIG_SH2_STAT5 303 306 PF00017 0.447
LIG_SH2_STAT5 310 313 PF00017 0.441
LIG_SH2_STAT5 4 7 PF00017 0.580
LIG_SH2_STAT5 74 77 PF00017 0.426
LIG_SH3_3 157 163 PF00018 0.505
LIG_SH3_3 455 461 PF00018 0.378
LIG_SUMO_SIM_par_1 22 28 PF11976 0.597
LIG_TRFH_1 228 232 PF08558 0.367
LIG_WRC_WIRS_1 70 75 PF05994 0.503
MOD_CDK_SPxxK_3 345 352 PF00069 0.405
MOD_CK1_1 104 110 PF00069 0.589
MOD_CK1_1 165 171 PF00069 0.574
MOD_CK2_1 388 394 PF00069 0.542
MOD_CK2_1 438 444 PF00069 0.543
MOD_CMANNOS 494 497 PF00535 0.451
MOD_GlcNHglycan 111 114 PF01048 0.658
MOD_GlcNHglycan 170 174 PF01048 0.620
MOD_GlcNHglycan 225 228 PF01048 0.355
MOD_GlcNHglycan 27 30 PF01048 0.545
MOD_GlcNHglycan 335 338 PF01048 0.685
MOD_GlcNHglycan 340 343 PF01048 0.594
MOD_GlcNHglycan 365 368 PF01048 0.595
MOD_GlcNHglycan 45 48 PF01048 0.330
MOD_GlcNHglycan 454 457 PF01048 0.636
MOD_GlcNHglycan 53 57 PF01048 0.482
MOD_GSK3_1 109 116 PF00069 0.585
MOD_GSK3_1 161 168 PF00069 0.503
MOD_GSK3_1 351 358 PF00069 0.605
MOD_GSK3_1 381 388 PF00069 0.545
MOD_GSK3_1 45 52 PF00069 0.605
MOD_GSK3_1 78 85 PF00069 0.536
MOD_GSK3_1 97 104 PF00069 0.614
MOD_N-GLC_1 104 109 PF02516 0.616
MOD_NEK2_1 25 30 PF00069 0.595
MOD_NEK2_1 287 292 PF00069 0.548
MOD_NEK2_1 33 38 PF00069 0.592
MOD_NEK2_1 351 356 PF00069 0.647
MOD_NEK2_2 14 19 PF00069 0.589
MOD_NEK2_2 401 406 PF00069 0.236
MOD_PIKK_1 233 239 PF00454 0.469
MOD_PKA_1 97 103 PF00069 0.605
MOD_PKA_2 165 171 PF00069 0.690
MOD_PKA_2 200 206 PF00069 0.533
MOD_PKA_2 351 357 PF00069 0.607
MOD_PKA_2 399 405 PF00069 0.515
MOD_PKA_2 422 428 PF00069 0.483
MOD_PKA_2 97 103 PF00069 0.651
MOD_PKB_1 95 103 PF00069 0.501
MOD_Plk_4 14 20 PF00069 0.638
MOD_Plk_4 200 206 PF00069 0.492
MOD_Plk_4 88 94 PF00069 0.638
MOD_ProDKin_1 345 351 PF00069 0.558
MOD_ProDKin_1 355 361 PF00069 0.468
MOD_ProDKin_1 82 88 PF00069 0.403
MOD_SUMO_for_1 50 53 PF00179 0.578
TRG_DiLeu_BaLyEn_6 139 144 PF01217 0.608
TRG_DiLeu_BaLyEn_6 464 469 PF01217 0.475
TRG_ENDOCYTIC_2 156 159 PF00928 0.378
TRG_ENDOCYTIC_2 220 223 PF00928 0.381
TRG_ENDOCYTIC_2 74 77 PF00928 0.449
TRG_ER_diArg_1 34 37 PF00400 0.510
TRG_ER_diArg_1 470 472 PF00400 0.412
TRG_ER_diArg_1 95 98 PF00400 0.625
TRG_NES_CRM1_1 372 385 PF08389 0.511
TRG_Pf-PMV_PEXEL_1 180 185 PF00026 0.563

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3M2 Leptomonas seymouri 59% 95%
A0A0S4JN24 Bodo saltans 33% 100%
A0A1X0NKI9 Trypanosomatidae 41% 100%
A0A3Q8ILR1 Leishmania donovani 90% 100%
A0A3R7NSD3 Trypanosoma rangeli 44% 100%
A4HM72 Leishmania braziliensis 80% 100%
A4IAT5 Leishmania infantum 90% 100%
D0A2C3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 96%
E9AEL1 Leishmania major 91% 100%
V5BIP8 Trypanosoma cruzi 41% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS