LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B5R8_LEIMU
TriTrypDb:
LmxM.34.0300
Length:
332

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B5R8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5R8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 125 129 PF00656 0.538
CLV_C14_Caspase3-7 40 44 PF00656 0.666
CLV_NRD_NRD_1 283 285 PF00675 0.636
CLV_NRD_NRD_1 328 330 PF00675 0.528
CLV_NRD_NRD_1 52 54 PF00675 0.631
CLV_PCSK_KEX2_1 258 260 PF00082 0.574
CLV_PCSK_KEX2_1 282 284 PF00082 0.491
CLV_PCSK_KEX2_1 328 330 PF00082 0.528
CLV_PCSK_KEX2_1 54 56 PF00082 0.635
CLV_PCSK_PC1ET2_1 258 260 PF00082 0.574
CLV_PCSK_PC1ET2_1 282 284 PF00082 0.491
CLV_PCSK_PC1ET2_1 54 56 PF00082 0.635
CLV_PCSK_SKI1_1 109 113 PF00082 0.498
CLV_PCSK_SKI1_1 127 131 PF00082 0.565
CLV_PCSK_SKI1_1 283 287 PF00082 0.482
DOC_MAPK_gen_1 258 265 PF00069 0.575
DOC_USP7_MATH_1 171 175 PF00917 0.749
DOC_USP7_MATH_1 190 194 PF00917 0.700
DOC_USP7_MATH_1 195 199 PF00917 0.714
DOC_USP7_MATH_1 38 42 PF00917 0.636
DOC_USP7_MATH_1 88 92 PF00917 0.599
DOC_USP7_UBL2_3 109 113 PF12436 0.494
DOC_USP7_UBL2_3 282 286 PF12436 0.478
DOC_WW_Pin1_4 160 165 PF00397 0.592
DOC_WW_Pin1_4 63 68 PF00397 0.558
LIG_14-3-3_CanoR_1 238 247 PF00244 0.690
LIG_14-3-3_CanoR_1 309 319 PF00244 0.546
LIG_BIR_III_4 128 132 PF00653 0.568
LIG_BRCT_BRCA1_1 107 111 PF00533 0.575
LIG_BRCT_BRCA1_1 30 34 PF00533 0.687
LIG_BRCT_BRCA1_1 65 69 PF00533 0.567
LIG_BRCT_BRCA1_2 107 113 PF00533 0.577
LIG_CaM_IQ_9 45 60 PF13499 0.547
LIG_FHA_1 2 8 PF00498 0.696
LIG_FHA_1 221 227 PF00498 0.783
LIG_FHA_1 25 31 PF00498 0.603
LIG_FHA_1 265 271 PF00498 0.642
LIG_FHA_2 123 129 PF00498 0.517
LIG_FHA_2 27 33 PF00498 0.653
LIG_FHA_2 270 276 PF00498 0.543
LIG_LIR_Nem_3 145 150 PF02991 0.461
LIG_LIR_Nem_3 293 299 PF02991 0.570
LIG_LIR_Nem_3 31 37 PF02991 0.687
LIG_LIR_Nem_3 313 319 PF02991 0.278
LIG_MAD2 156 164 PF02301 0.623
LIG_Pex14_2 292 296 PF04695 0.447
LIG_SH2_CRK 299 303 PF00017 0.614
LIG_SH2_STAT3 136 139 PF00017 0.636
LIG_SH3_3 4 10 PF00018 0.581
LIG_SH3_3 91 97 PF00018 0.622
MOD_CK1_1 101 107 PF00069 0.616
MOD_CK1_1 142 148 PF00069 0.525
MOD_CK1_1 193 199 PF00069 0.724
MOD_CK1_1 205 211 PF00069 0.747
MOD_CK1_1 242 248 PF00069 0.518
MOD_CK1_1 41 47 PF00069 0.540
MOD_CK2_1 142 148 PF00069 0.525
MOD_CK2_1 269 275 PF00069 0.565
MOD_CK2_1 291 297 PF00069 0.502
MOD_DYRK1A_RPxSP_1 63 67 PF00069 0.594
MOD_GlcNHglycan 193 196 PF01048 0.754
MOD_GlcNHglycan 197 200 PF01048 0.676
MOD_GlcNHglycan 212 215 PF01048 0.674
MOD_GlcNHglycan 226 229 PF01048 0.611
MOD_GlcNHglycan 241 244 PF01048 0.586
MOD_GlcNHglycan 251 254 PF01048 0.605
MOD_GlcNHglycan 90 93 PF01048 0.602
MOD_GSK3_1 101 108 PF00069 0.555
MOD_GSK3_1 167 174 PF00069 0.710
MOD_GSK3_1 191 198 PF00069 0.788
MOD_GSK3_1 20 27 PF00069 0.442
MOD_GSK3_1 204 211 PF00069 0.693
MOD_GSK3_1 216 223 PF00069 0.647
MOD_GSK3_1 238 245 PF00069 0.523
MOD_GSK3_1 264 271 PF00069 0.609
MOD_GSK3_1 37 44 PF00069 0.543
MOD_N-GLC_1 268 273 PF02516 0.376
MOD_NEK2_1 210 215 PF00069 0.728
MOD_NEK2_1 226 231 PF00069 0.785
MOD_NEK2_1 24 29 PF00069 0.599
MOD_NEK2_1 249 254 PF00069 0.558
MOD_NEK2_1 69 74 PF00069 0.470
MOD_NEK2_2 122 127 PF00069 0.540
MOD_PIKK_1 13 19 PF00454 0.505
MOD_PIKK_1 179 185 PF00454 0.679
MOD_PIKK_1 22 28 PF00454 0.430
MOD_PIKK_1 69 75 PF00454 0.548
MOD_PKA_2 101 107 PF00069 0.640
MOD_PKA_2 150 156 PF00069 0.517
MOD_PKA_2 208 214 PF00069 0.711
MOD_Plk_1 122 128 PF00069 0.550
MOD_Plk_1 171 177 PF00069 0.629
MOD_Plk_1 20 26 PF00069 0.644
MOD_Plk_1 205 211 PF00069 0.777
MOD_Plk_1 268 274 PF00069 0.579
MOD_Plk_1 56 62 PF00069 0.610
MOD_Plk_4 2 8 PF00069 0.609
MOD_ProDKin_1 160 166 PF00069 0.596
MOD_ProDKin_1 63 69 PF00069 0.553
MOD_SUMO_for_1 322 325 PF00179 0.457
MOD_SUMO_rev_2 134 142 PF00179 0.589
TRG_DiLeu_BaLyEn_6 7 12 PF01217 0.376
TRG_ENDOCYTIC_2 299 302 PF00928 0.614
TRG_ENDOCYTIC_2 319 322 PF00928 0.263
TRG_ER_diArg_1 283 285 PF00400 0.543
TRG_ER_diArg_1 53 56 PF00400 0.525
TRG_NES_CRM1_1 255 268 PF08389 0.641
TRG_Pf-PMV_PEXEL_1 144 148 PF00026 0.542
TRG_Pf-PMV_PEXEL_1 283 287 PF00026 0.575

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I316 Leptomonas seymouri 73% 100%
A0A1X0NJS6 Trypanosomatidae 38% 82%
A0A3Q8IFZ2 Leishmania donovani 93% 100%
A0A3R7MJB6 Trypanosoma rangeli 38% 94%
A4HM69 Leishmania braziliensis 81% 92%
A4IAT1 Leishmania infantum 93% 100%
D0A2C8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 100%
E9AEK7 Leishmania major 95% 100%
V5BSV2 Trypanosoma cruzi 39% 95%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS