LeishMANIAdb
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TMhelix containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
TMhelix containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B5R5_LEIMU
TriTrypDb:
LmxM.34.0270
Length:
77

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0016020 membrane 2 7
GO:0110165 cellular anatomical entity 1 7

Expansion

Sequence features

E9B5R5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5R5

Putative motif mimicry

Leishmania From To Domain/Motif Score
DEG_MDM2_SWIB_1 7 14 PF02201 0.210
DEG_Nend_Nbox_1 1 3 PF02207 0.666
DOC_USP7_MATH_1 45 49 PF00917 0.501
DOC_USP7_MATH_1 68 72 PF00917 0.629
DOC_USP7_UBL2_3 69 73 PF12436 0.606
LIG_Actin_WH2_2 49 67 PF00022 0.430
LIG_CtBP_PxDLS_1 28 32 PF00389 0.323
LIG_FHA_1 17 23 PF00498 0.355
LIG_LIR_Gen_1 19 28 PF02991 0.581
LIG_LIR_Gen_1 4 15 PF02991 0.454
LIG_LIR_Nem_3 19 23 PF02991 0.355
LIG_LIR_Nem_3 4 10 PF02991 0.556
LIG_Pex14_2 7 11 PF04695 0.410
LIG_SUMO_SIM_par_1 27 33 PF11976 0.394
LIG_WRC_WIRS_1 17 22 PF05994 0.376
MOD_CK1_1 16 22 PF00069 0.430
MOD_GlcNHglycan 47 50 PF01048 0.501
MOD_GSK3_1 68 75 PF00069 0.634
MOD_NEK2_1 1 6 PF00069 0.693
MOD_NEK2_1 13 18 PF00069 0.430
MOD_NEK2_2 68 73 PF00069 0.546
MOD_Plk_4 13 19 PF00069 0.379
MOD_Plk_4 6 12 PF00069 0.210
TRG_DiLeu_BaLyEn_6 50 55 PF01217 0.385

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P608 Leptomonas seymouri 63% 100%
A0A3Q8IIN9 Leishmania donovani 90% 100%
A4HM66 Leishmania braziliensis 77% 100%
A4IAS8 Leishmania infantum 90% 100%
D0A2D0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 97%
E9AEK4 Leishmania major 88% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS