Putative GTP-ase activating protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GTP-ase activating protein, putative

Species:

Leishmania mexicana

UniProt:

E9B5R4_LEIMU

TriTrypDb:

LmxM.34.0260

Length:

626

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B5R4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5R4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	10
GO:0005488	binding	1	10
GO:0005543	phospholipid binding	3	10
GO:0008047	enzyme activator activity	3	10
GO:0008289	lipid binding	2	10
GO:0030234	enzyme regulator activity	2	10
GO:0030695	GTPase regulator activity	4	10
GO:0060589	nucleoside-triphosphatase regulator activity	3	10
GO:0098772	molecular function regulator activity	1	10
GO:0140677	molecular function activator activity	2	10
GO:0003824	catalytic activity	1	4
GO:0003924	GTPase activity	7	4
GO:0003925	G protein activity	2	4
GO:0016462	pyrophosphatase activity	5	4
GO:0016787	hydrolase activity	2	4
GO:0016817	hydrolase activity, acting on acid anhydrides	3	4
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	4
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	171	173	PF00675	0.479
CLV_NRD_NRD_1	242	244	PF00675	0.680
CLV_NRD_NRD_1	245	247	PF00675	0.699
CLV_NRD_NRD_1	265	267	PF00675	0.770
CLV_NRD_NRD_1	28	30	PF00675	0.472
CLV_NRD_NRD_1	350	352	PF00675	0.439
CLV_NRD_NRD_1	435	437	PF00675	0.659
CLV_PCSK_FUR_1	243	247	PF00082	0.529
CLV_PCSK_KEX2_1	244	246	PF00082	0.680
CLV_PCSK_KEX2_1	28	30	PF00082	0.465
CLV_PCSK_KEX2_1	434	436	PF00082	0.485
CLV_PCSK_PC1ET2_1	244	246	PF00082	0.680
CLV_PCSK_SKI1_1	138	142	PF00082	0.394
CLV_PCSK_SKI1_1	408	412	PF00082	0.408
CLV_PCSK_SKI1_1	533	537	PF00082	0.630
CLV_PCSK_SKI1_1	76	80	PF00082	0.499
DEG_Nend_UBRbox_2	1	3	PF02207	0.660
DEG_SPOP_SBC_1	119	123	PF00917	0.478
DOC_MAPK_gen_1	172	179	PF00069	0.476
DOC_MAPK_gen_1	424	432	PF00069	0.485
DOC_MAPK_gen_1	51	59	PF00069	0.492
DOC_MAPK_MEF2A_6	495	504	PF00069	0.509
DOC_MAPK_RevD_3	228	244	PF00069	0.568
DOC_PP1_RVXF_1	136	143	PF00149	0.420
DOC_PP1_RVXF_1	593	599	PF00149	0.621
DOC_PP1_RVXF_1	74	81	PF00149	0.473
DOC_PP2B_LxvP_1	444	447	PF13499	0.690
DOC_PP4_FxxP_1	42	45	PF00568	0.465
DOC_USP7_MATH_1	115	119	PF00917	0.749
DOC_USP7_MATH_1	328	332	PF00917	0.444
DOC_USP7_MATH_1	393	397	PF00917	0.381
DOC_USP7_MATH_1	45	49	PF00917	0.483
DOC_USP7_MATH_1	586	590	PF00917	0.568
DOC_WW_Pin1_4	186	191	PF00397	0.485
DOC_WW_Pin1_4	250	255	PF00397	0.612
DOC_WW_Pin1_4	303	308	PF00397	0.461
LIG_14-3-3_CanoR_1	22	28	PF00244	0.600
LIG_14-3-3_CanoR_1	266	275	PF00244	0.622
LIG_14-3-3_CanoR_1	539	548	PF00244	0.568
LIG_APCC_ABBAyCdc20_2	54	60	PF00400	0.560
LIG_BRCT_BRCA1_1	395	399	PF00533	0.484
LIG_BRCT_BRCA1_1	588	592	PF00533	0.541
LIG_deltaCOP1_diTrp_1	364	373	PF00928	0.344
LIG_deltaCOP1_diTrp_1	576	584	PF00928	0.548
LIG_deltaCOP1_diTrp_1	612	618	PF00928	0.557
LIG_EVH1_1	444	448	PF00568	0.712
LIG_FHA_1	119	125	PF00498	0.722
LIG_FHA_1	163	169	PF00498	0.721
LIG_FHA_1	22	28	PF00498	0.463
LIG_FHA_1	392	398	PF00498	0.456
LIG_FHA_1	439	445	PF00498	0.670
LIG_FHA_1	477	483	PF00498	0.459
LIG_FHA_1	6	12	PF00498	0.452
LIG_FHA_2	267	273	PF00498	0.717
LIG_FHA_2	540	546	PF00498	0.455
LIG_FHA_2	607	613	PF00498	0.704
LIG_KLC1_Yacidic_2	55	60	PF13176	0.559
LIG_LIR_Gen_1	236	242	PF02991	0.688
LIG_LIR_Gen_1	331	340	PF02991	0.344
LIG_LIR_Gen_1	387	397	PF02991	0.444
LIG_LIR_Gen_1	521	531	PF02991	0.439
LIG_LIR_Gen_1	620	626	PF02991	0.551
LIG_LIR_Nem_3	152	158	PF02991	0.595
LIG_LIR_Nem_3	236	240	PF02991	0.614
LIG_LIR_Nem_3	331	335	PF02991	0.328
LIG_LIR_Nem_3	387	392	PF02991	0.333
LIG_LIR_Nem_3	521	527	PF02991	0.426
LIG_LIR_Nem_3	620	625	PF02991	0.441
LIG_LYPXL_SIV_4	69	77	PF13949	0.532
LIG_LYPXL_yS_3	155	158	PF13949	0.443
LIG_MYND_1	156	160	PF01753	0.460
LIG_NRBOX	5	11	PF00104	0.378
LIG_Pex14_1	614	618	PF04695	0.527
LIG_PTB_Apo_2	123	130	PF02174	0.614
LIG_PTB_Apo_2	80	87	PF02174	0.614
LIG_PTB_Phospho_1	123	129	PF10480	0.633
LIG_PTB_Phospho_1	80	86	PF10480	0.608
LIG_Rb_LxCxE_1	35	48	PF01857	0.533
LIG_REV1ctd_RIR_1	429	437	PF16727	0.408
LIG_SH2_CRK	496	500	PF00017	0.524
LIG_SH2_CRK	561	565	PF00017	0.495
LIG_SH2_CRK	622	626	PF00017	0.567
LIG_SH2_NCK_1	70	74	PF00017	0.607
LIG_SH2_PTP2	389	392	PF00017	0.408
LIG_SH2_SRC	58	61	PF00017	0.574
LIG_SH2_STAP1	309	313	PF00017	0.525
LIG_SH2_STAP1	427	431	PF00017	0.444
LIG_SH2_STAP1	86	90	PF00017	0.633
LIG_SH2_STAT3	129	132	PF00017	0.523
LIG_SH2_STAT5	129	132	PF00017	0.443
LIG_SH2_STAT5	389	392	PF00017	0.373
LIG_SH2_STAT5	40	43	PF00017	0.414
LIG_SH2_STAT5	561	564	PF00017	0.401
LIG_SH2_STAT5	58	61	PF00017	0.531
LIG_SH2_STAT5	99	102	PF00017	0.655
LIG_SH3_1	442	448	PF00018	0.694
LIG_SH3_3	207	213	PF00018	0.522
LIG_SH3_3	252	258	PF00018	0.726
LIG_SH3_3	387	393	PF00018	0.416
LIG_SH3_3	442	448	PF00018	0.655
LIG_SH3_3	580	586	PF00018	0.490
LIG_SH3_4	316	323	PF00018	0.444
LIG_SUMO_SIM_anti_2	215	224	PF11976	0.719
LIG_SUMO_SIM_anti_2	87	94	PF11976	0.628
LIG_SUMO_SIM_par_1	163	170	PF11976	0.467
LIG_SUMO_SIM_par_1	29	35	PF11976	0.375
LIG_SUMO_SIM_par_1	7	12	PF11976	0.407
LIG_TRAF2_1	239	242	PF00917	0.686
LIG_UBA3_1	144	153	PF00899	0.573
LIG_UBA3_1	499	505	PF00899	0.559
LIG_WRC_WIRS_1	410	415	PF05994	0.444
LIG_WW_1	493	496	PF00397	0.476
LIG_WW_3	492	496	PF00397	0.473
MOD_CK1_1	118	124	PF00069	0.648
MOD_CK1_1	189	195	PF00069	0.669
MOD_CK1_1	204	210	PF00069	0.691
MOD_CK1_1	21	27	PF00069	0.651
MOD_CK1_1	217	223	PF00069	0.679
MOD_CK1_1	412	418	PF00069	0.444
MOD_CK1_1	472	478	PF00069	0.740
MOD_CK1_1	606	612	PF00069	0.702
MOD_CK2_1	220	226	PF00069	0.616
MOD_CK2_1	366	372	PF00069	0.477
MOD_CK2_1	411	417	PF00069	0.401
MOD_CK2_1	462	468	PF00069	0.724
MOD_CK2_1	606	612	PF00069	0.716
MOD_GlcNHglycan	11	14	PF01048	0.360
MOD_GlcNHglycan	117	120	PF01048	0.611
MOD_GlcNHglycan	191	194	PF01048	0.681
MOD_GlcNHglycan	206	209	PF01048	0.770
MOD_GlcNHglycan	216	219	PF01048	0.717
MOD_GlcNHglycan	359	362	PF01048	0.441
MOD_GlcNHglycan	414	417	PF01048	0.436
MOD_GSK3_1	113	120	PF00069	0.663
MOD_GSK3_1	162	169	PF00069	0.693
MOD_GSK3_1	182	189	PF00069	0.636
MOD_GSK3_1	197	204	PF00069	0.680
MOD_GSK3_1	23	30	PF00069	0.467
MOD_GSK3_1	246	253	PF00069	0.487
MOD_GSK3_1	290	297	PF00069	0.639
MOD_GSK3_1	393	400	PF00069	0.452
MOD_GSK3_1	436	443	PF00069	0.623
MOD_GSK3_1	453	460	PF00069	0.771
MOD_GSK3_1	472	479	PF00069	0.486
MOD_GSK3_1	5	12	PF00069	0.453
MOD_GSK3_1	614	621	PF00069	0.499
MOD_LATS_1	212	218	PF00433	0.768
MOD_LATS_1	350	356	PF00433	0.441
MOD_LATS_1	537	543	PF00433	0.590
MOD_N-GLC_1	461	466	PF02516	0.513
MOD_N-GLC_1	469	474	PF02516	0.478
MOD_N-GLC_2	356	358	PF02516	0.444
MOD_NEK2_1	166	171	PF00069	0.638
MOD_NEK2_1	411	416	PF00069	0.500
MOD_NEK2_1	430	435	PF00069	0.245
MOD_NEK2_1	453	458	PF00069	0.726
MOD_NEK2_1	476	481	PF00069	0.503
MOD_NEK2_1	538	543	PF00069	0.578
MOD_NEK2_1	560	565	PF00069	0.538
MOD_NEK2_1	591	596	PF00069	0.515
MOD_NEK2_1	618	623	PF00069	0.421
MOD_NEK2_2	175	180	PF00069	0.552
MOD_NEK2_2	23	28	PF00069	0.571
MOD_NEK2_2	523	528	PF00069	0.537
MOD_PIKK_1	113	119	PF00454	0.611
MOD_PIKK_1	201	207	PF00454	0.520
MOD_PIKK_1	400	406	PF00454	0.439
MOD_PIKK_1	526	532	PF00454	0.547
MOD_PIKK_1	603	609	PF00454	0.696
MOD_PKA_1	266	272	PF00069	0.630
MOD_PKA_1	603	609	PF00069	0.664
MOD_PKA_2	149	155	PF00069	0.634
MOD_PKA_2	161	167	PF00069	0.461
MOD_PKA_2	21	27	PF00069	0.595
MOD_PKA_2	265	271	PF00069	0.788
MOD_PKA_2	418	424	PF00069	0.444
MOD_PKA_2	538	544	PF00069	0.571
MOD_PKB_1	434	442	PF00069	0.686
MOD_PKB_1	455	463	PF00069	0.767
MOD_Plk_1	162	168	PF00069	0.699
MOD_Plk_1	2	8	PF00069	0.481
MOD_Plk_1	453	459	PF00069	0.765
MOD_Plk_1	472	478	PF00069	0.560
MOD_Plk_2-3	2	8	PF00069	0.592
MOD_Plk_4	246	252	PF00069	0.537
MOD_Plk_4	393	399	PF00069	0.194
MOD_Plk_4	418	424	PF00069	0.444
MOD_Plk_4	483	489	PF00069	0.713
MOD_Plk_4	5	11	PF00069	0.460
MOD_Plk_4	560	566	PF00069	0.503
MOD_ProDKin_1	186	192	PF00069	0.486
MOD_ProDKin_1	250	256	PF00069	0.615
MOD_ProDKin_1	303	309	PF00069	0.458
MOD_SUMO_for_1	258	261	PF00179	0.771
MOD_SUMO_rev_2	43	48	PF00179	0.539
TRG_DiLeu_BaEn_1	531	536	PF01217	0.642
TRG_DiLeu_BaEn_1	88	93	PF01217	0.629
TRG_DiLeu_BaLyEn_6	140	145	PF01217	0.484
TRG_DiLeu_BaLyEn_6	73	78	PF01217	0.555
TRG_ENDOCYTIC_2	155	158	PF00928	0.650
TRG_ENDOCYTIC_2	237	240	PF00928	0.611
TRG_ENDOCYTIC_2	389	392	PF00928	0.369
TRG_ENDOCYTIC_2	427	430	PF00928	0.485
TRG_ENDOCYTIC_2	496	499	PF00928	0.431
TRG_ENDOCYTIC_2	561	564	PF00928	0.421
TRG_ENDOCYTIC_2	622	625	PF00928	0.485
TRG_ER_diArg_1	243	246	PF00400	0.630
TRG_ER_diArg_1	27	29	PF00400	0.485
TRG_ER_diArg_1	434	436	PF00400	0.485
TRG_ER_diArg_1	455	458	PF00400	0.811
TRG_ER_diArg_1	565	568	PF00400	0.597
TRG_NLS_MonoExtN_4	243	248	PF00514	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYE2	Leptomonas seymouri	59%	100%
A0A1X0NIZ1	Trypanosomatidae	35%	100%
A0A3S5IRI6	Trypanosoma rangeli	34%	100%
A0A3S7X8N7	Leishmania donovani	90%	100%
A4HM65	Leishmania braziliensis	79%	100%
A4IAS7	Leishmania infantum	89%	100%
E9AEK3	Leishmania major	89%	100%
V5B380	Trypanosoma cruzi	34%	100%