C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B5R1_LEIMU

TriTrypDb:

LmxM.34.0230

Length:

368

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B5R1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5R1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	191	195	PF00656	0.701
CLV_NRD_NRD_1	128	130	PF00675	0.658
CLV_PCSK_KEX2_1	127	129	PF00082	0.699
CLV_PCSK_KEX2_1	174	176	PF00082	0.726
CLV_PCSK_KEX2_1	245	247	PF00082	0.489
CLV_PCSK_KEX2_1	335	337	PF00082	0.742
CLV_PCSK_PC1ET2_1	174	176	PF00082	0.577
CLV_PCSK_PC1ET2_1	245	247	PF00082	0.511
CLV_PCSK_PC1ET2_1	335	337	PF00082	0.742
CLV_PCSK_SKI1_1	103	107	PF00082	0.518
CLV_PCSK_SKI1_1	266	270	PF00082	0.438
DEG_SPOP_SBC_1	12	16	PF00917	0.668
DOC_ANK_TNKS_1	126	133	PF00023	0.777
DOC_MAPK_MEF2A_6	34	41	PF00069	0.412
DOC_PP2B_LxvP_1	221	224	PF13499	0.478
DOC_USP7_MATH_1	173	177	PF00917	0.566
DOC_USP7_MATH_1	209	213	PF00917	0.512
DOC_USP7_MATH_1	48	52	PF00917	0.506
DOC_USP7_MATH_1	75	79	PF00917	0.452
DOC_USP7_MATH_1	86	90	PF00917	0.483
DOC_USP7_UBL2_3	241	245	PF12436	0.551
DOC_WW_Pin1_4	143	148	PF00397	0.672
DOC_WW_Pin1_4	16	21	PF00397	0.679
DOC_WW_Pin1_4	175	180	PF00397	0.607
DOC_WW_Pin1_4	304	309	PF00397	0.712
LIG_14-3-3_CanoR_1	103	112	PF00244	0.540
LIG_14-3-3_CanoR_1	122	131	PF00244	0.707
LIG_14-3-3_CanoR_1	157	167	PF00244	0.720
LIG_14-3-3_CanoR_1	175	179	PF00244	0.745
LIG_14-3-3_CanoR_1	341	347	PF00244	0.684
LIG_BRCT_BRCA1_1	80	84	PF00533	0.296
LIG_DCNL_PONY_1	1	4	PF03556	0.666
LIG_eIF4E_1	109	115	PF01652	0.431
LIG_FHA_2	189	195	PF00498	0.629
LIG_FHA_2	214	220	PF00498	0.437
LIG_LIR_Gen_1	106	115	PF02991	0.471
LIG_LIR_Gen_1	216	224	PF02991	0.431
LIG_LIR_LC3C_4	134	139	PF02991	0.736
LIG_LIR_Nem_3	106	112	PF02991	0.678
LIG_LIR_Nem_3	216	221	PF02991	0.413
LIG_MLH1_MIPbox_1	80	84	PF16413	0.296
LIG_PAM2_1	2	14	PF00658	0.678
LIG_PCNA_yPIPBox_3	266	278	PF02747	0.387
LIG_PTAP_UEV_1	282	287	PF05743	0.573
LIG_SH2_CRK	218	222	PF00017	0.438
LIG_SH2_GRB2like	42	45	PF00017	0.517
LIG_SH2_SRC	348	351	PF00017	0.558
LIG_SH2_SRC	42	45	PF00017	0.517
LIG_SH2_STAP1	218	222	PF00017	0.537
LIG_SH2_STAP1	278	282	PF00017	0.445
LIG_SH2_STAP1	348	352	PF00017	0.679
LIG_SH2_STAT3	278	281	PF00017	0.548
LIG_SH2_STAT3	311	314	PF00017	0.501
LIG_SH3_2	283	288	PF14604	0.707
LIG_SH3_3	141	147	PF00018	0.751
LIG_SH3_3	280	286	PF00018	0.650
LIG_SUMO_SIM_par_1	354	360	PF11976	0.650
MOD_CDK_SPxK_1	304	310	PF00069	0.735
MOD_CK1_1	110	116	PF00069	0.500
MOD_CK1_1	14	20	PF00069	0.723
MOD_CK1_1	153	159	PF00069	0.665
MOD_CK1_1	161	167	PF00069	0.645
MOD_CK1_1	177	183	PF00069	0.596
MOD_CK1_1	303	309	PF00069	0.708
MOD_CK1_1	317	323	PF00069	0.566
MOD_CK1_1	342	348	PF00069	0.741
MOD_CK1_1	78	84	PF00069	0.445
MOD_CK2_1	157	163	PF00069	0.690
MOD_CK2_1	319	325	PF00069	0.722
MOD_CK2_1	48	54	PF00069	0.564
MOD_CK2_1	86	92	PF00069	0.592
MOD_DYRK1A_RPxSP_1	175	179	PF00069	0.561
MOD_GlcNHglycan	160	163	PF01048	0.767
MOD_GlcNHglycan	167	170	PF01048	0.645
MOD_GlcNHglycan	20	23	PF01048	0.699
MOD_GlcNHglycan	283	286	PF01048	0.621
MOD_GlcNHglycan	295	298	PF01048	0.631
MOD_GSK3_1	103	110	PF00069	0.524
MOD_GSK3_1	152	159	PF00069	0.663
MOD_GSK3_1	161	168	PF00069	0.630
MOD_GSK3_1	173	180	PF00069	0.658
MOD_GSK3_1	209	216	PF00069	0.511
MOD_GSK3_1	299	306	PF00069	0.682
MOD_GSK3_1	310	317	PF00069	0.623
MOD_GSK3_1	337	344	PF00069	0.630
MOD_GSK3_1	57	64	PF00069	0.533
MOD_GSK3_1	7	14	PF00069	0.617
MOD_LATS_1	339	345	PF00433	0.688
MOD_N-GLC_1	342	347	PF02516	0.742
MOD_NEK2_1	137	142	PF00069	0.660
MOD_NEK2_1	165	170	PF00069	0.567
MOD_NEK2_1	301	306	PF00069	0.762
MOD_NEK2_1	330	335	PF00069	0.718
MOD_NEK2_1	337	342	PF00069	0.716
MOD_NEK2_1	70	75	PF00069	0.511
MOD_NEK2_1	84	89	PF00069	0.474
MOD_NEK2_2	107	112	PF00069	0.417
MOD_PIKK_1	225	231	PF00454	0.506
MOD_PIKK_1	310	316	PF00454	0.747
MOD_PIKK_1	63	69	PF00454	0.450
MOD_PIKK_1	84	90	PF00454	0.512
MOD_PKA_1	174	180	PF00069	0.561
MOD_PKA_2	156	162	PF00069	0.646
MOD_PKA_2	174	180	PF00069	0.745
MOD_PKA_2	57	63	PF00069	0.516
MOD_Plk_1	107	113	PF00069	0.609
MOD_Plk_1	120	126	PF00069	0.725
MOD_Plk_1	342	348	PF00069	0.744
MOD_Plk_4	213	219	PF00069	0.422
MOD_Plk_4	342	348	PF00069	0.692
MOD_ProDKin_1	143	149	PF00069	0.673
MOD_ProDKin_1	16	22	PF00069	0.681
MOD_ProDKin_1	175	181	PF00069	0.608
MOD_ProDKin_1	304	310	PF00069	0.712
TRG_ENDOCYTIC_2	109	112	PF00928	0.703
TRG_ENDOCYTIC_2	217	220	PF00928	0.406
TRG_ER_diArg_1	127	129	PF00400	0.754
TRG_ER_diArg_1	204	207	PF00400	0.507
TRG_NES_CRM1_1	67	77	PF08389	0.539
TRG_Pf-PMV_PEXEL_1	103	108	PF00026	0.624
TRG_Pf-PMV_PEXEL_1	260	264	PF00026	0.527

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3P9	Leptomonas seymouri	60%	99%
A0A1X0NKL5	Trypanosomatidae	42%	98%
A0A3Q8IV00	Leishmania donovani	92%	100%
A0A422NNF8	Trypanosoma rangeli	40%	99%
A4HM62	Leishmania braziliensis	75%	99%
A4IAS4	Leishmania infantum	92%	100%
E9AEK0	Leishmania major	92%	100%
V5BNB0	Trypanosoma cruzi	39%	100%