Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Kinetoplastid kinetochore protein 24, putative

Species:

Leishmania mexicana

UniProt:

E9B5Q6_LEIMU

TriTrypDb:

LmxM.34.0180

Length:

862

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B5Q6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5Q6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	408	412	PF00656	0.469
CLV_NRD_NRD_1	219	221	PF00675	0.513
CLV_NRD_NRD_1	244	246	PF00675	0.697
CLV_NRD_NRD_1	500	502	PF00675	0.600
CLV_NRD_NRD_1	639	641	PF00675	0.561
CLV_NRD_NRD_1	66	68	PF00675	0.561
CLV_NRD_NRD_1	683	685	PF00675	0.568
CLV_NRD_NRD_1	714	716	PF00675	0.560
CLV_NRD_NRD_1	782	784	PF00675	0.600
CLV_NRD_NRD_1	810	812	PF00675	0.612
CLV_PCSK_KEX2_1	244	246	PF00082	0.673
CLV_PCSK_KEX2_1	385	387	PF00082	0.472
CLV_PCSK_KEX2_1	638	640	PF00082	0.491
CLV_PCSK_KEX2_1	66	68	PF00082	0.607
CLV_PCSK_KEX2_1	683	685	PF00082	0.568
CLV_PCSK_KEX2_1	782	784	PF00082	0.660
CLV_PCSK_KEX2_1	794	796	PF00082	0.534
CLV_PCSK_KEX2_1	852	854	PF00082	0.618
CLV_PCSK_PC1ET2_1	385	387	PF00082	0.548
CLV_PCSK_PC1ET2_1	638	640	PF00082	0.500
CLV_PCSK_PC1ET2_1	683	685	PF00082	0.568
CLV_PCSK_PC1ET2_1	794	796	PF00082	0.592
CLV_PCSK_PC1ET2_1	852	854	PF00082	0.607
CLV_PCSK_PC7_1	848	854	PF00082	0.599
CLV_PCSK_SKI1_1	161	165	PF00082	0.563
CLV_PCSK_SKI1_1	313	317	PF00082	0.595
CLV_PCSK_SKI1_1	391	395	PF00082	0.553
CLV_PCSK_SKI1_1	44	48	PF00082	0.517
CLV_PCSK_SKI1_1	501	505	PF00082	0.539
CLV_PCSK_SKI1_1	67	71	PF00082	0.363
CLV_PCSK_SKI1_1	733	737	PF00082	0.441
CLV_PCSK_SKI1_1	751	755	PF00082	0.530
CLV_Separin_Metazoa	327	331	PF03568	0.569
DEG_APCC_DBOX_1	500	508	PF00400	0.588
DEG_APCC_DBOX_1	542	550	PF00400	0.544
DEG_APCC_DBOX_1	65	73	PF00400	0.589
DEG_APCC_DBOX_1	732	740	PF00400	0.568
DOC_CYCLIN_RxL_1	39	50	PF00134	0.455
DOC_MAPK_gen_1	426	434	PF00069	0.375
DOC_MAPK_gen_1	638	646	PF00069	0.523
DOC_MAPK_gen_1	818	825	PF00069	0.540
DOC_MAPK_MEF2A_6	447	455	PF00069	0.582
DOC_MAPK_MEF2A_6	794	801	PF00069	0.595
DOC_MAPK_NFAT4_5	794	802	PF00069	0.594
DOC_USP7_MATH_1	163	167	PF00917	0.564
DOC_USP7_MATH_1	194	198	PF00917	0.630
DOC_USP7_MATH_1	281	285	PF00917	0.699
DOC_USP7_MATH_1	651	655	PF00917	0.558
DOC_USP7_UBL2_3	44	48	PF12436	0.535
LIG_14-3-3_CanoR_1	15	23	PF00244	0.457
LIG_14-3-3_CanoR_1	178	182	PF00244	0.601
LIG_14-3-3_CanoR_1	244	254	PF00244	0.674
LIG_14-3-3_CanoR_1	489	497	PF00244	0.562
LIG_14-3-3_CanoR_1	501	507	PF00244	0.595
LIG_14-3-3_CanoR_1	591	597	PF00244	0.513
LIG_14-3-3_CanoR_1	66	72	PF00244	0.421
LIG_14-3-3_CanoR_1	742	750	PF00244	0.523
LIG_14-3-3_CanoR_1	811	821	PF00244	0.618
LIG_14-3-3_CanoR_1	839	847	PF00244	0.648
LIG_Actin_WH2_2	504	521	PF00022	0.572
LIG_Actin_WH2_2	803	820	PF00022	0.523
LIG_Actin_WH2_2	9	26	PF00022	0.594
LIG_APCC_ABBA_1	821	826	PF00400	0.679
LIG_BIR_II_1	1	5	PF00653	0.540
LIG_BRCT_BRCA1_1	455	459	PF00533	0.293
LIG_BRCT_BRCA1_1	632	636	PF00533	0.540
LIG_BRCT_BRCA1_2	632	638	PF00533	0.465
LIG_CaM_IQ_9	153	169	PF13499	0.410
LIG_Clathr_ClatBox_1	360	364	PF01394	0.580
LIG_Clathr_ClatBox_1	707	711	PF01394	0.396
LIG_FHA_1	169	175	PF00498	0.512
LIG_FHA_1	408	414	PF00498	0.571
LIG_FHA_1	608	614	PF00498	0.455
LIG_FHA_2	107	113	PF00498	0.515
LIG_FHA_2	15	21	PF00498	0.538
LIG_FHA_2	289	295	PF00498	0.587
LIG_FHA_2	494	500	PF00498	0.565
LIG_FHA_2	614	620	PF00498	0.474
LIG_FHA_2	630	636	PF00498	0.451
LIG_FHA_2	647	653	PF00498	0.330
LIG_FHA_2	68	74	PF00498	0.386
LIG_GBD_Chelix_1	789	797	PF00786	0.605
LIG_LIR_Gen_1	148	156	PF02991	0.543
LIG_LIR_Gen_1	347	357	PF02991	0.508
LIG_LIR_Gen_1	380	387	PF02991	0.522
LIG_LIR_Gen_1	400	409	PF02991	0.490
LIG_LIR_Gen_1	445	455	PF02991	0.451
LIG_LIR_Gen_1	49	60	PF02991	0.579
LIG_LIR_Gen_1	673	680	PF02991	0.383
LIG_LIR_Gen_1	769	778	PF02991	0.457
LIG_LIR_Nem_3	148	152	PF02991	0.545
LIG_LIR_Nem_3	347	352	PF02991	0.516
LIG_LIR_Nem_3	380	384	PF02991	0.598
LIG_LIR_Nem_3	400	406	PF02991	0.496
LIG_LIR_Nem_3	445	451	PF02991	0.451
LIG_LIR_Nem_3	49	55	PF02991	0.580
LIG_LIR_Nem_3	673	679	PF02991	0.382
LIG_LIR_Nem_3	769	774	PF02991	0.472
LIG_LIR_Nem_3	776	781	PF02991	0.521
LIG_NRBOX	548	554	PF00104	0.605
LIG_NRBOX	749	755	PF00104	0.519
LIG_PCNA_yPIPBox_3	4	12	PF02747	0.625
LIG_PCNA_yPIPBox_3	437	447	PF02747	0.384
LIG_Pex14_2	444	448	PF04695	0.553
LIG_SH2_CRK	771	775	PF00017	0.438
LIG_SH2_STAP1	107	111	PF00017	0.531
LIG_SH2_STAP1	149	153	PF00017	0.464
LIG_SH2_STAP1	356	360	PF00017	0.450
LIG_SH2_STAT5	697	700	PF00017	0.552
LIG_SUMO_SIM_anti_2	642	650	PF11976	0.606
LIG_SUMO_SIM_par_1	610	617	PF11976	0.448
LIG_TRAF2_1	40	43	PF00917	0.542
LIG_TRAF2_1	405	408	PF00917	0.467
LIG_TYR_ITIM	147	152	PF00017	0.311
LIG_UBA3_1	360	367	PF00899	0.615
MOD_CK1_1	131	137	PF00069	0.388
MOD_CK1_1	197	203	PF00069	0.482
MOD_CK1_1	305	311	PF00069	0.600
MOD_CK1_1	355	361	PF00069	0.549
MOD_CK1_1	428	434	PF00069	0.567
MOD_CK1_1	484	490	PF00069	0.629
MOD_CK1_1	493	499	PF00069	0.578
MOD_CK1_1	509	515	PF00069	0.441
MOD_CK1_1	671	677	PF00069	0.544
MOD_CK1_1	722	728	PF00069	0.511
MOD_CK1_1	745	751	PF00069	0.505
MOD_CK1_1	854	860	PF00069	0.713
MOD_CK2_1	14	20	PF00069	0.458
MOD_CK2_1	197	203	PF00069	0.641
MOD_CK2_1	258	264	PF00069	0.689
MOD_CK2_1	288	294	PF00069	0.661
MOD_CK2_1	402	408	PF00069	0.555
MOD_CK2_1	493	499	PF00069	0.516
MOD_CK2_1	502	508	PF00069	0.445
MOD_CK2_1	613	619	PF00069	0.426
MOD_CK2_1	67	73	PF00069	0.457
MOD_CK2_1	854	860	PF00069	0.656
MOD_GlcNHglycan	133	136	PF01048	0.424
MOD_GlcNHglycan	141	144	PF01048	0.420
MOD_GlcNHglycan	227	230	PF01048	0.656
MOD_GlcNHglycan	254	257	PF01048	0.747
MOD_GlcNHglycan	283	286	PF01048	0.708
MOD_GlcNHglycan	31	34	PF01048	0.624
MOD_GlcNHglycan	400	403	PF01048	0.574
MOD_GlcNHglycan	473	477	PF01048	0.632
MOD_GlcNHglycan	483	486	PF01048	0.621
MOD_GlcNHglycan	58	61	PF01048	0.577
MOD_GlcNHglycan	597	600	PF01048	0.325
MOD_GlcNHglycan	655	658	PF01048	0.483
MOD_GlcNHglycan	719	722	PF01048	0.515
MOD_GlcNHglycan	733	736	PF01048	0.356
MOD_GlcNHglycan	75	78	PF01048	0.586
MOD_GlcNHglycan	826	829	PF01048	0.639
MOD_GSK3_1	101	108	PF00069	0.423
MOD_GSK3_1	134	141	PF00069	0.531
MOD_GSK3_1	194	201	PF00069	0.532
MOD_GSK3_1	398	405	PF00069	0.587
MOD_GSK3_1	472	479	PF00069	0.494
MOD_GSK3_1	489	496	PF00069	0.516
MOD_GSK3_1	502	509	PF00069	0.441
MOD_GSK3_1	56	63	PF00069	0.486
MOD_GSK3_1	609	616	PF00069	0.459
MOD_GSK3_1	630	637	PF00069	0.561
MOD_GSK3_1	674	681	PF00069	0.521
MOD_GSK3_1	813	820	PF00069	0.551
MOD_GSK3_1	851	858	PF00069	0.732
MOD_LATS_1	849	855	PF00433	0.726
MOD_N-GLC_1	215	220	PF02516	0.526
MOD_N-GLC_1	397	402	PF02516	0.550
MOD_N-GLC_1	570	575	PF02516	0.640
MOD_N-GLC_1	628	633	PF02516	0.570
MOD_N-GLC_1	813	818	PF02516	0.599
MOD_N-GLC_1	840	845	PF02516	0.653
MOD_N-GLC_2	488	490	PF02516	0.486
MOD_NEK2_1	128	133	PF00069	0.616
MOD_NEK2_1	139	144	PF00069	0.519
MOD_NEK2_1	177	182	PF00069	0.523
MOD_NEK2_1	286	291	PF00069	0.633
MOD_NEK2_1	335	340	PF00069	0.498
MOD_NEK2_1	366	371	PF00069	0.479
MOD_NEK2_1	506	511	PF00069	0.619
MOD_NEK2_1	552	557	PF00069	0.592
MOD_NEK2_1	595	600	PF00069	0.566
MOD_NEK2_1	634	639	PF00069	0.545
MOD_NEK2_1	817	822	PF00069	0.647
MOD_NEK2_1	824	829	PF00069	0.685
MOD_PIKK_1	14	20	PF00454	0.458
MOD_PIKK_1	163	169	PF00454	0.330
MOD_PIKK_1	286	292	PF00454	0.643
MOD_PIKK_1	336	342	PF00454	0.671
MOD_PIKK_1	506	512	PF00454	0.529
MOD_PIKK_1	668	674	PF00454	0.474
MOD_PIKK_1	799	805	PF00454	0.514
MOD_PK_1	851	857	PF00069	0.519
MOD_PKA_1	168	174	PF00069	0.511
MOD_PKA_1	385	391	PF00069	0.551
MOD_PKA_1	67	73	PF00069	0.342
MOD_PKA_1	684	690	PF00069	0.548
MOD_PKA_1	851	857	PF00069	0.685
MOD_PKA_2	101	107	PF00069	0.628
MOD_PKA_2	14	20	PF00069	0.454
MOD_PKA_2	177	183	PF00069	0.563
MOD_PKA_2	286	292	PF00069	0.686
MOD_PKA_2	385	391	PF00069	0.478
MOD_PKA_2	428	434	PF00069	0.510
MOD_PKA_2	490	496	PF00069	0.556
MOD_PKA_2	524	530	PF00069	0.580
MOD_PKA_2	590	596	PF00069	0.526
MOD_Plk_1	215	221	PF00069	0.663
MOD_Plk_1	313	319	PF00069	0.548
MOD_Plk_1	379	385	PF00069	0.342
MOD_Plk_1	493	499	PF00069	0.543
MOD_Plk_1	570	576	PF00069	0.642
MOD_Plk_1	651	657	PF00069	0.370
MOD_Plk_1	813	819	PF00069	0.604
MOD_Plk_4	428	434	PF00069	0.536
MOD_Plk_4	502	508	PF00069	0.587
MOD_Plk_4	67	73	PF00069	0.342
MOD_SUMO_for_1	212	215	PF00179	0.597
MOD_SUMO_for_1	229	232	PF00179	0.602
MOD_SUMO_for_1	47	50	PF00179	0.593
MOD_SUMO_for_1	830	833	PF00179	0.666
MOD_SUMO_for_1	93	96	PF00179	0.573
MOD_SUMO_rev_2	38	47	PF00179	0.595
MOD_SUMO_rev_2	667	677	PF00179	0.456
MOD_SUMO_rev_2	705	714	PF00179	0.550
MOD_SUMO_rev_2	734	741	PF00179	0.570
MOD_SUMO_rev_2	787	796	PF00179	0.600
TRG_DiLeu_BaEn_1	548	553	PF01217	0.606
TRG_DiLeu_BaEn_1	756	761	PF01217	0.511
TRG_DiLeu_BaEn_4	214	220	PF01217	0.588
TRG_DiLeu_BaEn_4	242	248	PF01217	0.494
TRG_DiLeu_BaEn_4	249	255	PF01217	0.676
TRG_DiLeu_BaEn_4	562	568	PF01217	0.679
TRG_DiLeu_BaLyEn_6	201	206	PF01217	0.547
TRG_ENDOCYTIC_2	149	152	PF00928	0.466
TRG_ENDOCYTIC_2	771	774	PF00928	0.436
TRG_ER_diArg_1	459	462	PF00400	0.302
TRG_ER_diArg_1	65	67	PF00400	0.618
TRG_ER_diArg_1	781	783	PF00400	0.656
TRG_ER_diArg_1	83	86	PF00400	0.485
TRG_NES_CRM1_1	249	264	PF08389	0.441
TRG_NES_CRM1_1	791	804	PF08389	0.604
TRG_NES_CRM1_1	87	101	PF08389	0.499
TRG_NLS_MonoExtN_4	848	855	PF00514	0.601
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.597
TRG_Pf-PMV_PEXEL_1	235	240	PF00026	0.668
TRG_Pf-PMV_PEXEL_1	245	249	PF00026	0.524
TRG_Pf-PMV_PEXEL_1	600	605	PF00026	0.374

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBM4	Leptomonas seymouri	55%	100%
A0A1X0NIX3	Trypanosomatidae	32%	99%
A0A3Q8IHM9	Leishmania donovani	89%	100%
A0A422N7K6	Trypanosoma rangeli	31%	100%
A4HM57	Leishmania braziliensis	76%	100%
A4IAR9	Leishmania infantum	89%	100%
D0A2E3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AEJ5	Leishmania major	88%	100%
V5BIR1	Trypanosoma cruzi	31%	99%