DUF4200 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B5Q5_LEIMU

TriTrypDb:

LmxM.34.0170

Length:

332

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B5Q5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5Q5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.411
CLV_NRD_NRD_1	262	264	PF00675	0.426
CLV_NRD_NRD_1	279	281	PF00675	0.406
CLV_NRD_NRD_1	288	290	PF00675	0.413
CLV_NRD_NRD_1	45	47	PF00675	0.453
CLV_NRD_NRD_1	72	74	PF00675	0.537
CLV_PCSK_KEX2_1	18	20	PF00082	0.576
CLV_PCSK_KEX2_1	288	290	PF00082	0.413
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.576
CLV_PCSK_SKI1_1	134	138	PF00082	0.554
CLV_PCSK_SKI1_1	149	153	PF00082	0.406
CLV_PCSK_SKI1_1	174	178	PF00082	0.571
CLV_PCSK_SKI1_1	242	246	PF00082	0.392
CLV_PCSK_SKI1_1	280	284	PF00082	0.592
CLV_PCSK_SKI1_1	288	292	PF00082	0.401
CLV_PCSK_SKI1_1	75	79	PF00082	0.462
DEG_APCC_DBOX_1	287	295	PF00400	0.357
DEG_Nend_UBRbox_3	1	3	PF02207	0.609
DOC_CYCLIN_RxL_1	128	138	PF00134	0.546
DOC_CYCLIN_RxL_1	239	249	PF00134	0.355
DOC_MAPK_gen_1	186	195	PF00069	0.532
DOC_MAPK_gen_1	261	268	PF00069	0.495
DOC_PP1_RVXF_1	45	52	PF00149	0.543
DOC_PP2B_LxvP_1	321	324	PF13499	0.617
DOC_USP7_MATH_1	63	67	PF00917	0.361
DOC_USP7_UBL2_3	25	29	PF12436	0.475
DOC_USP7_UBL2_3	74	78	PF12436	0.446
DOC_WW_Pin1_4	158	163	PF00397	0.426
LIG_14-3-3_CanoR_1	156	162	PF00244	0.582
LIG_14-3-3_CanoR_1	289	295	PF00244	0.479
LIG_Actin_WH2_2	278	294	PF00022	0.439
LIG_BRCT_MDC1_1	328	332	PF00533	0.544
LIG_FHA_1	161	167	PF00498	0.670
LIG_FHA_1	26	32	PF00498	0.461
LIG_FHA_2	112	118	PF00498	0.576
LIG_FHA_2	39	45	PF00498	0.450
LIG_GBD_Chelix_1	91	99	PF00786	0.495
LIG_LIR_Gen_1	129	137	PF02991	0.345
LIG_LIR_Nem_3	129	133	PF02991	0.345
LIG_LIR_Nem_3	300	304	PF02991	0.448
LIG_NRBOX	12	18	PF00104	0.504
LIG_NRBOX	229	235	PF00104	0.444
LIG_PCNA_yPIPBox_3	36	49	PF02747	0.551
LIG_SH2_STAP1	201	205	PF00017	0.329
LIG_SH2_STAT5	20	23	PF00017	0.549
LIG_SH2_STAT5	48	51	PF00017	0.540
LIG_SH3_3	166	172	PF00018	0.449
LIG_SUMO_SIM_anti_2	163	170	PF11976	0.457
LIG_SUMO_SIM_par_1	309	315	PF11976	0.546
LIG_TRAF2_1	115	118	PF00917	0.509
LIG_TRAF2_1	30	33	PF00917	0.521
LIG_WRC_WIRS_1	127	132	PF05994	0.495
LIG_WRC_WIRS_1	219	224	PF05994	0.544
LIG_WRC_WIRS_1	298	303	PF05994	0.440
MOD_CK1_1	144	150	PF00069	0.566
MOD_CK1_1	155	161	PF00069	0.499
MOD_CK1_1	326	332	PF00069	0.632
MOD_CK2_1	111	117	PF00069	0.577
MOD_CK2_1	158	164	PF00069	0.656
MOD_CK2_1	27	33	PF00069	0.474
MOD_CK2_1	38	44	PF00069	0.436
MOD_GlcNHglycan	225	228	PF01048	0.407
MOD_GlcNHglycan	301	304	PF01048	0.478
MOD_GlcNHglycan	65	68	PF01048	0.365
MOD_GSK3_1	218	225	PF00069	0.617
MOD_GSK3_1	322	329	PF00069	0.591
MOD_LATS_1	23	29	PF00433	0.350
MOD_NEK2_1	141	146	PF00069	0.569
MOD_NEK2_1	152	157	PF00069	0.505
MOD_NEK2_1	218	223	PF00069	0.552
MOD_PKA_2	155	161	PF00069	0.575
MOD_PKA_2	269	275	PF00069	0.397
MOD_Plk_4	218	224	PF00069	0.442
MOD_ProDKin_1	158	164	PF00069	0.432
MOD_SUMO_for_1	35	38	PF00179	0.519
MOD_SUMO_rev_2	120	130	PF00179	0.407
MOD_SUMO_rev_2	71	80	PF00179	0.354
TRG_DiLeu_BaEn_1	12	17	PF01217	0.566
TRG_DiLeu_BaEn_1	214	219	PF01217	0.545
TRG_DiLeu_BaLyEn_6	171	176	PF01217	0.499
TRG_DiLeu_BaLyEn_6	229	234	PF01217	0.448
TRG_DiLeu_BaLyEn_6	65	70	PF01217	0.425
TRG_ENDOCYTIC_2	48	51	PF00928	0.540
TRG_ER_diArg_1	288	290	PF00400	0.413
TRG_ER_diArg_1	98	101	PF00400	0.467
TRG_NES_CRM1_1	257	271	PF08389	0.553
TRG_NES_CRM1_1	312	327	PF08389	0.522
TRG_NES_CRM1_1	89	103	PF08389	0.382
TRG_Pf-PMV_PEXEL_1	134	138	PF00026	0.554
TRG_Pf-PMV_PEXEL_1	232	236	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	29	33	PF00026	0.585
TRG_Pf-PMV_PEXEL_1	68	72	PF00026	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5M0	Leptomonas seymouri	38%	97%
A0A3Q8INY6	Leishmania donovani	84%	97%
A4HM56	Leishmania braziliensis	61%	100%
A4IAR8	Leishmania infantum	84%	97%
E9AEJ4	Leishmania major	84%	100%