Tc-38 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B5Q4_LEIMU

TriTrypDb:

LmxM.34.0160

Length:

278

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B5Q4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5Q4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	101	105	PF00656	0.264
CLV_NRD_NRD_1	168	170	PF00675	0.616
CLV_PCSK_SKI1_1	170	174	PF00082	0.500
CLV_PCSK_SKI1_1	20	24	PF00082	0.468
CLV_PCSK_SKI1_1	229	233	PF00082	0.466
CLV_PCSK_SKI1_1	236	240	PF00082	0.503
CLV_PCSK_SKI1_1	66	70	PF00082	0.538
DOC_CYCLIN_RxL_1	208	218	PF00134	0.419
DOC_MAPK_gen_1	89	97	PF00069	0.486
DOC_PP2B_LxvP_1	254	257	PF13499	0.455
DOC_PP2B_LxvP_1	47	50	PF13499	0.502
DOC_PP4_FxxP_1	115	118	PF00568	0.279
DOC_PP4_FxxP_1	45	48	PF00568	0.419
DOC_USP7_MATH_1	171	175	PF00917	0.462
DOC_USP7_MATH_1	48	52	PF00917	0.605
DOC_WW_Pin1_4	114	119	PF00397	0.279
DOC_WW_Pin1_4	38	43	PF00397	0.620
LIG_14-3-3_CanoR_1	236	241	PF00244	0.447
LIG_14-3-3_CanoR_1	263	267	PF00244	0.620
LIG_14-3-3_CanoR_1	44	48	PF00244	0.400
LIG_APCC_ABBA_1	119	124	PF00400	0.167
LIG_BIR_II_1	1	5	PF00653	0.375
LIG_BRCT_BRCA1_1	115	119	PF00533	0.409
LIG_BRCT_BRCA1_1	92	96	PF00533	0.609
LIG_Clathr_ClatBox_1	240	244	PF01394	0.533
LIG_deltaCOP1_diTrp_1	244	249	PF00928	0.655
LIG_EH_1	201	205	PF12763	0.436
LIG_FHA_1	145	151	PF00498	0.409
LIG_FHA_1	194	200	PF00498	0.504
LIG_FHA_1	28	34	PF00498	0.321
LIG_FHA_1	44	50	PF00498	0.442
LIG_FHA_1	65	71	PF00498	0.301
LIG_FHA_2	237	243	PF00498	0.552
LIG_FHA_2	33	39	PF00498	0.585
LIG_LIR_Apic_2	112	118	PF02991	0.283
LIG_LIR_Apic_2	43	48	PF02991	0.489
LIG_LIR_Gen_1	129	137	PF02991	0.636
LIG_LIR_Gen_1	244	254	PF02991	0.596
LIG_LIR_Gen_1	272	278	PF02991	0.519
LIG_LIR_Nem_3	129	135	PF02991	0.574
LIG_LIR_Nem_3	244	249	PF02991	0.606
LIG_LIR_Nem_3	272	278	PF02991	0.689
LIG_PCNA_yPIPBox_3	20	28	PF02747	0.565
LIG_Pex14_2	115	119	PF04695	0.264
LIG_Pex14_2	27	31	PF04695	0.557
LIG_REV1ctd_RIR_1	66	74	PF16727	0.450
LIG_REV1ctd_RIR_1	94	103	PF16727	0.264
LIG_SH2_STAP1	15	19	PF00017	0.559
LIG_SH2_STAT3	14	17	PF00017	0.432
LIG_SH2_STAT5	132	135	PF00017	0.614
LIG_SH3_3	82	88	PF00018	0.584
LIG_SUMO_SIM_par_1	142	147	PF11976	0.493
LIG_SUMO_SIM_par_1	239	244	PF11976	0.533
LIG_TRAF2_1	35	38	PF00917	0.673
LIG_TRAF2_1	98	101	PF00917	0.279
LIG_UBA3_1	3	9	PF00899	0.382
MOD_CDK_SPxK_1	38	44	PF00069	0.458
MOD_CK2_1	236	242	PF00069	0.636
MOD_CK2_1	32	38	PF00069	0.635
MOD_GlcNHglycan	129	132	PF01048	0.642
MOD_GlcNHglycan	177	180	PF01048	0.646
MOD_GlcNHglycan	58	61	PF01048	0.547
MOD_GlcNHglycan	92	95	PF01048	0.650
MOD_GSK3_1	142	149	PF00069	0.518
MOD_GSK3_1	171	178	PF00069	0.605
MOD_GSK3_1	193	200	PF00069	0.432
MOD_N-GLC_1	20	25	PF02516	0.557
MOD_N-GLC_1	270	275	PF02516	0.681
MOD_NEK2_1	113	118	PF00069	0.440
MOD_NEK2_1	146	151	PF00069	0.453
MOD_NEK2_1	262	267	PF00069	0.684
MOD_NEK2_2	270	275	PF00069	0.706
MOD_PIKK_1	213	219	PF00454	0.392
MOD_PKA_2	225	231	PF00069	0.406
MOD_PKA_2	262	268	PF00069	0.584
MOD_PKA_2	43	49	PF00069	0.405
MOD_Plk_1	20	26	PF00069	0.579
MOD_Plk_1	270	276	PF00069	0.580
MOD_Plk_2-3	155	161	PF00069	0.434
MOD_Plk_4	146	152	PF00069	0.503
MOD_Plk_4	270	276	PF00069	0.555
MOD_ProDKin_1	114	120	PF00069	0.279
MOD_ProDKin_1	38	44	PF00069	0.617
TRG_ENDOCYTIC_2	132	135	PF00928	0.614
TRG_ENDOCYTIC_2	15	18	PF00928	0.497
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.542

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P611	Leptomonas seymouri	64%	85%
A0A0S4JHS2	Bodo saltans	34%	71%
A0A1X0NJ57	Trypanosomatidae	45%	90%
A0A3R7LQI0	Trypanosoma rangeli	47%	89%
A0A3S7X8M8	Leishmania donovani	93%	88%
A4HM55	Leishmania braziliensis	86%	100%
A4IAR7	Leishmania infantum	93%	88%
D0A2E5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	90%
E9AEJ3	Leishmania major	93%	100%
V5DJR0	Trypanosoma cruzi	48%	89%