LMBR1 domain-containing protein 2

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

LMBR1-like membrane protein, putative

Species:

Leishmania mexicana

UniProt:

E9B5Q0_LEIMU

TriTrypDb:

LmxM.34.0120

Length:

448

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

E9B5Q0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5Q0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.300
CLV_C14_Caspase3-7	32	36	PF00656	0.521
CLV_NRD_NRD_1	218	220	PF00675	0.286
CLV_NRD_NRD_1	241	243	PF00675	0.426
CLV_NRD_NRD_1	248	250	PF00675	0.435
CLV_PCSK_KEX2_1	218	220	PF00082	0.301
CLV_PCSK_KEX2_1	241	243	PF00082	0.416
CLV_PCSK_SKI1_1	192	196	PF00082	0.284
CLV_PCSK_SKI1_1	236	240	PF00082	0.373
CLV_PCSK_SKI1_1	432	436	PF00082	0.455
CLV_PCSK_SKI1_1	77	81	PF00082	0.463
DEG_APCC_DBOX_1	112	120	PF00400	0.541
DEG_MDM2_SWIB_1	72	80	PF02201	0.273
DEG_Nend_Nbox_1	1	3	PF02207	0.377
DEG_SPOP_SBC_1	157	161	PF00917	0.373
DOC_CYCLIN_RxL_1	232	243	PF00134	0.625
DOC_CYCLIN_yCln2_LP_2	343	349	PF00134	0.634
DOC_CYCLIN_yCln2_LP_2	55	61	PF00134	0.315
DOC_MAPK_gen_1	203	210	PF00069	0.541
DOC_MAPK_gen_1	232	240	PF00069	0.577
DOC_MAPK_MEF2A_6	113	120	PF00069	0.533
DOC_MAPK_MEF2A_6	40	49	PF00069	0.330
DOC_PP1_RVXF_1	234	241	PF00149	0.545
DOC_PP1_RVXF_1	301	308	PF00149	0.389
DOC_PP2B_LxvP_1	343	346	PF13499	0.656
DOC_PP2B_LxvP_1	422	425	PF13499	0.429
DOC_PP2B_LxvP_1	55	58	PF13499	0.315
DOC_PP4_FxxP_1	188	191	PF00568	0.500
DOC_USP7_MATH_1	103	107	PF00917	0.500
DOC_USP7_MATH_1	158	162	PF00917	0.393
DOC_USP7_UBL2_3	232	236	PF12436	0.621
DOC_WW_Pin1_4	99	104	PF00397	0.541
LIG_Actin_WH2_2	167	184	PF00022	0.450
LIG_BRCT_BRCA1_1	68	72	PF00533	0.273
LIG_BRCT_BRCA1_1	84	88	PF00533	0.450
LIG_CaM_NSCaTE_8	76	83	PF13499	0.429
LIG_Clathr_ClatBox_1	56	60	PF01394	0.370
LIG_CSL_BTD_1	36	39	PF09270	0.517
LIG_deltaCOP1_diTrp_1	71	76	PF00928	0.322
LIG_FHA_1	419	425	PF00498	0.182
LIG_FHA_1	433	439	PF00498	0.501
LIG_FHA_1	44	50	PF00498	0.442
LIG_FHA_2	193	199	PF00498	0.478
LIG_GBD_Chelix_1	11	19	PF00786	0.409
LIG_GBD_Chelix_1	408	416	PF00786	0.256
LIG_LIR_Gen_1	106	117	PF02991	0.503
LIG_LIR_Gen_1	162	172	PF02991	0.372
LIG_LIR_Gen_1	370	380	PF02991	0.385
LIG_LIR_Gen_1	423	434	PF02991	0.457
LIG_LIR_Nem_3	106	112	PF02991	0.479
LIG_LIR_Nem_3	162	168	PF02991	0.362
LIG_LIR_Nem_3	370	375	PF02991	0.343
LIG_LIR_Nem_3	381	385	PF02991	0.240
LIG_LIR_Nem_3	423	429	PF02991	0.351
LIG_NRBOX	286	292	PF00104	0.373
LIG_PCNA_PIPBox_1	301	310	PF02747	0.395
LIG_PCNA_yPIPBox_3	203	214	PF02747	0.533
LIG_PCNA_yPIPBox_3	406	420	PF02747	0.366
LIG_Pex14_1	165	169	PF04695	0.315
LIG_Pex14_2	126	130	PF04695	0.375
LIG_Pex14_2	163	167	PF04695	0.450
LIG_Pex14_2	2	6	PF04695	0.356
LIG_Pex14_2	70	74	PF04695	0.350
LIG_Pex14_2	93	97	PF04695	0.375
LIG_Pex3_1	287	298	PF04882	0.433
LIG_REV1ctd_RIR_1	185	190	PF16727	0.534
LIG_SH2_CRK	414	418	PF00017	0.429
LIG_SH2_CRK	52	56	PF00017	0.380
LIG_SH2_CRK	84	88	PF00017	0.446
LIG_SH2_STAP1	320	324	PF00017	0.370
LIG_SH2_STAP1	414	418	PF00017	0.450
LIG_SH2_STAP1	84	88	PF00017	0.412
LIG_SH2_STAT3	407	410	PF00017	0.346
LIG_SH2_STAT5	155	158	PF00017	0.321
LIG_SH2_STAT5	22	25	PF00017	0.330
LIG_SH2_STAT5	264	267	PF00017	0.575
LIG_SH2_STAT5	322	325	PF00017	0.318
LIG_SH2_STAT5	326	329	PF00017	0.284
LIG_SH2_STAT5	407	410	PF00017	0.273
LIG_SH3_2	346	351	PF14604	0.621
LIG_SH3_3	343	349	PF00018	0.599
LIG_SH3_3	394	400	PF00018	0.391
LIG_SH3_3	86	92	PF00018	0.348
LIG_Sin3_3	13	20	PF02671	0.450
LIG_SUMO_SIM_anti_2	115	120	PF11976	0.383
LIG_SUMO_SIM_anti_2	364	370	PF11976	0.405
LIG_SUMO_SIM_par_1	364	370	PF11976	0.374
LIG_SUMO_SIM_par_1	40	46	PF11976	0.426
LIG_SUMO_SIM_par_1	415	421	PF11976	0.227
LIG_SUMO_SIM_par_1	57	62	PF11976	0.357
LIG_TRAF2_1	28	31	PF00917	0.518
LIG_TYR_ITIM	412	417	PF00017	0.312
LIG_UBA3_1	55	64	PF00899	0.159
MOD_CK1_1	107	113	PF00069	0.556
MOD_CK1_1	381	387	PF00069	0.329
MOD_CK2_1	192	198	PF00069	0.483
MOD_CK2_1	25	31	PF00069	0.518
MOD_Cter_Amidation	216	219	PF01082	0.317
MOD_GlcNHglycan	260	263	PF01048	0.416
MOD_GlcNHglycan	27	30	PF01048	0.326
MOD_GlcNHglycan	338	341	PF01048	0.408
MOD_GlcNHglycan	369	372	PF01048	0.412
MOD_GSK3_1	139	146	PF00069	0.299
MOD_GSK3_1	258	265	PF00069	0.487
MOD_GSK3_1	381	388	PF00069	0.334
MOD_GSK3_1	432	439	PF00069	0.675
MOD_GSK3_1	97	104	PF00069	0.553
MOD_NEK2_1	156	161	PF00069	0.375
MOD_NEK2_1	314	319	PF00069	0.370
MOD_NEK2_1	328	333	PF00069	0.327
MOD_NEK2_1	361	366	PF00069	0.366
MOD_NEK2_1	367	372	PF00069	0.318
MOD_NEK2_1	395	400	PF00069	0.357
MOD_NEK2_1	420	425	PF00069	0.434
MOD_NEK2_1	59	64	PF00069	0.231
MOD_NEK2_1	97	102	PF00069	0.532
MOD_NEK2_2	262	267	PF00069	0.421
MOD_PIKK_1	101	107	PF00454	0.553
MOD_PKA_2	112	118	PF00069	0.556
MOD_PKA_2	248	254	PF00069	0.619
MOD_PKA_2	25	31	PF00069	0.541
MOD_PKA_2	352	358	PF00069	0.593
MOD_PKA_2	66	72	PF00069	0.356
MOD_PKB_1	190	198	PF00069	0.505
MOD_Plk_1	59	65	PF00069	0.352
MOD_Plk_2-3	66	72	PF00069	0.357
MOD_Plk_4	104	110	PF00069	0.514
MOD_Plk_4	279	285	PF00069	0.383
MOD_Plk_4	314	320	PF00069	0.389
MOD_Plk_4	328	334	PF00069	0.392
MOD_Plk_4	352	358	PF00069	0.509
MOD_Plk_4	361	367	PF00069	0.285
MOD_Plk_4	386	392	PF00069	0.354
MOD_Plk_4	82	88	PF00069	0.434
MOD_ProDKin_1	99	105	PF00069	0.541
MOD_SUMO_rev_2	243	251	PF00179	0.594
TRG_DiLeu_BaEn_1	209	214	PF01217	0.483
TRG_DiLeu_BaEn_1	443	448	PF01217	0.604
TRG_ENDOCYTIC_2	322	325	PF00928	0.309
TRG_ENDOCYTIC_2	414	417	PF00928	0.331
TRG_ENDOCYTIC_2	52	55	PF00928	0.396
TRG_ENDOCYTIC_2	84	87	PF00928	0.383
TRG_ER_diArg_1	190	193	PF00400	0.480
TRG_ER_diArg_1	218	220	PF00400	0.515
TRG_ER_diArg_1	240	242	PF00400	0.622
TRG_ER_diArg_1	350	353	PF00400	0.597
TRG_Pf-PMV_PEXEL_1	218	223	PF00026	0.297

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRR8	Leptomonas seymouri	23%	94%
A0A0N1I533	Leptomonas seymouri	65%	100%
A0A0S4IQ17	Bodo saltans	28%	93%
A0A0S4JTI8	Bodo saltans	32%	87%
A0A1X0NKT2	Trypanosomatidae	32%	100%
A0A1X0NM00	Trypanosomatidae	24%	96%
A0A3Q8IGK4	Leishmania donovani	22%	93%
A0A3S5H7Y2	Leishmania donovani	95%	100%
A0A422P212	Trypanosoma rangeli	26%	94%
A4HE60	Leishmania braziliensis	22%	100%
A4HM51	Leishmania braziliensis	84%	100%
A4I1F8	Leishmania infantum	22%	93%
A4IAR3	Leishmania infantum	95%	100%
C9ZK11	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	94%
D0A2E9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	95%
E9AEI9	Leishmania major	95%	100%
E9AXJ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
Q0VGV9	Xenopus tropicalis	21%	83%
Q4Q9X7	Leishmania major	23%	100%
Q658I5	Oryza sativa subsp. japonica	23%	88%
Q7SYR6	Xenopus laevis	22%	83%
Q9M028	Arabidopsis thaliana	24%	88%
Q9SR93	Arabidopsis thaliana	24%	88%