Putative transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

transporter, putative

Species:

Leishmania mexicana

UniProt:

E9B5P6_LEIMU

TriTrypDb:

LmxM.34.0080

Length:

579

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

E9B5P6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5P6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0006811	monoatomic ion transport	4	12
GO:0006812	monoatomic cation transport	5	12
GO:0006813	potassium ion transport	7	12
GO:0030001	metal ion transport	6	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	12
GO:0008324	monoatomic cation transmembrane transporter activity	4	12
GO:0015075	monoatomic ion transmembrane transporter activity	3	12
GO:0022857	transmembrane transporter activity	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	303	307	PF00656	0.776
CLV_C14_Caspase3-7	518	522	PF00656	0.325
CLV_NRD_NRD_1	184	186	PF00675	0.414
CLV_NRD_NRD_1	284	286	PF00675	0.364
CLV_NRD_NRD_1	450	452	PF00675	0.415
CLV_PCSK_KEX2_1	179	181	PF00082	0.353
CLV_PCSK_KEX2_1	184	186	PF00082	0.366
CLV_PCSK_KEX2_1	284	286	PF00082	0.359
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.405
CLV_PCSK_PC7_1	180	186	PF00082	0.443
CLV_PCSK_SKI1_1	13	17	PF00082	0.543
CLV_PCSK_SKI1_1	131	135	PF00082	0.501
CLV_PCSK_SKI1_1	159	163	PF00082	0.396
CLV_PCSK_SKI1_1	454	458	PF00082	0.421
CLV_PCSK_SKI1_1	463	467	PF00082	0.274
CLV_PCSK_SKI1_1	501	505	PF00082	0.487
DEG_SCF_FBW7_1	24	31	PF00400	0.746
DEG_SPOP_SBC_1	141	145	PF00917	0.449
DOC_CDC14_PxL_1	44	52	PF14671	0.713
DOC_CDC14_PxL_1	91	99	PF14671	0.471
DOC_CKS1_1	25	30	PF01111	0.745
DOC_CYCLIN_RxL_1	495	508	PF00134	0.305
DOC_MAPK_gen_1	546	554	PF00069	0.495
DOC_MAPK_MEF2A_6	546	554	PF00069	0.490
DOC_PP1_RVXF_1	466	472	PF00149	0.387
DOC_PP2B_LxvP_1	134	137	PF13499	0.475
DOC_PP2B_LxvP_1	517	520	PF13499	0.290
DOC_PP4_FxxP_1	45	48	PF00568	0.720
DOC_SPAK_OSR1_1	495	499	PF12202	0.362
DOC_USP7_MATH_1	106	110	PF00917	0.292
DOC_USP7_MATH_1	190	194	PF00917	0.449
DOC_USP7_MATH_1	232	236	PF00917	0.210
DOC_USP7_MATH_1	327	331	PF00917	0.689
DOC_USP7_MATH_1	347	351	PF00917	0.602
DOC_USP7_MATH_1	415	419	PF00917	0.331
DOC_WW_Pin1_4	166	171	PF00397	0.635
DOC_WW_Pin1_4	193	198	PF00397	0.363
DOC_WW_Pin1_4	24	29	PF00397	0.787
DOC_WW_Pin1_4	296	301	PF00397	0.679
DOC_WW_Pin1_4	323	328	PF00397	0.604
DOC_WW_Pin1_4	329	334	PF00397	0.547
LIG_14-3-3_CanoR_1	310	318	PF00244	0.770
LIG_14-3-3_CanoR_1	328	332	PF00244	0.645
LIG_14-3-3_CanoR_1	39	45	PF00244	0.687
LIG_14-3-3_CanoR_1	458	462	PF00244	0.486
LIG_14-3-3_CanoR_1	463	472	PF00244	0.472
LIG_AP2alpha_1	529	533	PF02296	0.184
LIG_APCC_ABBA_1	478	483	PF00400	0.415
LIG_BRCT_BRCA1_1	234	238	PF00533	0.355
LIG_BRCT_BRCA1_1	466	470	PF00533	0.344
LIG_deltaCOP1_diTrp_1	122	130	PF00928	0.367
LIG_deltaCOP1_diTrp_1	276	281	PF00928	0.530
LIG_FHA_1	194	200	PF00498	0.396
LIG_FHA_1	249	255	PF00498	0.404
LIG_FHA_1	313	319	PF00498	0.729
LIG_FHA_1	364	370	PF00498	0.474
LIG_FHA_1	38	44	PF00498	0.740
LIG_FHA_1	457	463	PF00498	0.506
LIG_FHA_1	464	470	PF00498	0.352
LIG_FHA_1	472	478	PF00498	0.337
LIG_FHA_1	498	504	PF00498	0.287
LIG_FHA_1	79	85	PF00498	0.430
LIG_FHA_2	167	173	PF00498	0.622
LIG_FHA_2	347	353	PF00498	0.503
LIG_FHA_2	500	506	PF00498	0.319
LIG_GBD_Chelix_1	282	290	PF00786	0.236
LIG_GBD_Chelix_1	461	469	PF00786	0.337
LIG_IRF3_LxIS_1	439	445	PF10401	0.417
LIG_LIR_Gen_1	101	110	PF02991	0.223
LIG_LIR_Gen_1	196	204	PF02991	0.415
LIG_LIR_Gen_1	221	231	PF02991	0.339
LIG_LIR_Gen_1	494	504	PF02991	0.292
LIG_LIR_Gen_1	530	541	PF02991	0.439
LIG_LIR_Gen_1	555	565	PF02991	0.591
LIG_LIR_Gen_1	81	90	PF02991	0.447
LIG_LIR_Nem_3	101	107	PF02991	0.256
LIG_LIR_Nem_3	128	133	PF02991	0.369
LIG_LIR_Nem_3	143	149	PF02991	0.326
LIG_LIR_Nem_3	196	201	PF02991	0.387
LIG_LIR_Nem_3	221	226	PF02991	0.355
LIG_LIR_Nem_3	263	268	PF02991	0.338
LIG_LIR_Nem_3	276	280	PF02991	0.504
LIG_LIR_Nem_3	330	334	PF02991	0.616
LIG_LIR_Nem_3	355	359	PF02991	0.595
LIG_LIR_Nem_3	387	392	PF02991	0.358
LIG_LIR_Nem_3	397	403	PF02991	0.282
LIG_LIR_Nem_3	418	422	PF02991	0.383
LIG_LIR_Nem_3	467	473	PF02991	0.329
LIG_LIR_Nem_3	502	507	PF02991	0.274
LIG_LIR_Nem_3	525	529	PF02991	0.347
LIG_LIR_Nem_3	530	536	PF02991	0.391
LIG_LIR_Nem_3	555	561	PF02991	0.592
LIG_LIR_Nem_3	81	85	PF02991	0.447
LIG_MYND_1	24	28	PF01753	0.743
LIG_MYND_1	48	52	PF01753	0.687
LIG_MYND_3	420	424	PF01753	0.397
LIG_NRBOX	285	291	PF00104	0.652
LIG_Pex14_1	453	457	PF04695	0.625
LIG_Pex14_2	198	202	PF04695	0.262
LIG_Pex14_2	529	533	PF04695	0.378
LIG_Pex14_2	66	70	PF04695	0.577
LIG_REV1ctd_RIR_1	64	73	PF16727	0.604
LIG_SH2_CRK	188	192	PF00017	0.413
LIG_SH2_GRB2like	425	428	PF00017	0.341
LIG_SH2_SRC	438	441	PF00017	0.449
LIG_SH2_STAP1	188	192	PF00017	0.361
LIG_SH2_STAP1	244	248	PF00017	0.391
LIG_SH2_STAP1	278	282	PF00017	0.518
LIG_SH2_STAT5	200	203	PF00017	0.367
LIG_SH2_STAT5	396	399	PF00017	0.447
LIG_SH2_STAT5	403	406	PF00017	0.340
LIG_SH2_STAT5	438	441	PF00017	0.412
LIG_SH2_STAT5	71	74	PF00017	0.344
LIG_SH2_STAT5	78	81	PF00017	0.344
LIG_SH3_3	158	164	PF00018	0.595
LIG_SH3_3	22	28	PF00018	0.776
LIG_SH3_3	437	443	PF00018	0.344
LIG_SH3_3	46	52	PF00018	0.607
LIG_TRAF2_1	169	172	PF00917	0.581
LIG_TYR_ITIM	186	191	PF00017	0.513
LIG_UBA3_1	60	69	PF00899	0.633
MOD_CDK_SPK_2	323	328	PF00069	0.534
MOD_CK1_1	125	131	PF00069	0.278
MOD_CK1_1	193	199	PF00069	0.449
MOD_CK1_1	218	224	PF00069	0.365
MOD_CK1_1	38	44	PF00069	0.725
MOD_CK1_1	522	528	PF00069	0.309
MOD_CK1_1	560	566	PF00069	0.709
MOD_CK2_1	166	172	PF00069	0.648
MOD_CK2_1	302	308	PF00069	0.741
MOD_CK2_1	346	352	PF00069	0.658
MOD_CK2_1	499	505	PF00069	0.276
MOD_CK2_1	566	572	PF00069	0.694
MOD_GlcNHglycan	124	127	PF01048	0.619
MOD_GlcNHglycan	192	195	PF01048	0.407
MOD_GlcNHglycan	2	5	PF01048	0.510
MOD_GlcNHglycan	316	321	PF01048	0.530
MOD_GlcNHglycan	507	510	PF01048	0.476
MOD_GSK3_1	121	128	PF00069	0.366
MOD_GSK3_1	211	218	PF00069	0.329
MOD_GSK3_1	24	31	PF00069	0.801
MOD_GSK3_1	248	255	PF00069	0.409
MOD_GSK3_1	312	319	PF00069	0.743
MOD_GSK3_1	323	330	PF00069	0.560
MOD_GSK3_1	442	449	PF00069	0.540
MOD_GSK3_1	515	522	PF00069	0.282
MOD_GSK3_1	556	563	PF00069	0.655
MOD_GSK3_1	568	575	PF00069	0.698
MOD_N-GLC_1	204	209	PF02516	0.319
MOD_N-GLC_1	215	220	PF02516	0.575
MOD_N-GLC_1	522	527	PF02516	0.557
MOD_NEK2_1	211	216	PF00069	0.340
MOD_NEK2_1	226	231	PF00069	0.259
MOD_NEK2_1	233	238	PF00069	0.287
MOD_NEK2_1	260	265	PF00069	0.348
MOD_NEK2_1	423	428	PF00069	0.333
MOD_NEK2_1	456	461	PF00069	0.614
MOD_NEK2_1	464	469	PF00069	0.360
MOD_NEK2_1	491	496	PF00069	0.300
MOD_NEK2_1	499	504	PF00069	0.268
MOD_NEK2_1	515	520	PF00069	0.286
MOD_NEK2_1	529	534	PF00069	0.378
MOD_NEK2_1	556	561	PF00069	0.629
MOD_NEK2_2	363	368	PF00069	0.566
MOD_PIKK_1	38	44	PF00454	0.678
MOD_PKA_2	327	333	PF00069	0.662
MOD_PKA_2	361	367	PF00069	0.601
MOD_PKA_2	38	44	PF00069	0.704
MOD_PKA_2	457	463	PF00069	0.504
MOD_PKA_2	572	578	PF00069	0.720
MOD_Plk_1	215	221	PF00069	0.387
MOD_Plk_1	446	452	PF00069	0.609
MOD_Plk_1	522	528	PF00069	0.352
MOD_Plk_2-3	302	308	PF00069	0.772
MOD_Plk_4	125	131	PF00069	0.391
MOD_Plk_4	204	210	PF00069	0.406
MOD_Plk_4	218	224	PF00069	0.372
MOD_Plk_4	233	239	PF00069	0.328
MOD_Plk_4	276	282	PF00069	0.608
MOD_Plk_4	363	369	PF00069	0.470
MOD_Plk_4	374	380	PF00069	0.424
MOD_Plk_4	415	421	PF00069	0.317
MOD_Plk_4	430	436	PF00069	0.449
MOD_Plk_4	457	463	PF00069	0.497
MOD_Plk_4	522	528	PF00069	0.298
MOD_Plk_4	78	84	PF00069	0.359
MOD_ProDKin_1	166	172	PF00069	0.632
MOD_ProDKin_1	193	199	PF00069	0.363
MOD_ProDKin_1	24	30	PF00069	0.784
MOD_ProDKin_1	296	302	PF00069	0.683
MOD_ProDKin_1	323	329	PF00069	0.602
TRG_DiLeu_BaEn_1	46	51	PF01217	0.706
TRG_DiLeu_BaLyEn_6	145	150	PF01217	0.344
TRG_DiLeu_BaLyEn_6	418	423	PF01217	0.386
TRG_DiLeu_BaLyEn_6	460	465	PF01217	0.517
TRG_ENDOCYTIC_2	188	191	PF00928	0.381
TRG_ENDOCYTIC_2	200	203	PF00928	0.288
TRG_ENDOCYTIC_2	331	334	PF00928	0.653
TRG_ENDOCYTIC_2	403	406	PF00928	0.361
TRG_ER_diArg_1	184	186	PF00400	0.647
TRG_ER_diArg_1	283	285	PF00400	0.566
TRG_ER_diArg_1	546	549	PF00400	0.551
TRG_NLS_MonoExtN_4	448	455	PF00514	0.626
TRG_Pf-PMV_PEXEL_1	501	505	PF00026	0.498
TRG_Pf-PMV_PEXEL_1	58	62	PF00026	0.457

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD62	Leptomonas seymouri	66%	100%
A0A0S4JPJ1	Bodo saltans	23%	100%
A0A1X0NIY1	Trypanosomatidae	54%	88%
A0A3Q8IIM6	Leishmania donovani	92%	100%
A0A3R7RF53	Trypanosoma rangeli	51%	98%
A4HM47	Leishmania braziliensis	81%	100%
A4IAQ9	Leishmania infantum	92%	100%
D0A2F4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	97%
E9AEI5	Leishmania major	91%	100%
V5B392	Trypanosoma cruzi	47%	98%