Pyruvate kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Pyruvate kinase

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania mexicana

UniProt:

E9B5P0_LEIMU

TriTrypDb:

Length:

264

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B5P0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5P0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0000287	magnesium ion binding	5	2
GO:0003824	catalytic activity	1	2
GO:0004743	pyruvate kinase activity	5	2
GO:0005488	binding	1	2
GO:0005524	ATP binding	5	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	2
GO:0017076	purine nucleotide binding	4	2
GO:0030554	adenyl nucleotide binding	5	2
GO:0030955	potassium ion binding	6	2
GO:0031420	alkali metal ion binding	5	2
GO:0032553	ribonucleotide binding	3	2
GO:0032555	purine ribonucleotide binding	4	2
GO:0032559	adenyl ribonucleotide binding	5	2
GO:0035639	purine ribonucleoside triphosphate binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2
GO:0097159	organic cyclic compound binding	2	2
GO:0097367	carbohydrate derivative binding	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	183	185	PF00675	0.449
CLV_NRD_NRD_1	231	233	PF00675	0.449
CLV_PCSK_KEX2_1	183	185	PF00082	0.449
CLV_PCSK_SKI1_1	112	116	PF00082	0.449
CLV_PCSK_SKI1_1	232	236	PF00082	0.449
DEG_Nend_Nbox_1	1	3	PF02207	0.777
DOC_MAPK_gen_1	238	245	PF00069	0.650
DOC_WW_Pin1_4	196	201	PF00397	0.650
LIG_14-3-3_CanoR_1	3	8	PF00244	0.738
LIG_14-3-3_CanoR_1	58	68	PF00244	0.650
LIG_DCNL_PONY_1	1	4	PF03556	0.775
LIG_FHA_1	113	119	PF00498	0.650
LIG_FHA_1	15	21	PF00498	0.656
LIG_FHA_1	28	34	PF00498	0.487
LIG_FHA_1	38	44	PF00498	0.525
LIG_FHA_2	177	183	PF00498	0.650
LIG_KLC1_Yacidic_2	131	136	PF13176	0.650
LIG_LIR_Gen_1	136	144	PF02991	0.650
LIG_LIR_Gen_1	215	225	PF02991	0.650
LIG_LIR_Nem_3	131	137	PF02991	0.650
LIG_LIR_Nem_3	19	24	PF02991	0.665
LIG_LIR_Nem_3	215	221	PF02991	0.650
LIG_SH2_CRK	137	141	PF00017	0.650
LIG_SH2_GRB2like	137	140	PF00017	0.650
LIG_SH2_PTP2	149	152	PF00017	0.650
LIG_SH2_SRC	149	152	PF00017	0.650
LIG_SH2_STAT5	117	120	PF00017	0.650
LIG_SH2_STAT5	134	137	PF00017	0.437
LIG_SH2_STAT5	149	152	PF00017	0.462
LIG_SH3_3	140	146	PF00018	0.650
LIG_SH3_3	183	189	PF00018	0.650
LIG_SH3_3	190	196	PF00018	0.562
LIG_SUMO_SIM_anti_2	153	160	PF11976	0.650
LIG_SUMO_SIM_anti_2	241	246	PF11976	0.650
LIG_SUMO_SIM_par_1	16	22	PF11976	0.659
LIG_TYR_ITIM	135	140	PF00017	0.650
LIG_UBA3_1	242	247	PF00899	0.650
LIG_WRC_WIRS_1	218	223	PF05994	0.650
MOD_CDK_SPK_2	196	201	PF00069	0.650
MOD_CK1_1	39	45	PF00069	0.650
MOD_CK1_1	52	58	PF00069	0.487
MOD_CK1_1	62	68	PF00069	0.525
MOD_CK2_1	16	22	PF00069	0.659
MOD_CK2_1	256	262	PF00069	0.650
MOD_GlcNHglycan	223	226	PF01048	0.449
MOD_GlcNHglycan	51	54	PF01048	0.449
MOD_GSK3_1	112	119	PF00069	0.650
MOD_GSK3_1	166	173	PF00069	0.650
MOD_GSK3_1	217	224	PF00069	0.650
MOD_GSK3_1	3	10	PF00069	0.720
MOD_GSK3_1	32	39	PF00069	0.650
MOD_N-GLC_1	138	143	PF02516	0.449
MOD_N-GLC_1	14	19	PF02516	0.644
MOD_N-GLC_1	59	64	PF02516	0.449
MOD_NEK2_1	16	21	PF00069	0.502
MOD_NEK2_1	170	175	PF00069	0.650
MOD_NEK2_1	49	54	PF00069	0.650
MOD_NEK2_1	59	64	PF00069	0.525
MOD_NEK2_1	7	12	PF00069	0.675
MOD_PIKK_1	37	43	PF00454	0.650
MOD_PIKK_1	7	13	PF00454	0.665
MOD_PKA_2	27	33	PF00069	0.549
MOD_Plk_1	14	20	PF00069	0.649
MOD_Plk_1	166	172	PF00069	0.650
MOD_Plk_4	16	22	PF00069	0.659
MOD_Plk_4	217	223	PF00069	0.650
MOD_Plk_4	256	262	PF00069	0.650
MOD_ProDKin_1	196	202	PF00069	0.650
TRG_ENDOCYTIC_2	137	140	PF00928	0.650
TRG_ENDOCYTIC_2	149	152	PF00928	0.500

Homologs


Protein	Taxonomy	Sequence identity	Coverage
B0B7Q0	CHLT2	40%	54%
B8BJ39	ORYSI	28%	50%
B8BM17	ORYSI	29%	50%
O05118	METEA	35%	55%
O08309	CLOAB	41%	56%
O44006	EIMTE	41%	50%
O51323	BORBU	33%	55%
O62619	DROME	52%	50%
O65595	ARATH	43%	53%
O94122	AGABI	49%	50%
P00548	CHICK	50%	50%
P00549	YEAST	49%	53%
P0AD61	ECOLI	42%	56%
P0AD62	ECO57	42%	56%
P0CE21	CHLTR	40%	54%
P11974	RABIT	51%	50%
P11979	FELCA	51%	50%
P11980	RAT	51%	50%
P12928	RAT	49%	46%
P14618	HUMAN	51%	50%
P19680	SPICI	46%	100%
P21599	ECOLI	34%	55%
P22200	SOLTU	42%	52%
P22360	EMENI	51%	50%
P30613	HUMAN	52%	46%
P30614	YARLI	50%	51%
P30615	TRYBB	74%	53%
P30616	TRYBB	74%	53%
P31865	HYPJE	53%	49%
P32044	THEAC	31%	49%
P34038	LACDE	39%	45%
P43924	HAEIN	33%	55%
P46614	CANAL	53%	52%
P47458	MYCGE	33%	52%
P51181	BACLI	46%	45%
P51182	SPOPS	42%	45%
P52480	MOUSE	51%	50%
P52489	YEAST	49%	52%
P53657	MOUSE	50%	46%
P55964	RICCO	31%	63%
P57404	BUCAI	31%	55%
P70789	AGRVI	34%	56%
P73534	SYNY3	38%	45%
P77983	SALTY	42%	56%
P78031	MYCPN	30%	52%
P80885	BACSU	46%	45%
P94939	MYCIT	36%	56%
P9WKE4	MYCTO	36%	56%
P9WKE5	MYCTU	36%	56%
Q02499	GEOSE	44%	45%
Q04668	LEIBR	91%	100%
Q07637	LACLA	30%	53%
Q10208	SCHPO	54%	52%
Q12669	ASPNG	50%	50%
Q27686	LEIME	94%	53%
Q27788	TRYBO	57%	53%
Q29536	CANLF	50%	46%
Q2FG40	STAA3	43%	45%
Q2FXM9	STAA8	43%	45%
Q2QXR8	ORYSJ	29%	50%
Q2RAK2	ORYSJ	28%	50%
Q2YTE3	STAAB	43%	45%
Q40545	TOBAC	31%	45%
Q40546	TOBAC	37%	47%
Q42806	SOYBN	42%	52%
Q42954	TOBAC	42%	52%
Q43117	RICCO	31%	45%
Q44473	AGRVI	32%	55%
Q46078	CORGL	39%	56%
Q46289	CLOPE	42%	56%
Q49YC7	STAS1	44%	45%
Q4L739	STAHJ	43%	45%
Q54RF5	DICDI	47%	52%
Q55863	SYNY3	38%	55%
Q56301	THELN	34%	56%
Q57572	METJA	28%	59%
Q5HF76	STAAC	43%	45%
Q5HNK7	STAEQ	43%	45%
Q5NVN0	PONAB	51%	50%
Q6BS75	DEBHA	49%	52%
Q6FIS9	CANGA	51%	53%
Q6FV12	CANGA	49%	52%
Q6G8M9	STAAS	43%	45%
Q6GG09	STAAR	43%	45%
Q759A9	ASHGO	49%	53%
Q7A0N4	STAAW	43%	45%
Q7A559	STAAN	43%	45%
Q7RVA8	NEUCR	51%	50%
Q875M9	KLULA	50%	53%
Q875S4	LACK1	51%	53%
Q875Z9	NAUCC	49%	53%
Q89AI8	BUCBP	31%	55%
Q8CS69	STAES	43%	45%
Q8FP04	COREF	40%	56%
Q8K9M3	BUCAP	31%	55%
Q8SQP0	ENCCU	37%	62%
Q8Z6K2	SALTI	42%	56%
Q8ZNW0	SALTY	35%	55%
Q8ZYE0	PYRAE	24%	57%
Q92122	XENLA	52%	50%
Q93Z53	ARATH	37%	46%
Q99TG5	STAAM	43%	45%
Q9FLW9	ARATH	36%	46%
Q9LIK0	ARATH	32%	44%
Q9PK61	CHLMU	40%	55%
Q9WY51	THEMA	30%	57%
Q9YEU2	AERPE	32%	58%
Q9Z984	CHLPN	39%	55%