Cyclic nucleotide-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cyclic nucleotide-binding domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B5N9_LEIMU

TriTrypDb:

LmxM.33.4620

Length:

801

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B5N9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5N9

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009116	nucleoside metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044281	small molecule metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901657	glycosyl compound metabolic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	227	231	PF00656	0.737
CLV_C14_Caspase3-7	35	39	PF00656	0.734
CLV_C14_Caspase3-7	4	8	PF00656	0.511
CLV_NRD_NRD_1	143	145	PF00675	0.406
CLV_NRD_NRD_1	181	183	PF00675	0.475
CLV_NRD_NRD_1	261	263	PF00675	0.643
CLV_NRD_NRD_1	275	277	PF00675	0.439
CLV_NRD_NRD_1	325	327	PF00675	0.450
CLV_NRD_NRD_1	463	465	PF00675	0.456
CLV_NRD_NRD_1	746	748	PF00675	0.540
CLV_PCSK_KEX2_1	137	139	PF00082	0.479
CLV_PCSK_KEX2_1	143	145	PF00082	0.406
CLV_PCSK_KEX2_1	275	277	PF00082	0.375
CLV_PCSK_KEX2_1	323	325	PF00082	0.482
CLV_PCSK_KEX2_1	463	465	PF00082	0.466
CLV_PCSK_KEX2_1	605	607	PF00082	0.591
CLV_PCSK_KEX2_1	746	748	PF00082	0.572
CLV_PCSK_KEX2_1	780	782	PF00082	0.552
CLV_PCSK_PC1ET2_1	137	139	PF00082	0.503
CLV_PCSK_PC1ET2_1	323	325	PF00082	0.560
CLV_PCSK_PC1ET2_1	605	607	PF00082	0.591
CLV_PCSK_PC1ET2_1	780	782	PF00082	0.552
CLV_PCSK_PC7_1	271	277	PF00082	0.483
CLV_PCSK_SKI1_1	134	138	PF00082	0.497
CLV_PCSK_SKI1_1	218	222	PF00082	0.446
CLV_PCSK_SKI1_1	382	386	PF00082	0.550
CLV_PCSK_SKI1_1	463	467	PF00082	0.544
CLV_PCSK_SKI1_1	491	495	PF00082	0.420
CLV_PCSK_SKI1_1	625	629	PF00082	0.513
CLV_PCSK_SKI1_1	659	663	PF00082	0.433
CLV_PCSK_SKI1_1	758	762	PF00082	0.470
CLV_PCSK_SKI1_1	792	796	PF00082	0.426
CLV_Separin_Metazoa	379	383	PF03568	0.580
DEG_APCC_DBOX_1	365	373	PF00400	0.462
DEG_APCC_DBOX_1	791	799	PF00400	0.436
DOC_CDC14_PxL_1	79	87	PF14671	0.454
DOC_CYCLIN_RxL_1	491	501	PF00134	0.382
DOC_CYCLIN_RxL_1	622	633	PF00134	0.427
DOC_CYCLIN_RxL_1	752	765	PF00134	0.504
DOC_CYCLIN_yClb1_LxF_4	657	662	PF00134	0.463
DOC_CYCLIN_yCln2_LP_2	240	246	PF00134	0.452
DOC_MAPK_gen_1	182	188	PF00069	0.468
DOC_MAPK_gen_1	275	283	PF00069	0.553
DOC_MAPK_gen_1	463	471	PF00069	0.489
DOC_MAPK_gen_1	602	612	PF00069	0.580
DOC_MAPK_HePTP_8	98	110	PF00069	0.403
DOC_MAPK_MEF2A_6	101	110	PF00069	0.403
DOC_MAPK_MEF2A_6	275	283	PF00069	0.440
DOC_PP1_RVXF_1	657	663	PF00149	0.460
DOC_PP2B_LxvP_1	178	181	PF13499	0.434
DOC_PP2B_LxvP_1	240	243	PF13499	0.489
DOC_PP2B_LxvP_1	486	489	PF13499	0.375
DOC_PP4_FxxP_1	50	53	PF00568	0.577
DOC_USP7_MATH_1	305	309	PF00917	0.473
DOC_USP7_MATH_1	550	554	PF00917	0.589
DOC_USP7_MATH_1	595	599	PF00917	0.638
DOC_USP7_MATH_1	71	75	PF00917	0.655
DOC_USP7_UBL2_3	133	137	PF12436	0.497
DOC_WW_Pin1_4	189	194	PF00397	0.527
DOC_WW_Pin1_4	310	315	PF00397	0.608
DOC_WW_Pin1_4	371	376	PF00397	0.542
DOC_WW_Pin1_4	579	584	PF00397	0.559
DOC_WW_Pin1_4	67	72	PF00397	0.685
DOC_WW_Pin1_4	686	691	PF00397	0.568
LIG_14-3-3_CanoR_1	247	256	PF00244	0.548
LIG_14-3-3_CanoR_1	326	332	PF00244	0.485
LIG_14-3-3_CanoR_1	463	469	PF00244	0.488
LIG_14-3-3_CanoR_1	634	639	PF00244	0.484
LIG_14-3-3_CanoR_1	680	688	PF00244	0.639
LIG_Actin_WH2_2	123	139	PF00022	0.497
LIG_Actin_WH2_2	40	57	PF00022	0.690
LIG_AP2alpha_1	185	189	PF02296	0.484
LIG_APCC_ABBA_1	210	215	PF00400	0.461
LIG_APCC_ABBA_1	430	435	PF00400	0.445
LIG_BIR_II_1	1	5	PF00653	0.715
LIG_BIR_III_4	230	234	PF00653	0.617
LIG_BRCT_BRCA1_1	191	195	PF00533	0.481
LIG_BRCT_BRCA1_1	297	301	PF00533	0.590
LIG_BRCT_BRCA1_1	403	407	PF00533	0.581
LIG_BRCT_BRCA1_1	445	449	PF00533	0.551
LIG_BRCT_BRCA1_1	556	560	PF00533	0.573
LIG_eIF4E_1	535	541	PF01652	0.490
LIG_FHA_1	124	130	PF00498	0.398
LIG_FHA_1	173	179	PF00498	0.409
LIG_FHA_1	272	278	PF00498	0.477
LIG_FHA_1	282	288	PF00498	0.419
LIG_FHA_1	311	317	PF00498	0.642
LIG_FHA_1	335	341	PF00498	0.436
LIG_FHA_1	344	350	PF00498	0.384
LIG_FHA_1	536	542	PF00498	0.492
LIG_FHA_1	584	590	PF00498	0.314
LIG_FHA_1	670	676	PF00498	0.573
LIG_FHA_1	687	693	PF00498	0.379
LIG_FHA_1	85	91	PF00498	0.503
LIG_FHA_2	559	565	PF00498	0.481
LIG_FHA_2	727	733	PF00498	0.511
LIG_FHA_2	87	93	PF00498	0.483
LIG_HCF-1_HBM_1	117	120	PF13415	0.497
LIG_IBAR_NPY_1	452	454	PF08397	0.471
LIG_Integrin_RGD_1	651	653	PF01839	0.431
LIG_LIR_Gen_1	102	110	PF02991	0.403
LIG_LIR_Gen_1	209	216	PF02991	0.439
LIG_LIR_Gen_1	264	272	PF02991	0.523
LIG_LIR_Gen_1	282	293	PF02991	0.416
LIG_LIR_Gen_1	353	362	PF02991	0.316
LIG_LIR_Gen_1	557	568	PF02991	0.477
LIG_LIR_Nem_3	209	213	PF02991	0.414
LIG_LIR_Nem_3	264	270	PF02991	0.521
LIG_LIR_Nem_3	282	288	PF02991	0.406
LIG_LIR_Nem_3	353	358	PF02991	0.316
LIG_LIR_Nem_3	531	537	PF02991	0.466
LIG_LIR_Nem_3	757	762	PF02991	0.437
LIG_NRBOX	536	542	PF00104	0.496
LIG_NRBOX	623	629	PF00104	0.435
LIG_Pex14_2	185	189	PF04695	0.385
LIG_Pex14_2	351	355	PF04695	0.235
LIG_Rb_LxCxE_1	353	374	PF01857	0.540
LIG_SH2_CRK	428	432	PF00017	0.449
LIG_SH2_CRK	722	726	PF00017	0.481
LIG_SH2_GRB2like	454	457	PF00017	0.502
LIG_SH2_PTP2	285	288	PF00017	0.534
LIG_SH2_SRC	115	118	PF00017	0.481
LIG_SH2_SRC	285	288	PF00017	0.534
LIG_SH2_STAP1	238	242	PF00017	0.366
LIG_SH2_STAP1	454	458	PF00017	0.521
LIG_SH2_STAT5	115	118	PF00017	0.457
LIG_SH2_STAT5	120	123	PF00017	0.471
LIG_SH2_STAT5	25	28	PF00017	0.599
LIG_SH2_STAT5	272	275	PF00017	0.468
LIG_SH2_STAT5	285	288	PF00017	0.412
LIG_SH2_STAT5	296	299	PF00017	0.555
LIG_SH2_STAT5	437	440	PF00017	0.487
LIG_SH2_STAT5	535	538	PF00017	0.456
LIG_SH2_STAT5	737	740	PF00017	0.433
LIG_SH2_STAT5	759	762	PF00017	0.463
LIG_SH3_1	65	71	PF00018	0.647
LIG_SH3_3	65	71	PF00018	0.706
LIG_SH3_3	651	657	PF00018	0.400
LIG_SH3_3	772	778	PF00018	0.740
LIG_SUMO_SIM_anti_2	126	132	PF11976	0.408
LIG_SUMO_SIM_anti_2	175	181	PF11976	0.411
LIG_SUMO_SIM_anti_2	284	290	PF11976	0.496
LIG_SUMO_SIM_anti_2	337	343	PF11976	0.509
LIG_SUMO_SIM_anti_2	94	100	PF11976	0.570
LIG_SUMO_SIM_par_1	284	290	PF11976	0.446
LIG_SUMO_SIM_par_1	571	577	PF11976	0.530
LIG_SUMO_SIM_par_1	86	92	PF11976	0.544
LIG_TRAF2_1	89	92	PF00917	0.586
LIG_TYR_ITIM	265	270	PF00017	0.428
LIG_TYR_ITIM	283	288	PF00017	0.347
LIG_UBA3_1	176	183	PF00899	0.391
LIG_UBA3_1	357	364	PF00899	0.514
LIG_UBA3_1	461	466	PF00899	0.411
LIG_UBA3_1	496	505	PF00899	0.538
LIG_WRC_WIRS_1	207	212	PF05994	0.487
LIG_WRC_WIRS_1	352	357	PF05994	0.234
LIG_WRC_WIRS_1	628	633	PF05994	0.483
LIG_WRC_WIRS_1	75	80	PF05994	0.529
MOD_CDK_SPK_2	67	72	PF00069	0.715
MOD_CK1_1	172	178	PF00069	0.390
MOD_CK1_1	224	230	PF00069	0.639
MOD_CK1_1	236	242	PF00069	0.499
MOD_CK1_1	251	257	PF00069	0.494
MOD_CK1_1	393	399	PF00069	0.404
MOD_CK1_1	512	518	PF00069	0.594
MOD_CK1_1	579	585	PF00069	0.533
MOD_CK1_1	598	604	PF00069	0.535
MOD_CK1_1	663	669	PF00069	0.504
MOD_CK1_1	70	76	PF00069	0.587
MOD_CK2_1	373	379	PF00069	0.577
MOD_CK2_1	393	399	PF00069	0.514
MOD_CK2_1	405	411	PF00069	0.481
MOD_CK2_1	469	475	PF00069	0.523
MOD_CK2_1	558	564	PF00069	0.520
MOD_CK2_1	579	585	PF00069	0.575
MOD_CK2_1	663	669	PF00069	0.518
MOD_CK2_1	680	686	PF00069	0.421
MOD_CK2_1	86	92	PF00069	0.492
MOD_Cter_Amidation	321	324	PF01082	0.574
MOD_Cter_Amidation	603	606	PF01082	0.607
MOD_GlcNHglycan	123	126	PF01048	0.391
MOD_GlcNHglycan	226	229	PF01048	0.687
MOD_GlcNHglycan	235	238	PF01048	0.542
MOD_GlcNHglycan	251	254	PF01048	0.418
MOD_GlcNHglycan	3	6	PF01048	0.723
MOD_GlcNHglycan	375	378	PF01048	0.553
MOD_GlcNHglycan	392	395	PF01048	0.684
MOD_GlcNHglycan	40	43	PF01048	0.557
MOD_GlcNHglycan	500	503	PF01048	0.475
MOD_GlcNHglycan	513	517	PF01048	0.580
MOD_GlcNHglycan	568	571	PF01048	0.463
MOD_GlcNHglycan	592	595	PF01048	0.396
MOD_GlcNHglycan	640	643	PF01048	0.495
MOD_GlcNHglycan	696	699	PF01048	0.571
MOD_GlcNHglycan	784	787	PF01048	0.441
MOD_GSK3_1	165	172	PF00069	0.392
MOD_GSK3_1	222	229	PF00069	0.616
MOD_GSK3_1	232	239	PF00069	0.568
MOD_GSK3_1	401	408	PF00069	0.520
MOD_GSK3_1	443	450	PF00069	0.581
MOD_GSK3_1	550	557	PF00069	0.564
MOD_GSK3_1	579	586	PF00069	0.544
MOD_GSK3_1	623	630	PF00069	0.425
MOD_GSK3_1	634	641	PF00069	0.420
MOD_GSK3_1	67	74	PF00069	0.663
MOD_LATS_1	142	148	PF00433	0.408
MOD_N-GLC_1	197	202	PF02516	0.511
MOD_N-GLC_1	279	284	PF02516	0.429
MOD_N-GLC_1	36	41	PF02516	0.731
MOD_N-GLC_1	442	447	PF02516	0.508
MOD_N-GLC_1	489	494	PF02516	0.443
MOD_N-GLC_1	509	514	PF02516	0.356
MOD_N-GLC_1	579	584	PF02516	0.504
MOD_N-GLC_1	638	643	PF02516	0.441
MOD_N-GLC_1	678	683	PF02516	0.527
MOD_N-GLC_1	771	776	PF02516	0.677
MOD_NEK2_1	1	6	PF00069	0.732
MOD_NEK2_1	221	226	PF00069	0.590
MOD_NEK2_1	248	253	PF00069	0.481
MOD_NEK2_1	351	356	PF00069	0.331
MOD_NEK2_1	590	595	PF00069	0.362
MOD_NEK2_1	627	632	PF00069	0.460
MOD_NEK2_1	660	665	PF00069	0.448
MOD_NEK2_1	712	717	PF00069	0.452
MOD_NEK2_1	721	726	PF00069	0.450
MOD_NEK2_1	733	738	PF00069	0.382
MOD_NEK2_1	751	756	PF00069	0.496
MOD_NEK2_1	78	83	PF00069	0.463
MOD_NEK2_2	208	213	PF00069	0.545
MOD_NEK2_2	489	494	PF00069	0.532
MOD_PIKK_1	101	107	PF00454	0.403
MOD_PIKK_1	198	204	PF00454	0.554
MOD_PIKK_1	287	293	PF00454	0.510
MOD_PIKK_1	305	311	PF00454	0.405
MOD_PIKK_1	712	718	PF00454	0.524
MOD_PK_1	464	470	PF00069	0.289
MOD_PK_1	634	640	PF00069	0.480
MOD_PKA_2	249	255	PF00069	0.463
MOD_PKA_2	590	596	PF00069	0.554
MOD_PKA_2	679	685	PF00069	0.639
MOD_PKA_2	751	757	PF00069	0.556
MOD_PKB_1	552	560	PF00069	0.563
MOD_Plk_1	101	107	PF00069	0.373
MOD_Plk_1	165	171	PF00069	0.381
MOD_Plk_1	279	285	PF00069	0.508
MOD_Plk_1	420	426	PF00069	0.559
MOD_Plk_1	489	495	PF00069	0.478
MOD_Plk_1	612	618	PF00069	0.445
MOD_Plk_1	91	97	PF00069	0.544
MOD_Plk_2-3	295	301	PF00069	0.618
MOD_Plk_2-3	509	515	PF00069	0.658
MOD_Plk_2-3	669	675	PF00069	0.529
MOD_Plk_2-3	92	98	PF00069	0.561
MOD_Plk_4	144	150	PF00069	0.446
MOD_Plk_4	172	178	PF00069	0.432
MOD_Plk_4	251	257	PF00069	0.444
MOD_Plk_4	281	287	PF00069	0.384
MOD_Plk_4	334	340	PF00069	0.495
MOD_Plk_4	457	463	PF00069	0.485
MOD_Plk_4	464	470	PF00069	0.487
MOD_Plk_4	733	739	PF00069	0.483
MOD_Plk_4	74	80	PF00069	0.603
MOD_Plk_4	771	777	PF00069	0.650
MOD_ProDKin_1	189	195	PF00069	0.519
MOD_ProDKin_1	310	316	PF00069	0.594
MOD_ProDKin_1	371	377	PF00069	0.532
MOD_ProDKin_1	579	585	PF00069	0.559
MOD_ProDKin_1	67	73	PF00069	0.677
MOD_ProDKin_1	686	692	PF00069	0.564
MOD_SUMO_for_1	439	442	PF00179	0.282
MOD_SUMO_rev_2	501	507	PF00179	0.525
TRG_DiLeu_BaEn_1	56	61	PF01217	0.735
TRG_DiLeu_BaEn_4	111	117	PF01217	0.460
TRG_DiLeu_BaEn_4	91	97	PF01217	0.574
TRG_DiLeu_BaLyEn_6	687	692	PF01217	0.615
TRG_ENDOCYTIC_2	103	106	PF00928	0.387
TRG_ENDOCYTIC_2	267	270	PF00928	0.568
TRG_ENDOCYTIC_2	285	288	PF00928	0.485
TRG_ENDOCYTIC_2	428	431	PF00928	0.429
TRG_ENDOCYTIC_2	533	536	PF00928	0.515
TRG_ENDOCYTIC_2	722	725	PF00928	0.442
TRG_ER_diArg_1	143	145	PF00400	0.406
TRG_ER_diArg_1	275	277	PF00400	0.525
TRG_ER_diArg_1	324	326	PF00400	0.447
TRG_ER_diArg_1	365	368	PF00400	0.426
TRG_ER_diArg_1	462	464	PF00400	0.467
TRG_ER_diArg_1	551	554	PF00400	0.570
TRG_NES_CRM1_1	347	361	PF08389	0.396
TRG_NLS_MonoCore_2	322	327	PF00514	0.570
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.524
TRG_Pf-PMV_PEXEL_1	505	509	PF00026	0.456
TRG_Pf-PMV_PEXEL_1	740	744	PF00026	0.455

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ14	Leptomonas seymouri	76%	100%
A0A0S4JKK7	Bodo saltans	33%	100%
A0A1X0NTY5	Trypanosomatidae	30%	82%
A0A1X0PB50	Trypanosomatidae	47%	100%
A0A3Q8IHX4	Leishmania donovani	91%	100%
A0A3R7L5E3	Trypanosoma rangeli	30%	82%
A0A3R7MMZ6	Trypanosoma rangeli	46%	100%
A4H882	Leishmania braziliensis	27%	76%
A4HBG8	Leishmania braziliensis	79%	100%
A4IAJ9	Leishmania infantum	91%	100%
Q4Q279	Leishmania major	90%	100%
V5BRC6	Trypanosoma cruzi	45%	100%