Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B5N8_LEIMU

TriTrypDb:

LmxM.33.4610

Length:

555

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B5N8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5N8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	411	415	PF00656	0.585
CLV_C14_Caspase3-7	79	83	PF00656	0.657
CLV_NRD_NRD_1	104	106	PF00675	0.662
CLV_NRD_NRD_1	256	258	PF00675	0.626
CLV_NRD_NRD_1	299	301	PF00675	0.669
CLV_NRD_NRD_1	370	372	PF00675	0.626
CLV_NRD_NRD_1	391	393	PF00675	0.588
CLV_NRD_NRD_1	477	479	PF00675	0.657
CLV_NRD_NRD_1	505	507	PF00675	0.553
CLV_NRD_NRD_1	552	554	PF00675	0.691
CLV_PCSK_FUR_1	100	104	PF00082	0.743
CLV_PCSK_FUR_1	502	506	PF00082	0.552
CLV_PCSK_KEX2_1	102	104	PF00082	0.671
CLV_PCSK_KEX2_1	153	155	PF00082	0.649
CLV_PCSK_KEX2_1	256	258	PF00082	0.626
CLV_PCSK_KEX2_1	299	301	PF00082	0.669
CLV_PCSK_KEX2_1	370	372	PF00082	0.734
CLV_PCSK_KEX2_1	391	393	PF00082	0.588
CLV_PCSK_KEX2_1	479	481	PF00082	0.682
CLV_PCSK_KEX2_1	504	506	PF00082	0.576
CLV_PCSK_PC1ET2_1	153	155	PF00082	0.649
CLV_PCSK_PC1ET2_1	479	481	PF00082	0.682
CLV_PCSK_PC1ET2_1	504	506	PF00082	0.566
CLV_PCSK_PC7_1	100	106	PF00082	0.662
CLV_PCSK_PC7_1	149	155	PF00082	0.356
CLV_PCSK_SKI1_1	104	108	PF00082	0.762
CLV_PCSK_SKI1_1	265	269	PF00082	0.548
CLV_PCSK_SKI1_1	38	42	PF00082	0.556
CLV_PCSK_SKI1_1	505	509	PF00082	0.523
CLV_PCSK_SKI1_1	65	69	PF00082	0.633
CLV_Separin_Metazoa	344	348	PF03568	0.715
DEG_APCC_DBOX_1	102	110	PF00400	0.549
DEG_APCC_DBOX_1	505	513	PF00400	0.530
DEG_Nend_Nbox_1	1	3	PF02207	0.674
DOC_CYCLIN_RxL_1	262	269	PF00134	0.549
DOC_CYCLIN_yCln2_LP_2	311	317	PF00134	0.697
DOC_MAPK_gen_1	502	511	PF00069	0.536
DOC_MAPK_MEF2A_6	444	453	PF00069	0.776
DOC_MAPK_RevD_3	285	300	PF00069	0.593
DOC_PP1_RVXF_1	152	159	PF00149	0.563
DOC_PP1_RVXF_1	93	99	PF00149	0.438
DOC_PP4_FxxP_1	41	44	PF00568	0.479
DOC_USP7_MATH_1	31	35	PF00917	0.597
DOC_USP7_MATH_1	412	416	PF00917	0.646
DOC_USP7_MATH_1	47	51	PF00917	0.591
DOC_USP7_MATH_1	516	520	PF00917	0.403
DOC_USP7_UBL2_3	450	454	PF12436	0.646
DOC_WW_Pin1_4	185	190	PF00397	0.579
LIG_14-3-3_CanoR_1	170	175	PF00244	0.657
LIG_14-3-3_CanoR_1	237	244	PF00244	0.583
LIG_14-3-3_CanoR_1	291	295	PF00244	0.477
LIG_14-3-3_CterR_2	553	555	PF00244	0.684
LIG_Actin_WH2_2	81	99	PF00022	0.429
LIG_DLG_GKlike_1	170	177	PF00625	0.649
LIG_FHA_1	1	7	PF00498	0.758
LIG_FHA_1	105	111	PF00498	0.681
LIG_FHA_1	282	288	PF00498	0.552
LIG_FHA_1	291	297	PF00498	0.573
LIG_FHA_1	334	340	PF00498	0.475
LIG_FHA_1	385	391	PF00498	0.566
LIG_FHA_1	544	550	PF00498	0.623
LIG_FHA_1	64	70	PF00498	0.643
LIG_FHA_1	75	81	PF00498	0.618
LIG_FHA_2	230	236	PF00498	0.704
LIG_FHA_2	246	252	PF00498	0.436
LIG_FHA_2	409	415	PF00498	0.588
LIG_Integrin_RGD_1	70	72	PF01839	0.649
LIG_LIR_Gen_1	544	549	PF02991	0.546
LIG_LIR_Nem_3	178	184	PF02991	0.521
LIG_LIR_Nem_3	544	548	PF02991	0.551
LIG_MYND_1	314	318	PF01753	0.698
LIG_NRBOX	263	269	PF00104	0.590
LIG_Pex14_1	54	58	PF04695	0.459
LIG_Pex14_2	36	40	PF04695	0.567
LIG_REV1ctd_RIR_1	38	43	PF16727	0.486
LIG_RPA_C_Fungi	252	264	PF08784	0.624
LIG_SH2_STAP1	2	6	PF00017	0.739
LIG_SH2_STAT3	531	534	PF00017	0.646
LIG_SH2_STAT5	2	5	PF00017	0.759
LIG_SH2_STAT5	315	318	PF00017	0.619
LIG_SH2_STAT5	531	534	PF00017	0.646
LIG_SH3_3	41	47	PF00018	0.489
LIG_Sin3_3	285	292	PF02671	0.569
LIG_Sin3_3	353	360	PF02671	0.617
LIG_SUMO_SIM_anti_2	227	236	PF11976	0.426
LIG_SUMO_SIM_par_1	21	27	PF11976	0.696
LIG_SUMO_SIM_par_1	283	290	PF11976	0.471
LIG_SUMO_SIM_par_1	513	519	PF11976	0.451
LIG_SUMO_SIM_par_1	72	79	PF11976	0.513
LIG_TRAF2_1	233	236	PF00917	0.693
LIG_TRAF2_1	248	251	PF00917	0.461
LIG_UBA3_1	470	479	PF00899	0.660
LIG_WRC_WIRS_1	160	165	PF05994	0.577
LIG_WW_3	62	66	PF00397	0.705
MOD_CDK_SPK_2	185	190	PF00069	0.579
MOD_CDK_SPxxK_3	185	192	PF00069	0.599
MOD_CK1_1	11	17	PF00069	0.635
MOD_CK1_1	137	143	PF00069	0.570
MOD_CK1_1	222	228	PF00069	0.671
MOD_CK1_1	229	235	PF00069	0.547
MOD_CK1_1	26	32	PF00069	0.547
MOD_CK1_1	290	296	PF00069	0.543
MOD_CK1_1	333	339	PF00069	0.669
MOD_CK1_1	34	40	PF00069	0.756
MOD_CK1_1	78	84	PF00069	0.734
MOD_CK2_1	185	191	PF00069	0.605
MOD_CK2_1	229	235	PF00069	0.612
MOD_CK2_1	245	251	PF00069	0.592
MOD_CK2_1	334	340	PF00069	0.673
MOD_CK2_1	403	409	PF00069	0.485
MOD_CK2_1	516	522	PF00069	0.485
MOD_GlcNHglycan	10	13	PF01048	0.664
MOD_GlcNHglycan	136	139	PF01048	0.450
MOD_GlcNHglycan	221	224	PF01048	0.685
MOD_GlcNHglycan	238	241	PF01048	0.461
MOD_GlcNHglycan	33	36	PF01048	0.595
MOD_GlcNHglycan	414	417	PF01048	0.630
MOD_GlcNHglycan	49	52	PF01048	0.694
MOD_GSK3_1	104	111	PF00069	0.677
MOD_GSK3_1	222	229	PF00069	0.556
MOD_GSK3_1	272	279	PF00069	0.579
MOD_GSK3_1	283	290	PF00069	0.542
MOD_GSK3_1	330	337	PF00069	0.663
MOD_GSK3_1	380	387	PF00069	0.548
MOD_GSK3_1	394	401	PF00069	0.685
MOD_GSK3_1	4	11	PF00069	0.676
MOD_GSK3_1	408	415	PF00069	0.555
MOD_GSK3_1	543	550	PF00069	0.531
MOD_GSK3_1	74	81	PF00069	0.653
MOD_N-GLC_1	170	175	PF02516	0.555
MOD_N-GLC_1	384	389	PF02516	0.474
MOD_NEK2_1	110	115	PF00069	0.607
MOD_NEK2_1	219	224	PF00069	0.612
MOD_NEK2_1	226	231	PF00069	0.618
MOD_NEK2_1	287	292	PF00069	0.548
MOD_NEK2_1	331	336	PF00069	0.596
MOD_NEK2_1	363	368	PF00069	0.595
MOD_NEK2_1	381	386	PF00069	0.460
MOD_NEK2_1	548	553	PF00069	0.662
MOD_NEK2_1	98	103	PF00069	0.730
MOD_PIKK_1	276	282	PF00454	0.374
MOD_PKA_1	104	110	PF00069	0.760
MOD_PKA_1	391	397	PF00069	0.588
MOD_PKA_2	104	110	PF00069	0.760
MOD_PKA_2	236	242	PF00069	0.681
MOD_PKA_2	290	296	PF00069	0.543
MOD_PKA_2	391	397	PF00069	0.763
MOD_PKA_2	8	14	PF00069	0.738
MOD_PKB_1	102	110	PF00069	0.763
MOD_Plk_1	124	130	PF00069	0.612
MOD_Plk_1	170	176	PF00069	0.553
MOD_Plk_1	384	390	PF00069	0.569
MOD_Plk_1	543	549	PF00069	0.551
MOD_Plk_4	204	210	PF00069	0.569
MOD_Plk_4	226	232	PF00069	0.671
MOD_Plk_4	283	289	PF00069	0.552
MOD_Plk_4	391	397	PF00069	0.723
MOD_Plk_4	544	550	PF00069	0.434
MOD_ProDKin_1	185	191	PF00069	0.578
MOD_SUMO_rev_2	445	451	PF00179	0.641
MOD_SUMO_rev_2	519	528	PF00179	0.550
TRG_DiLeu_BaEn_1	191	196	PF01217	0.646
TRG_DiLeu_BaLyEn_6	419	424	PF01217	0.631
TRG_ER_diArg_1	100	103	PF00400	0.671
TRG_ER_diArg_1	104	106	PF00400	0.646
TRG_ER_diArg_1	390	392	PF00400	0.580
TRG_ER_diArg_1	420	423	PF00400	0.641
TRG_ER_diArg_1	94	97	PF00400	0.644
TRG_NLS_MonoExtC_3	477	482	PF00514	0.681
TRG_NLS_MonoExtN_4	476	483	PF00514	0.688
TRG_NLS_MonoExtN_4	502	508	PF00514	0.532
TRG_Pf-PMV_PEXEL_1	265	269	PF00026	0.570

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2P1	Leptomonas seymouri	44%	99%
A0A3S7X8N2	Leishmania donovani	84%	100%
A4HBG7	Leishmania braziliensis	73%	100%
A4IAL3	Leishmania infantum	84%	100%
Q4Q280	Leishmania major	84%	100%