RNA-binding protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Double RNA binding domain protein 7

Species:

Leishmania mexicana

UniProt:

E9B5N3_LEIMU

TriTrypDb:

LmxM.33.4560

Length:

390

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0032991	protein-containing complex	1	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9B5N3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5N3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	89	91	PF00675	0.282
CLV_PCSK_SKI1_1	149	153	PF00082	0.335
CLV_PCSK_SKI1_1	335	339	PF00082	0.504
CLV_PCSK_SKI1_1	361	365	PF00082	0.571
CLV_PCSK_SKI1_1	39	43	PF00082	0.725
CLV_PCSK_SKI1_1	77	81	PF00082	0.335
CLV_Separin_Metazoa	332	336	PF03568	0.591
DEG_Nend_UBRbox_2	1	3	PF02207	0.666
DEG_SCF_FBW7_1	277	283	PF00400	0.685
DEG_SCF_FBW7_1	40	46	PF00400	0.579
DOC_CKS1_1	106	111	PF01111	0.592
DOC_CKS1_1	277	282	PF01111	0.659
DOC_CKS1_1	40	45	PF01111	0.630
DOC_MAPK_gen_1	80	89	PF00069	0.464
DOC_MAPK_MEF2A_6	12	19	PF00069	0.607
DOC_PP4_FxxP_1	251	254	PF00568	0.734
DOC_PP4_FxxP_1	324	327	PF00568	0.547
DOC_USP7_MATH_1	191	195	PF00917	0.468
DOC_USP7_MATH_1	265	269	PF00917	0.437
DOC_USP7_MATH_1	43	47	PF00917	0.535
DOC_WW_Pin1_4	105	110	PF00397	0.491
DOC_WW_Pin1_4	150	155	PF00397	0.500
DOC_WW_Pin1_4	229	234	PF00397	0.609
DOC_WW_Pin1_4	237	242	PF00397	0.637
DOC_WW_Pin1_4	243	248	PF00397	0.666
DOC_WW_Pin1_4	249	254	PF00397	0.486
DOC_WW_Pin1_4	257	262	PF00397	0.389
DOC_WW_Pin1_4	276	281	PF00397	0.525
DOC_WW_Pin1_4	33	38	PF00397	0.632
DOC_WW_Pin1_4	39	44	PF00397	0.578
LIG_APCC_ABBA_1	119	124	PF00400	0.489
LIG_EVH1_1	276	280	PF00568	0.665
LIG_FHA_1	184	190	PF00498	0.482
LIG_FHA_1	285	291	PF00498	0.700
LIG_FHA_1	328	334	PF00498	0.558
LIG_FHA_1	378	384	PF00498	0.515
LIG_FHA_1	40	46	PF00498	0.559
LIG_FHA_1	74	80	PF00498	0.453
LIG_FHA_2	55	61	PF00498	0.525
LIG_GBD_Chelix_1	369	377	PF00786	0.512
LIG_LIR_Apic_2	321	327	PF02991	0.536
LIG_LIR_Nem_3	153	158	PF02991	0.444
LIG_LIR_Nem_3	174	179	PF02991	0.464
LIG_LIR_Nem_3	246	251	PF02991	0.624
LIG_LIR_Nem_3	340	344	PF02991	0.531
LIG_LIR_Nem_3	65	70	PF02991	0.458
LIG_PDZ_Class_2	385	390	PF00595	0.470
LIG_PTB_Apo_2	78	85	PF02174	0.535
LIG_SH2_CRK	155	159	PF00017	0.535
LIG_SH2_STAP1	208	212	PF00017	0.463
LIG_SH2_STAP1	303	307	PF00017	0.624
LIG_SH3_3	272	278	PF00018	0.666
LIG_SH3_3	305	311	PF00018	0.627
LIG_SH3_3	37	43	PF00018	0.691
LIG_TRAF2_1	181	184	PF00917	0.505
LIG_UBA3_1	164	172	PF00899	0.343
LIG_WW_1	300	303	PF00397	0.650
MOD_CDC14_SPxK_1	36	39	PF00782	0.689
MOD_CDK_SPxK_1	33	39	PF00069	0.692
MOD_CDK_SPxxK_3	229	236	PF00069	0.622
MOD_CK1_1	243	249	PF00069	0.694
MOD_CK2_1	178	184	PF00069	0.320
MOD_CK2_1	337	343	PF00069	0.498
MOD_GlcNHglycan	173	176	PF01048	0.334
MOD_GlcNHglycan	20	23	PF01048	0.758
MOD_GlcNHglycan	210	213	PF01048	0.601
MOD_GlcNHglycan	267	270	PF01048	0.641
MOD_GlcNHglycan	27	31	PF01048	0.665
MOD_GlcNHglycan	303	306	PF01048	0.640
MOD_GlcNHglycan	324	327	PF01048	0.469
MOD_GlcNHglycan	93	96	PF01048	0.299
MOD_GSK3_1	239	246	PF00069	0.707
MOD_GSK3_1	249	256	PF00069	0.696
MOD_GSK3_1	26	33	PF00069	0.662
MOD_GSK3_1	276	283	PF00069	0.592
MOD_GSK3_1	373	380	PF00069	0.538
MOD_GSK3_1	39	46	PF00069	0.574
MOD_N-GLC_1	30	35	PF02516	0.692
MOD_N-GLC_1	351	356	PF02516	0.585
MOD_N-GLC_1	373	378	PF02516	0.480
MOD_N-GLC_1	99	104	PF02516	0.321
MOD_NEK2_1	115	120	PF00069	0.403
MOD_NEK2_1	322	327	PF00069	0.464
MOD_NEK2_1	337	342	PF00069	0.454
MOD_NEK2_1	373	378	PF00069	0.453
MOD_PIKK_1	102	108	PF00454	0.561
MOD_PIKK_1	178	184	PF00454	0.399
MOD_PIKK_1	284	290	PF00454	0.680
MOD_PKA_2	191	197	PF00069	0.343
MOD_PKB_1	359	367	PF00069	0.527
MOD_Plk_1	99	105	PF00069	0.343
MOD_Plk_2-3	193	199	PF00069	0.460
MOD_Plk_4	110	116	PF00069	0.560
MOD_Plk_4	253	259	PF00069	0.645
MOD_Plk_4	373	379	PF00069	0.460
MOD_ProDKin_1	105	111	PF00069	0.488
MOD_ProDKin_1	150	156	PF00069	0.368
MOD_ProDKin_1	229	235	PF00069	0.612
MOD_ProDKin_1	237	243	PF00069	0.636
MOD_ProDKin_1	249	255	PF00069	0.487
MOD_ProDKin_1	257	263	PF00069	0.388
MOD_ProDKin_1	276	282	PF00069	0.528
MOD_ProDKin_1	33	39	PF00069	0.629
TRG_DiLeu_BaEn_1	160	165	PF01217	0.418
TRG_DiLeu_BaEn_1	332	337	PF01217	0.586
TRG_ENDOCYTIC_2	155	158	PF00928	0.375
TRG_ENDOCYTIC_2	248	251	PF00928	0.651
TRG_ENDOCYTIC_2	296	299	PF00928	0.618
TRG_ENDOCYTIC_2	341	344	PF00928	0.426
TRG_ENDOCYTIC_2	67	70	PF00928	0.381
TRG_ER_diArg_1	358	361	PF00400	0.508
TRG_Pf-PMV_PEXEL_1	137	141	PF00026	0.319

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHL9	Leptomonas seymouri	83%	100%
A0A1X0P4T3	Trypanosomatidae	26%	70%
A0A1X0PA83	Trypanosomatidae	57%	100%
A0A3R7NF39	Trypanosoma rangeli	24%	67%
A0A3S7X8L4	Leishmania donovani	98%	100%
A4HBG2	Leishmania braziliensis	89%	100%
A4IAK8	Leishmania infantum	98%	100%
C9ZLN3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
C9ZYQ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	70%
O04319	Arabidopsis thaliana	26%	73%
Q4Q285	Leishmania major	96%	100%
Q74ZS6	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	27%	67%
V5BW06	Trypanosoma cruzi	53%	97%