LeishMANIAdb
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Proteasome subunit beta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Proteasome subunit beta
Gene product:
20s proteasome beta 7 subunit, (putative)
Species:
Leishmania mexicana
UniProt:
E9B5M9_LEIMU
TriTrypDb:
LmxM.33.4340
Length:
220

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 6
Silverman et al. no yes: 0
Pissara et al. yes yes: 28
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
TermNameLevelCount
GO:0005634 nucleus 5 13
GO:0005737 cytoplasm 2 13
GO:0005839 proteasome core complex 3 13
GO:0019774 proteasome core complex, beta-subunit complex 2 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0032991 protein-containing complex 1 13
GO:0043226 organelle 2 13
GO:0043227 membrane-bounded organelle 3 13
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Expansion

Sequence features

E9B5M9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5M9

PDB structure(s): 6qm7_b , 6qm7_N , 6qm8_b , 6qm8_N , 6tcz_n , 6td5_n

Function

Biological processes
TermNameLevelCount
GO:0006508 proteolysis 4 13
GO:0006807 nitrogen compound metabolic process 2 13
GO:0008152 metabolic process 1 13
GO:0009056 catabolic process 2 1
GO:0009057 macromolecule catabolic process 4 1
GO:0010498 proteasomal protein catabolic process 5 1
GO:0019538 protein metabolic process 3 13
GO:0030163 protein catabolic process 4 1
GO:0043170 macromolecule metabolic process 3 13
GO:0044238 primary metabolic process 2 13
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Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 11
GO:0004175 endopeptidase activity 4 11
GO:0004298 threonine-type endopeptidase activity 5 11
GO:0008233 peptidase activity 3 11
GO:0016787 hydrolase activity 2 11
GO:0070003 threonine-type peptidase activity 4 11
GO:0140096 catalytic activity, acting on a protein 2 11
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_PCSK_KEX2_1 95 97 PF00082 0.294
CLV_PCSK_PC1ET2_1 95 97 PF00082 0.294
CLV_PCSK_SKI1_1 147 151 PF00082 0.311
CLV_PCSK_SKI1_1 171 175 PF00082 0.317
DOC_CDC14_PxL_1 140 148 PF14671 0.564
DOC_CYCLIN_RxL_1 168 177 PF00134 0.512
DOC_MAPK_DCC_7 31 40 PF00069 0.494
DOC_MAPK_MEF2A_6 31 40 PF00069 0.494
DOC_PP1_RVXF_1 169 175 PF00149 0.492
DOC_USP7_MATH_1 111 115 PF00917 0.402
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0S4IKM4 Bodo saltans 61% 89%
A0A1X0PA78 Trypanosomatidae 67% 100%
A0A381MU64 Leishmania infantum 94% 100%
A0A3Q8IIL6 Leishmania donovani 94% 100%
A0A3Q8INX1 Leishmania donovani 94% 100%
A0A3R7K5Z0 Trypanosoma rangeli 70% 100%
A0RU86 Cenarchaeum symbiosum (strain A) 25% 100%
A1RX71 Thermofilum pendens (strain DSM 2475 / Hrk 5) 23% 100%
A3MXQ6 Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1) 24% 100%
A4HBF5 Leishmania braziliensis 89% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS