LeishMANIAdb
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Proteasome subunit beta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Proteasome subunit beta
Gene product:
20s proteasome beta 7 subunit, (putative)
Species:
Leishmania mexicana
UniProt:
E9B5M9_LEIMU
TriTrypDb:
LmxM.33.4340
Length:
220

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 6
Silverman et al. no yes: 0
Pissara et al. yes yes: 28
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 13
GO:0005737 cytoplasm 2 13
GO:0005839 proteasome core complex 3 13
GO:0032991 protein-containing complex 1 13
GO:0043226 organelle 2 13
GO:0043227 membrane-bounded organelle 3 13
GO:0043229 intracellular organelle 3 13
GO:0043231 intracellular membrane-bounded organelle 4 13
GO:0110165 cellular anatomical entity 1 13
GO:0140535 intracellular protein-containing complex 2 13
GO:1902494 catalytic complex 2 13
GO:0019774 proteasome core complex, beta-subunit complex 2 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1

Expansion

Sequence features

E9B5M9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5M9

PDB structure(s): 6qm7_b , 6qm7_N , 6qm8_b , 6qm8_N , 6tcz_n , 6td5_n

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 13
GO:0006807 nitrogen compound metabolic process 2 13
GO:0008152 metabolic process 1 13
GO:0019538 protein metabolic process 3 13
GO:0043170 macromolecule metabolic process 3 13
GO:0044238 primary metabolic process 2 13
GO:0051603 proteolysis involved in protein catabolic process 5 13
GO:0071704 organic substance metabolic process 2 13
GO:1901564 organonitrogen compound metabolic process 3 13
GO:0009056 catabolic process 2 1
GO:0009057 macromolecule catabolic process 4 1
GO:0010498 proteasomal protein catabolic process 5 1
GO:0030163 protein catabolic process 4 1
GO:1901565 organonitrogen compound catabolic process 4 1
GO:1901575 organic substance catabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 11
GO:0004175 endopeptidase activity 4 11
GO:0004298 threonine-type endopeptidase activity 5 11
GO:0008233 peptidase activity 3 11
GO:0016787 hydrolase activity 2 11
GO:0070003 threonine-type peptidase activity 4 11
GO:0140096 catalytic activity, acting on a protein 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_KEX2_1 95 97 PF00082 0.294
CLV_PCSK_PC1ET2_1 95 97 PF00082 0.294
CLV_PCSK_SKI1_1 147 151 PF00082 0.311
CLV_PCSK_SKI1_1 171 175 PF00082 0.317
DOC_CDC14_PxL_1 140 148 PF14671 0.564
DOC_CYCLIN_RxL_1 168 177 PF00134 0.512
DOC_MAPK_DCC_7 31 40 PF00069 0.494
DOC_MAPK_MEF2A_6 31 40 PF00069 0.494
DOC_PP1_RVXF_1 169 175 PF00149 0.492
DOC_USP7_MATH_1 111 115 PF00917 0.402
DOC_USP7_MATH_1 49 53 PF00917 0.562
DOC_USP7_MATH_2 81 87 PF00917 0.562
LIG_14-3-3_CanoR_1 195 199 PF00244 0.477
LIG_BIR_II_1 1 5 PF00653 0.511
LIG_BIR_III_4 188 192 PF00653 0.445
LIG_BRCT_BRCA1_1 113 117 PF00533 0.529
LIG_BRCT_BRCA1_1 196 200 PF00533 0.444
LIG_BRCT_BRCA1_1 81 85 PF00533 0.529
LIG_deltaCOP1_diTrp_1 203 213 PF00928 0.444
LIG_eIF4E_1 12 18 PF01652 0.512
LIG_FHA_1 165 171 PF00498 0.559
LIG_FHA_1 214 220 PF00498 0.430
LIG_FHA_2 124 130 PF00498 0.541
LIG_FHA_2 202 208 PF00498 0.414
LIG_LIR_Gen_1 43 49 PF02991 0.495
LIG_LIR_Gen_1 50 60 PF02991 0.492
LIG_LIR_Gen_1 82 93 PF02991 0.527
LIG_LIR_Nem_3 135 140 PF02991 0.564
LIG_LIR_Nem_3 207 211 PF02991 0.406
LIG_LIR_Nem_3 25 29 PF02991 0.494
LIG_LIR_Nem_3 43 47 PF02991 0.495
LIG_LIR_Nem_3 50 56 PF02991 0.492
LIG_LIR_Nem_3 82 88 PF02991 0.531
LIG_SH2_CRK 26 30 PF00017 0.494
LIG_SH2_CRK 44 48 PF00017 0.402
LIG_SH2_GRB2like 73 76 PF00017 0.575
LIG_SH2_STAT5 87 90 PF00017 0.511
LIG_SH3_3 30 36 PF00018 0.494
LIG_TYR_ITIM 24 29 PF00017 0.494
MOD_CK1_1 25 31 PF00069 0.494
MOD_CK1_1 3 9 PF00069 0.496
MOD_CK2_1 123 129 PF00069 0.541
MOD_CK2_1 201 207 PF00069 0.451
MOD_GlcNHglycan 2 5 PF01048 0.294
MOD_GlcNHglycan 44 47 PF01048 0.362
MOD_GSK3_1 79 86 PF00069 0.533
MOD_NEK2_1 213 218 PF00069 0.446
MOD_NEK2_1 40 45 PF00069 0.528
MOD_NEK2_1 88 93 PF00069 0.586
MOD_PKA_2 111 117 PF00069 0.622
MOD_PKA_2 194 200 PF00069 0.464
MOD_Plk_1 213 219 PF00069 0.420
MOD_Plk_4 113 119 PF00069 0.580
MOD_Plk_4 19 25 PF00069 0.494
MOD_Plk_4 3 9 PF00069 0.505
MOD_SUMO_rev_2 77 82 PF00179 0.402
TRG_DiLeu_BaLyEn_6 141 146 PF01217 0.494
TRG_ENDOCYTIC_2 137 140 PF00928 0.565
TRG_ENDOCYTIC_2 208 211 PF00928 0.459
TRG_ENDOCYTIC_2 26 29 PF00928 0.494
TRG_ENDOCYTIC_2 44 47 PF00928 0.496
TRG_ENDOCYTIC_2 53 56 PF00928 0.492
TRG_ENDOCYTIC_2 73 76 PF00928 0.393
TRG_Pf-PMV_PEXEL_1 90 94 PF00026 0.414

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0S4IKM4 Bodo saltans 61% 89%
A0A1X0PA78 Trypanosomatidae 67% 100%
A0A381MU64 Leishmania infantum 94% 100%
A0A3Q8IIL6 Leishmania donovani 94% 100%
A0A3Q8INX1 Leishmania donovani 94% 100%
A0A3R7K5Z0 Trypanosoma rangeli 70% 100%
A0RU86 Cenarchaeum symbiosum (strain A) 25% 100%
A1RX71 Thermofilum pendens (strain DSM 2475 / Hrk 5) 23% 100%
A3MXQ6 Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1) 24% 100%
A4HBF5 Leishmania braziliensis 89% 100%
A4HBF8 Leishmania braziliensis 88% 100%
A4IAL6 Leishmania infantum 95% 100%
A8AA46 Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125) 25% 100%
B1L6X8 Korarchaeum cryptofilum (strain OPF8) 24% 100%
B8D673 Desulfurococcus amylolyticus (strain DSM 18924 / JCM 16383 / VKM B-2413 / 1221n) 24% 100%
C3MRE5 Sulfolobus islandicus (strain L.S.2.15 / Lassen #1) 24% 100%
C3MY41 Sulfolobus islandicus (strain M.14.25 / Kamchatka #1) 24% 100%
C3MZI0 Sulfolobus islandicus (strain M.16.27) 24% 100%
C3N7K2 Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1) 24% 100%
C3NFX2 Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2) 24% 100%
C4KIR0 Sulfolobus islandicus (strain M.16.4 / Kamchatka #3) 24% 100%
C9ZLN7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 70% 100%
D0KRX1 Saccharolobus solfataricus (strain 98/2) 24% 100%
D2PDG6 Sulfolobus islandicus (strain L.D.8.5 / Lassen #2) 24% 100%
O57983 Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) 29% 100%
P28024 Xenopus laevis 37% 91%
P28070 Homo sapiens 41% 83%
P30657 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 33% 83%
P34067 Rattus norvegicus 39% 84%
P99026 Mus musculus 41% 83%
Q3T108 Bos taurus 41% 83%
Q4JAY3 Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) 24% 100%
Q4Q289 Leishmania major 95% 100%
Q556Q0 Dictyostelium discoideum 42% 85%
Q5JHL8 Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) 26% 100%
Q7DLR9 Arabidopsis thaliana 37% 89%
Q8SS01 Encephalitozoon cuniculi (strain GB-M1) 29% 97%
Q8TW10 Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) 25% 100%
Q8U4C9 Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) 26% 100%
Q8ZST5 Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2) 24% 100%
Q975U8 Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) 25% 100%
Q980L4 Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) 24% 100%
Q9USQ9 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 33% 84%
Q9V247 Pyrococcus abyssi (strain GE5 / Orsay) 26% 100%
Q9VNA5 Drosophila melanogaster 34% 82%
Q9YES4 Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) 26% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS