Proteasome subunit beta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

20s proteasome beta 7 subunit, (putative)

Species:

Leishmania mexicana

UniProt:

E9B5M9_LEIMU

TriTrypDb:

LmxM.33.4340

Length:

220

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 28

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	13
GO:0005737	cytoplasm	2	13
GO:0005839	proteasome core complex	3	13
GO:0019774	proteasome core complex, beta-subunit complex	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0032991	protein-containing complex	1	13
GO:0043226	organelle	2	13
GO:0043227	membrane-bounded organelle	3	13

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Expansion

Sequence features

E9B5M9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5M9

PDB structure(s): 6qm7_b , 6qm7_N , 6qm8_b , 6qm8_N , 6tcz_n , 6td5_n

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	13
GO:0030163	protein catabolic process	4	1
GO:0043170	macromolecule metabolic process	3	13
GO:0044238	primary metabolic process	2	13

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004175	endopeptidase activity	4	11
GO:0004298	threonine-type endopeptidase activity	5	11
GO:0008233	peptidase activity	3	11
GO:0016787	hydrolase activity	2	11
GO:0070003	threonine-type peptidase activity	4	11
GO:0140096	catalytic activity, acting on a protein	2	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	95	97	PF00082	0.294
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.294
CLV_PCSK_SKI1_1	147	151	PF00082	0.311
CLV_PCSK_SKI1_1	171	175	PF00082	0.317
DOC_CDC14_PxL_1	140	148	PF14671	0.564
DOC_CYCLIN_RxL_1	168	177	PF00134	0.512
DOC_MAPK_DCC_7	31	40	PF00069	0.494
DOC_MAPK_MEF2A_6	31	40	PF00069	0.494
DOC_PP1_RVXF_1	169	175	PF00149	0.492
DOC_USP7_MATH_1	111	115	PF00917	0.402

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IKM4	Bodo saltans	61%	89%
A0A1X0PA78	Trypanosomatidae	67%	100%
A0A381MU64	Leishmania infantum	94%	100%
A0A3Q8IIL6	Leishmania donovani	94%	100%
A0A3Q8INX1	Leishmania donovani	94%	100%
A0A3R7K5Z0	Trypanosoma rangeli	70%	100%
A0RU86	Cenarchaeum symbiosum (strain A)	25%	100%
A1RX71	Thermofilum pendens (strain DSM 2475 / Hrk 5)	23%	100%
A3MXQ6	Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)	24%	100%
A4HBF5	Leishmania braziliensis	89%	100%

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