Coatomer subunit alpha

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

coatomer alpha subunit, putative

Species:

Leishmania mexicana

UniProt:

E9B5M6_LEIMU

TriTrypDb:

LmxM.33.4310

Length:

1196

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	12
GO:0005840	ribosome	5	12
GO:0016020	membrane	2	12
GO:0030117	membrane coat	3	12
GO:0030120	vesicle coat	4	12
GO:0030126	COPI vesicle coat	5	12
GO:0031090	organelle membrane	3	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12

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Expansion

Sequence features

E9B5M6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5M6

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0006886	intracellular protein transport	4	12
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	12
GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	6	1
GO:0006891	intra-Golgi vesicle-mediated transport	6	1
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0016192	vesicle-mediated transport	4	12
GO:0033036	macromolecule localization	2	12

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Molecular functions
Term	Name	Level	Count
GO:0005198	structural molecule activity	1	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	844	848	PF00656	0.537
CLV_NRD_NRD_1	1101	1103	PF00675	0.303
CLV_NRD_NRD_1	124	126	PF00675	0.581
CLV_NRD_NRD_1	169	171	PF00675	0.533
CLV_NRD_NRD_1	278	280	PF00675	0.469
CLV_NRD_NRD_1	574	576	PF00675	0.368
CLV_NRD_NRD_1	661	663	PF00675	0.286
CLV_NRD_NRD_1	780	782	PF00675	0.464
CLV_NRD_NRD_1	83	85	PF00675	0.332
CLV_PCSK_KEX2_1	1101	1103	PF00082	0.303

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2R6	Leptomonas seymouri	80%	100%
A0A0S4IPS1	Bodo saltans	47%	99%
A0A1X0PA85	Trypanosomatidae	58%	100%
A0A3Q8IGV8	Leishmania donovani	22%	100%
A0A3R7KSI4	Trypanosoma rangeli	57%	100%
A0A3S7X8J8	Leishmania donovani	95%	100%
A4HBF3	Leishmania braziliensis	89%	100%
A4HM28	Leishmania braziliensis	23%	100%
A4I9G2	Leishmania infantum	22%	100%
A4IAK2	Leishmania infantum	95%	100%

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