Palmitoyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DHHC palmitoyltransferase, putative

Species:

Leishmania mexicana

UniProt:

E9B5M5_LEIMU

TriTrypDb:

LmxM.33.4300

Length:

266

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 8
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005783	endoplasmic reticulum	5	1
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9B5M5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5M5

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	1
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018198	peptidyl-cysteine modification	6	1
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	1
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	1
GO:0018345	protein palmitoylation	6	1
GO:0019538	protein metabolic process	3	1
GO:0033036	macromolecule localization	2	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043543	protein acylation	5	1
GO:0044238	primary metabolic process	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0071705	nitrogen compound transport	4	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016409	palmitoyltransferase activity	5	10
GO:0016417	S-acyltransferase activity	5	10
GO:0016740	transferase activity	2	10
GO:0016746	acyltransferase activity	3	10
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	10
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	10
GO:0019707	protein-cysteine S-acyltransferase activity	3	10
GO:0140096	catalytic activity, acting on a protein	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	18	20	PF00675	0.373
CLV_NRD_NRD_1	229	231	PF00675	0.413
CLV_PCSK_FUR_1	16	20	PF00082	0.424
CLV_PCSK_FUR_1	226	230	PF00082	0.436
CLV_PCSK_KEX2_1	15	17	PF00082	0.396
CLV_PCSK_KEX2_1	18	20	PF00082	0.361
CLV_PCSK_KEX2_1	226	228	PF00082	0.410
CLV_PCSK_KEX2_1	229	231	PF00082	0.411
CLV_PCSK_PC1ET2_1	15	17	PF00082	0.403
CLV_PCSK_SKI1_1	179	183	PF00082	0.521
CLV_PCSK_SKI1_1	246	250	PF00082	0.419
DEG_Nend_UBRbox_3	1	3	PF02207	0.682
DOC_CDC14_PxL_1	37	45	PF14671	0.447
DOC_CYCLIN_RxL_1	186	197	PF00134	0.352
DOC_MAPK_gen_1	186	196	PF00069	0.345
DOC_MAPK_MEF2A_6	186	195	PF00069	0.384
DOC_PP2B_LxvP_1	185	188	PF13499	0.266
DOC_PP4_FxxP_1	253	256	PF00568	0.679
DOC_SPAK_OSR1_1	230	234	PF12202	0.571
DOC_WW_Pin1_4	51	56	PF00397	0.440
LIG_14-3-3_CanoR_1	104	112	PF00244	0.551
LIG_14-3-3_CanoR_1	213	217	PF00244	0.532
LIG_14-3-3_CanoR_1	246	256	PF00244	0.617
LIG_APCC_ABBA_1	68	73	PF00400	0.272
LIG_BRCT_BRCA1_1	237	241	PF00533	0.640
LIG_BRCT_BRCA1_1	249	253	PF00533	0.637
LIG_BRCT_BRCA1_1	53	57	PF00533	0.225
LIG_eIF4E_1	133	139	PF01652	0.444
LIG_FHA_1	3	9	PF00498	0.711
LIG_FHA_1	63	69	PF00498	0.306
LIG_FHA_2	108	114	PF00498	0.586
LIG_IRF3_LxIS_1	72	79	PF10401	0.194
LIG_LIR_Apic_2	250	256	PF02991	0.675
LIG_LIR_Gen_1	180	190	PF02991	0.334
LIG_LIR_Gen_1	208	217	PF02991	0.441
LIG_LIR_Gen_1	69	78	PF02991	0.351
LIG_LIR_Gen_1	91	101	PF02991	0.555
LIG_LIR_Nem_3	180	185	PF02991	0.282
LIG_LIR_Nem_3	208	212	PF02991	0.441
LIG_LIR_Nem_3	215	219	PF02991	0.570
LIG_LIR_Nem_3	69	74	PF02991	0.250
LIG_LIR_Nem_3	91	97	PF02991	0.585
LIG_NRBOX	82	88	PF00104	0.390
LIG_Pex14_2	178	182	PF04695	0.367
LIG_Pex14_2	241	245	PF04695	0.570
LIG_Pex14_2	249	253	PF04695	0.567
LIG_Pex14_2	71	75	PF04695	0.194
LIG_PTB_Apo_2	149	156	PF02174	0.444
LIG_SH2_CRK	214	218	PF00017	0.569
LIG_SH2_CRK	219	223	PF00017	0.585
LIG_SH2_CRK	258	262	PF00017	0.660
LIG_SH2_STAP1	214	218	PF00017	0.591
LIG_SH2_STAT5	133	136	PF00017	0.444
LIG_SH2_STAT5	214	217	PF00017	0.535
LIG_SH2_STAT5	30	33	PF00017	0.252
LIG_SH3_3	49	55	PF00018	0.447
LIG_SH3_3	86	92	PF00018	0.474
LIG_SUMO_SIM_anti_2	79	85	PF11976	0.276
LIG_SUMO_SIM_par_1	192	197	PF11976	0.488
LIG_SUMO_SIM_par_1	49	54	PF11976	0.322
LIG_SUMO_SIM_par_1	64	69	PF11976	0.311
LIG_SUMO_SIM_par_1	85	91	PF11976	0.405
LIG_TYR_ITIM	212	217	PF00017	0.425
LIG_WRC_WIRS_1	206	211	PF05994	0.485
MOD_CK1_1	170	176	PF00069	0.354
MOD_Cter_Amidation	16	19	PF01082	0.409
MOD_GlcNHglycan	232	236	PF01048	0.446
MOD_GlcNHglycan	78	81	PF01048	0.476
MOD_GSK3_1	2	9	PF00069	0.732
MOD_GSK3_1	208	215	PF00069	0.232
MOD_GSK3_1	231	238	PF00069	0.636
MOD_GSK3_1	51	58	PF00069	0.461
MOD_GSK3_1	99	106	PF00069	0.628
MOD_N-GLC_2	130	132	PF02516	0.361
MOD_NEK2_1	169	174	PF00069	0.316
MOD_NEK2_1	177	182	PF00069	0.336
MOD_NEK2_1	194	199	PF00069	0.465
MOD_NEK2_1	212	217	PF00069	0.463
MOD_NEK2_1	231	236	PF00069	0.594
MOD_NEK2_1	241	246	PF00069	0.583
MOD_NEK2_1	76	81	PF00069	0.245
MOD_NEK2_2	221	226	PF00069	0.543
MOD_PKA_2	103	109	PF00069	0.551
MOD_PKA_2	164	170	PF00069	0.364
MOD_PKA_2	17	23	PF00069	0.626
MOD_PKA_2	212	218	PF00069	0.485
MOD_Plk_4	177	183	PF00069	0.324
MOD_Plk_4	205	211	PF00069	0.379
MOD_Plk_4	212	218	PF00069	0.397
MOD_Plk_4	62	68	PF00069	0.366
MOD_ProDKin_1	51	57	PF00069	0.436
TRG_ENDOCYTIC_2	133	136	PF00928	0.439
TRG_ENDOCYTIC_2	214	217	PF00928	0.536
TRG_ENDOCYTIC_2	219	222	PF00928	0.548
TRG_ENDOCYTIC_2	258	261	PF00928	0.662
TRG_ER_diArg_1	16	19	PF00400	0.621
TRG_ER_diArg_1	225	228	PF00400	0.616
TRG_ER_diArg_1	229	231	PF00400	0.608
TRG_NLS_MonoExtC_3	14	19	PF00514	0.593

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0L0	Leptomonas seymouri	50%	100%
A0A1X0PBJ7	Trypanosomatidae	30%	100%
A0A3R7M6T4	Trypanosoma rangeli	25%	100%
A0A3S7X8K2	Leishmania donovani	89%	100%
A4HBF2	Leishmania braziliensis	69%	100%
A4IAK1	Leishmania infantum	90%	100%
Q4Q2B1	Leishmania major	87%	100%
V5BW09	Trypanosoma cruzi	28%	100%