H/ACA ribonucleoprotein complex subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleolar protein family a, putative

Species:

Leishmania mexicana

UniProt:

E9B5M4_LEIMU

TriTrypDb:

LmxM.33.4290

Length:

232

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

E9B5M4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5M4

Function

Biological processes
Term	Name	Level	Count
GO:0001522	pseudouridine synthesis	6	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006364	rRNA processing	8	2
GO:0006396	RNA processing	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009451	RNA modification	5	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0016072	rRNA metabolic process	7	2
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034660	ncRNA metabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	137	141	PF00082	0.735
DOC_CKS1_1	132	137	PF01111	0.549
DOC_PP4_FxxP_1	139	142	PF00568	0.744
DOC_PP4_FxxP_1	20	23	PF00568	0.860
DOC_WW_Pin1_4	109	114	PF00397	0.549
DOC_WW_Pin1_4	126	131	PF00397	0.252
LIG_14-3-3_CanoR_1	137	142	PF00244	0.740
LIG_APCC_ABBA_1	136	141	PF00400	0.725
LIG_BRCT_BRCA1_1	16	20	PF00533	0.861
LIG_FHA_1	100	106	PF00498	0.549
LIG_LIR_Apic_2	124	130	PF02991	0.549
LIG_LIR_Apic_2	17	23	PF02991	0.859
LIG_LIR_Nem_3	131	136	PF02991	0.549
LIG_SH2_PTP2	127	130	PF00017	0.549
LIG_SH2_STAT5	127	130	PF00017	0.549
LIG_SH2_STAT5	85	88	PF00017	0.549
LIG_SH3_3	139	145	PF00018	0.762
LIG_SH3_3	44	50	PF00018	0.756
LIG_WRC_WIRS_1	56	61	PF05994	0.549
MOD_CDK_SPxK_1	131	137	PF00069	0.549
MOD_CK2_1	116	122	PF00069	0.549
MOD_GSK3_1	105	112	PF00069	0.549
MOD_N-GLC_1	100	105	PF02516	0.549
MOD_PIKK_1	128	134	PF00454	0.549
MOD_PKA_2	174	180	PF00069	0.850
MOD_PKA_2	184	190	PF00069	0.676
MOD_PKA_2	194	200	PF00069	0.503
MOD_PKA_2	204	210	PF00069	0.508
MOD_PKA_2	212	218	PF00069	0.542
MOD_Plk_4	55	61	PF00069	0.549
MOD_ProDKin_1	109	115	PF00069	0.549
MOD_ProDKin_1	126	132	PF00069	0.252
TRG_DiLeu_BaEn_3	54	60	PF01217	0.549
TRG_ER_diArg_1	145	148	PF00400	0.815

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A1CVY3	NEOFI	49%	100%
A3GHP2	PICST	46%	100%
A6SDR8	BOTFB	44%	100%
P0CN78	CRYNJ	41%	100%
P0CN79	CRYNB	41%	100%
P28007	YEAST	42%	100%
Q06975	SCHPO	43%	100%
Q1E6M1	COCIM	45%	100%
Q2HH48	CHAGB	48%	100%
Q4P5P0	USTMA	46%	100%
Q54XE6	DICDI	33%	100%
Q5RJV1	XENTR	46%	100%
Q61B10	CAEBR	41%	94%
Q6AYA1	RAT	44%	100%
Q6BVF9	DEBHA	47%	100%
Q6CJ45	KLULA	43%	100%
Q6FSB0	CANGA	47%	100%
Q757V8	ASHGO	42%	100%
Q7KVQ0	DROME	35%	98%
Q7ZVE0	DANRE	37%	100%
Q8VZT0	ARATH	43%	100%
Q9CY66	MOUSE	45%	100%
Q9FK53	ARATH	42%	100%
Q9NY12	HUMAN	38%	100%
Q9TYK1	CAEEL	39%	95%