ANK_REP_REGION domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ankyrin repeats (3 copies), putative

Species:

Leishmania mexicana

UniProt:

E9B5M3_LEIMU

TriTrypDb:

LmxM.33.4280

Length:

405

Annotations

LeishMANIAdb annotations

An expanding group of Kinetoplastid proteins. Some members of this group have a hydrophobic C-terminal segment that might help membrane attachment

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9B5M3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5M3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	294	296	PF00675	0.563
CLV_PCSK_KEX2_1	96	98	PF00082	0.487
CLV_PCSK_PC1ET2_1	96	98	PF00082	0.487
CLV_PCSK_SKI1_1	159	163	PF00082	0.511
CLV_PCSK_SKI1_1	25	29	PF00082	0.633
CLV_PCSK_SKI1_1	347	351	PF00082	0.640
DEG_Nend_UBRbox_2	1	3	PF02207	0.435
DOC_CKS1_1	109	114	PF01111	0.287
DOC_CYCLIN_RxL_1	235	246	PF00134	0.217
DOC_CYCLIN_yClb1_LxF_4	72	77	PF00134	0.387
DOC_CYCLIN_yCln2_LP_2	365	371	PF00134	0.354
DOC_MAPK_gen_1	375	384	PF00069	0.293
DOC_PP1_RVXF_1	72	78	PF00149	0.376
DOC_PP2B_LxvP_1	251	254	PF13499	0.317
DOC_USP7_MATH_1	23	27	PF00917	0.365
DOC_USP7_MATH_1	357	361	PF00917	0.426
DOC_USP7_MATH_1	44	48	PF00917	0.270
DOC_WW_Pin1_4	108	113	PF00397	0.309
DOC_WW_Pin1_4	141	146	PF00397	0.242
DOC_WW_Pin1_4	221	226	PF00397	0.378
DOC_WW_Pin1_4	312	317	PF00397	0.404
LIG_14-3-3_CanoR_1	119	128	PF00244	0.309
LIG_14-3-3_CanoR_1	186	192	PF00244	0.246
LIG_14-3-3_CanoR_1	299	305	PF00244	0.448
LIG_14-3-3_CanoR_1	74	82	PF00244	0.316
LIG_FHA_1	142	148	PF00498	0.267
LIG_FHA_1	384	390	PF00498	0.359
LIG_FHA_2	136	142	PF00498	0.253
LIG_LIR_Apic_2	194	198	PF02991	0.345
LIG_LIR_Gen_1	24	35	PF02991	0.375
LIG_LIR_Gen_1	256	267	PF02991	0.283
LIG_LIR_Nem_3	108	113	PF02991	0.251
LIG_LIR_Nem_3	24	30	PF02991	0.390
LIG_LIR_Nem_3	256	262	PF02991	0.314
LIG_PTB_Apo_2	34	41	PF02174	0.309
LIG_PTB_Phospho_1	34	40	PF10480	0.309
LIG_SH2_CRK	259	263	PF00017	0.283
LIG_SH2_CRK	82	86	PF00017	0.303
LIG_SH2_NCK_1	228	232	PF00017	0.287
LIG_SH2_NCK_1	82	86	PF00017	0.303
LIG_SH2_STAP1	181	185	PF00017	0.341
LIG_SH2_STAP1	82	86	PF00017	0.303
LIG_SH2_STAT3	160	163	PF00017	0.287
LIG_SH2_STAT5	160	163	PF00017	0.287
LIG_SH2_STAT5	181	184	PF00017	0.359
LIG_SH2_STAT5	393	396	PF00017	0.370
LIG_SH3_3	231	237	PF00018	0.375
LIG_SH3_3	313	319	PF00018	0.503
LIG_SH3_3	320	326	PF00018	0.415
LIG_Sin3_3	281	288	PF02671	0.279
LIG_SUMO_SIM_anti_2	2	9	PF11976	0.407
LIG_TYR_ITIM	257	262	PF00017	0.324
LIG_TYR_ITIM	80	85	PF00017	0.238
MOD_CDK_SPxK_1	221	227	PF00069	0.382
MOD_CK1_1	360	366	PF00069	0.396
MOD_CK2_1	11	17	PF00069	0.368
MOD_CK2_1	135	141	PF00069	0.182
MOD_GlcNHglycan	121	124	PF01048	0.486
MOD_GlcNHglycan	13	16	PF01048	0.576
MOD_GlcNHglycan	263	266	PF01048	0.534
MOD_GlcNHglycan	311	315	PF01048	0.695
MOD_GSK3_1	137	144	PF00069	0.287
MOD_GSK3_1	61	68	PF00069	0.347
MOD_N-GLC_2	29	31	PF02516	0.569
MOD_NEK2_1	179	184	PF00069	0.294
MOD_NEK2_1	187	192	PF00069	0.317
MOD_NEK2_1	284	289	PF00069	0.350
MOD_NEK2_1	383	388	PF00069	0.276
MOD_NEK2_1	6	11	PF00069	0.323
MOD_NEK2_1	75	80	PF00069	0.350
MOD_PIKK_1	197	203	PF00454	0.364
MOD_Plk_1	23	29	PF00069	0.396
MOD_Plk_4	23	29	PF00069	0.408
MOD_Plk_4	258	264	PF00069	0.325
MOD_Plk_4	377	383	PF00069	0.309
MOD_Plk_4	6	12	PF00069	0.286
MOD_ProDKin_1	108	114	PF00069	0.309
MOD_ProDKin_1	141	147	PF00069	0.242
MOD_ProDKin_1	221	227	PF00069	0.382
MOD_ProDKin_1	312	318	PF00069	0.399
MOD_SUMO_rev_2	292	297	PF00179	0.397
MOD_SUMO_rev_2	355	363	PF00179	0.368
TRG_DiLeu_BaEn_2	339	345	PF01217	0.376
TRG_ENDOCYTIC_2	259	262	PF00928	0.295
TRG_ENDOCYTIC_2	82	85	PF00928	0.341
TRG_ER_diArg_1	118	121	PF00400	0.287
TRG_ER_diArg_1	401	404	PF00400	0.658
TRG_Pf-PMV_PEXEL_1	126	130	PF00026	0.437
TRG_Pf-PMV_PEXEL_1	159	163	PF00026	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P716	Leptomonas seymouri	54%	100%
A0A0S4IPR4	Bodo saltans	34%	89%
A0A1X0PAB7	Trypanosomatidae	34%	100%
A0A3Q8IUY8	Leishmania donovani	84%	100%
E9AHS2	Leishmania infantum	84%	100%
Q4Q2B3	Leishmania major	82%	100%