Dymeclin

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Dymeclin

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B5M0_LEIMU

TriTrypDb:

LmxM.33.4250

Length:

592

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B5M0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5M0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	164	168	PF00656	0.525
CLV_C14_Caspase3-7	504	508	PF00656	0.382
CLV_C14_Caspase3-7	87	91	PF00656	0.727
CLV_NRD_NRD_1	101	103	PF00675	0.568
CLV_NRD_NRD_1	170	172	PF00675	0.553
CLV_NRD_NRD_1	225	227	PF00675	0.688
CLV_NRD_NRD_1	567	569	PF00675	0.756
CLV_PCSK_KEX2_1	101	103	PF00082	0.604
CLV_PCSK_KEX2_1	147	149	PF00082	0.462
CLV_PCSK_KEX2_1	170	172	PF00082	0.553
CLV_PCSK_KEX2_1	225	227	PF00082	0.642
CLV_PCSK_KEX2_1	4	6	PF00082	0.647
CLV_PCSK_KEX2_1	567	569	PF00082	0.756
CLV_PCSK_KEX2_1	61	63	PF00082	0.733
CLV_PCSK_PC1ET2_1	147	149	PF00082	0.462
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.659
CLV_PCSK_PC1ET2_1	61	63	PF00082	0.770
CLV_PCSK_SKI1_1	141	145	PF00082	0.497
CLV_PCSK_SKI1_1	276	280	PF00082	0.409
CLV_PCSK_SKI1_1	367	371	PF00082	0.392
CLV_PCSK_SKI1_1	540	544	PF00082	0.498
DEG_APCC_DBOX_1	275	283	PF00400	0.480
DEG_SPOP_SBC_1	572	576	PF00917	0.586
DEG_SPOP_SBC_1	85	89	PF00917	0.597
DOC_ANK_TNKS_1	240	247	PF00023	0.409
DOC_CDC14_PxL_1	346	354	PF14671	0.532
DOC_CKS1_1	403	408	PF01111	0.619
DOC_CYCLIN_RxL_1	273	280	PF00134	0.435
DOC_CYCLIN_yCln2_LP_2	297	303	PF00134	0.537
DOC_CYCLIN_yCln2_LP_2	348	354	PF00134	0.409
DOC_MAPK_gen_1	170	176	PF00069	0.546
DOC_MAPK_gen_1	4	12	PF00069	0.748
DOC_MAPK_MEF2A_6	276	283	PF00069	0.403
DOC_MAPK_MEF2A_6	295	303	PF00069	0.486
DOC_MAPK_MEF2A_6	357	365	PF00069	0.558
DOC_PP2B_LxvP_1	20	23	PF13499	0.639
DOC_PP2B_LxvP_1	291	294	PF13499	0.521
DOC_PP2B_LxvP_1	297	300	PF13499	0.531
DOC_PP2B_LxvP_1	492	495	PF13499	0.426
DOC_USP7_MATH_1	258	262	PF00917	0.718
DOC_USP7_MATH_1	274	278	PF00917	0.286
DOC_USP7_MATH_1	43	47	PF00917	0.605
DOC_USP7_MATH_1	501	505	PF00917	0.575
DOC_USP7_MATH_1	572	576	PF00917	0.682
DOC_USP7_MATH_1	70	74	PF00917	0.748
DOC_USP7_MATH_1	80	84	PF00917	0.661
DOC_USP7_UBL2_3	422	426	PF12436	0.507
DOC_WW_Pin1_4	208	213	PF00397	0.617
DOC_WW_Pin1_4	23	28	PF00397	0.755
DOC_WW_Pin1_4	285	290	PF00397	0.536
DOC_WW_Pin1_4	336	341	PF00397	0.280
DOC_WW_Pin1_4	402	407	PF00397	0.612
DOC_WW_Pin1_4	73	78	PF00397	0.714
DOC_WW_Pin1_4	81	86	PF00397	0.456
LIG_14-3-3_CanoR_1	216	224	PF00244	0.640
LIG_14-3-3_CanoR_1	295	300	PF00244	0.586
LIG_14-3-3_CanoR_1	357	365	PF00244	0.523
LIG_14-3-3_CanoR_1	401	406	PF00244	0.623
LIG_14-3-3_CanoR_1	458	466	PF00244	0.509
LIG_14-3-3_CanoR_1	502	509	PF00244	0.580
LIG_14-3-3_CanoR_1	552	561	PF00244	0.417
LIG_14-3-3_CanoR_1	56	63	PF00244	0.760
LIG_14-3-3_CanoR_1	64	72	PF00244	0.749
LIG_14-3-3_CanoR_1	75	85	PF00244	0.762
LIG_14-3-3_CanoR_1	86	92	PF00244	0.716
LIG_Actin_WH2_2	341	359	PF00022	0.542
LIG_BIR_II_1	1	5	PF00653	0.695
LIG_CaM_IQ_9	306	321	PF13499	0.486
LIG_EH1_1	196	204	PF00400	0.356
LIG_FHA_1	151	157	PF00498	0.544
LIG_FHA_1	194	200	PF00498	0.462
LIG_FHA_1	333	339	PF00498	0.541
LIG_FHA_1	356	362	PF00498	0.539
LIG_FHA_1	371	377	PF00498	0.394
LIG_FHA_1	381	387	PF00498	0.412
LIG_FHA_1	415	421	PF00498	0.225
LIG_FHA_1	460	466	PF00498	0.570
LIG_FHA_1	489	495	PF00498	0.540
LIG_FHA_1	50	56	PF00498	0.628
LIG_FHA_2	164	170	PF00498	0.595
LIG_FHA_2	331	337	PF00498	0.439
LIG_FHA_2	403	409	PF00498	0.603
LIG_FHA_2	48	54	PF00498	0.739
LIG_FHA_2	568	574	PF00498	0.794
LIG_FHA_2	578	584	PF00498	0.727
LIG_FHA_2	85	91	PF00498	0.743
LIG_GBD_Chelix_1	12	20	PF00786	0.689
LIG_GBD_Chelix_1	172	180	PF00786	0.544
LIG_GBD_Chelix_1	194	202	PF00786	0.514
LIG_GBD_Chelix_1	521	529	PF00786	0.403
LIG_LIR_Gen_1	121	131	PF02991	0.410
LIG_LIR_Gen_1	468	478	PF02991	0.404
LIG_LIR_Gen_1	527	535	PF02991	0.409
LIG_LIR_Nem_3	121	127	PF02991	0.355
LIG_LIR_Nem_3	468	474	PF02991	0.420
LIG_LIR_Nem_3	527	531	PF02991	0.395
LIG_NRBOX	129	135	PF00104	0.467
LIG_NRBOX	274	280	PF00104	0.374
LIG_NRBOX	311	317	PF00104	0.571
LIG_PCNA_PIPBox_1	191	200	PF02747	0.525
LIG_PCNA_yPIPBox_3	191	200	PF02747	0.506
LIG_SH2_CRK	471	475	PF00017	0.358
LIG_SH2_STAP1	471	475	PF00017	0.358
LIG_SH3_3	21	27	PF00018	0.767
LIG_SH3_3	358	364	PF00018	0.564
LIG_SH3_3	400	406	PF00018	0.466
LIG_SH3_3	79	85	PF00018	0.722
LIG_SUMO_SIM_anti_2	129	135	PF11976	0.253
LIG_SUMO_SIM_anti_2	277	283	PF11976	0.491
LIG_SUMO_SIM_anti_2	327	333	PF11976	0.378
LIG_SUMO_SIM_anti_2	8	15	PF11976	0.749
LIG_SUMO_SIM_anti_2	95	101	PF11976	0.646
LIG_SUMO_SIM_par_1	129	135	PF11976	0.348
LIG_SUMO_SIM_par_1	327	333	PF11976	0.438
LIG_TRAF2_1	334	337	PF00917	0.601
LIG_TRAF2_1	542	545	PF00917	0.296
LIG_WRC_WIRS_1	194	199	PF05994	0.467
MOD_CDK_SPK_2	81	86	PF00069	0.742
MOD_CK1_1	123	129	PF00069	0.469
MOD_CK1_1	217	223	PF00069	0.605
MOD_CK1_1	237	243	PF00069	0.721
MOD_CK1_1	261	267	PF00069	0.578
MOD_CK1_1	269	275	PF00069	0.396
MOD_CK1_1	277	283	PF00069	0.354
MOD_CK1_1	425	431	PF00069	0.637
MOD_CK1_1	442	448	PF00069	0.480
MOD_CK1_1	534	540	PF00069	0.512
MOD_CK1_1	66	72	PF00069	0.681
MOD_CK1_1	73	79	PF00069	0.665
MOD_CK1_1	81	87	PF00069	0.455
MOD_CK2_1	12	18	PF00069	0.653
MOD_CK2_1	123	129	PF00069	0.538
MOD_CK2_1	324	330	PF00069	0.358
MOD_CK2_1	356	362	PF00069	0.497
MOD_CK2_1	402	408	PF00069	0.631
MOD_CK2_1	457	463	PF00069	0.549
MOD_CK2_1	567	573	PF00069	0.724
MOD_GlcNHglycan	236	239	PF01048	0.749
MOD_GlcNHglycan	358	361	PF01048	0.519
MOD_GlcNHglycan	380	383	PF01048	0.384
MOD_GlcNHglycan	436	439	PF01048	0.494
MOD_GlcNHglycan	467	470	PF01048	0.418
MOD_GlcNHglycan	533	536	PF01048	0.471
MOD_GlcNHglycan	562	565	PF01048	0.476
MOD_GlcNHglycan	67	71	PF01048	0.551
MOD_GlcNHglycan	78	81	PF01048	0.697
MOD_GSK3_1	119	126	PF00069	0.460
MOD_GSK3_1	233	240	PF00069	0.668
MOD_GSK3_1	314	321	PF00069	0.495
MOD_GSK3_1	33	40	PF00069	0.798
MOD_GSK3_1	332	339	PF00069	0.491
MOD_GSK3_1	378	385	PF00069	0.446
MOD_GSK3_1	393	400	PF00069	0.469
MOD_GSK3_1	43	50	PF00069	0.595
MOD_GSK3_1	453	460	PF00069	0.554
MOD_GSK3_1	501	508	PF00069	0.594
MOD_GSK3_1	530	537	PF00069	0.491
MOD_GSK3_1	567	574	PF00069	0.780
MOD_GSK3_1	62	69	PF00069	0.687
MOD_GSK3_1	71	78	PF00069	0.631
MOD_GSK3_1	80	87	PF00069	0.695
MOD_LATS_1	35	41	PF00433	0.502
MOD_N-GLC_1	285	290	PF02516	0.538
MOD_N-GLC_1	370	375	PF02516	0.371
MOD_N-GLC_1	43	48	PF02516	0.683
MOD_NEK2_1	176	181	PF00069	0.544
MOD_NEK2_1	198	203	PF00069	0.497
MOD_NEK2_1	214	219	PF00069	0.478
MOD_NEK2_1	356	361	PF00069	0.504
MOD_NEK2_1	380	385	PF00069	0.471
MOD_NEK2_1	397	402	PF00069	0.458
MOD_NEK2_1	414	419	PF00069	0.289
MOD_NEK2_1	453	458	PF00069	0.495
MOD_NEK2_1	465	470	PF00069	0.419
MOD_NEK2_1	47	52	PF00069	0.566
MOD_NEK2_1	530	535	PF00069	0.427
MOD_NEK2_2	488	493	PF00069	0.628
MOD_PIKK_1	318	324	PF00454	0.467
MOD_PIKK_1	387	393	PF00454	0.462
MOD_PK_1	295	301	PF00069	0.499
MOD_PKA_1	567	573	PF00069	0.580
MOD_PKA_2	215	221	PF00069	0.657
MOD_PKA_2	318	324	PF00069	0.520
MOD_PKA_2	356	362	PF00069	0.486
MOD_PKA_2	457	463	PF00069	0.567
MOD_PKA_2	501	507	PF00069	0.530
MOD_PKA_2	55	61	PF00069	0.710
MOD_PKA_2	566	572	PF00069	0.761
MOD_PKA_2	63	69	PF00069	0.776
MOD_PKA_2	85	91	PF00069	0.724
MOD_PKB_1	399	407	PF00069	0.658
MOD_Plk_1	119	125	PF00069	0.420
MOD_Plk_1	43	49	PF00069	0.678
MOD_Plk_2-3	129	135	PF00069	0.253
MOD_Plk_4	129	135	PF00069	0.339
MOD_Plk_4	151	157	PF00069	0.533
MOD_Plk_4	176	182	PF00069	0.502
MOD_Plk_4	193	199	PF00069	0.398
MOD_Plk_4	277	283	PF00069	0.465
MOD_Plk_4	324	330	PF00069	0.344
MOD_Plk_4	442	448	PF00069	0.491
MOD_Plk_4	476	482	PF00069	0.439
MOD_ProDKin_1	208	214	PF00069	0.619
MOD_ProDKin_1	23	29	PF00069	0.758
MOD_ProDKin_1	285	291	PF00069	0.536
MOD_ProDKin_1	336	342	PF00069	0.279
MOD_ProDKin_1	402	408	PF00069	0.605
MOD_ProDKin_1	73	79	PF00069	0.717
MOD_ProDKin_1	81	87	PF00069	0.455
MOD_SUMO_for_1	421	424	PF00179	0.383
MOD_SUMO_rev_2	260	269	PF00179	0.629
MOD_SUMO_rev_2	541	549	PF00179	0.579
TRG_DiLeu_BaEn_1	129	134	PF01217	0.462
TRG_DiLeu_BaEn_1	341	346	PF01217	0.340
TRG_DiLeu_BaEn_1	545	550	PF01217	0.519
TRG_DiLeu_BaEn_1	582	587	PF01217	0.643
TRG_DiLeu_BaLyEn_6	297	302	PF01217	0.542
TRG_DiLeu_LyEn_5	341	346	PF01217	0.374
TRG_ENDOCYTIC_2	470	473	PF00928	0.350
TRG_ER_diArg_1	100	102	PF00400	0.616
TRG_ER_diArg_1	170	172	PF00400	0.553
TRG_ER_diArg_1	224	226	PF00400	0.535

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P709	Leptomonas seymouri	41%	99%
A0A0S4KM98	Bodo saltans	24%	80%
A0A1X0PAI7	Trypanosomatidae	30%	100%
A0A3R7M5G0	Trypanosoma rangeli	31%	100%
A0A3S7X8L9	Leishmania donovani	85%	100%
A4HBE8	Leishmania braziliensis	72%	100%
A4IAJ6	Leishmania infantum	85%	100%
C9ZLP4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
Q4Q2B6	Leishmania major	84%	100%
V5BRD9	Trypanosoma cruzi	32%	100%