FHA domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

FHA domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B5L9_LEIMU

TriTrypDb:

LmxM.33.4240

Length:

410

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B5L9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5L9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	248	252	PF00656	0.517
CLV_NRD_NRD_1	131	133	PF00675	0.716
CLV_NRD_NRD_1	310	312	PF00675	0.603
CLV_NRD_NRD_1	341	343	PF00675	0.444
CLV_PCSK_KEX2_1	209	211	PF00082	0.571
CLV_PCSK_KEX2_1	260	262	PF00082	0.324
CLV_PCSK_KEX2_1	310	312	PF00082	0.599
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.662
CLV_PCSK_PC1ET2_1	260	262	PF00082	0.324
CLV_PCSK_SKI1_1	206	210	PF00082	0.679
CLV_PCSK_SKI1_1	263	267	PF00082	0.288
CLV_PCSK_SKI1_1	97	101	PF00082	0.333
DEG_SCF_FBW7_1	114	120	PF00400	0.479
DEG_SCF_FBW7_2	148	155	PF00400	0.477
DEG_SPOP_SBC_1	217	221	PF00917	0.619
DOC_CKS1_1	114	119	PF01111	0.749
DOC_CKS1_1	201	206	PF01111	0.489
DOC_CKS1_1	281	286	PF01111	0.519
DOC_CYCLIN_yClb5_NLxxxL_5	34	43	PF00134	0.430
DOC_CYCLIN_yCln2_LP_2	39	45	PF00134	0.430
DOC_MAPK_gen_1	11	19	PF00069	0.461
DOC_MAPK_gen_1	129	139	PF00069	0.722
DOC_MAPK_gen_1	287	295	PF00069	0.453
DOC_MAPK_MEF2A_6	297	304	PF00069	0.569
DOC_MAPK_MEF2A_6	77	84	PF00069	0.349
DOC_PP1_RVXF_1	95	101	PF00149	0.398
DOC_PP1_SILK_1	399	404	PF00149	0.473
DOC_USP7_MATH_1	117	121	PF00917	0.595
DOC_USP7_MATH_1	127	131	PF00917	0.546
DOC_USP7_MATH_1	162	166	PF00917	0.758
DOC_USP7_MATH_1	216	220	PF00917	0.698
DOC_USP7_MATH_1	300	304	PF00917	0.552
DOC_USP7_MATH_1	358	362	PF00917	0.448
DOC_USP7_MATH_2	30	36	PF00917	0.433
DOC_WW_Pin1_4	113	118	PF00397	0.622
DOC_WW_Pin1_4	123	128	PF00397	0.555
DOC_WW_Pin1_4	148	153	PF00397	0.701
DOC_WW_Pin1_4	190	195	PF00397	0.779
DOC_WW_Pin1_4	200	205	PF00397	0.653
DOC_WW_Pin1_4	280	285	PF00397	0.462
DOC_WW_Pin1_4	343	348	PF00397	0.498
DOC_WW_Pin1_4	38	43	PF00397	0.345
DOC_WW_Pin1_4	90	95	PF00397	0.414
LIG_14-3-3_CanoR_1	132	140	PF00244	0.649
LIG_14-3-3_CanoR_1	26	30	PF00244	0.384
LIG_BIR_II_1	1	5	PF00653	0.550
LIG_BIR_III_2	344	348	PF00653	0.507
LIG_FHA_1	132	138	PF00498	0.710
LIG_FHA_1	171	177	PF00498	0.727
LIG_FHA_1	257	263	PF00498	0.488
LIG_FHA_1	281	287	PF00498	0.508
LIG_FHA_2	107	113	PF00498	0.557
LIG_FHA_2	209	215	PF00498	0.683
LIG_FHA_2	246	252	PF00498	0.552
LIG_FHA_2	310	316	PF00498	0.384
LIG_FHA_2	330	336	PF00498	0.406
LIG_LIR_Gen_1	106	115	PF02991	0.557
LIG_LIR_Gen_1	3	10	PF02991	0.472
LIG_LIR_Gen_1	35	44	PF02991	0.328
LIG_LIR_Gen_1	395	406	PF02991	0.379
LIG_LIR_Nem_3	106	110	PF02991	0.488
LIG_LIR_Nem_3	3	9	PF02991	0.436
LIG_LIR_Nem_3	35	39	PF02991	0.328
LIG_LIR_Nem_3	395	401	PF02991	0.353
LIG_LIR_Nem_3	72	76	PF02991	0.346
LIG_MYND_3	167	171	PF01753	0.425
LIG_Rb_pABgroove_1	392	400	PF01858	0.490
LIG_SH2_CRK	398	402	PF00017	0.362
LIG_SH2_CRK	6	10	PF00017	0.421
LIG_SH2_NCK_1	331	335	PF00017	0.427
LIG_SH2_NCK_1	6	10	PF00017	0.466
LIG_SH2_STAP1	398	402	PF00017	0.352
LIG_SH2_STAP1	6	10	PF00017	0.463
LIG_SH2_STAT3	15	18	PF00017	0.505
LIG_SH2_STAT5	169	172	PF00017	0.641
LIG_SH2_STAT5	306	309	PF00017	0.520
LIG_SH2_STAT5	331	334	PF00017	0.443
LIG_SH3_1	198	204	PF00018	0.738
LIG_SH3_2	201	206	PF14604	0.701
LIG_SH3_3	111	117	PF00018	0.725
LIG_SH3_3	198	204	PF00018	0.721
LIG_SH3_3	278	284	PF00018	0.464
LIG_SUMO_SIM_par_1	277	283	PF11976	0.448
LIG_SUMO_SIM_par_1	300	305	PF11976	0.552
LIG_SUMO_SIM_par_1	320	327	PF11976	0.245
LIG_TRFH_1	90	94	PF08558	0.350
LIG_TYR_ITSM	2	9	PF00017	0.509
LIG_WRC_WIRS_1	104	109	PF05994	0.445
MOD_CDC14_SPxK_1	126	129	PF00782	0.480
MOD_CDK_SPK_2	285	290	PF00069	0.461
MOD_CDK_SPxK_1	123	129	PF00069	0.540
MOD_CDK_SPxK_1	148	154	PF00069	0.725
MOD_CDK_SPxK_1	190	196	PF00069	0.789
MOD_CDK_SPxK_1	200	206	PF00069	0.586
MOD_CDK_SPxxK_3	280	287	PF00069	0.466
MOD_CDK_SPxxK_3	90	97	PF00069	0.430
MOD_CK1_1	323	329	PF00069	0.326
MOD_CK1_1	360	366	PF00069	0.515
MOD_CK2_1	106	112	PF00069	0.553
MOD_CK2_1	208	214	PF00069	0.647
MOD_CK2_1	329	335	PF00069	0.445
MOD_GlcNHglycan	119	122	PF01048	0.534
MOD_GlcNHglycan	129	132	PF01048	0.458
MOD_GlcNHglycan	214	217	PF01048	0.671
MOD_GlcNHglycan	251	254	PF01048	0.180
MOD_GlcNHglycan	373	376	PF01048	0.546
MOD_GlcNHglycan	406	409	PF01048	0.438
MOD_GSK3_1	113	120	PF00069	0.541
MOD_GSK3_1	123	130	PF00069	0.529
MOD_GSK3_1	170	177	PF00069	0.666
MOD_GSK3_1	183	190	PF00069	0.630
MOD_GSK3_1	208	215	PF00069	0.688
MOD_GSK3_1	226	233	PF00069	0.477
MOD_GSK3_1	245	252	PF00069	0.414
MOD_GSK3_1	323	330	PF00069	0.457
MOD_GSK3_1	358	365	PF00069	0.472
MOD_GSK3_1	61	68	PF00069	0.309
MOD_N-GLC_1	148	153	PF02516	0.683
MOD_N-GLC_1	66	71	PF02516	0.311
MOD_NEK2_1	1	6	PF00069	0.500
MOD_NEK2_1	170	175	PF00069	0.664
MOD_NEK2_1	183	188	PF00069	0.701
MOD_NEK2_1	208	213	PF00069	0.734
MOD_NEK2_1	397	402	PF00069	0.456
MOD_NEK2_2	218	223	PF00069	0.757
MOD_PK_1	362	368	PF00069	0.498
MOD_PKA_2	131	137	PF00069	0.707
MOD_PKA_2	183	189	PF00069	0.794
MOD_PKA_2	25	31	PF00069	0.430
MOD_PKA_2	309	315	PF00069	0.313
MOD_Plk_4	32	38	PF00069	0.335
MOD_Plk_4	397	403	PF00069	0.419
MOD_Plk_4	69	75	PF00069	0.325
MOD_ProDKin_1	113	119	PF00069	0.626
MOD_ProDKin_1	123	129	PF00069	0.556
MOD_ProDKin_1	148	154	PF00069	0.707
MOD_ProDKin_1	190	196	PF00069	0.781
MOD_ProDKin_1	200	206	PF00069	0.655
MOD_ProDKin_1	280	286	PF00069	0.462
MOD_ProDKin_1	343	349	PF00069	0.488
MOD_ProDKin_1	38	44	PF00069	0.345
MOD_ProDKin_1	90	96	PF00069	0.414
TRG_DiLeu_BaEn_2	31	37	PF01217	0.430
TRG_DiLeu_BaEn_4	171	177	PF01217	0.472
TRG_DiLeu_BaLyEn_6	344	349	PF01217	0.495
TRG_ENDOCYTIC_2	398	401	PF00928	0.344
TRG_ENDOCYTIC_2	6	9	PF00928	0.365
TRG_ENDOCYTIC_2	89	92	PF00928	0.385
TRG_NLS_Bipartite_1	191	213	PF00514	0.727
TRG_NLS_MonoExtC_3	208	214	PF00514	0.648
TRG_NLS_MonoExtN_4	206	213	PF00514	0.656
TRG_Pf-PMV_PEXEL_1	154	159	PF00026	0.687

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILS6	Leptomonas seymouri	59%	96%
A0A0S4IL96	Bodo saltans	30%	86%
A0A3R7KTI0	Trypanosoma rangeli	37%	100%
A0A3S7X8R1	Leishmania donovani	88%	100%
A4HBE7	Leishmania braziliensis	79%	100%
A4IAJ5	Leishmania infantum	88%	100%
C9ZLP5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	95%
Q4Q2B7	Leishmania major	89%	100%
V5BW13	Trypanosoma cruzi	38%	100%