DNA polymerase delta subunit 3

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B5L6_LEIMU

TriTrypDb:

LmxM.33.4210

Length:

490

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B5L6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5L6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	210	212	PF00675	0.511
CLV_NRD_NRD_1	248	250	PF00675	0.659
CLV_NRD_NRD_1	66	68	PF00675	0.650
CLV_PCSK_KEX2_1	210	212	PF00082	0.710
CLV_PCSK_KEX2_1	248	250	PF00082	0.659
CLV_PCSK_SKI1_1	12	16	PF00082	0.491
CLV_PCSK_SKI1_1	230	234	PF00082	0.611
CLV_PCSK_SKI1_1	347	351	PF00082	0.473
CLV_PCSK_SKI1_1	4	8	PF00082	0.428
CLV_PCSK_SKI1_1	466	470	PF00082	0.741
CLV_Separin_Metazoa	169	173	PF03568	0.630
DEG_Nend_UBRbox_2	1	3	PF02207	0.510
DOC_CKS1_1	336	341	PF01111	0.729
DOC_CYCLIN_RxL_1	9	19	PF00134	0.445
DOC_CYCLIN_yCln2_LP_2	222	228	PF00134	0.562
DOC_PP2B_LxvP_1	160	163	PF13499	0.571
DOC_USP7_MATH_1	148	152	PF00917	0.659
DOC_USP7_MATH_1	244	248	PF00917	0.578
DOC_USP7_MATH_1	258	262	PF00917	0.605
DOC_USP7_MATH_1	442	446	PF00917	0.758
DOC_USP7_MATH_1	464	468	PF00917	0.555
DOC_USP7_MATH_1	57	61	PF00917	0.612
DOC_USP7_UBL2_3	229	233	PF12436	0.688
DOC_WW_Pin1_4	171	176	PF00397	0.784
DOC_WW_Pin1_4	188	193	PF00397	0.653
DOC_WW_Pin1_4	330	335	PF00397	0.626
DOC_WW_Pin1_4	433	438	PF00397	0.682
DOC_WW_Pin1_4	445	450	PF00397	0.634
DOC_WW_Pin1_4	460	465	PF00397	0.653
LIG_14-3-3_CanoR_1	12	18	PF00244	0.485
LIG_14-3-3_CanoR_1	121	127	PF00244	0.656
LIG_14-3-3_CanoR_1	33	39	PF00244	0.310
LIG_14-3-3_CanoR_1	402	412	PF00244	0.557
LIG_BIR_III_2	319	323	PF00653	0.519
LIG_BRCT_BRCA1_1	265	269	PF00533	0.686
LIG_BRCT_BRCA1_1	365	369	PF00533	0.524
LIG_EVH1_2	321	325	PF00568	0.541
LIG_FHA_1	107	113	PF00498	0.457
LIG_FHA_1	140	146	PF00498	0.527
LIG_FHA_1	177	183	PF00498	0.667
LIG_FHA_1	235	241	PF00498	0.566
LIG_FHA_1	406	412	PF00498	0.452
LIG_FHA_1	419	425	PF00498	0.462
LIG_FHA_1	60	66	PF00498	0.512
LIG_FHA_2	133	139	PF00498	0.638
LIG_FHA_2	14	20	PF00498	0.469
LIG_FHA_2	195	201	PF00498	0.598
LIG_Integrin_RGD_1	115	117	PF01839	0.492
LIG_LIR_Gen_1	197	207	PF02991	0.658
LIG_LIR_Gen_1	43	53	PF02991	0.423
LIG_LIR_Gen_1	77	87	PF02991	0.541
LIG_LIR_Nem_3	109	113	PF02991	0.516
LIG_LIR_Nem_3	366	371	PF02991	0.323
LIG_LIR_Nem_3	43	49	PF02991	0.512
LIG_LIR_Nem_3	77	82	PF02991	0.554
LIG_LYPXL_yS_3	110	113	PF13949	0.659
LIG_MLH1_MIPbox_1	365	369	PF16413	0.524
LIG_PCNA_PIPBox_1	362	371	PF02747	0.486
LIG_PTB_Apo_2	389	396	PF02174	0.433
LIG_REV1ctd_RIR_1	482	490	PF16727	0.612
LIG_SH2_CRK	46	50	PF00017	0.487
LIG_SH2_CRK	79	83	PF00017	0.526
LIG_SH2_STAT5	380	383	PF00017	0.423
LIG_SH2_STAT5	46	49	PF00017	0.483
LIG_SH3_1	331	337	PF00018	0.535
LIG_SH3_2	225	230	PF14604	0.580
LIG_SH3_3	177	183	PF00018	0.717
LIG_SH3_3	222	228	PF00018	0.595
LIG_SH3_3	302	308	PF00018	0.627
LIG_SH3_3	331	337	PF00018	0.678
LIG_SH3_3	443	449	PF00018	0.702
LIG_SH3_4	220	227	PF00018	0.681
LIG_SUMO_SIM_par_1	13	19	PF11976	0.393
LIG_SUMO_SIM_par_1	2	11	PF11976	0.471
LIG_SUMO_SIM_par_1	80	85	PF11976	0.668
LIG_TRAF2_1	183	186	PF00917	0.514
LIG_TRAF2_1	295	298	PF00917	0.563
LIG_TRAF2_1	468	471	PF00917	0.584
LIG_UBA3_1	198	203	PF00899	0.626
LIG_WRC_WIRS_1	365	370	PF05994	0.514
LIG_WRC_WIRS_1	481	486	PF05994	0.587
LIG_WW_3	169	173	PF00397	0.630
MOD_CDK_SPK_2	190	195	PF00069	0.634
MOD_CDK_SPxK_1	335	341	PF00069	0.701
MOD_CDK_SPxK_1	460	466	PF00069	0.559
MOD_CDK_SPxxK_3	188	195	PF00069	0.576
MOD_CDK_SPxxK_3	335	342	PF00069	0.702
MOD_CDK_SPxxK_3	433	440	PF00069	0.670
MOD_CK1_1	106	112	PF00069	0.450
MOD_CK1_1	153	159	PF00069	0.691
MOD_CK1_1	285	291	PF00069	0.639
MOD_CK1_1	429	435	PF00069	0.530
MOD_CK1_1	445	451	PF00069	0.718
MOD_CK1_1	460	466	PF00069	0.654
MOD_CK1_1	91	97	PF00069	0.628
MOD_CK2_1	13	19	PF00069	0.563
MOD_CK2_1	132	138	PF00069	0.636
MOD_CK2_1	286	292	PF00069	0.629
MOD_CK2_1	307	313	PF00069	0.583
MOD_CK2_1	410	416	PF00069	0.441
MOD_CK2_1	49	55	PF00069	0.566
MOD_GlcNHglycan	250	253	PF01048	0.696
MOD_GlcNHglycan	254	257	PF01048	0.728
MOD_GlcNHglycan	350	353	PF01048	0.629
MOD_GlcNHglycan	405	408	PF01048	0.553
MOD_GlcNHglycan	431	434	PF01048	0.624
MOD_GlcNHglycan	440	443	PF01048	0.685
MOD_GlcNHglycan	466	469	PF01048	0.550
MOD_GlcNHglycan	59	62	PF01048	0.590
MOD_GlcNHglycan	73	79	PF01048	0.676
MOD_GlcNHglycan	90	93	PF01048	0.601
MOD_GSK3_1	184	191	PF00069	0.626
MOD_GSK3_1	211	218	PF00069	0.555
MOD_GSK3_1	231	238	PF00069	0.639
MOD_GSK3_1	244	251	PF00069	0.552
MOD_GSK3_1	258	265	PF00069	0.609
MOD_GSK3_1	282	289	PF00069	0.566
MOD_GSK3_1	34	41	PF00069	0.498
MOD_GSK3_1	4	11	PF00069	0.329
MOD_GSK3_1	429	436	PF00069	0.655
MOD_GSK3_1	438	445	PF00069	0.715
MOD_GSK3_1	44	51	PF00069	0.406
MOD_GSK3_1	460	467	PF00069	0.686
MOD_GSK3_1	480	487	PF00069	0.415
MOD_N-GLC_1	235	240	PF02516	0.596
MOD_N-GLC_1	282	287	PF02516	0.513
MOD_N-GLC_1	88	93	PF02516	0.652
MOD_NEK2_1	424	429	PF00069	0.654
MOD_NEK2_1	48	53	PF00069	0.413
MOD_NEK2_1	484	489	PF00069	0.516
MOD_NEK2_1	8	13	PF00069	0.450
MOD_NEK2_1	82	87	PF00069	0.567
MOD_NEK2_1	90	95	PF00069	0.638
MOD_NEK2_2	477	482	PF00069	0.542
MOD_PIKK_1	426	432	PF00454	0.562
MOD_PIKK_1	466	472	PF00454	0.627
MOD_PKA_1	248	254	PF00069	0.559
MOD_PKA_1	347	353	PF00069	0.565
MOD_PKA_2	244	250	PF00069	0.649
MOD_Plk_1	103	109	PF00069	0.652
MOD_Plk_1	235	241	PF00069	0.593
MOD_Plk_1	74	80	PF00069	0.605
MOD_Plk_2-3	410	416	PF00069	0.384
MOD_Plk_4	194	200	PF00069	0.581
MOD_Plk_4	364	370	PF00069	0.513
MOD_Plk_4	44	50	PF00069	0.435
MOD_Plk_4	480	486	PF00069	0.504
MOD_ProDKin_1	171	177	PF00069	0.780
MOD_ProDKin_1	188	194	PF00069	0.651
MOD_ProDKin_1	330	336	PF00069	0.627
MOD_ProDKin_1	433	439	PF00069	0.686
MOD_ProDKin_1	445	451	PF00069	0.638
MOD_ProDKin_1	460	466	PF00069	0.653
MOD_SUMO_for_1	183	186	PF00179	0.755
MOD_SUMO_for_1	232	235	PF00179	0.614
MOD_SUMO_for_1	295	298	PF00179	0.563
MOD_SUMO_for_1	388	391	PF00179	0.469
MOD_SUMO_rev_2	383	390	PF00179	0.514
TRG_DiLeu_BaEn_2	390	396	PF01217	0.512
TRG_DiLeu_BaLyEn_6	10	15	PF01217	0.511
TRG_DiLeu_BaLyEn_6	331	336	PF01217	0.475
TRG_ENDOCYTIC_2	110	113	PF00928	0.565
TRG_ENDOCYTIC_2	46	49	PF00928	0.449
TRG_ENDOCYTIC_2	79	82	PF00928	0.528
TRG_ER_diArg_1	210	213	PF00400	0.560
TRG_Pf-PMV_PEXEL_1	268	272	PF00026	0.617

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYZ0	Leptomonas seymouri	46%	95%
A0A1X0PAH9	Trypanosomatidae	27%	94%
A0A3S7X8I7	Leishmania donovani	82%	100%
A4HBE4	Leishmania braziliensis	62%	99%
A4IAJ2	Leishmania infantum	82%	100%
Q4Q2C0	Leishmania major	81%	100%
V5B669	Trypanosoma cruzi	31%	97%