Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF1193), putative

Species:

Leishmania mexicana

UniProt:

E9B5L3_LEIMU

TriTrypDb:

LmxM.33.4180

Length:

584

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9B5L3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5L3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	52	56	PF00656	0.458
CLV_NRD_NRD_1	11	13	PF00675	0.470
CLV_NRD_NRD_1	277	279	PF00675	0.589
CLV_NRD_NRD_1	387	389	PF00675	0.583
CLV_NRD_NRD_1	494	496	PF00675	0.521
CLV_NRD_NRD_1	535	537	PF00675	0.584
CLV_PCSK_FUR_1	492	496	PF00082	0.534
CLV_PCSK_KEX2_1	11	13	PF00082	0.478
CLV_PCSK_KEX2_1	402	404	PF00082	0.622
CLV_PCSK_KEX2_1	494	496	PF00082	0.524
CLV_PCSK_PC1ET2_1	402	404	PF00082	0.622
CLV_PCSK_SKI1_1	175	179	PF00082	0.703
CLV_PCSK_SKI1_1	243	247	PF00082	0.551
CLV_PCSK_SKI1_1	256	260	PF00082	0.479
CLV_PCSK_SKI1_1	415	419	PF00082	0.497
DEG_APCC_DBOX_1	402	410	PF00400	0.416
DEG_SPOP_SBC_1	100	104	PF00917	0.547
DOC_CKS1_1	48	53	PF01111	0.476
DOC_CYCLIN_yCln2_LP_2	376	382	PF00134	0.321
DOC_MAPK_gen_1	11	21	PF00069	0.469
DOC_MAPK_gen_1	536	542	PF00069	0.367
DOC_MAPK_JIP1_4	15	21	PF00069	0.518
DOC_MAPK_MEF2A_6	12	21	PF00069	0.480
DOC_MAPK_MEF2A_6	301	310	PF00069	0.334
DOC_PP1_RVXF_1	2	8	PF00149	0.675
DOC_PP1_RVXF_1	293	300	PF00149	0.327
DOC_PP2B_LxvP_1	376	379	PF13499	0.315
DOC_PP4_FxxP_1	562	565	PF00568	0.327
DOC_PP4_FxxP_1	78	81	PF00568	0.548
DOC_SPAK_OSR1_1	331	335	PF12202	0.403
DOC_USP7_MATH_1	123	127	PF00917	0.544
DOC_USP7_MATH_1	247	251	PF00917	0.343
DOC_USP7_MATH_1	59	63	PF00917	0.542
DOC_USP7_MATH_2	134	140	PF00917	0.462
DOC_USP7_UBL2_3	456	460	PF12436	0.353
DOC_WW_Pin1_4	150	155	PF00397	0.469
DOC_WW_Pin1_4	319	324	PF00397	0.327
DOC_WW_Pin1_4	47	52	PF00397	0.468
DOC_WW_Pin1_4	71	76	PF00397	0.565
LIG_14-3-3_CanoR_1	15	20	PF00244	0.542
LIG_14-3-3_CanoR_1	213	219	PF00244	0.419
LIG_14-3-3_CanoR_1	220	225	PF00244	0.428
LIG_14-3-3_CanoR_1	301	307	PF00244	0.304
LIG_14-3-3_CanoR_1	351	358	PF00244	0.384
LIG_14-3-3_CanoR_1	41	49	PF00244	0.558
LIG_14-3-3_CanoR_1	492	501	PF00244	0.327
LIG_14-3-3_CanoR_1	553	562	PF00244	0.419
LIG_Actin_WH2_2	255	272	PF00022	0.419
LIG_BRCT_BRCA1_1	321	325	PF00533	0.318
LIG_CtBP_PxDLS_1	16	20	PF00389	0.391
LIG_deltaCOP1_diTrp_1	287	293	PF00928	0.381
LIG_DLG_GKlike_1	15	22	PF00625	0.518
LIG_EH_1	478	482	PF12763	0.389
LIG_FHA_1	125	131	PF00498	0.609
LIG_FHA_1	144	150	PF00498	0.589
LIG_FHA_1	348	354	PF00498	0.383
LIG_FHA_1	358	364	PF00498	0.229
LIG_FHA_1	42	48	PF00498	0.571
LIG_FHA_2	213	219	PF00498	0.389
LIG_FHA_2	440	446	PF00498	0.346
LIG_FHA_2	503	509	PF00498	0.320
LIG_FHA_2	555	561	PF00498	0.377
LIG_FHA_2	576	582	PF00498	0.497
LIG_KLC1_Yacidic_2	204	209	PF13176	0.380
LIG_LIR_Apic_2	560	565	PF02991	0.342
LIG_LIR_Gen_1	160	168	PF02991	0.224
LIG_LIR_Gen_1	185	193	PF02991	0.395
LIG_LIR_Gen_1	298	307	PF02991	0.340
LIG_LIR_Gen_1	313	321	PF02991	0.296
LIG_LIR_Gen_1	326	336	PF02991	0.374
LIG_LIR_Gen_1	373	382	PF02991	0.337
LIG_LIR_Gen_1	416	422	PF02991	0.338
LIG_LIR_Gen_1	496	504	PF02991	0.317
LIG_LIR_Gen_1	566	573	PF02991	0.442
LIG_LIR_Gen_1	64	75	PF02991	0.430
LIG_LIR_Nem_3	160	165	PF02991	0.326
LIG_LIR_Nem_3	185	191	PF02991	0.391
LIG_LIR_Nem_3	286	291	PF02991	0.301
LIG_LIR_Nem_3	298	302	PF02991	0.306
LIG_LIR_Nem_3	30	35	PF02991	0.368
LIG_LIR_Nem_3	304	310	PF02991	0.248
LIG_LIR_Nem_3	313	317	PF02991	0.255
LIG_LIR_Nem_3	326	332	PF02991	0.341
LIG_LIR_Nem_3	373	378	PF02991	0.303
LIG_LIR_Nem_3	416	421	PF02991	0.332
LIG_LIR_Nem_3	496	501	PF02991	0.321
LIG_LIR_Nem_3	566	570	PF02991	0.409
LIG_LIR_Nem_3	64	70	PF02991	0.540
LIG_LYPXL_yS_3	512	515	PF13949	0.377
LIG_MYND_1	131	135	PF01753	0.466
LIG_MYND_1	150	154	PF01753	0.487
LIG_MYND_1	91	95	PF01753	0.585
LIG_Pex14_1	289	293	PF04695	0.382
LIG_Pex14_1	328	332	PF04695	0.316
LIG_Pex14_2	325	329	PF04695	0.331
LIG_PTB_Apo_2	476	483	PF02174	0.424
LIG_SH2_CRK	162	166	PF00017	0.407
LIG_SH2_CRK	321	325	PF00017	0.342
LIG_SH2_CRK	567	571	PF00017	0.445
LIG_SH2_NCK_1	282	286	PF00017	0.374
LIG_SH2_NCK_1	53	57	PF00017	0.442
LIG_SH2_SRC	391	394	PF00017	0.364
LIG_SH2_SRC	463	466	PF00017	0.364
LIG_SH2_STAP1	162	166	PF00017	0.429
LIG_SH2_STAP1	349	353	PF00017	0.437
LIG_SH2_STAT3	349	352	PF00017	0.415
LIG_SH2_STAT5	207	210	PF00017	0.431
LIG_SH2_STAT5	235	238	PF00017	0.319
LIG_SH2_STAT5	314	317	PF00017	0.362
LIG_SH2_STAT5	349	352	PF00017	0.362
LIG_SH2_STAT5	391	394	PF00017	0.324
LIG_SH2_STAT5	463	466	PF00017	0.358
LIG_SH2_STAT5	504	507	PF00017	0.340
LIG_SH2_STAT5	547	550	PF00017	0.382
LIG_SH2_STAT5	556	559	PF00017	0.428
LIG_SH3_1	128	134	PF00018	0.471
LIG_SH3_1	178	184	PF00018	0.463
LIG_SH3_2	106	111	PF14604	0.572
LIG_SH3_2	181	186	PF14604	0.469
LIG_SH3_3	103	109	PF00018	0.546
LIG_SH3_3	128	134	PF00018	0.592
LIG_SH3_3	178	184	PF00018	0.398
LIG_SH3_3	196	202	PF00018	0.259
LIG_SH3_3	303	309	PF00018	0.290
LIG_SH3_3	34	40	PF00018	0.557
LIG_SH3_3	45	51	PF00018	0.543
LIG_SH3_3	567	573	PF00018	0.401
LIG_SH3_3	78	84	PF00018	0.594
LIG_SH3_3	88	94	PF00018	0.596
LIG_SUMO_SIM_anti_2	96	104	PF11976	0.443
LIG_SUMO_SIM_par_1	25	30	PF11976	0.363
LIG_TYR_ITIM	312	317	PF00017	0.329
LIG_TYR_ITIM	319	324	PF00017	0.342
LIG_WRC_WIRS_1	158	163	PF05994	0.290
LIG_WRC_WIRS_1	372	377	PF05994	0.324
MOD_CK1_1	104	110	PF00069	0.546
MOD_CK1_1	144	150	PF00069	0.558
MOD_CK1_1	354	360	PF00069	0.354
MOD_CK1_1	441	447	PF00069	0.387
MOD_CK1_1	469	475	PF00069	0.356
MOD_CK1_1	530	536	PF00069	0.383
MOD_CK1_1	62	68	PF00069	0.538
MOD_CK2_1	439	445	PF00069	0.242
MOD_CK2_1	469	475	PF00069	0.356
MOD_CK2_1	493	499	PF00069	0.350
MOD_CK2_1	502	508	PF00069	0.378
MOD_CK2_1	554	560	PF00069	0.362
MOD_GlcNHglycan	103	106	PF01048	0.702
MOD_GlcNHglycan	138	141	PF01048	0.775
MOD_GlcNHglycan	146	149	PF01048	0.778
MOD_GSK3_1	100	107	PF00069	0.508
MOD_GSK3_1	114	121	PF00069	0.373
MOD_GSK3_1	144	151	PF00069	0.542
MOD_GSK3_1	319	326	PF00069	0.296
MOD_GSK3_1	347	354	PF00069	0.381
MOD_GSK3_1	422	429	PF00069	0.421
MOD_GSK3_1	465	472	PF00069	0.327
MOD_LATS_1	13	19	PF00433	0.518
MOD_N-GLC_1	220	225	PF02516	0.641
MOD_N-GLC_1	336	341	PF02516	0.559
MOD_N-GLC_1	41	46	PF02516	0.707
MOD_N-GLC_2	550	552	PF02516	0.551
MOD_NEK2_1	260	265	PF00069	0.387
MOD_NEK2_1	27	32	PF00069	0.380
MOD_NEK2_1	398	403	PF00069	0.419
MOD_NEK2_1	413	418	PF00069	0.331
MOD_NEK2_1	493	498	PF00069	0.332
MOD_PIKK_1	273	279	PF00454	0.313
MOD_PIKK_1	323	329	PF00454	0.296
MOD_PKA_1	494	500	PF00069	0.332
MOD_PKA_2	136	142	PF00069	0.603
MOD_PKA_2	212	218	PF00069	0.410
MOD_PKA_2	426	432	PF00069	0.460
MOD_PKA_2	486	492	PF00069	0.345
MOD_PKA_2	493	499	PF00069	0.298
MOD_PKA_2	59	65	PF00069	0.547
MOD_PKB_1	492	500	PF00069	0.317
MOD_Plk_1	154	160	PF00069	0.396
MOD_Plk_1	220	226	PF00069	0.412
MOD_Plk_1	354	360	PF00069	0.329
MOD_Plk_1	382	388	PF00069	0.412
MOD_Plk_1	413	419	PF00069	0.352
MOD_Plk_1	42	48	PF00069	0.547
MOD_Plk_1	518	524	PF00069	0.415
MOD_Plk_1	575	581	PF00069	0.466
MOD_Plk_2-3	560	566	PF00069	0.385
MOD_Plk_2-3	575	581	PF00069	0.480
MOD_Plk_4	157	163	PF00069	0.349
MOD_Plk_4	302	308	PF00069	0.333
MOD_Plk_4	371	377	PF00069	0.312
MOD_Plk_4	382	388	PF00069	0.307
MOD_Plk_4	466	472	PF00069	0.330
MOD_Plk_4	530	536	PF00069	0.359
MOD_Plk_4	62	68	PF00069	0.486
MOD_ProDKin_1	150	156	PF00069	0.464
MOD_ProDKin_1	319	325	PF00069	0.325
MOD_ProDKin_1	47	53	PF00069	0.468
MOD_ProDKin_1	71	77	PF00069	0.568
TRG_DiLeu_BaEn_4	574	580	PF01217	0.447
TRG_DiLeu_BaLyEn_6	510	515	PF01217	0.398
TRG_ENDOCYTIC_2	162	165	PF00928	0.425
TRG_ENDOCYTIC_2	282	285	PF00928	0.337
TRG_ENDOCYTIC_2	314	317	PF00928	0.316
TRG_ENDOCYTIC_2	321	324	PF00928	0.328
TRG_ENDOCYTIC_2	461	464	PF00928	0.298
TRG_ENDOCYTIC_2	512	515	PF00928	0.356
TRG_ENDOCYTIC_2	567	570	PF00928	0.386
TRG_ER_diArg_1	10	12	PF00400	0.672
TRG_ER_diArg_1	403	406	PF00400	0.417
TRG_ER_diArg_1	493	495	PF00400	0.311
TRG_ER_diArg_1	551	554	PF00400	0.413
TRG_NES_CRM1_1	156	169	PF08389	0.405
TRG_NES_CRM1_1	411	426	PF08389	0.333
TRG_NLS_Bipartite_1	388	406	PF00514	0.415

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5V7	Leptomonas seymouri	63%	100%
A0A0S4IP10	Bodo saltans	25%	100%
A0A0S4KMJ1	Bodo saltans	48%	100%
A0A1X0PB74	Trypanosomatidae	52%	100%
A0A3S5IRZ3	Trypanosoma rangeli	56%	100%
A0A3S7X8K5	Leishmania donovani	90%	100%
A4HBE1	Leishmania braziliensis	81%	99%
A4IAI9	Leishmania infantum	90%	100%
C9ZLP9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
C9ZS63	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	90%
Q4Q2C3	Leishmania major	90%	100%
V5BRE4	Trypanosoma cruzi	53%	100%