Zinc knuckle-domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc knuckle, putative

Species:

Leishmania mexicana

UniProt:

E9B5L2_LEIMU

TriTrypDb:

LmxM.33.4170

Length:

247

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 2
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B5L2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5L2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	212	216	PF00656	0.604
CLV_PCSK_KEX2_1	121	123	PF00082	0.516
CLV_PCSK_PC1ET2_1	121	123	PF00082	0.516
CLV_PCSK_SKI1_1	140	144	PF00082	0.341
CLV_PCSK_SKI1_1	180	184	PF00082	0.612
CLV_PCSK_SKI1_1	191	195	PF00082	0.469
CLV_PCSK_SKI1_1	6	10	PF00082	0.604
DOC_CKS1_1	67	72	PF01111	0.766
DOC_MAPK_gen_1	39	47	PF00069	0.626
DOC_PP4_FxxP_1	134	137	PF00568	0.516
DOC_PP4_FxxP_1	225	228	PF00568	0.618
DOC_PP4_FxxP_1	47	50	PF00568	0.766
DOC_USP7_MATH_1	146	150	PF00917	0.516
DOC_USP7_MATH_1	204	208	PF00917	0.620
DOC_USP7_MATH_1	209	213	PF00917	0.688
DOC_USP7_MATH_1	32	36	PF00917	0.633
DOC_USP7_MATH_1	68	72	PF00917	0.598
DOC_USP7_UBL2_3	104	108	PF12436	0.703
DOC_WW_Pin1_4	63	68	PF00397	0.752
LIG_14-3-3_CanoR_1	41	46	PF00244	0.626
LIG_14-3-3_CanoR_1	6	15	PF00244	0.602
LIG_14-3-3_CanoR_1	80	89	PF00244	0.587
LIG_BIR_II_1	1	5	PF00653	0.609
LIG_BRCT_BRCA1_1	169	173	PF00533	0.716
LIG_deltaCOP1_diTrp_1	130	134	PF00928	0.341
LIG_FHA_1	151	157	PF00498	0.399
LIG_FHA_1	193	199	PF00498	0.657
LIG_FHA_1	25	31	PF00498	0.610
LIG_FHA_1	81	87	PF00498	0.671
LIG_FHA_2	176	182	PF00498	0.567
LIG_LIR_Apic_2	133	137	PF02991	0.516
LIG_LIR_Apic_2	44	50	PF02991	0.603
LIG_LIR_Nem_3	2	8	PF02991	0.609
LIG_MYND_1	50	54	PF01753	0.560
LIG_SH2_CRK	110	114	PF00017	0.620
LIG_SH2_CRK	5	9	PF00017	0.610
LIG_SH2_SRC	59	62	PF00017	0.588
LIG_SH2_STAT5	59	62	PF00017	0.588
LIG_SH3_3	171	177	PF00018	0.568
LIG_SH3_3	47	53	PF00018	0.749
LIG_SH3_3	64	70	PF00018	0.637
LIG_SUMO_SIM_anti_2	83	90	PF11976	0.595
LIG_TYR_ITSM	1	8	PF00017	0.610
LIG_UBA3_1	88	94	PF00899	0.568
LIG_WW_3	36	40	PF00397	0.620
MOD_CK1_1	149	155	PF00069	0.516
MOD_CK1_1	21	27	PF00069	0.604
MOD_CK1_1	40	46	PF00069	0.627
MOD_CK1_1	63	69	PF00069	0.696
MOD_CK2_1	124	130	PF00069	0.341
MOD_CK2_1	175	181	PF00069	0.527
MOD_GlcNHglycan	140	143	PF01048	0.452
MOD_GlcNHglycan	144	147	PF01048	0.415
MOD_GlcNHglycan	148	151	PF01048	0.371
MOD_GlcNHglycan	169	172	PF01048	0.713
MOD_GlcNHglycan	206	209	PF01048	0.723
MOD_GlcNHglycan	21	24	PF01048	0.602
MOD_GlcNHglycan	211	214	PF01048	0.692
MOD_GSK3_1	122	129	PF00069	0.516
MOD_GSK3_1	138	145	PF00069	0.341
MOD_GSK3_1	14	21	PF00069	0.601
MOD_GSK3_1	146	153	PF00069	0.376
MOD_GSK3_1	37	44	PF00069	0.729
MOD_N-GLC_1	117	122	PF02516	0.516
MOD_NEK2_1	138	143	PF00069	0.499
MOD_NEK2_1	15	20	PF00069	0.610
MOD_NEK2_1	156	161	PF00069	0.224
MOD_NEK2_1	233	238	PF00069	0.620
MOD_NEK2_2	150	155	PF00069	0.516
MOD_PIKK_1	156	162	PF00454	0.399
MOD_PK_1	108	114	PF00069	0.741
MOD_PKA_2	40	46	PF00069	0.732
MOD_PKA_2	48	54	PF00069	0.672
MOD_PKB_1	39	47	PF00069	0.626
MOD_Plk_2-3	130	136	PF00069	0.341
MOD_Plk_4	233	239	PF00069	0.621
MOD_Plk_4	69	75	PF00069	0.674
MOD_ProDKin_1	63	69	PF00069	0.752
MOD_SUMO_for_1	228	231	PF00179	0.675
MOD_SUMO_for_1	238	241	PF00179	0.686
MOD_SUMO_rev_2	181	190	PF00179	0.517
MOD_SUMO_rev_2	197	204	PF00179	0.541
MOD_SUMO_rev_2	212	218	PF00179	0.518
TRG_ENDOCYTIC_2	5	8	PF00928	0.612
TRG_ENDOCYTIC_2	97	100	PF00928	0.546
TRG_ER_diArg_1	38	41	PF00400	0.627

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5IRZ4	Trypanosoma rangeli	45%	100%
Q4Q2C4	Leishmania major	81%	100%