CST complex subunit CTC1

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B5L0_LEIMU

TriTrypDb:

LmxM.33.4150

Length:

645

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B5L0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5L0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	171	175	PF00656	0.489
CLV_C14_Caspase3-7	231	235	PF00656	0.434
CLV_C14_Caspase3-7	436	440	PF00656	0.705
CLV_C14_Caspase3-7	600	604	PF00656	0.392
CLV_NRD_NRD_1	142	144	PF00675	0.429
CLV_NRD_NRD_1	212	214	PF00675	0.747
CLV_NRD_NRD_1	402	404	PF00675	0.500
CLV_PCSK_KEX2_1	142	144	PF00082	0.426
CLV_PCSK_KEX2_1	212	214	PF00082	0.752
CLV_PCSK_KEX2_1	345	347	PF00082	0.521
CLV_PCSK_KEX2_1	613	615	PF00082	0.513
CLV_PCSK_PC1ET2_1	345	347	PF00082	0.546
CLV_PCSK_PC1ET2_1	613	615	PF00082	0.513
CLV_PCSK_SKI1_1	221	225	PF00082	0.389
CLV_PCSK_SKI1_1	389	393	PF00082	0.446
CLV_PCSK_SKI1_1	490	494	PF00082	0.405
CLV_Separin_Metazoa	487	491	PF03568	0.342
DEG_APCC_DBOX_1	402	410	PF00400	0.457
DEG_APCC_DBOX_1	489	497	PF00400	0.433
DEG_Nend_UBRbox_2	1	3	PF02207	0.495
DOC_CDC14_PxL_1	584	592	PF14671	0.362
DOC_CYCLIN_RxL_1	221	231	PF00134	0.482
DOC_MAPK_gen_1	348	356	PF00069	0.438
DOC_MAPK_gen_1	463	470	PF00069	0.636
DOC_MAPK_MEF2A_6	27	36	PF00069	0.405
DOC_MAPK_MEF2A_6	463	472	PF00069	0.540
DOC_MAPK_MEF2A_6	528	537	PF00069	0.243
DOC_MAPK_MEF2A_6	583	591	PF00069	0.376
DOC_MAPK_NFAT4_5	463	471	PF00069	0.488
DOC_PP1_RVXF_1	186	192	PF00149	0.317
DOC_PP2B_LxvP_1	68	71	PF13499	0.337
DOC_SPAK_OSR1_1	54	58	PF12202	0.368
DOC_USP7_MATH_1	154	158	PF00917	0.614
DOC_USP7_MATH_1	197	201	PF00917	0.671
DOC_USP7_MATH_1	46	50	PF00917	0.645
DOC_USP7_MATH_1	498	502	PF00917	0.367
DOC_USP7_MATH_1	554	558	PF00917	0.413
DOC_WW_Pin1_4	147	152	PF00397	0.666
DOC_WW_Pin1_4	216	221	PF00397	0.625
DOC_WW_Pin1_4	430	435	PF00397	0.746
DOC_WW_Pin1_4	455	460	PF00397	0.756
DOC_WW_Pin1_4	473	478	PF00397	0.461
DOC_WW_Pin1_4	559	564	PF00397	0.479
LIG_14-3-3_CanoR_1	212	222	PF00244	0.677
LIG_14-3-3_CanoR_1	348	354	PF00244	0.515
LIG_14-3-3_CanoR_1	403	413	PF00244	0.382
LIG_APCC_ABBA_1	489	494	PF00400	0.391
LIG_BIR_III_2	444	448	PF00653	0.664
LIG_BRCT_BRCA1_1	218	222	PF00533	0.528
LIG_BRCT_BRCA1_1	4	8	PF00533	0.402
LIG_deltaCOP1_diTrp_1	23	29	PF00928	0.458
LIG_deltaCOP1_diTrp_1	388	392	PF00928	0.347
LIG_FHA_1	117	123	PF00498	0.575
LIG_FHA_1	184	190	PF00498	0.460
LIG_FHA_1	31	37	PF00498	0.416
LIG_FHA_1	318	324	PF00498	0.493
LIG_FHA_1	410	416	PF00498	0.521
LIG_FHA_1	476	482	PF00498	0.406
LIG_FHA_1	517	523	PF00498	0.503
LIG_FHA_1	530	536	PF00498	0.463
LIG_FHA_2	72	78	PF00498	0.484
LIG_LIR_Gen_1	53	63	PF02991	0.369
LIG_LIR_Gen_1	629	638	PF02991	0.527
LIG_LIR_Gen_1	64	75	PF02991	0.337
LIG_LIR_Nem_3	373	378	PF02991	0.374
LIG_LIR_Nem_3	53	59	PF02991	0.380
LIG_LIR_Nem_3	629	634	PF02991	0.518
LIG_LIR_Nem_3	64	70	PF02991	0.305
LIG_LYPXL_yS_3	42	45	PF13949	0.552
LIG_SH2_GRB2like	115	118	PF00017	0.499
LIG_SH2_PTP2	326	329	PF00017	0.414
LIG_SH2_PTP2	56	59	PF00017	0.337
LIG_SH2_STAT3	569	572	PF00017	0.298
LIG_SH2_STAT5	326	329	PF00017	0.519
LIG_SH2_STAT5	56	59	PF00017	0.262
LIG_SH2_STAT5	569	572	PF00017	0.360
LIG_SH3_3	104	110	PF00018	0.365
LIG_SH3_3	388	394	PF00018	0.444
LIG_SH3_3	40	46	PF00018	0.544
LIG_SH3_3	453	459	PF00018	0.698
LIG_SH3_3	474	480	PF00018	0.500
LIG_SH3_3	485	491	PF00018	0.360
LIG_SH3_3	582	588	PF00018	0.390
LIG_SH3_3	66	72	PF00018	0.385
LIG_SUMO_SIM_anti_2	313	320	PF11976	0.361
LIG_SUMO_SIM_par_1	313	320	PF11976	0.543
LIG_SUMO_SIM_par_1	468	474	PF11976	0.440
LIG_SxIP_EBH_1	509	523	PF03271	0.330
LIG_TRAF2_1	282	285	PF00917	0.459
LIG_WRC_WIRS_1	628	633	PF05994	0.596
MOD_CDK_SPK_2	216	221	PF00069	0.625
MOD_CDK_SPxxK_3	430	437	PF00069	0.690
MOD_CK1_1	116	122	PF00069	0.528
MOD_CK1_1	136	142	PF00069	0.319
MOD_CK1_1	157	163	PF00069	0.465
MOD_CK1_1	200	206	PF00069	0.679
MOD_CK1_1	211	217	PF00069	0.690
MOD_CK1_1	352	358	PF00069	0.412
MOD_CK1_1	359	365	PF00069	0.528
MOD_CK1_1	408	414	PF00069	0.451
MOD_CK1_1	433	439	PF00069	0.716
MOD_CK1_1	512	518	PF00069	0.495
MOD_CK2_1	124	130	PF00069	0.455
MOD_CK2_1	279	285	PF00069	0.534
MOD_CK2_1	554	560	PF00069	0.444
MOD_CK2_1	57	63	PF00069	0.435
MOD_CK2_1	630	636	PF00069	0.574
MOD_CK2_1	71	77	PF00069	0.315
MOD_GlcNHglycan	135	138	PF01048	0.521
MOD_GlcNHglycan	156	159	PF01048	0.444
MOD_GlcNHglycan	215	218	PF01048	0.580
MOD_GlcNHglycan	288	291	PF01048	0.625
MOD_GlcNHglycan	300	303	PF01048	0.428
MOD_GlcNHglycan	358	361	PF01048	0.518
MOD_GlcNHglycan	364	367	PF01048	0.552
MOD_GlcNHglycan	450	453	PF01048	0.717
MOD_GlcNHglycan	524	527	PF01048	0.581
MOD_GlcNHglycan	573	576	PF01048	0.382
MOD_GlcNHglycan	618	621	PF01048	0.608
MOD_GlcNHglycan	625	628	PF01048	0.524
MOD_GlcNHglycan	639	642	PF01048	0.568
MOD_GSK3_1	197	204	PF00069	0.594
MOD_GSK3_1	267	274	PF00069	0.631
MOD_GSK3_1	325	332	PF00069	0.435
MOD_GSK3_1	337	344	PF00069	0.442
MOD_GSK3_1	352	359	PF00069	0.396
MOD_GSK3_1	404	411	PF00069	0.368
MOD_GSK3_1	46	53	PF00069	0.513
MOD_GSK3_1	512	519	PF00069	0.480
MOD_GSK3_1	57	64	PF00069	0.298
MOD_GSK3_1	616	623	PF00069	0.573
MOD_LATS_1	402	408	PF00433	0.311
MOD_N-GLC_1	116	121	PF02516	0.624
MOD_N-GLC_2	182	184	PF02516	0.497
MOD_NEK2_1	13	18	PF00069	0.498
MOD_NEK2_1	298	303	PF00069	0.472
MOD_NEK2_1	356	361	PF00069	0.374
MOD_NEK2_1	409	414	PF00069	0.473
MOD_NEK2_1	76	81	PF00069	0.466
MOD_NEK2_1	92	97	PF00069	0.283
MOD_PIKK_1	157	163	PF00454	0.462
MOD_PIKK_1	337	343	PF00454	0.533
MOD_PIKK_1	500	506	PF00454	0.467
MOD_PK_1	509	515	PF00069	0.394
MOD_PKA_2	208	214	PF00069	0.661
MOD_PKA_2	402	408	PF00069	0.383
MOD_PKA_2	428	434	PF00069	0.661
MOD_Plk_1	116	122	PF00069	0.521
MOD_Plk_1	279	285	PF00069	0.445
MOD_Plk_1	370	376	PF00069	0.357
MOD_Plk_1	76	82	PF00069	0.515
MOD_Plk_4	136	142	PF00069	0.530
MOD_Plk_4	325	331	PF00069	0.389
MOD_Plk_4	370	376	PF00069	0.399
MOD_Plk_4	405	411	PF00069	0.378
MOD_Plk_4	503	509	PF00069	0.618
MOD_Plk_4	554	560	PF00069	0.370
MOD_Plk_4	620	626	PF00069	0.542
MOD_ProDKin_1	147	153	PF00069	0.670
MOD_ProDKin_1	216	222	PF00069	0.612
MOD_ProDKin_1	430	436	PF00069	0.746
MOD_ProDKin_1	455	461	PF00069	0.752
MOD_ProDKin_1	473	479	PF00069	0.461
MOD_ProDKin_1	559	565	PF00069	0.482
TRG_DiLeu_BaLyEn_6	118	123	PF01217	0.529
TRG_ENDOCYTIC_2	326	329	PF00928	0.449
TRG_ENDOCYTIC_2	42	45	PF00928	0.502
TRG_ENDOCYTIC_2	56	59	PF00928	0.296
TRG_ER_diArg_1	141	143	PF00400	0.389
TRG_ER_diArg_1	249	252	PF00400	0.504
TRG_ER_diArg_1	346	349	PF00400	0.540
TRG_Pf-PMV_PEXEL_1	121	125	PF00026	0.570
TRG_Pf-PMV_PEXEL_1	225	230	PF00026	0.419

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7E9	Leptomonas seymouri	52%	98%
A0A0S4KIT9	Bodo saltans	27%	94%
A0A1X0PA76	Trypanosomatidae	32%	100%
A0A3Q8IHL1	Leishmania donovani	87%	98%
A0A422NVA9	Trypanosoma rangeli	35%	100%
A4HBD8	Leishmania braziliensis	75%	100%
A4IAI6	Leishmania infantum	87%	98%
C9ZLQ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
Q4Q2C6	Leishmania major	88%	100%
V5DMS9	Trypanosoma cruzi	34%	100%