Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B5K9_LEIMU

TriTrypDb:

LmxM.33.4140

Length:

465

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B5K9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5K9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	324	328	PF00656	0.549
CLV_C14_Caspase3-7	443	447	PF00656	0.551
CLV_NRD_NRD_1	159	161	PF00675	0.571
CLV_NRD_NRD_1	211	213	PF00675	0.492
CLV_NRD_NRD_1	38	40	PF00675	0.457
CLV_NRD_NRD_1	52	54	PF00675	0.476
CLV_NRD_NRD_1	99	101	PF00675	0.508
CLV_PCSK_FUR_1	36	40	PF00082	0.457
CLV_PCSK_FUR_1	50	54	PF00082	0.466
CLV_PCSK_KEX2_1	38	40	PF00082	0.457
CLV_PCSK_KEX2_1	456	458	PF00082	0.539
CLV_PCSK_KEX2_1	52	54	PF00082	0.476
CLV_PCSK_KEX2_1	99	101	PF00082	0.508
CLV_PCSK_PC1ET2_1	456	458	PF00082	0.539
CLV_PCSK_SKI1_1	109	113	PF00082	0.578
CLV_PCSK_SKI1_1	154	158	PF00082	0.562
CLV_PCSK_SKI1_1	191	195	PF00082	0.445
CLV_PCSK_SKI1_1	25	29	PF00082	0.563
CLV_PCSK_SKI1_1	337	341	PF00082	0.499
CLV_PCSK_SKI1_1	39	43	PF00082	0.427
CLV_Separin_Metazoa	110	114	PF03568	0.584
CLV_Separin_Metazoa	44	48	PF03568	0.510
DEG_APCC_DBOX_1	38	46	PF00400	0.514
DEG_SCF_FBW7_1	239	246	PF00400	0.505
DEG_SPOP_SBC_1	243	247	PF00917	0.575
DEG_SPOP_SBC_1	309	313	PF00917	0.499
DOC_CKS1_1	240	245	PF01111	0.506
DOC_CYCLIN_RxL_1	148	159	PF00134	0.568
DOC_CYCLIN_RxL_1	33	44	PF00134	0.436
DOC_MAPK_gen_1	33	42	PF00069	0.515
DOC_PP1_RVXF_1	335	342	PF00149	0.613
DOC_PP2B_LxvP_1	155	158	PF13499	0.560
DOC_PP2B_LxvP_1	233	236	PF13499	0.557
DOC_PP4_FxxP_1	448	451	PF00568	0.582
DOC_USP7_MATH_1	10	14	PF00917	0.622
DOC_USP7_MATH_1	146	150	PF00917	0.624
DOC_USP7_MATH_1	175	179	PF00917	0.570
DOC_USP7_MATH_1	248	252	PF00917	0.626
DOC_USP7_MATH_1	259	263	PF00917	0.505
DOC_USP7_MATH_1	309	313	PF00917	0.583
DOC_USP7_MATH_1	420	424	PF00917	0.641
DOC_USP7_MATH_1	56	60	PF00917	0.564
DOC_USP7_MATH_1	85	89	PF00917	0.594
DOC_USP7_UBL2_3	133	137	PF12436	0.646
DOC_WW_Pin1_4	120	125	PF00397	0.452
DOC_WW_Pin1_4	142	147	PF00397	0.609
DOC_WW_Pin1_4	239	244	PF00397	0.548
DOC_WW_Pin1_4	283	288	PF00397	0.558
DOC_WW_Pin1_4	289	294	PF00397	0.552
DOC_WW_Pin1_4	298	303	PF00397	0.623
DOC_WW_Pin1_4	409	414	PF00397	0.686
DOC_WW_Pin1_4	431	436	PF00397	0.625
LIG_14-3-3_CanoR_1	20	28	PF00244	0.520
LIG_14-3-3_CanoR_1	232	236	PF00244	0.599
LIG_14-3-3_CanoR_1	249	253	PF00244	0.492
LIG_14-3-3_CanoR_1	337	342	PF00244	0.652
LIG_14-3-3_CanoR_1	370	380	PF00244	0.540
LIG_14-3-3_CanoR_1	405	415	PF00244	0.658
LIG_14-3-3_CanoR_1	90	96	PF00244	0.538
LIG_BIR_II_1	1	5	PF00653	0.659
LIG_FHA_1	261	267	PF00498	0.477
LIG_FHA_1	298	304	PF00498	0.598
LIG_FHA_1	321	327	PF00498	0.626
LIG_FHA_1	362	368	PF00498	0.657
LIG_FHA_2	391	397	PF00498	0.647
LIG_FHA_2	441	447	PF00498	0.663
LIG_FHA_2	74	80	PF00498	0.512
LIG_FHA_2	92	98	PF00498	0.572
LIG_LIR_Apic_2	446	451	PF02991	0.554
LIG_LIR_Nem_3	126	132	PF02991	0.531
LIG_LIR_Nem_3	345	351	PF02991	0.636
LIG_LIR_Nem_3	353	359	PF02991	0.569
LIG_LIR_Nem_3	374	379	PF02991	0.602
LIG_LIR_Nem_3	393	397	PF02991	0.639
LIG_LIR_Nem_3	458	464	PF02991	0.610
LIG_PTAP_UEV_1	383	388	PF05743	0.653
LIG_SH2_CRK	240	244	PF00017	0.627
LIG_SH2_CRK	348	352	PF00017	0.482
LIG_SH2_CRK	376	380	PF00017	0.572
LIG_SH2_STAT3	403	406	PF00017	0.513
LIG_SH2_STAT5	117	120	PF00017	0.605
LIG_SH2_STAT5	130	133	PF00017	0.788
LIG_SH2_STAT5	297	300	PF00017	0.607
LIG_SH3_2	236	241	PF14604	0.557
LIG_SH3_3	233	239	PF00018	0.654
LIG_SH3_3	247	253	PF00018	0.499
LIG_SH3_3	336	342	PF00018	0.785
LIG_SH3_3	349	355	PF00018	0.522
LIG_SH3_3	381	387	PF00018	0.671
LIG_TRAF2_1	41	44	PF00917	0.382
LIG_WW_3	413	417	PF00397	0.683
MOD_CDC14_SPxK_1	145	148	PF00782	0.562
MOD_CDC14_SPxK_1	292	295	PF00782	0.548
MOD_CDC14_SPxK_1	301	304	PF00782	0.648
MOD_CDK_SPxK_1	142	148	PF00069	0.560
MOD_CDK_SPxK_1	289	295	PF00069	0.548
MOD_CDK_SPxK_1	298	304	PF00069	0.652
MOD_CDK_SPxxK_3	409	416	PF00069	0.646
MOD_CK1_1	231	237	PF00069	0.521
MOD_CK1_1	262	268	PF00069	0.527
MOD_CK1_1	385	391	PF00069	0.593
MOD_CK1_1	429	435	PF00069	0.816
MOD_CK1_1	59	65	PF00069	0.581
MOD_CK1_1	68	74	PF00069	0.606
MOD_CK2_1	31	37	PF00069	0.472
MOD_CK2_1	390	396	PF00069	0.666
MOD_CK2_1	73	79	PF00069	0.534
MOD_CK2_1	91	97	PF00069	0.576
MOD_GlcNHglycan	105	108	PF01048	0.467
MOD_GlcNHglycan	118	121	PF01048	0.554
MOD_GlcNHglycan	148	151	PF01048	0.724
MOD_GlcNHglycan	177	180	PF01048	0.552
MOD_GlcNHglycan	191	194	PF01048	0.494
MOD_GlcNHglycan	246	249	PF01048	0.661
MOD_GlcNHglycan	280	283	PF01048	0.465
MOD_GlcNHglycan	344	347	PF01048	0.610
MOD_GlcNHglycan	360	364	PF01048	0.530
MOD_GlcNHglycan	373	376	PF01048	0.724
MOD_GlcNHglycan	384	387	PF01048	0.563
MOD_GlcNHglycan	422	425	PF01048	0.621
MOD_GlcNHglycan	72	75	PF01048	0.666
MOD_GSK3_1	116	123	PF00069	0.497
MOD_GSK3_1	142	149	PF00069	0.624
MOD_GSK3_1	183	190	PF00069	0.616
MOD_GSK3_1	239	246	PF00069	0.584
MOD_GSK3_1	262	269	PF00069	0.480
MOD_GSK3_1	274	281	PF00069	0.581
MOD_GSK3_1	289	296	PF00069	0.518
MOD_GSK3_1	316	323	PF00069	0.619
MOD_GSK3_1	333	340	PF00069	0.628
MOD_GSK3_1	395	402	PF00069	0.773
MOD_GSK3_1	431	438	PF00069	0.587
MOD_GSK3_1	58	65	PF00069	0.599
MOD_N-GLC_1	65	70	PF02516	0.587
MOD_NEK2_1	320	325	PF00069	0.630
MOD_NEK2_1	333	338	PF00069	0.630
MOD_NEK2_1	359	364	PF00069	0.640
MOD_NEK2_1	397	402	PF00069	0.700
MOD_PIKK_1	166	172	PF00454	0.555
MOD_PIKK_1	395	401	PF00454	0.602
MOD_PKA_2	223	229	PF00069	0.643
MOD_PKA_2	231	237	PF00069	0.593
MOD_PKA_2	248	254	PF00069	0.487
MOD_PKA_2	316	322	PF00069	0.493
MOD_PKA_2	369	375	PF00069	0.549
MOD_PKA_2	59	65	PF00069	0.562
MOD_PKB_1	306	314	PF00069	0.501
MOD_PKB_1	416	424	PF00069	0.539
MOD_Plk_2-3	31	37	PF00069	0.516
MOD_Plk_4	293	299	PF00069	0.594
MOD_Plk_4	316	322	PF00069	0.608
MOD_Plk_4	440	446	PF00069	0.620
MOD_Plk_4	450	456	PF00069	0.573
MOD_ProDKin_1	120	126	PF00069	0.452
MOD_ProDKin_1	142	148	PF00069	0.612
MOD_ProDKin_1	239	245	PF00069	0.548
MOD_ProDKin_1	283	289	PF00069	0.556
MOD_ProDKin_1	298	304	PF00069	0.626
MOD_ProDKin_1	409	415	PF00069	0.685
MOD_ProDKin_1	431	437	PF00069	0.627
MOD_SUMO_for_1	455	458	PF00179	0.608
MOD_SUMO_rev_2	208	215	PF00179	0.499
TRG_DiLeu_BaLyEn_6	151	156	PF01217	0.636
TRG_ENDOCYTIC_2	348	351	PF00928	0.485
TRG_ENDOCYTIC_2	376	379	PF00928	0.593
TRG_ER_diArg_1	303	306	PF00400	0.552
TRG_ER_diArg_1	38	40	PF00400	0.471
TRG_ER_diArg_1	50	53	PF00400	0.502
TRG_ER_diArg_1	98	100	PF00400	0.515
TRG_Pf-PMV_PEXEL_1	100	105	PF00026	0.495
TRG_Pf-PMV_PEXEL_1	268	273	PF00026	0.653
TRG_Pf-PMV_PEXEL_1	38	43	PF00026	0.450

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P706	Leptomonas seymouri	34%	89%
A0A3S7X8Q0	Leishmania donovani	81%	100%
A4HBD7	Leishmania braziliensis	59%	100%
A4IAI5	Leishmania infantum	81%	100%
Q4Q2C7	Leishmania major	79%	100%