ER membrane protein complex subunit 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF1620), putative

Species:

Leishmania mexicana

UniProt:

E9B5K8_LEIMU

TriTrypDb:

LmxM.33.4130

Length:

815

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 10, no: 1
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	12
GO:0072546	EMC complex	3	12
GO:0098796	membrane protein complex	2	12
GO:0140534	endoplasmic reticulum protein-containing complex	2	12

Expansion

Sequence features

E9B5K8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5K8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	224	228	PF00656	0.364
CLV_MEL_PAP_1	361	367	PF00089	0.518
CLV_NRD_NRD_1	330	332	PF00675	0.543
CLV_NRD_NRD_1	516	518	PF00675	0.578
CLV_NRD_NRD_1	540	542	PF00675	0.479
CLV_NRD_NRD_1	684	686	PF00675	0.419
CLV_NRD_NRD_1	741	743	PF00675	0.546
CLV_NRD_NRD_1	806	808	PF00675	0.232
CLV_PCSK_KEX2_1	152	154	PF00082	0.541
CLV_PCSK_KEX2_1	330	332	PF00082	0.554
CLV_PCSK_KEX2_1	516	518	PF00082	0.569
CLV_PCSK_KEX2_1	540	542	PF00082	0.479
CLV_PCSK_KEX2_1	646	648	PF00082	0.432
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.541
CLV_PCSK_PC1ET2_1	646	648	PF00082	0.433
CLV_PCSK_SKI1_1	357	361	PF00082	0.445
CLV_PCSK_SKI1_1	703	707	PF00082	0.484
CLV_PCSK_SKI1_1	737	741	PF00082	0.455
CLV_PCSK_SKI1_1	742	746	PF00082	0.429
CLV_PCSK_SKI1_1	784	788	PF00082	0.442
CLV_PCSK_SKI1_1	807	811	PF00082	0.253
DEG_Nend_Nbox_1	1	3	PF02207	0.498
DEG_SCF_FBW7_2	448	455	PF00400	0.370
DEG_SPOP_SBC_1	767	771	PF00917	0.251
DOC_CDC14_PxL_1	292	300	PF14671	0.258
DOC_CKS1_1	449	454	PF01111	0.332
DOC_CYCLIN_RxL_1	781	789	PF00134	0.219
DOC_MAPK_DCC_7	652	661	PF00069	0.233
DOC_MAPK_gen_1	652	661	PF00069	0.233
DOC_MAPK_gen_1	717	726	PF00069	0.315
DOC_MAPK_MEF2A_6	3	12	PF00069	0.359
DOC_MAPK_MEF2A_6	302	311	PF00069	0.370
DOC_MAPK_MEF2A_6	652	661	PF00069	0.219
DOC_MAPK_MEF2A_6	696	704	PF00069	0.267
DOC_MAPK_RevD_3	632	647	PF00069	0.312
DOC_PP1_RVXF_1	735	741	PF00149	0.255
DOC_PP2B_LxvP_1	724	727	PF13499	0.343
DOC_PP4_FxxP_1	782	785	PF00568	0.324
DOC_USP7_MATH_1	132	136	PF00917	0.351
DOC_USP7_MATH_1	169	173	PF00917	0.349
DOC_USP7_MATH_1	510	514	PF00917	0.349
DOC_USP7_MATH_1	624	628	PF00917	0.283
DOC_USP7_MATH_1	672	676	PF00917	0.210
DOC_WW_Pin1_4	107	112	PF00397	0.355
DOC_WW_Pin1_4	448	453	PF00397	0.321
DOC_WW_Pin1_4	620	625	PF00397	0.280
DOC_WW_Pin1_4	83	88	PF00397	0.398
LIG_14-3-3_CanoR_1	275	279	PF00244	0.348
LIG_14-3-3_CanoR_1	463	472	PF00244	0.275
LIG_14-3-3_CanoR_1	516	524	PF00244	0.306
LIG_14-3-3_CanoR_1	540	544	PF00244	0.367
LIG_14-3-3_CanoR_1	685	689	PF00244	0.242
LIG_14-3-3_CanoR_1	719	727	PF00244	0.314
LIG_14-3-3_CanoR_1	742	748	PF00244	0.252
LIG_14-3-3_CanoR_1	768	775	PF00244	0.209
LIG_14-3-3_CanoR_1	80	90	PF00244	0.284
LIG_Actin_WH2_2	260	277	PF00022	0.412
LIG_BRCT_BRCA1_1	727	731	PF00533	0.312
LIG_Clathr_ClatBox_1	297	301	PF01394	0.268
LIG_CtBP_PxDLS_1	74	80	PF00389	0.276
LIG_FHA_1	111	117	PF00498	0.316
LIG_FHA_1	126	132	PF00498	0.290
LIG_FHA_1	194	200	PF00498	0.249
LIG_FHA_1	271	277	PF00498	0.338
LIG_FHA_1	413	419	PF00498	0.287
LIG_FHA_1	449	455	PF00498	0.396
LIG_FHA_1	495	501	PF00498	0.342
LIG_FHA_1	516	522	PF00498	0.330
LIG_FHA_1	571	577	PF00498	0.327
LIG_FHA_1	692	698	PF00498	0.262
LIG_FHA_2	222	228	PF00498	0.362
LIG_FHA_2	267	273	PF00498	0.323
LIG_FHA_2	275	281	PF00498	0.266
LIG_FHA_2	440	446	PF00498	0.380
LIG_FHA_2	565	571	PF00498	0.248
LIG_FHA_2	643	649	PF00498	0.312
LIG_FHA_2	747	753	PF00498	0.241
LIG_GBD_Chelix_1	10	18	PF00786	0.540
LIG_GBD_Chelix_1	698	706	PF00786	0.385
LIG_LIR_Apic_2	367	372	PF02991	0.272
LIG_LIR_Apic_2	780	785	PF02991	0.322
LIG_LIR_Gen_1	677	688	PF02991	0.299
LIG_LIR_Gen_1	793	801	PF02991	0.144
LIG_LIR_Nem_3	293	298	PF02991	0.370
LIG_LIR_Nem_3	363	368	PF02991	0.245
LIG_LIR_Nem_3	677	683	PF02991	0.194
LIG_LIR_Nem_3	78	82	PF02991	0.303
LIG_LIR_Nem_3	793	797	PF02991	0.155
LIG_LYPXL_S_1	526	530	PF13949	0.531
LIG_LYPXL_yS_3	295	298	PF13949	0.256
LIG_LYPXL_yS_3	527	530	PF13949	0.325
LIG_NRBOX	701	707	PF00104	0.233
LIG_Pex14_2	382	386	PF04695	0.198
LIG_PTB_Apo_2	776	783	PF02174	0.217
LIG_SH2_CRK	369	373	PF00017	0.229
LIG_SH2_CRK	472	476	PF00017	0.261
LIG_SH2_CRK	680	684	PF00017	0.299
LIG_SH2_NCK_1	170	174	PF00017	0.338
LIG_SH2_NCK_1	680	684	PF00017	0.299
LIG_SH2_SRC	419	422	PF00017	0.226
LIG_SH2_SRC	554	557	PF00017	0.315
LIG_SH2_SRC	602	605	PF00017	0.255
LIG_SH2_STAP1	486	490	PF00017	0.393
LIG_SH2_STAT3	120	123	PF00017	0.370
LIG_SH2_STAT5	181	184	PF00017	0.331
LIG_SH2_STAT5	472	475	PF00017	0.285
LIG_SH2_STAT5	56	59	PF00017	0.265
LIG_SH2_STAT5	602	605	PF00017	0.290
LIG_SH2_STAT5	610	613	PF00017	0.329
LIG_SH2_STAT5	766	769	PF00017	0.230
LIG_SH2_STAT5	803	806	PF00017	0.409
LIG_SH3_3	280	286	PF00018	0.309
LIG_SH3_3	497	503	PF00018	0.276
LIG_SH3_3	664	670	PF00018	0.147
LIG_SH3_3	735	741	PF00018	0.277
LIG_Sin3_3	4	11	PF02671	0.333
LIG_SUMO_SIM_anti_2	185	190	PF11976	0.363
LIG_SUMO_SIM_anti_2	306	313	PF11976	0.310
LIG_SUMO_SIM_anti_2	567	573	PF11976	0.302
LIG_SUMO_SIM_par_1	104	110	PF11976	0.292
LIG_SUMO_SIM_par_1	306	313	PF11976	0.263
LIG_SUMO_SIM_par_1	317	322	PF11976	0.207
LIG_SUMO_SIM_par_1	358	363	PF11976	0.265
LIG_SUMO_SIM_par_1	429	435	PF11976	0.345
LIG_SUMO_SIM_par_1	590	595	PF11976	0.240
LIG_SUMO_SIM_par_1	696	701	PF11976	0.209
LIG_SUMO_SIM_par_1	784	789	PF11976	0.223
LIG_TRAF2_1	159	162	PF00917	0.407
LIG_TRAF2_1	556	559	PF00917	0.357
LIG_TYR_ITIM	470	475	PF00017	0.267
LIG_TYR_ITIM	598	603	PF00017	0.251
LIG_TYR_ITSM	676	683	PF00017	0.234
LIG_UBA3_1	430	437	PF00899	0.232
LIG_WRC_WIRS_1	638	643	PF05994	0.219
LIG_WRC_WIRS_1	726	731	PF05994	0.255
LIG_WRC_WIRS_1	791	796	PF05994	0.144
MOD_CK1_1	110	116	PF00069	0.298
MOD_CK1_1	281	287	PF00069	0.367
MOD_CK1_1	290	296	PF00069	0.331
MOD_CK1_1	440	446	PF00069	0.291
MOD_CK1_1	651	657	PF00069	0.240
MOD_CK1_1	675	681	PF00069	0.180
MOD_CK1_1	684	690	PF00069	0.139
MOD_CK1_1	83	89	PF00069	0.350
MOD_CK2_1	274	280	PF00069	0.267
MOD_CK2_1	439	445	PF00069	0.316
MOD_CK2_1	473	479	PF00069	0.304
MOD_CK2_1	528	534	PF00069	0.409
MOD_CK2_1	554	560	PF00069	0.341
MOD_CK2_1	642	648	PF00069	0.312
MOD_CK2_1	746	752	PF00069	0.212
MOD_GlcNHglycan	171	174	PF01048	0.544
MOD_GlcNHglycan	280	283	PF01048	0.482
MOD_GlcNHglycan	321	324	PF01048	0.467
MOD_GlcNHglycan	421	424	PF01048	0.577
MOD_GlcNHglycan	43	46	PF01048	0.585
MOD_GlcNHglycan	479	482	PF01048	0.521
MOD_GlcNHglycan	488	491	PF01048	0.547
MOD_GlcNHglycan	503	506	PF01048	0.551
MOD_GlcNHglycan	530	533	PF01048	0.602
MOD_GlcNHglycan	759	762	PF01048	0.424
MOD_GlcNHglycan	770	773	PF01048	0.443
MOD_GlcNHglycan	83	86	PF01048	0.567
MOD_GSK3_1	112	119	PF00069	0.352
MOD_GSK3_1	121	128	PF00069	0.328
MOD_GSK3_1	142	149	PF00069	0.349
MOD_GSK3_1	157	164	PF00069	0.391
MOD_GSK3_1	171	178	PF00069	0.220
MOD_GSK3_1	222	229	PF00069	0.236
MOD_GSK3_1	266	273	PF00069	0.298
MOD_GSK3_1	274	281	PF00069	0.294
MOD_GSK3_1	360	367	PF00069	0.277
MOD_GSK3_1	436	443	PF00069	0.321
MOD_GSK3_1	458	465	PF00069	0.366
MOD_GSK3_1	473	480	PF00069	0.311
MOD_GSK3_1	560	567	PF00069	0.271
MOD_GSK3_1	572	579	PF00069	0.327
MOD_GSK3_1	620	627	PF00069	0.272
MOD_GSK3_1	647	654	PF00069	0.247
MOD_GSK3_1	659	666	PF00069	0.285
MOD_GSK3_1	672	679	PF00069	0.242
MOD_GSK3_1	742	749	PF00069	0.266
MOD_GSK3_1	786	793	PF00069	0.234
MOD_N-GLC_1	528	533	PF02516	0.511
MOD_N-GLC_1	75	80	PF02516	0.565
MOD_N-GLC_2	287	289	PF02516	0.475
MOD_NEK2_1	13	18	PF00069	0.353
MOD_NEK2_1	274	279	PF00069	0.344
MOD_NEK2_1	310	315	PF00069	0.310
MOD_NEK2_1	319	324	PF00069	0.263
MOD_NEK2_1	360	365	PF00069	0.251
MOD_NEK2_1	564	569	PF00069	0.257
MOD_NEK2_1	577	582	PF00069	0.347
MOD_NEK2_1	642	647	PF00069	0.242
MOD_NEK2_1	674	679	PF00069	0.233
MOD_NEK2_1	730	735	PF00069	0.248
MOD_NEK2_1	75	80	PF00069	0.316
MOD_NEK2_1	750	755	PF00069	0.241
MOD_NEK2_1	786	791	PF00069	0.252
MOD_NEK2_2	458	463	PF00069	0.375
MOD_PIKK_1	384	390	PF00454	0.392
MOD_PK_1	206	212	PF00069	0.287
MOD_PK_1	437	443	PF00069	0.281
MOD_PKA_1	742	748	PF00069	0.255
MOD_PKA_2	274	280	PF00069	0.352
MOD_PKA_2	462	468	PF00069	0.310
MOD_PKA_2	494	500	PF00069	0.371
MOD_PKA_2	515	521	PF00069	0.319
MOD_PKA_2	539	545	PF00069	0.368
MOD_PKA_2	651	657	PF00069	0.233
MOD_PKA_2	684	690	PF00069	0.251
MOD_PKA_2	767	773	PF00069	0.242
MOD_Plk_1	116	122	PF00069	0.281
MOD_Plk_1	161	167	PF00069	0.451
MOD_Plk_1	206	212	PF00069	0.283
MOD_Plk_1	226	232	PF00069	0.262
MOD_Plk_1	270	276	PF00069	0.385
MOD_Plk_1	458	464	PF00069	0.376
MOD_Plk_1	672	678	PF00069	0.229
MOD_Plk_1	75	81	PF00069	0.371
MOD_Plk_2-3	479	485	PF00069	0.375
MOD_Plk_4	104	110	PF00069	0.284
MOD_Plk_4	146	152	PF00069	0.258
MOD_Plk_4	182	188	PF00069	0.300
MOD_Plk_4	364	370	PF00069	0.301
MOD_Plk_4	470	476	PF00069	0.357
MOD_Plk_4	494	500	PF00069	0.349
MOD_Plk_4	560	566	PF00069	0.259
MOD_Plk_4	572	578	PF00069	0.259
MOD_Plk_4	637	643	PF00069	0.209
MOD_Plk_4	684	690	PF00069	0.237
MOD_Plk_4	725	731	PF00069	0.261
MOD_Plk_4	746	752	PF00069	0.327
MOD_Plk_4	795	801	PF00069	0.277
MOD_Plk_4	93	99	PF00069	0.253
MOD_ProDKin_1	107	113	PF00069	0.359
MOD_ProDKin_1	448	454	PF00069	0.318
MOD_ProDKin_1	620	626	PF00069	0.280
MOD_ProDKin_1	83	89	PF00069	0.394
MOD_SUMO_rev_2	432	439	PF00179	0.362
MOD_SUMO_rev_2	586	592	PF00179	0.363
TRG_DiLeu_BaEn_1	560	565	PF01217	0.272
TRG_DiLeu_BaEn_1	701	706	PF01217	0.268
TRG_DiLeu_BaLyEn_6	293	298	PF01217	0.249
TRG_DiLeu_BaLyEn_6	700	705	PF01217	0.193
TRG_DiLeu_BaLyEn_6	782	787	PF01217	0.312
TRG_ENDOCYTIC_2	295	298	PF00928	0.256
TRG_ENDOCYTIC_2	472	475	PF00928	0.353
TRG_ENDOCYTIC_2	527	530	PF00928	0.392
TRG_ENDOCYTIC_2	600	603	PF00928	0.209
TRG_ENDOCYTIC_2	680	683	PF00928	0.277
TRG_ER_diArg_1	329	331	PF00400	0.346
TRG_ER_diArg_1	515	517	PF00400	0.381
TRG_ER_diArg_1	539	541	PF00400	0.295

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0K5	Leptomonas seymouri	67%	93%
A0A0S4KM87	Bodo saltans	32%	95%
A0A1X0PA62	Trypanosomatidae	39%	99%
A0A3S7X8I3	Leishmania donovani	92%	100%
A0A422NVA5	Trypanosoma rangeli	44%	100%
A4HBD6	Leishmania braziliensis	82%	100%
A4IAI4	Leishmania infantum	91%	100%
C9ZLQ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
Q4Q2C8	Leishmania major	89%	100%
Q5ZL00	Gallus gallus	23%	83%
Q8N766	Homo sapiens	23%	82%
V5BW22	Trypanosoma cruzi	43%	100%