AB hydrolase-1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Alpha/beta hydrolase family, putative

Species:

Leishmania mexicana

UniProt:

E9B5K7_LEIMU

TriTrypDb:

LmxM.33.4120

Length:

274

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B5K7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5K7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	139	141	PF00675	0.448
CLV_NRD_NRD_1	175	177	PF00675	0.538
CLV_PCSK_KEX2_1	139	141	PF00082	0.448
CLV_PCSK_KEX2_1	175	177	PF00082	0.540
CLV_PCSK_SKI1_1	165	169	PF00082	0.516
CLV_PCSK_SKI1_1	235	239	PF00082	0.466
CLV_Separin_Metazoa	136	140	PF03568	0.439
DEG_Nend_UBRbox_2	1	3	PF02207	0.582
DOC_MAPK_DCC_7	250	258	PF00069	0.400
DOC_MAPK_FxFP_2	130	133	PF00069	0.280
DOC_MAPK_gen_1	228	236	PF00069	0.512
DOC_MAPK_gen_1	250	258	PF00069	0.334
DOC_MAPK_MEF2A_6	228	236	PF00069	0.515
DOC_MAPK_MEF2A_6	250	258	PF00069	0.400
DOC_PP2B_LxvP_1	105	108	PF13499	0.432
DOC_PP2B_LxvP_1	196	199	PF13499	0.496
DOC_PP4_FxxP_1	130	133	PF00568	0.280
DOC_PP4_FxxP_1	204	207	PF00568	0.463
DOC_USP7_MATH_1	110	114	PF00917	0.490
DOC_USP7_MATH_1	199	203	PF00917	0.539
DOC_USP7_MATH_1	61	65	PF00917	0.535
DOC_USP7_MATH_1	71	75	PF00917	0.474
DOC_WW_Pin1_4	217	222	PF00397	0.588
DOC_WW_Pin1_4	36	41	PF00397	0.404
LIG_EH1_1	131	139	PF00400	0.434
LIG_eIF4E_1	132	138	PF01652	0.493
LIG_FHA_1	113	119	PF00498	0.371
LIG_FHA_1	169	175	PF00498	0.411
LIG_FHA_1	39	45	PF00498	0.433
LIG_FHA_2	217	223	PF00498	0.318
LIG_FHA_2	239	245	PF00498	0.551
LIG_FHA_2	37	43	PF00498	0.418
LIG_LIR_Apic_2	201	207	PF02991	0.468
LIG_LIR_Gen_1	109	118	PF02991	0.379
LIG_LIR_Nem_3	109	114	PF02991	0.386
LIG_NRBOX	21	27	PF00104	0.353
LIG_SH2_NCK_1	190	194	PF00017	0.440
LIG_SH2_STAT5	15	18	PF00017	0.468
LIG_SH2_STAT5	154	157	PF00017	0.467
LIG_SH2_STAT5	190	193	PF00017	0.518
LIG_SH2_STAT5	211	214	PF00017	0.469
LIG_SH2_STAT5	47	50	PF00017	0.502
LIG_SH2_STAT5	68	71	PF00017	0.399
LIG_SH3_1	37	43	PF00018	0.529
LIG_SH3_3	156	162	PF00018	0.440
LIG_SH3_3	37	43	PF00018	0.411
LIG_SUMO_SIM_par_1	8	14	PF11976	0.413
LIG_TRAF2_1	221	224	PF00917	0.540
MOD_CK1_1	112	118	PF00069	0.350
MOD_CK1_1	18	24	PF00069	0.424
MOD_CK1_1	202	208	PF00069	0.456
MOD_CK1_1	36	42	PF00069	0.437
MOD_CK1_1	64	70	PF00069	0.249
MOD_CK2_1	217	223	PF00069	0.577
MOD_CK2_1	238	244	PF00069	0.550
MOD_CK2_1	36	42	PF00069	0.485
MOD_GlcNHglycan	196	199	PF01048	0.444
MOD_GlcNHglycan	63	66	PF01048	0.488
MOD_GSK3_1	238	245	PF00069	0.475
MOD_GSK3_1	60	67	PF00069	0.272
MOD_GSK3_1	94	101	PF00069	0.430
MOD_N-GLC_1	26	31	PF02516	0.551
MOD_N-GLC_1	54	59	PF02516	0.393
MOD_NEK2_1	194	199	PF00069	0.537
MOD_NEK2_1	246	251	PF00069	0.472
MOD_NEK2_1	257	262	PF00069	0.465
MOD_NEK2_1	26	31	PF00069	0.475
MOD_NEK2_1	98	103	PF00069	0.437
MOD_PIKK_1	238	244	PF00454	0.542
MOD_PKA_2	181	187	PF00069	0.416
MOD_Plk_1	200	206	PF00069	0.309
MOD_Plk_1	26	32	PF00069	0.517
MOD_Plk_4	112	118	PF00069	0.327
MOD_Plk_4	205	211	PF00069	0.402
MOD_Plk_4	64	70	PF00069	0.375
MOD_Plk_4	94	100	PF00069	0.442
MOD_ProDKin_1	217	223	PF00069	0.583
MOD_ProDKin_1	36	42	PF00069	0.403
TRG_DiLeu_BaEn_1	164	169	PF01217	0.476
TRG_ER_diArg_1	138	140	PF00400	0.442
TRG_ER_diArg_1	174	176	PF00400	0.538
TRG_ER_diArg_1	178	181	PF00400	0.278
TRG_ER_diArg_1	227	230	PF00400	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7A3	Leptomonas seymouri	61%	88%
A0A0S4KLY1	Bodo saltans	30%	79%
A0A1X0PB14	Trypanosomatidae	43%	87%
A0A3Q8INV4	Leishmania donovani	91%	100%
A0A422NVB8	Trypanosoma rangeli	41%	85%
A4HBD5	Leishmania braziliensis	81%	100%
A4IAI3	Leishmania infantum	90%	100%
C9ZLQ5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	86%
Q4Q2C9	Leishmania major	88%	100%
V5BLS2	Trypanosoma cruzi	41%	86%