GRIP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GRIP domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B5K4_LEIMU

TriTrypDb:

LmxM.33.4090

Length:

433

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B5K4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5K4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	205	209	PF00656	0.632
CLV_C14_Caspase3-7	313	317	PF00656	0.704
CLV_NRD_NRD_1	105	107	PF00675	0.382
CLV_NRD_NRD_1	130	132	PF00675	0.540
CLV_NRD_NRD_1	338	340	PF00675	0.564
CLV_NRD_NRD_1	358	360	PF00675	0.485
CLV_NRD_NRD_1	365	367	PF00675	0.679
CLV_PCSK_KEX2_1	105	107	PF00082	0.596
CLV_PCSK_KEX2_1	129	131	PF00082	0.534
CLV_PCSK_KEX2_1	338	340	PF00082	0.619
CLV_PCSK_KEX2_1	358	360	PF00082	0.389
CLV_PCSK_KEX2_1	365	367	PF00082	0.587
CLV_PCSK_PC1ET2_1	129	131	PF00082	0.527
CLV_PCSK_SKI1_1	105	109	PF00082	0.457
CLV_PCSK_SKI1_1	19	23	PF00082	0.652
CLV_PCSK_SKI1_1	334	338	PF00082	0.358
CLV_PCSK_SKI1_1	365	369	PF00082	0.508
CLV_PCSK_SKI1_1	402	406	PF00082	0.369
CLV_PCSK_SKI1_1	424	428	PF00082	0.580
CLV_PCSK_SKI1_1	88	92	PF00082	0.641
DEG_APCC_DBOX_1	18	26	PF00400	0.401
DEG_APCC_DBOX_1	401	409	PF00400	0.444
DEG_Nend_UBRbox_1	1	4	PF02207	0.545
DOC_CDC14_PxL_1	22	30	PF14671	0.374
DOC_CYCLIN_RxL_1	16	23	PF00134	0.562
DOC_CYCLIN_RxL_1	399	409	PF00134	0.401
DOC_MAPK_DCC_7	402	410	PF00069	0.429
DOC_MAPK_gen_1	358	364	PF00069	0.593
DOC_MAPK_gen_1	399	407	PF00069	0.438
DOC_MAPK_MEF2A_6	402	410	PF00069	0.429
DOC_MIT_MIM_1	127	135	PF04212	0.567
DOC_PP1_RVXF_1	342	348	PF00149	0.545
DOC_USP7_MATH_1	100	104	PF00917	0.473
DOC_USP7_MATH_1	217	221	PF00917	0.560
DOC_USP7_MATH_1	245	249	PF00917	0.552
DOC_USP7_MATH_1	308	312	PF00917	0.767
DOC_WW_Pin1_4	219	224	PF00397	0.681
DOC_WW_Pin1_4	304	309	PF00397	0.584
DOC_WW_Pin1_4	315	320	PF00397	0.547
DOC_WW_Pin1_4	68	73	PF00397	0.743
LIG_14-3-3_CanoR_1	344	348	PF00244	0.572
LIG_Actin_WH2_2	320	336	PF00022	0.443
LIG_Actin_WH2_2	397	415	PF00022	0.444
LIG_Actin_WH2_2	83	100	PF00022	0.602
LIG_BIR_III_2	242	246	PF00653	0.455
LIG_BIR_III_4	303	307	PF00653	0.492
LIG_BRCT_BRCA1_1	32	36	PF00533	0.583
LIG_CaM_IQ_9	83	98	PF13499	0.646
LIG_FHA_1	106	112	PF00498	0.624
LIG_FHA_1	113	119	PF00498	0.564
LIG_FHA_1	328	334	PF00498	0.679
LIG_FHA_1	7	13	PF00498	0.540
LIG_FHA_1	81	87	PF00498	0.532
LIG_FHA_2	167	173	PF00498	0.600
LIG_FHA_2	311	317	PF00498	0.750
LIG_FHA_2	413	419	PF00498	0.449
LIG_FHA_2	79	85	PF00498	0.681
LIG_FHA_2	87	93	PF00498	0.513
LIG_GBD_Chelix_1	387	395	PF00786	0.485
LIG_LIR_Gen_1	250	260	PF02991	0.508
LIG_LIR_Gen_1	346	355	PF02991	0.541
LIG_LIR_Nem_3	152	158	PF02991	0.472
LIG_LIR_Nem_3	250	256	PF02991	0.492
LIG_LIR_Nem_3	346	350	PF02991	0.612
LIG_NRBOX	287	293	PF00104	0.571
LIG_NRBOX	407	413	PF00104	0.344
LIG_RPA_C_Fungi	353	365	PF08784	0.564
LIG_SH2_SRC	38	41	PF00017	0.586
LIG_SH2_STAP1	38	42	PF00017	0.610
LIG_SH2_STAT3	29	32	PF00017	0.658
LIG_SH2_STAT5	253	256	PF00017	0.582
LIG_SH2_STAT5	29	32	PF00017	0.624
LIG_SH2_STAT5	383	386	PF00017	0.344
LIG_SUMO_SIM_par_1	323	330	PF11976	0.416
LIG_UBA3_1	404	413	PF00899	0.444
MOD_CK1_1	175	181	PF00069	0.564
MOD_CK1_1	221	227	PF00069	0.565
MOD_CK1_1	80	86	PF00069	0.649
MOD_CK2_1	166	172	PF00069	0.552
MOD_CK2_1	354	360	PF00069	0.620
MOD_CK2_1	78	84	PF00069	0.692
MOD_GlcNHglycan	237	241	PF01048	0.496
MOD_GlcNHglycan	310	313	PF01048	0.693
MOD_GlcNHglycan	56	59	PF01048	0.643
MOD_GlcNHglycan	60	63	PF01048	0.555
MOD_GSK3_1	145	152	PF00069	0.492
MOD_GSK3_1	217	224	PF00069	0.710
MOD_GSK3_1	304	311	PF00069	0.713
MOD_GSK3_1	323	330	PF00069	0.442
MOD_GSK3_1	54	61	PF00069	0.585
MOD_GSK3_1	64	71	PF00069	0.790
MOD_GSK3_1	74	81	PF00069	0.642
MOD_GSK3_1	82	89	PF00069	0.493
MOD_N-GLC_1	138	143	PF02516	0.587
MOD_N-GLC_1	304	309	PF02516	0.657
MOD_NEK2_1	12	17	PF00069	0.515
MOD_NEK2_1	147	152	PF00069	0.481
MOD_NEK2_1	166	171	PF00069	0.583
MOD_NEK2_1	218	223	PF00069	0.511
MOD_NEK2_1	28	33	PF00069	0.431
MOD_NEK2_1	292	297	PF00069	0.606
MOD_NEK2_1	327	332	PF00069	0.594
MOD_NEK2_1	354	359	PF00069	0.497
MOD_NEK2_1	391	396	PF00069	0.414
MOD_NEK2_1	427	432	PF00069	0.538
MOD_NEK2_1	54	59	PF00069	0.568
MOD_NEK2_1	78	83	PF00069	0.649
MOD_NEK2_1	86	91	PF00069	0.516
MOD_NEK2_2	100	105	PF00069	0.336
MOD_NEK2_2	138	143	PF00069	0.551
MOD_NEK2_2	6	11	PF00069	0.335
MOD_PIKK_1	175	181	PF00454	0.620
MOD_PIKK_1	28	34	PF00454	0.553
MOD_PKA_1	105	111	PF00069	0.628
MOD_PKA_2	105	111	PF00069	0.620
MOD_PKA_2	175	181	PF00069	0.503
MOD_PKA_2	273	279	PF00069	0.453
MOD_PKA_2	343	349	PF00069	0.491
MOD_Plk_1	138	144	PF00069	0.509
MOD_Plk_1	292	298	PF00069	0.518
MOD_Plk_4	221	227	PF00069	0.681
MOD_Plk_4	343	349	PF00069	0.428
MOD_Plk_4	406	412	PF00069	0.372
MOD_ProDKin_1	219	225	PF00069	0.687
MOD_ProDKin_1	304	310	PF00069	0.585
MOD_ProDKin_1	315	321	PF00069	0.547
MOD_ProDKin_1	68	74	PF00069	0.741
MOD_SUMO_rev_2	255	263	PF00179	0.477
TRG_DiLeu_BaEn_1	280	285	PF01217	0.606
TRG_DiLeu_BaEn_1	287	292	PF01217	0.624
TRG_ENDOCYTIC_2	253	256	PF00928	0.483
TRG_ENDOCYTIC_2	260	263	PF00928	0.460
TRG_ER_diArg_1	104	106	PF00400	0.340
TRG_ER_diArg_1	130	132	PF00400	0.514
TRG_ER_diArg_1	337	339	PF00400	0.617
TRG_ER_diArg_1	364	366	PF00400	0.680
TRG_NLS_MonoExtC_3	128	134	PF00514	0.427
TRG_Pf-PMV_PEXEL_1	105	110	PF00026	0.335
TRG_Pf-PMV_PEXEL_1	130	134	PF00026	0.540
TRG_Pf-PMV_PEXEL_1	19	23	PF00026	0.629
TRG_Pf-PMV_PEXEL_1	192	196	PF00026	0.560
TRG_Pf-PMV_PEXEL_1	286	290	PF00026	0.550

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF68	Leptomonas seymouri	41%	92%
A0A1X0PB65	Trypanosomatidae	25%	95%
A0A3S7X8J7	Leishmania donovani	83%	100%
A4HBD2	Leishmania braziliensis	64%	100%
A4IAI0	Leishmania infantum	83%	89%
C9ZLQ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	94%
Q4Q2D2	Leishmania major	82%	100%
V5BW28	Trypanosoma cruzi	28%	91%