J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B5K3_LEIMU

TriTrypDb:

LmxM.33.4080

Length:

262

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9B5K3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5K3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	107	109	PF00675	0.408
CLV_NRD_NRD_1	218	220	PF00675	0.609
CLV_NRD_NRD_1	3	5	PF00675	0.419
CLV_NRD_NRD_1	8	10	PF00675	0.413
CLV_PCSK_KEX2_1	107	109	PF00082	0.408
CLV_PCSK_KEX2_1	218	220	PF00082	0.549
CLV_PCSK_KEX2_1	3	5	PF00082	0.419
CLV_PCSK_KEX2_1	8	10	PF00082	0.413
CLV_PCSK_PC1ET2_1	218	220	PF00082	0.543
CLV_PCSK_PC7_1	4	10	PF00082	0.344
CLV_PCSK_SKI1_1	45	49	PF00082	0.384
CLV_PCSK_SKI1_1	53	57	PF00082	0.382
CLV_PCSK_SKI1_1	93	97	PF00082	0.459
DEG_Nend_Nbox_1	1	3	PF02207	0.711
DEG_SCF_FBW7_1	224	231	PF00400	0.438
DOC_CKS1_1	225	230	PF01111	0.392
DOC_CYCLIN_yCln2_LP_2	186	192	PF00134	0.401
DOC_MAPK_gen_1	197	205	PF00069	0.420
DOC_MAPK_gen_1	48	56	PF00069	0.514
DOC_MAPK_MEF2A_6	50	58	PF00069	0.574
DOC_USP7_MATH_1	228	232	PF00917	0.416
DOC_USP7_MATH_1	251	255	PF00917	0.487
DOC_USP7_UBL2_3	44	48	PF12436	0.531
DOC_WW_Pin1_4	122	127	PF00397	0.499
DOC_WW_Pin1_4	224	229	PF00397	0.454
DOC_WW_Pin1_4	254	259	PF00397	0.424
LIG_14-3-3_CanoR_1	120	126	PF00244	0.629
LIG_14-3-3_CanoR_1	163	169	PF00244	0.404
LIG_CSL_BTD_1	186	189	PF09270	0.396
LIG_deltaCOP1_diTrp_1	184	190	PF00928	0.480
LIG_FHA_1	113	119	PF00498	0.603
LIG_FHA_1	143	149	PF00498	0.187
LIG_FHA_1	209	215	PF00498	0.324
LIG_FHA_2	211	217	PF00498	0.254
LIG_FHA_2	41	47	PF00498	0.562
LIG_LIR_Gen_1	135	143	PF02991	0.313
LIG_LIR_Gen_1	66	75	PF02991	0.515
LIG_LIR_Nem_3	135	139	PF02991	0.325
LIG_LIR_Nem_3	66	72	PF02991	0.541
LIG_SH2_CRK	111	115	PF00017	0.628
LIG_SH2_GRB2like	111	114	PF00017	0.613
LIG_SH2_STAP1	155	159	PF00017	0.361
LIG_SH2_STAP1	168	172	PF00017	0.418
LIG_SH2_STAT5	150	153	PF00017	0.397
LIG_SH2_STAT5	155	158	PF00017	0.318
LIG_SH2_STAT5	177	180	PF00017	0.384
LIG_SH2_STAT5	226	229	PF00017	0.415
LIG_SH3_3	222	228	PF00018	0.385
LIG_SUMO_SIM_anti_2	201	207	PF11976	0.422
LIG_SUMO_SIM_par_1	139	145	PF11976	0.171
LIG_WW_1	223	226	PF00397	0.478
MOD_CDK_SPxxK_3	122	129	PF00069	0.498
MOD_CK1_1	164	170	PF00069	0.364
MOD_CK1_1	254	260	PF00069	0.524
MOD_CK2_1	164	170	PF00069	0.366
MOD_CMANNOS	187	190	PF00535	0.593
MOD_GlcNHglycan	18	21	PF01048	0.446
MOD_GlcNHglycan	230	233	PF01048	0.646
MOD_GlcNHglycan	253	256	PF01048	0.731
MOD_GlcNHglycan	4	7	PF01048	0.473
MOD_GlcNHglycan	98	101	PF01048	0.440
MOD_GSK3_1	206	213	PF00069	0.348
MOD_GSK3_1	224	231	PF00069	0.455
MOD_GSK3_1	253	260	PF00069	0.421
MOD_N-GLC_1	112	117	PF02516	0.402
MOD_NEK2_1	114	119	PF00069	0.603
MOD_NEK2_1	151	156	PF00069	0.316
MOD_NEK2_1	2	7	PF00069	0.647
MOD_NEK2_1	206	211	PF00069	0.329
MOD_NEK2_1	78	83	PF00069	0.601
MOD_PKA_2	119	125	PF00069	0.599
MOD_PKA_2	164	170	PF00069	0.352
MOD_PKA_2	2	8	PF00069	0.631
MOD_Plk_4	29	35	PF00069	0.525
MOD_ProDKin_1	122	128	PF00069	0.498
MOD_ProDKin_1	224	230	PF00069	0.453
MOD_ProDKin_1	254	260	PF00069	0.423
MOD_SUMO_for_1	95	98	PF00179	0.666
TRG_DiLeu_BaEn_1	74	79	PF01217	0.515
TRG_ENDOCYTIC_2	11	14	PF00928	0.625
TRG_ENDOCYTIC_2	111	114	PF00928	0.587
TRG_ER_diArg_1	106	108	PF00400	0.620
TRG_ER_diArg_1	162	165	PF00400	0.383
TRG_ER_diArg_1	2	4	PF00400	0.626
TRG_ER_diArg_1	7	9	PF00400	0.614
TRG_NLS_MonoExtC_3	218	223	PF00514	0.280
TRG_NLS_MonoExtN_4	218	223	PF00514	0.280
TRG_Pf-PMV_PEXEL_1	180	184	PF00026	0.505
TRG_Pf-PMV_PEXEL_1	212	216	PF00026	0.568

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILG9	Leptomonas seymouri	73%	100%
A0A0S4KRJ1	Bodo saltans	41%	100%
A0A1X0PA98	Trypanosomatidae	54%	100%
A0A3S7X8J5	Leishmania donovani	92%	98%
A0A422NVC0	Trypanosoma rangeli	53%	100%
A4HBD1	Leishmania braziliensis	83%	100%
A4IAH9	Leishmania infantum	92%	98%
C9ZLR0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
Q4Q2D3	Leishmania major	90%	100%