Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

conserved protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B5K0_LEIMU

TriTrypDb:

LmxM.33.4050

Length:

674

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B5K0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5K0

Function

Biological processes
Term	Name	Level	Count
GO:0044145	modulation of formation of structure involved in a symbiotic process	3	1
GO:0050789	regulation of biological process	2	1
GO:0065007	biological regulation	1	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	259	263	PF00656	0.660
CLV_C14_Caspase3-7	391	395	PF00656	0.606
CLV_NRD_NRD_1	350	352	PF00675	0.587
CLV_NRD_NRD_1	36	38	PF00675	0.644
CLV_NRD_NRD_1	368	370	PF00675	0.610
CLV_NRD_NRD_1	431	433	PF00675	0.610
CLV_NRD_NRD_1	632	634	PF00675	0.797
CLV_NRD_NRD_1	637	639	PF00675	0.810
CLV_PCSK_FUR_1	27	31	PF00082	0.647
CLV_PCSK_KEX2_1	130	132	PF00082	0.486
CLV_PCSK_KEX2_1	29	31	PF00082	0.624
CLV_PCSK_KEX2_1	350	352	PF00082	0.593
CLV_PCSK_KEX2_1	36	38	PF00082	0.632
CLV_PCSK_KEX2_1	367	369	PF00082	0.480
CLV_PCSK_KEX2_1	430	432	PF00082	0.677
CLV_PCSK_KEX2_1	607	609	PF00082	0.575
CLV_PCSK_KEX2_1	632	634	PF00082	0.805
CLV_PCSK_KEX2_1	637	639	PF00082	0.791
CLV_PCSK_PC1ET2_1	130	132	PF00082	0.550
CLV_PCSK_PC1ET2_1	29	31	PF00082	0.624
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.632
CLV_PCSK_PC1ET2_1	607	609	PF00082	0.600
CLV_PCSK_PC7_1	633	639	PF00082	0.588
CLV_PCSK_SKI1_1	176	180	PF00082	0.449
CLV_PCSK_SKI1_1	368	372	PF00082	0.654
CLV_PCSK_SKI1_1	452	456	PF00082	0.575
CLV_PCSK_SKI1_1	483	487	PF00082	0.493
CLV_PCSK_SKI1_1	638	642	PF00082	0.771
CLV_PCSK_SKI1_1	670	674	PF00082	0.701
CLV_Separin_Metazoa	197	201	PF03568	0.374
DEG_APCC_DBOX_1	430	438	PF00400	0.715
DEG_APCC_DBOX_1	482	490	PF00400	0.493
DEG_Nend_UBRbox_2	1	3	PF02207	0.686
DEG_SCF_FBW7_1	135	142	PF00400	0.465
DEG_SPOP_SBC_1	139	143	PF00917	0.746
DOC_CKS1_1	136	141	PF01111	0.464
DOC_CKS1_1	83	88	PF01111	0.609
DOC_MAPK_gen_1	102	110	PF00069	0.647
DOC_MAPK_gen_1	350	358	PF00069	0.576
DOC_MAPK_gen_1	36	44	PF00069	0.577
DOC_MAPK_gen_1	430	436	PF00069	0.628
DOC_MAPK_gen_1	549	557	PF00069	0.495
DOC_MAPK_gen_1	607	613	PF00069	0.605
DOC_MAPK_MEF2A_6	284	291	PF00069	0.447
DOC_MAPK_NFAT4_5	284	292	PF00069	0.448
DOC_PP2B_LxvP_1	287	290	PF13499	0.513
DOC_PP2B_LxvP_1	533	536	PF13499	0.650
DOC_PP4_FxxP_1	591	594	PF00568	0.713
DOC_USP7_MATH_1	139	143	PF00917	0.670
DOC_USP7_MATH_1	225	229	PF00917	0.568
DOC_USP7_MATH_1	275	279	PF00917	0.565
DOC_USP7_MATH_1	439	443	PF00917	0.640
DOC_USP7_MATH_1	49	53	PF00917	0.713
DOC_USP7_MATH_1	550	554	PF00917	0.618
DOC_USP7_MATH_1	561	565	PF00917	0.412
DOC_USP7_MATH_1	640	644	PF00917	0.696
DOC_USP7_MATH_2	166	172	PF00917	0.696
DOC_USP7_UBL2_3	658	662	PF12436	0.776
DOC_WW_Pin1_4	135	140	PF00397	0.575
DOC_WW_Pin1_4	162	167	PF00397	0.760
DOC_WW_Pin1_4	290	295	PF00397	0.544
DOC_WW_Pin1_4	404	409	PF00397	0.630
DOC_WW_Pin1_4	582	587	PF00397	0.631
DOC_WW_Pin1_4	82	87	PF00397	0.613
LIG_14-3-3_CanoR_1	37	44	PF00244	0.469
LIG_14-3-3_CanoR_1	413	419	PF00244	0.541
LIG_14-3-3_CanoR_1	580	585	PF00244	0.611
LIG_14-3-3_CanoR_1	598	604	PF00244	0.653
LIG_14-3-3_CanoR_1	655	665	PF00244	0.618
LIG_Actin_WH2_2	137	152	PF00022	0.471
LIG_Actin_WH2_2	196	213	PF00022	0.457
LIG_Actin_WH2_2	472	489	PF00022	0.509
LIG_BRCT_BRCA1_1	445	449	PF00533	0.635
LIG_BRCT_BRCA1_1	587	591	PF00533	0.725
LIG_FHA_1	144	150	PF00498	0.699
LIG_FHA_1	2	8	PF00498	0.529
LIG_FHA_1	283	289	PF00498	0.437
LIG_FHA_1	379	385	PF00498	0.574
LIG_FHA_1	405	411	PF00498	0.573
LIG_FHA_1	55	61	PF00498	0.553
LIG_FHA_1	63	69	PF00498	0.474
LIG_FHA_2	163	169	PF00498	0.704
LIG_FHA_2	38	44	PF00498	0.386
LIG_FHA_2	472	478	PF00498	0.633
LIG_FHA_2	98	104	PF00498	0.508
LIG_GBD_Chelix_1	341	349	PF00786	0.520
LIG_Integrin_RGD_1	633	635	PF01839	0.593
LIG_LIR_Apic_2	588	594	PF02991	0.687
LIG_LIR_Apic_2	81	86	PF02991	0.582
LIG_LIR_Gen_1	117	123	PF02991	0.554
LIG_LIR_Gen_1	228	236	PF02991	0.610
LIG_LIR_Gen_1	67	76	PF02991	0.537
LIG_LIR_Nem_3	117	122	PF02991	0.566
LIG_LIR_Nem_3	228	233	PF02991	0.540
LIG_LIR_Nem_3	643	648	PF02991	0.596
LIG_LIR_Nem_3	67	72	PF02991	0.536
LIG_NRBOX	189	195	PF00104	0.462
LIG_NRBOX	71	77	PF00104	0.596
LIG_PDZ_Class_2	669	674	PF00595	0.712
LIG_Rb_LxCxE_1	238	259	PF01857	0.613
LIG_SH2_CRK	301	305	PF00017	0.475
LIG_SH2_STAP1	204	208	PF00017	0.548
LIG_SH2_STAT3	218	221	PF00017	0.501
LIG_SH2_STAT3	25	28	PF00017	0.632
LIG_SH2_STAT5	202	205	PF00017	0.395
LIG_SH2_STAT5	230	233	PF00017	0.592
LIG_SH2_STAT5	25	28	PF00017	0.659
LIG_SH2_STAT5	527	530	PF00017	0.607
LIG_SH2_STAT5	600	603	PF00017	0.679
LIG_SH3_3	133	139	PF00018	0.452
LIG_SH3_3	294	300	PF00018	0.463
LIG_SH3_3	433	439	PF00018	0.632
LIG_SH3_3	623	629	PF00018	0.757
LIG_SUMO_SIM_anti_2	180	189	PF11976	0.521
LIG_SUMO_SIM_anti_2	228	235	PF11976	0.509
LIG_SUMO_SIM_anti_2	57	63	PF11976	0.495
LIG_SUMO_SIM_anti_2	89	94	PF11976	0.548
LIG_SUMO_SIM_par_1	2	8	PF11976	0.529
LIG_SUMO_SIM_par_1	376	381	PF11976	0.647
LIG_SUMO_SIM_par_1	52	59	PF11976	0.591
LIG_SUMO_SIM_par_1	529	539	PF11976	0.633
LIG_TRAF2_1	474	477	PF00917	0.571
MOD_CDK_SPxK_1	82	88	PF00069	0.612
MOD_CK1_1	143	149	PF00069	0.757
MOD_CK1_1	159	165	PF00069	0.661
MOD_CK1_1	171	177	PF00069	0.559
MOD_CK1_1	3	9	PF00069	0.738
MOD_CK1_1	404	410	PF00069	0.666
MOD_CK1_1	442	448	PF00069	0.460
MOD_CK1_1	564	570	PF00069	0.540
MOD_CK1_1	599	605	PF00069	0.695
MOD_CK1_1	62	68	PF00069	0.543
MOD_CK2_1	106	112	PF00069	0.563
MOD_CK2_1	114	120	PF00069	0.593
MOD_CK2_1	123	129	PF00069	0.620
MOD_CK2_1	162	168	PF00069	0.592
MOD_CK2_1	171	177	PF00069	0.507
MOD_CK2_1	275	281	PF00069	0.661
MOD_CK2_1	37	43	PF00069	0.508
MOD_CK2_1	442	448	PF00069	0.540
MOD_CK2_1	471	477	PF00069	0.658
MOD_CK2_1	550	556	PF00069	0.634
MOD_CK2_1	97	103	PF00069	0.539
MOD_Cter_Amidation	428	431	PF01082	0.724
MOD_Cter_Amidation	635	638	PF01082	0.725
MOD_GlcNHglycan	116	119	PF01048	0.521
MOD_GlcNHglycan	153	156	PF01048	0.716
MOD_GlcNHglycan	258	261	PF01048	0.717
MOD_GlcNHglycan	262	266	PF01048	0.717
MOD_GlcNHglycan	273	276	PF01048	0.540
MOD_GlcNHglycan	277	280	PF01048	0.424
MOD_GlcNHglycan	423	426	PF01048	0.410
MOD_GlcNHglycan	441	444	PF01048	0.390
MOD_GlcNHglycan	566	569	PF01048	0.537
MOD_GlcNHglycan	594	597	PF01048	0.697
MOD_GlcNHglycan	658	661	PF01048	0.582
MOD_GlcNHglycan	7	10	PF01048	0.522
MOD_GSK3_1	1	8	PF00069	0.667
MOD_GSK3_1	135	142	PF00069	0.494
MOD_GSK3_1	156	163	PF00069	0.684
MOD_GSK3_1	177	184	PF00069	0.454
MOD_GSK3_1	252	259	PF00069	0.638
MOD_GSK3_1	271	278	PF00069	0.680
MOD_GSK3_1	316	323	PF00069	0.711
MOD_GSK3_1	333	340	PF00069	0.525
MOD_GSK3_1	439	446	PF00069	0.489
MOD_GSK3_1	592	599	PF00069	0.657
MOD_GSK3_1	624	631	PF00069	0.623
MOD_GSK3_1	640	647	PF00069	0.743
MOD_LATS_1	578	584	PF00433	0.588
MOD_LATS_1	95	101	PF00433	0.437
MOD_N-GLC_1	464	469	PF02516	0.655
MOD_NEK2_1	1	6	PF00069	0.690
MOD_NEK2_1	123	128	PF00069	0.605
MOD_NEK2_1	144	149	PF00069	0.763
MOD_NEK2_1	179	184	PF00069	0.419
MOD_NEK2_1	186	191	PF00069	0.348
MOD_NEK2_1	203	208	PF00069	0.414
MOD_NEK2_1	21	26	PF00069	0.582
MOD_NEK2_1	226	231	PF00069	0.589
MOD_NEK2_1	254	259	PF00069	0.666
MOD_NEK2_1	337	342	PF00069	0.473
MOD_NEK2_1	378	383	PF00069	0.619
MOD_NEK2_1	401	406	PF00069	0.659
MOD_NEK2_1	457	462	PF00069	0.561
MOD_NEK2_2	145	150	PF00069	0.614
MOD_NEK2_2	64	69	PF00069	0.433
MOD_PIKK_1	559	565	PF00454	0.665
MOD_PK_1	156	162	PF00069	0.698
MOD_PKA_1	37	43	PF00069	0.603
MOD_PKA_2	123	129	PF00069	0.659
MOD_PKA_2	439	445	PF00069	0.573
MOD_PKA_2	550	556	PF00069	0.496
MOD_PKA_2	654	660	PF00069	0.753
MOD_Plk_1	1	7	PF00069	0.642
MOD_Plk_1	333	339	PF00069	0.505
MOD_Plk_1	464	470	PF00069	0.615
MOD_Plk_2-3	106	112	PF00069	0.661
MOD_Plk_4	106	112	PF00069	0.628
MOD_Plk_4	226	232	PF00069	0.605
MOD_Plk_4	344	350	PF00069	0.543
MOD_Plk_4	414	420	PF00069	0.449
MOD_Plk_4	64	70	PF00069	0.590
MOD_ProDKin_1	135	141	PF00069	0.576
MOD_ProDKin_1	162	168	PF00069	0.760
MOD_ProDKin_1	290	296	PF00069	0.552
MOD_ProDKin_1	404	410	PF00069	0.630
MOD_ProDKin_1	582	588	PF00069	0.631
MOD_ProDKin_1	82	88	PF00069	0.612
MOD_SUMO_for_1	651	654	PF00179	0.531
MOD_SUMO_rev_2	553	562	PF00179	0.595
TRG_DiLeu_BaEn_1	181	186	PF01217	0.465
TRG_DiLeu_BaEn_1	71	76	PF01217	0.569
TRG_DiLeu_BaEn_2	105	111	PF01217	0.656
TRG_DiLeu_BaEn_2	608	614	PF01217	0.629
TRG_DiLeu_BaLyEn_6	13	18	PF01217	0.544
TRG_DiLeu_BaLyEn_6	480	485	PF01217	0.582
TRG_DiLeu_LyEn_5	71	76	PF01217	0.542
TRG_ENDOCYTIC_2	230	233	PF00928	0.637
TRG_ENDOCYTIC_2	301	304	PF00928	0.477
TRG_ER_diArg_1	349	351	PF00400	0.575
TRG_ER_diArg_1	366	369	PF00400	0.556
TRG_ER_diArg_1	430	432	PF00400	0.706
TRG_NES_CRM1_1	181	195	PF08389	0.460
TRG_NLS_MonoExtC_3	35	41	PF00514	0.657
TRG_Pf-PMV_PEXEL_1	121	125	PF00026	0.668
TRG_Pf-PMV_PEXEL_1	30	35	PF00026	0.586
TRG_Pf-PMV_PEXEL_1	452	456	PF00026	0.539
TRG_Pf-PMV_PEXEL_1	473	477	PF00026	0.457
TRG_Pf-PMV_PEXEL_1	612	616	PF00026	0.627

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7E6	Leptomonas seymouri	47%	100%
A0A0S4KLZ0	Bodo saltans	27%	84%
A0A1X0PAG6	Trypanosomatidae	34%	100%
A0A3Q8IIY0	Leishmania donovani	87%	100%
A0A422NVB5	Trypanosoma rangeli	32%	100%
A4HBC8	Leishmania braziliensis	72%	100%
A4IAH6	Leishmania infantum	87%	100%
C9ZLR4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
Q4Q2D6	Leishmania major	84%	98%
V5BRF7	Trypanosoma cruzi	33%	100%