Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B5J9_LEIMU

TriTrypDb:

LmxM.33.4040

Length:

339

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B5J9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5J9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	4	8	PF00656	0.635
CLV_C14_Caspase3-7	50	54	PF00656	0.726
CLV_NRD_NRD_1	21	23	PF00675	0.569
CLV_NRD_NRD_1	210	212	PF00675	0.434
CLV_NRD_NRD_1	274	276	PF00675	0.556
CLV_NRD_NRD_1	63	65	PF00675	0.755
CLV_PCSK_KEX2_1	160	162	PF00082	0.384
CLV_PCSK_KEX2_1	21	23	PF00082	0.591
CLV_PCSK_KEX2_1	210	212	PF00082	0.413
CLV_PCSK_KEX2_1	63	65	PF00082	0.722
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.384
CLV_PCSK_SKI1_1	110	114	PF00082	0.506
CLV_PCSK_SKI1_1	211	215	PF00082	0.476
CLV_PCSK_SKI1_1	289	293	PF00082	0.409
CLV_PCSK_SKI1_1	312	316	PF00082	0.413
DEG_APCC_DBOX_1	183	191	PF00400	0.348
DEG_APCC_DBOX_1	25	33	PF00400	0.518
DEG_APCC_DBOX_1	288	296	PF00400	0.405
DEG_Nend_UBRbox_2	1	3	PF02207	0.668
DEG_SCF_FBW7_2	332	337	PF00400	0.522
DEG_SPOP_SBC_1	133	137	PF00917	0.414
DOC_MAPK_gen_1	160	166	PF00069	0.410
DOC_MAPK_gen_1	319	329	PF00069	0.494
DOC_PP2B_LxvP_1	164	167	PF13499	0.472
DOC_PP4_FxxP_1	82	85	PF00568	0.549
DOC_USP7_MATH_1	12	16	PF00917	0.561
DOC_USP7_MATH_1	206	210	PF00917	0.542
DOC_USP7_MATH_1	59	63	PF00917	0.724
DOC_WW_Pin1_4	254	259	PF00397	0.515
DOC_WW_Pin1_4	269	274	PF00397	0.518
DOC_WW_Pin1_4	330	335	PF00397	0.426
DOC_WW_Pin1_4	55	60	PF00397	0.747
DOC_WW_Pin1_4	76	81	PF00397	0.495
LIG_14-3-3_CanoR_1	141	151	PF00244	0.501
LIG_14-3-3_CanoR_1	210	219	PF00244	0.484
LIG_14-3-3_CanoR_1	275	281	PF00244	0.624
LIG_14-3-3_CanoR_1	324	328	PF00244	0.496
LIG_Actin_WH2_2	114	130	PF00022	0.518
LIG_BRCT_BRCA1_1	325	329	PF00533	0.419
LIG_BRCT_BRCA1_1	78	82	PF00533	0.442
LIG_CaM_NSCaTE_8	28	35	PF13499	0.477
LIG_deltaCOP1_diTrp_1	73	82	PF00928	0.523
LIG_EVH1_1	164	168	PF00568	0.520
LIG_FHA_1	11	17	PF00498	0.536
LIG_FHA_1	200	206	PF00498	0.537
LIG_FHA_1	297	303	PF00498	0.462
LIG_FHA_1	84	90	PF00498	0.554
LIG_FHA_2	102	108	PF00498	0.559
LIG_FHA_2	133	139	PF00498	0.449
LIG_FHA_2	142	148	PF00498	0.500
LIG_LIR_Apic_2	79	85	PF02991	0.470
LIG_LIR_Gen_1	326	336	PF02991	0.434
LIG_LIR_LC3C_4	185	189	PF02991	0.474
LIG_LIR_Nem_3	326	332	PF02991	0.439
LIG_LIR_Nem_3	79	84	PF02991	0.497
LIG_MLH1_MIPbox_1	78	82	PF16413	0.442
LIG_NRBOX	108	114	PF00104	0.497
LIG_SH2_PTP2	267	270	PF00017	0.457
LIG_SH2_STAT5	267	270	PF00017	0.371
LIG_SH2_STAT5	38	41	PF00017	0.564
LIG_SH2_STAT5	81	84	PF00017	0.461
LIG_SH3_3	162	168	PF00018	0.457
LIG_SUMO_SIM_anti_2	123	128	PF11976	0.488
LIG_SUMO_SIM_anti_2	144	153	PF11976	0.519
LIG_SUMO_SIM_anti_2	185	192	PF11976	0.399
LIG_SUMO_SIM_par_1	12	17	PF11976	0.584
LIG_SUMO_SIM_par_1	185	192	PF11976	0.483
LIG_TRAF2_1	40	43	PF00917	0.682
LIG_WRC_WIRS_1	6	11	PF05994	0.605
MOD_CDC14_SPxK_1	272	275	PF00782	0.315
MOD_CDK_SPK_2	254	259	PF00069	0.515
MOD_CDK_SPK_2	55	60	PF00069	0.747
MOD_CDK_SPxK_1	269	275	PF00069	0.285
MOD_CDK_SPxxK_3	269	276	PF00069	0.300
MOD_CK1_1	269	275	PF00069	0.410
MOD_CK1_1	330	336	PF00069	0.424
MOD_CK1_1	58	64	PF00069	0.727
MOD_CK1_1	76	82	PF00069	0.321
MOD_CK1_1	83	89	PF00069	0.439
MOD_CK2_1	141	147	PF00069	0.510
MOD_CK2_1	179	185	PF00069	0.528
MOD_CK2_1	291	297	PF00069	0.331
MOD_GlcNHglycan	181	184	PF01048	0.461
MOD_GlcNHglycan	75	78	PF01048	0.556
MOD_GSK3_1	1	8	PF00069	0.552
MOD_GSK3_1	10	17	PF00069	0.498
MOD_GSK3_1	276	283	PF00069	0.617
MOD_GSK3_1	323	330	PF00069	0.416
MOD_GSK3_1	42	49	PF00069	0.648
MOD_GSK3_1	55	62	PF00069	0.663
MOD_GSK3_1	76	83	PF00069	0.498
MOD_NEK2_1	1	6	PF00069	0.626
MOD_NEK2_1	241	246	PF00069	0.426
MOD_NEK2_1	280	285	PF00069	0.484
MOD_NEK2_1	327	332	PF00069	0.536
MOD_PIKK_1	211	217	PF00454	0.475
MOD_PKA_2	142	148	PF00069	0.490
MOD_PKA_2	323	329	PF00069	0.513
MOD_PKA_2	59	65	PF00069	0.736
MOD_PKB_1	141	149	PF00069	0.489
MOD_Plk_1	1	7	PF00069	0.631
MOD_Plk_1	42	48	PF00069	0.641
MOD_Plk_4	1	7	PF00069	0.651
MOD_Plk_4	241	247	PF00069	0.381
MOD_Plk_4	266	272	PF00069	0.527
MOD_Plk_4	291	297	PF00069	0.251
MOD_Plk_4	323	329	PF00069	0.423
MOD_ProDKin_1	254	260	PF00069	0.513
MOD_ProDKin_1	269	275	PF00069	0.526
MOD_ProDKin_1	330	336	PF00069	0.424
MOD_ProDKin_1	55	61	PF00069	0.748
MOD_ProDKin_1	76	82	PF00069	0.484
MOD_SUMO_for_1	117	120	PF00179	0.505
TRG_DiLeu_BaEn_1	147	152	PF01217	0.496
TRG_DiLeu_BaEn_1	229	234	PF01217	0.403
TRG_DiLeu_BaEn_1	287	292	PF01217	0.391
TRG_ENDOCYTIC_2	267	270	PF00928	0.387
TRG_ENDOCYTIC_2	81	84	PF00928	0.570
TRG_ER_diArg_1	63	66	PF00400	0.707
TRG_NES_CRM1_1	107	123	PF08389	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P703	Leptomonas seymouri	59%	80%
A0A0S4KKR7	Bodo saltans	31%	66%
A0A1X0PA52	Trypanosomatidae	46%	84%
A0A3S7X8N4	Leishmania donovani	91%	100%
A0A422NVD0	Trypanosoma rangeli	44%	90%
A4HBC7	Leishmania braziliensis	82%	100%
A4IAH5	Leishmania infantum	91%	100%
C9ZLR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	89%
Q4Q2D7	Leishmania major	91%	100%
V5BW32	Trypanosoma cruzi	41%	89%