Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ubiquitin modifier-specific peptidase 1, putative

Species:

Leishmania mexicana

UniProt:

E9B5J5_LEIMU

TriTrypDb:

LmxM.33.4000

Length:

506

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B5J5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5J5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	230	232	PF00675	0.462
CLV_NRD_NRD_1	353	355	PF00675	0.333
CLV_PCSK_KEX2_1	229	231	PF00082	0.458
CLV_PCSK_KEX2_1	353	355	PF00082	0.349
CLV_PCSK_KEX2_1	400	402	PF00082	0.340
CLV_PCSK_PC1ET2_1	400	402	PF00082	0.336
CLV_PCSK_PC7_1	225	231	PF00082	0.490
CLV_PCSK_SKI1_1	176	180	PF00082	0.354
CLV_PCSK_SKI1_1	191	195	PF00082	0.389
CLV_PCSK_SKI1_1	369	373	PF00082	0.315
CLV_PCSK_SKI1_1	81	85	PF00082	0.502
DEG_Nend_UBRbox_2	1	3	PF02207	0.636
DOC_CKS1_1	127	132	PF01111	0.552
DOC_CYCLIN_RxL_1	173	182	PF00134	0.434
DOC_CYCLIN_yCln2_LP_2	216	222	PF00134	0.250
DOC_MAPK_gen_1	21	28	PF00069	0.426
DOC_MAPK_gen_1	423	432	PF00069	0.213
DOC_PP2B_LxvP_1	237	240	PF13499	0.411
DOC_PP2B_LxvP_1	495	498	PF13499	0.328
DOC_PP4_FxxP_1	422	425	PF00568	0.473
DOC_USP7_MATH_1	161	165	PF00917	0.602
DOC_USP7_MATH_1	168	172	PF00917	0.528
DOC_USP7_MATH_1	328	332	PF00917	0.316
DOC_USP7_MATH_1	348	352	PF00917	0.171
DOC_USP7_MATH_1	40	44	PF00917	0.449
DOC_USP7_MATH_1	73	77	PF00917	0.519
DOC_USP7_UBL2_3	470	474	PF12436	0.341
DOC_USP7_UBL2_3	481	485	PF12436	0.390
DOC_WW_Pin1_4	126	131	PF00397	0.525
DOC_WW_Pin1_4	282	287	PF00397	0.449
DOC_WW_Pin1_4	421	426	PF00397	0.382
DOC_WW_Pin1_4	59	64	PF00397	0.518
LIG_14-3-3_CanoR_1	132	142	PF00244	0.357
LIG_14-3-3_CanoR_1	21	27	PF00244	0.430
LIG_14-3-3_CanoR_1	280	286	PF00244	0.462
LIG_14-3-3_CanoR_1	330	336	PF00244	0.360
LIG_14-3-3_CanoR_1	74	80	PF00244	0.426
LIG_BRCT_BRCA1_1	214	218	PF00533	0.398
LIG_BRCT_BRCA1_1	483	487	PF00533	0.364
LIG_Clathr_ClatBox_1	416	420	PF01394	0.315
LIG_deltaCOP1_diTrp_1	209	218	PF00928	0.430
LIG_deltaCOP1_diTrp_1	377	382	PF00928	0.300
LIG_FHA_1	134	140	PF00498	0.497
LIG_FHA_1	172	178	PF00498	0.429
LIG_FHA_1	23	29	PF00498	0.351
LIG_FHA_1	301	307	PF00498	0.328
LIG_FHA_1	43	49	PF00498	0.389
LIG_FHA_2	154	160	PF00498	0.578
LIG_FHA_2	204	210	PF00498	0.411
LIG_FHA_2	222	228	PF00498	0.455
LIG_FHA_2	254	260	PF00498	0.450
LIG_Integrin_RGD_1	107	109	PF01839	0.402
LIG_LIR_Apic_2	125	130	PF02991	0.565
LIG_LIR_Apic_2	420	425	PF02991	0.466
LIG_LIR_Gen_1	114	124	PF02991	0.494
LIG_LIR_Gen_1	381	388	PF02991	0.300
LIG_LIR_Gen_1	452	462	PF02991	0.360
LIG_LIR_LC3C_4	302	306	PF02991	0.195
LIG_LIR_Nem_3	114	120	PF02991	0.485
LIG_LIR_Nem_3	255	260	PF02991	0.455
LIG_LIR_Nem_3	307	313	PF02991	0.350
LIG_LIR_Nem_3	452	458	PF02991	0.360
LIG_LIR_Nem_3	459	465	PF02991	0.360
LIG_LIR_Nem_3	491	495	PF02991	0.318
LIG_MLH1_MIPbox_1	483	487	PF16413	0.360
LIG_MYND_3	392	396	PF01753	0.304
LIG_PCNA_PIPBox_1	385	394	PF02747	0.376
LIG_PCNA_PIPBox_1	415	424	PF02747	0.300
LIG_Pex14_1	325	329	PF04695	0.300
LIG_Pex14_1	378	382	PF04695	0.300
LIG_SH2_CRK	329	333	PF00017	0.344
LIG_SH2_SRC	391	394	PF00017	0.322
LIG_SH2_STAP1	437	441	PF00017	0.300
LIG_SH2_STAT3	465	468	PF00017	0.376
LIG_SH2_STAT5	391	394	PF00017	0.360
LIG_SH2_STAT5	455	458	PF00017	0.300
LIG_SH2_STAT5	477	480	PF00017	0.360
LIG_SH3_3	144	150	PF00018	0.494
LIG_SH3_3	207	213	PF00018	0.410
LIG_SH3_3	293	299	PF00018	0.526
LIG_SH3_3	57	63	PF00018	0.466
LIG_SUMO_SIM_anti_2	383	388	PF11976	0.300
LIG_SUMO_SIM_par_1	302	307	PF11976	0.328
LIG_SUMO_SIM_par_1	415	420	PF11976	0.267
LIG_UBA3_1	384	390	PF00899	0.195
LIG_WRC_WIRS_1	379	384	PF05994	0.300
MOD_CDC14_SPxK_1	285	288	PF00782	0.408
MOD_CDK_SPK_2	421	426	PF00069	0.195
MOD_CDK_SPxK_1	126	132	PF00069	0.358
MOD_CDK_SPxK_1	282	288	PF00069	0.410
MOD_CK1_1	171	177	PF00069	0.497
MOD_CK1_1	294	300	PF00069	0.500
MOD_CK1_1	331	337	PF00069	0.317
MOD_CK2_1	108	114	PF00069	0.548
MOD_CK2_1	142	148	PF00069	0.601
MOD_CK2_1	179	185	PF00069	0.442
MOD_CK2_1	197	203	PF00069	0.515
MOD_CK2_1	259	265	PF00069	0.321
MOD_CK2_1	48	54	PF00069	0.410
MOD_CMANNOS	254	257	PF00535	0.448
MOD_GlcNHglycan	109	113	PF01048	0.638
MOD_GlcNHglycan	163	166	PF01048	0.586
MOD_GlcNHglycan	181	184	PF01048	0.290
MOD_GlcNHglycan	293	296	PF01048	0.471
MOD_GlcNHglycan	306	309	PF01048	0.276
MOD_GlcNHglycan	462	465	PF01048	0.360
MOD_GlcNHglycan	50	53	PF01048	0.520
MOD_GlcNHglycan	99	102	PF01048	0.480
MOD_GSK3_1	108	115	PF00069	0.474
MOD_GSK3_1	149	156	PF00069	0.552
MOD_GSK3_1	168	175	PF00069	0.617
MOD_GSK3_1	267	274	PF00069	0.524
MOD_GSK3_1	300	307	PF00069	0.344
MOD_GSK3_1	433	440	PF00069	0.330
MOD_GSK3_1	460	467	PF00069	0.342
MOD_GSK3_1	73	80	PF00069	0.407
MOD_N-GLC_1	161	166	PF02516	0.417
MOD_N-GLC_1	91	96	PF02516	0.380
MOD_N-GLC_2	494	496	PF02516	0.300
MOD_NEK2_1	172	177	PF00069	0.447
MOD_NEK2_1	179	184	PF00069	0.366
MOD_NEK2_1	304	309	PF00069	0.380
MOD_NEK2_1	395	400	PF00069	0.322
MOD_NEK2_1	48	53	PF00069	0.440
MOD_NEK2_1	79	84	PF00069	0.466
MOD_OFUCOSY	72	77	PF10250	0.368
MOD_PIKK_1	259	265	PF00454	0.290
MOD_PIKK_1	464	470	PF00454	0.360
MOD_PK_1	267	273	PF00069	0.425
MOD_PKA_2	73	79	PF00069	0.390
MOD_Plk_1	108	114	PF00069	0.654
MOD_Plk_1	395	401	PF00069	0.287
MOD_Plk_1	410	416	PF00069	0.382
MOD_Plk_4	112	118	PF00069	0.543
MOD_Plk_4	168	174	PF00069	0.408
MOD_Plk_4	212	218	PF00069	0.385
MOD_Plk_4	267	273	PF00069	0.486
MOD_Plk_4	300	306	PF00069	0.362
MOD_Plk_4	331	337	PF00069	0.305
MOD_Plk_4	340	346	PF00069	0.300
MOD_Plk_4	437	443	PF00069	0.329
MOD_Plk_4	488	494	PF00069	0.283
MOD_ProDKin_1	126	132	PF00069	0.539
MOD_ProDKin_1	282	288	PF00069	0.459
MOD_ProDKin_1	421	427	PF00069	0.382
MOD_ProDKin_1	59	65	PF00069	0.518
MOD_SUMO_rev_2	259	269	PF00179	0.383
TRG_DiLeu_BaEn_1	233	238	PF01217	0.307
TRG_DiLeu_BaEn_1	452	457	PF01217	0.300
TRG_DiLeu_BaEn_2	53	59	PF01217	0.428
TRG_ENDOCYTIC_2	329	332	PF00928	0.344
TRG_ENDOCYTIC_2	455	458	PF00928	0.360
TRG_ER_diArg_1	229	231	PF00400	0.426
TRG_ER_diArg_1	352	354	PF00400	0.336
TRG_NES_CRM1_1	377	389	PF08389	0.300
TRG_Pf-PMV_PEXEL_1	176	181	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	353	357	PF00026	0.376

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0K1	Leptomonas seymouri	58%	99%
A0A3Q8IHV3	Leishmania donovani	89%	100%
A4HBC3	Leishmania braziliensis	78%	100%
A4IAH1	Leishmania infantum	89%	100%
C9ZLS0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
Q4Q2E1	Leishmania major	87%	100%