Arrestin_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B5J4_LEIMU

TriTrypDb:

LmxM.33.3990

Length:

478

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	1
GO:0005829	cytosol	2	1
GO:0016020	membrane	2	1
GO:0031090	organelle membrane	3	1
GO:0032045	guanyl-nucleotide exchange factor complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0034066	Ric1-Rgp1 guanyl-nucleotide exchange factor complex	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0140535	intracellular protein-containing complex	2	1

Expansion

Sequence features

E9B5J4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5J4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0009987	cellular process	1	1
GO:0016192	vesicle-mediated transport	4	1
GO:0016197	endosomal transport	4	1
GO:0016482	cytosolic transport	4	1
GO:0042147	retrograde transport, endosome to Golgi	5	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	22	28	PF00089	0.493
CLV_NRD_NRD_1	383	385	PF00675	0.592
CLV_NRD_NRD_1	433	435	PF00675	0.624
CLV_PCSK_KEX2_1	134	136	PF00082	0.608
CLV_PCSK_KEX2_1	333	335	PF00082	0.686
CLV_PCSK_KEX2_1	383	385	PF00082	0.568
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.641
CLV_PCSK_PC1ET2_1	333	335	PF00082	0.686
DEG_APCC_DBOX_1	24	32	PF00400	0.565
DEG_APCC_DBOX_1	277	285	PF00400	0.634
DEG_Nend_UBRbox_2	1	3	PF02207	0.625
DEG_ODPH_VHL_1	452	464	PF01847	0.525
DEG_SIAH_1	453	461	PF03145	0.523
DEG_SPOP_SBC_1	410	414	PF00917	0.339
DOC_ANK_TNKS_1	438	445	PF00023	0.607
DOC_CKS1_1	236	241	PF01111	0.697
DOC_CKS1_1	394	399	PF01111	0.593
DOC_MAPK_DCC_7	190	198	PF00069	0.534
DOC_MAPK_DCC_7	334	344	PF00069	0.480
DOC_MAPK_gen_1	110	118	PF00069	0.548
DOC_MAPK_gen_1	190	198	PF00069	0.503
DOC_MAPK_gen_1	69	77	PF00069	0.486
DOC_MAPK_MEF2A_6	190	198	PF00069	0.500
DOC_MAPK_MEF2A_6	278	285	PF00069	0.604
DOC_MAPK_MEF2A_6	69	77	PF00069	0.563
DOC_PP1_RVXF_1	87	94	PF00149	0.692
DOC_PP2B_LxvP_1	283	286	PF13499	0.603
DOC_PP2B_LxvP_1	451	454	PF13499	0.522
DOC_PP2B_LxvP_1	462	465	PF13499	0.436
DOC_PP2B_PxIxI_1	243	249	PF00149	0.446
DOC_PP4_FxxP_1	145	148	PF00568	0.419
DOC_PP4_FxxP_1	213	216	PF00568	0.586
DOC_PP4_FxxP_1	403	406	PF00568	0.487
DOC_USP7_MATH_1	108	112	PF00917	0.692
DOC_USP7_MATH_1	174	178	PF00917	0.532
DOC_USP7_MATH_1	95	99	PF00917	0.700
DOC_USP7_MATH_2	58	64	PF00917	0.461
DOC_WW_Pin1_4	102	107	PF00397	0.596
DOC_WW_Pin1_4	228	233	PF00397	0.550
DOC_WW_Pin1_4	235	240	PF00397	0.595
DOC_WW_Pin1_4	352	357	PF00397	0.575
DOC_WW_Pin1_4	393	398	PF00397	0.593
LIG_14-3-3_CanoR_1	110	119	PF00244	0.640
LIG_14-3-3_CanoR_1	176	186	PF00244	0.666
LIG_14-3-3_CanoR_1	25	29	PF00244	0.577
LIG_14-3-3_CanoR_1	257	263	PF00244	0.704
LIG_14-3-3_CanoR_1	278	284	PF00244	0.634
LIG_14-3-3_CanoR_1	434	438	PF00244	0.543
LIG_Actin_WH2_2	241	259	PF00022	0.700
LIG_Actin_WH2_2	411	428	PF00022	0.573
LIG_BRCT_BRCA1_1	466	470	PF00533	0.608
LIG_Clathr_ClatBox_1	80	84	PF01394	0.559
LIG_eIF4E_1	446	452	PF01652	0.381
LIG_EVH1_1	213	217	PF00568	0.592
LIG_FHA_1	343	349	PF00498	0.521
LIG_FHA_1	394	400	PF00498	0.551
LIG_FHA_1	410	416	PF00498	0.399
LIG_FHA_1	417	423	PF00498	0.476
LIG_FHA_2	124	130	PF00498	0.585
LIG_FHA_2	36	42	PF00498	0.712
LIG_FHA_2	412	418	PF00498	0.612
LIG_FHA_2	57	63	PF00498	0.581
LIG_LIR_Apic_2	142	148	PF02991	0.445
LIG_LIR_Apic_2	211	216	PF02991	0.608
LIG_LIR_Apic_2	402	406	PF02991	0.494
LIG_LIR_Gen_1	390	399	PF02991	0.475
LIG_LIR_Nem_3	171	175	PF02991	0.559
LIG_LIR_Nem_3	311	315	PF02991	0.554
LIG_LIR_Nem_3	390	394	PF02991	0.476
LIG_MYND_1	450	454	PF01753	0.614
LIG_PCNA_PIPBox_1	206	215	PF02747	0.631
LIG_SH2_NCK_1	136	140	PF00017	0.609
LIG_SH2_SRC	16	19	PF00017	0.466
LIG_SH2_STAP1	136	140	PF00017	0.598
LIG_SH2_STAP1	169	173	PF00017	0.330
LIG_SH2_STAT5	117	120	PF00017	0.531
LIG_SH2_STAT5	16	19	PF00017	0.557
LIG_SH2_STAT5	307	310	PF00017	0.584
LIG_SH2_STAT5	53	56	PF00017	0.631
LIG_SH3_2	466	471	PF14604	0.659
LIG_SH3_3	180	186	PF00018	0.548
LIG_SH3_3	188	194	PF00018	0.488
LIG_SH3_3	211	217	PF00018	0.547
LIG_SH3_3	233	239	PF00018	0.584
LIG_SH3_3	245	251	PF00018	0.668
LIG_SH3_3	394	400	PF00018	0.613
LIG_SH3_3	460	466	PF00018	0.472
LIG_SH3_3	84	90	PF00018	0.584
LIG_SUMO_SIM_anti_2	347	352	PF11976	0.531
LIG_SUMO_SIM_anti_2	74	79	PF11976	0.457
LIG_SUMO_SIM_par_1	340	345	PF11976	0.601
LIG_SUMO_SIM_par_1	71	76	PF11976	0.530
LIG_SUMO_SIM_par_1	79	84	PF11976	0.483
LIG_TRAF2_1	126	129	PF00917	0.510
LIG_TRFH_1	213	217	PF08558	0.592
LIG_TRFH_1	446	450	PF08558	0.391
LIG_WRC_WIRS_1	418	423	PF05994	0.531
MOD_CDK_SPK_2	102	107	PF00069	0.596
MOD_CK1_1	177	183	PF00069	0.707
MOD_CK1_1	200	206	PF00069	0.634
MOD_CK1_1	413	419	PF00069	0.533
MOD_CK1_1	63	69	PF00069	0.635
MOD_CK2_1	123	129	PF00069	0.545
MOD_CK2_1	35	41	PF00069	0.676
MOD_CK2_1	56	62	PF00069	0.662
MOD_CK2_1	95	101	PF00069	0.726
MOD_Cter_Amidation	122	125	PF01082	0.512
MOD_Cter_Amidation	331	334	PF01082	0.480
MOD_GlcNHglycan	112	115	PF01048	0.636
MOD_GlcNHglycan	137	140	PF01048	0.560
MOD_GlcNHglycan	177	180	PF01048	0.599
MOD_GlcNHglycan	218	221	PF01048	0.618
MOD_GlcNHglycan	7	10	PF01048	0.519
MOD_GSK3_1	1	8	PF00069	0.593
MOD_GSK3_1	119	126	PF00069	0.440
MOD_GSK3_1	164	171	PF00069	0.538
MOD_GSK3_1	177	184	PF00069	0.434
MOD_GSK3_1	266	273	PF00069	0.682
MOD_GSK3_1	310	317	PF00069	0.619
MOD_GSK3_1	318	325	PF00069	0.626
MOD_GSK3_1	340	347	PF00069	0.607
MOD_GSK3_1	409	416	PF00069	0.598
MOD_GSK3_1	433	440	PF00069	0.363
MOD_GSK3_1	52	59	PF00069	0.755
MOD_NEK2_1	1	6	PF00069	0.537
MOD_NEK2_1	119	124	PF00069	0.525
MOD_NEK2_1	256	261	PF00069	0.688
MOD_NEK2_1	270	275	PF00069	0.593
MOD_NEK2_1	297	302	PF00069	0.467
MOD_NEK2_1	308	313	PF00069	0.437
MOD_NEK2_1	378	383	PF00069	0.563
MOD_NEK2_1	401	406	PF00069	0.455
MOD_NEK2_1	437	442	PF00069	0.584
MOD_NEK2_2	208	213	PF00069	0.635
MOD_PKA_2	175	181	PF00069	0.565
MOD_PKA_2	24	30	PF00069	0.543
MOD_PKA_2	256	262	PF00069	0.663
MOD_PKA_2	365	371	PF00069	0.397
MOD_PKA_2	433	439	PF00069	0.554
MOD_Plk_1	1	7	PF00069	0.597
MOD_Plk_1	164	170	PF00069	0.428
MOD_Plk_1	401	407	PF00069	0.532
MOD_Plk_1	416	422	PF00069	0.617
MOD_Plk_4	168	174	PF00069	0.530
MOD_Plk_4	208	214	PF00069	0.593
MOD_Plk_4	279	285	PF00069	0.575
MOD_Plk_4	417	423	PF00069	0.535
MOD_Plk_4	83	89	PF00069	0.617
MOD_ProDKin_1	102	108	PF00069	0.594
MOD_ProDKin_1	228	234	PF00069	0.560
MOD_ProDKin_1	235	241	PF00069	0.600
MOD_ProDKin_1	352	358	PF00069	0.581
MOD_ProDKin_1	393	399	PF00069	0.585
MOD_SUMO_rev_2	259	269	PF00179	0.652
TRG_DiLeu_BaEn_1	76	81	PF01217	0.512
TRG_DiLeu_BaLyEn_6	205	210	PF01217	0.536
TRG_DiLeu_BaLyEn_6	241	246	PF01217	0.440
TRG_DiLeu_BaLyEn_6	447	452	PF01217	0.595
TRG_DiLeu_BaLyEn_6	457	462	PF01217	0.446
TRG_ENDOCYTIC_2	53	56	PF00928	0.678
TRG_ER_diArg_1	383	385	PF00400	0.598
TRG_ER_diArg_1	68	71	PF00400	0.596
TRG_Pf-PMV_PEXEL_1	125	129	PF00026	0.533
TRG_Pf-PMV_PEXEL_1	71	76	PF00026	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I798	Leptomonas seymouri	57%	100%
A0A1X0PA91	Trypanosomatidae	23%	100%
A0A3Q8ILJ7	Leishmania donovani	92%	100%
A0A422NVD8	Trypanosoma rangeli	25%	100%
A4HBC2	Leishmania braziliensis	77%	100%
A4IAH0	Leishmania infantum	92%	100%
C9ZLS1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
Q4Q2E2	Leishmania major	90%	100%
V5BRG2	Trypanosoma cruzi	26%	100%