LeishMANIAdb
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Nucleolar protein family a member-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Nucleolar protein family a member-like protein
Gene product:
nucleolar protein family a member-like protein
Species:
Leishmania mexicana
UniProt:
E9B5J3_LEIMU
TriTrypDb:
LmxM.33.3980
Length:
148

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 1
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 7
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
TermNameLevelCount
GO:0005654 nucleoplasm 2 1
GO:0005730 nucleolus 5 1
GO:0005732 sno(s)RNA-containing ribonucleoprotein complex 3 1
GO:0005737 cytoplasm 2 1
GO:0005840 ribosome 5 5
GO:0031429 box H/ACA snoRNP complex 3 1
GO:0032991 protein-containing complex 1 11
GO:0043226 organelle 2 6
GO:0043228 non-membrane-bounded organelle 3 6
GO:0043229 intracellular organelle 3 6
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Expansion

Sequence features

E9B5J3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5J3

Function

Biological processes
TermNameLevelCount
GO:0000154 rRNA modification 6 1
GO:0000469 cleavage involved in rRNA processing 7 1
GO:0000470 maturation of LSU-rRNA 9 1
GO:0001522 pseudouridine synthesis 6 1
GO:0006139 nucleobase-containing compound metabolic process 3 2
GO:0006364 rRNA processing 8 1
GO:0006396 RNA processing 6 2
GO:0006399 tRNA metabolic process 7 1
GO:0006412 translation 4 1
GO:0006518 peptide metabolic process 4 1
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Molecular functions
TermNameLevelCount
GO:0003676 nucleic acid binding 3 2
GO:0003723 RNA binding 4 2
GO:0003735 structural constituent of ribosome 2 1
GO:0005198 structural molecule activity 1 1
GO:0005488 binding 1 2
GO:0019843 rRNA binding 5 1
GO:0030515 snoRNA binding 5 1
GO:0034513 box H/ACA snoRNA binding 6 1
GO:0097159 organic cyclic compound binding 2 2
GO:1901363 heterocyclic compound binding 2 2
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_NRD_NRD_1 66 68 PF00675 0.292
CLV_PCSK_KEX2_1 116 118 PF00082 0.260
CLV_PCSK_KEX2_1 52 54 PF00082 0.301
CLV_PCSK_PC1ET2_1 116 118 PF00082 0.260
CLV_PCSK_PC1ET2_1 52 54 PF00082 0.275
CLV_PCSK_SKI1_1 116 120 PF00082 0.286
CLV_PCSK_SKI1_1 136 140 PF00082 0.403
CLV_PCSK_SKI1_1 45 49 PF00082 0.303
CLV_PCSK_SKI1_1 57 61 PF00082 0.280
CLV_PCSK_SKI1_1 71 75 PF00082 0.339
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1HQX1 Leptomonas seymouri 30% 69%
A0A0N1I8X8 Leptomonas seymouri 93% 100%
A0A0N1PEF5 Leptomonas seymouri 30% 100%
A0A0S4JKB4 Bodo saltans 29% 100%
A0A0S4KMG7 Bodo saltans 77% 100%
A0A1X0NU51 Trypanosomatidae 31% 100%
A0A1X0PA41 Trypanosomatidae 82% 100%
A0A3Q8IDI1 Leishmania donovani 30% 100%
A0A3R7MN38 Trypanosoma rangeli 88% 99%
A0A3R7NA40 Trypanosoma rangeli 31% 100%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS