Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B5I8_LEIMU

TriTrypDb:

LmxM.33.3950

Length:

270

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0020016	ciliary pocket	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B5I8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5I8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	161	163	PF00675	0.568
CLV_NRD_NRD_1	206	208	PF00675	0.497
CLV_NRD_NRD_1	66	68	PF00675	0.488
CLV_NRD_NRD_1	73	75	PF00675	0.337
CLV_PCSK_FUR_1	204	208	PF00082	0.514
CLV_PCSK_KEX2_1	160	162	PF00082	0.560
CLV_PCSK_KEX2_1	206	208	PF00082	0.497
CLV_PCSK_KEX2_1	66	68	PF00082	0.487
CLV_PCSK_SKI1_1	161	165	PF00082	0.545
CLV_PCSK_SKI1_1	173	177	PF00082	0.455
CLV_PCSK_SKI1_1	209	213	PF00082	0.596
CLV_PCSK_SKI1_1	217	221	PF00082	0.552
CLV_PCSK_SKI1_1	75	79	PF00082	0.513
DEG_COP1_1	9	18	PF00400	0.494
DEG_SCF_FBW7_1	164	171	PF00400	0.355
DOC_CYCLIN_RxL_1	69	81	PF00134	0.553
DOC_MAPK_gen_1	160	172	PF00069	0.550
DOC_MAPK_MEF2A_6	165	172	PF00069	0.595
DOC_MAPK_RevD_3	51	67	PF00069	0.533
DOC_PP2B_LxvP_1	130	133	PF13499	0.447
DOC_PP4_FxxP_1	114	117	PF00568	0.637
DOC_USP7_MATH_1	153	157	PF00917	0.610
DOC_USP7_MATH_1	18	22	PF00917	0.709
DOC_USP7_MATH_1	6	10	PF00917	0.494
DOC_USP7_MATH_2	133	139	PF00917	0.434
DOC_WW_Pin1_4	164	169	PF00397	0.599
DOC_WW_Pin1_4	247	252	PF00397	0.580
DOC_WW_Pin1_4	254	259	PF00397	0.553
LIG_14-3-3_CanoR_1	105	115	PF00244	0.688
LIG_14-3-3_CanoR_1	136	142	PF00244	0.558
LIG_14-3-3_CanoR_1	39	49	PF00244	0.677
LIG_APCC_ABBA_1	49	54	PF00400	0.621
LIG_BIR_II_1	1	5	PF00653	0.732
LIG_FHA_1	107	113	PF00498	0.699
LIG_FHA_1	165	171	PF00498	0.587
LIG_FHA_1	236	242	PF00498	0.650
LIG_LIR_Apic_2	10	16	PF02991	0.672
LIG_LIR_Apic_2	113	117	PF02991	0.638
LIG_LIR_Gen_1	257	267	PF02991	0.606
LIG_LIR_Nem_3	205	211	PF02991	0.497
LIG_LIR_Nem_3	257	263	PF02991	0.616
LIG_SH2_CRK	260	264	PF00017	0.563
LIG_SH2_STAP1	137	141	PF00017	0.427
LIG_SH2_STAT5	218	221	PF00017	0.478
LIG_SH2_STAT5	256	259	PF00017	0.566
LIG_SH2_STAT5	92	95	PF00017	0.517
LIG_WRC_WIRS_1	188	193	PF05994	0.563
LIG_WW_3	265	269	PF00397	0.628
MOD_CDK_SPK_2	254	259	PF00069	0.585
MOD_CK1_1	106	112	PF00069	0.633
MOD_CK1_1	21	27	PF00069	0.686
MOD_CK1_1	247	253	PF00069	0.691
MOD_CK1_1	261	267	PF00069	0.559
MOD_CK1_1	96	102	PF00069	0.674
MOD_CK2_1	116	122	PF00069	0.599
MOD_CK2_1	153	159	PF00069	0.502
MOD_CK2_1	8	14	PF00069	0.501
MOD_GlcNHglycan	1	4	PF01048	0.696
MOD_GlcNHglycan	10	13	PF01048	0.554
MOD_GlcNHglycan	109	112	PF01048	0.668
MOD_GlcNHglycan	127	130	PF01048	0.706
MOD_GlcNHglycan	144	147	PF01048	0.410
MOD_GlcNHglycan	16	19	PF01048	0.634
MOD_GlcNHglycan	93	96	PF01048	0.641
MOD_GSK3_1	103	110	PF00069	0.598
MOD_GSK3_1	116	123	PF00069	0.630
MOD_GSK3_1	14	21	PF00069	0.723
MOD_GSK3_1	164	171	PF00069	0.471
MOD_GSK3_1	235	242	PF00069	0.585
MOD_GSK3_1	243	250	PF00069	0.680
MOD_GSK3_1	254	261	PF00069	0.587
MOD_GSK3_1	35	42	PF00069	0.622
MOD_GSK3_1	91	98	PF00069	0.627
MOD_N-GLC_1	230	235	PF02516	0.630
MOD_N-GLC_1	40	45	PF02516	0.429
MOD_NEK2_1	230	235	PF00069	0.703
MOD_NEK2_1	240	245	PF00069	0.559
MOD_NEK2_2	168	173	PF00069	0.341
MOD_PIKK_1	21	27	PF00454	0.647
MOD_PIKK_1	245	251	PF00454	0.672
MOD_PKA_2	135	141	PF00069	0.597
MOD_PKA_2	21	27	PF00069	0.702
MOD_PKA_2	258	264	PF00069	0.680
MOD_Plk_1	182	188	PF00069	0.585
MOD_Plk_1	235	241	PF00069	0.442
MOD_Plk_4	110	116	PF00069	0.512
MOD_Plk_4	182	188	PF00069	0.537
MOD_ProDKin_1	164	170	PF00069	0.589
MOD_ProDKin_1	247	253	PF00069	0.585
MOD_ProDKin_1	254	260	PF00069	0.555
MOD_SUMO_for_1	45	48	PF00179	0.601
TRG_DiLeu_BaEn_1	159	164	PF01217	0.588
TRG_DiLeu_BaLyEn_6	207	212	PF01217	0.594
TRG_DiLeu_LyEn_5	159	164	PF01217	0.550
TRG_ENDOCYTIC_2	260	263	PF00928	0.567
TRG_ER_diArg_1	160	162	PF00400	0.541
TRG_ER_diArg_1	206	208	PF00400	0.497
TRG_Pf-PMV_PEXEL_1	58	62	PF00026	0.556
TRG_Pf-PMV_PEXEL_1	75	79	PF00026	0.606

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P700	Leptomonas seymouri	48%	100%
A0A0S4JIE0	Bodo saltans	35%	100%
A0A1X0PA42	Trypanosomatidae	36%	100%
A0A3R7M3X3	Trypanosoma rangeli	37%	100%
A0A3S7X8G3	Leishmania donovani	85%	100%
A4HBB6	Leishmania braziliensis	68%	100%
A4IAG4	Leishmania infantum	85%	100%
Q4Q2E7	Leishmania major	84%	100%