Expression site-associated protein 5 (ESAG5),putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

expression site-associated protein 5 (ESAG5), putative

Species:

Leishmania mexicana

UniProt:

E9B5I6_LEIMU

TriTrypDb:

LmxM.33.3930

Length:

548

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 3, no: 5
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9B5I6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5I6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	9
GO:0008289	lipid binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	172	176	PF00656	0.381
CLV_C14_Caspase3-7	47	51	PF00656	0.614
CLV_NRD_NRD_1	21	23	PF00675	0.584
CLV_NRD_NRD_1	235	237	PF00675	0.430
CLV_NRD_NRD_1	423	425	PF00675	0.589
CLV_PCSK_FUR_1	424	428	PF00082	0.517
CLV_PCSK_KEX2_1	13	15	PF00082	0.714
CLV_PCSK_KEX2_1	23	25	PF00082	0.530
CLV_PCSK_KEX2_1	426	428	PF00082	0.581
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.597
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.437
CLV_PCSK_PC1ET2_1	426	428	PF00082	0.512
CLV_PCSK_SKI1_1	151	155	PF00082	0.558
CLV_PCSK_SKI1_1	236	240	PF00082	0.535
CLV_PCSK_SKI1_1	261	265	PF00082	0.430
CLV_PCSK_SKI1_1	490	494	PF00082	0.433
DEG_APCC_DBOX_1	48	56	PF00400	0.483
DEG_SPOP_SBC_1	74	78	PF00917	0.496
DOC_CYCLIN_yClb1_LxF_4	509	514	PF00134	0.467
DOC_CYCLIN_yCln2_LP_2	510	516	PF00134	0.416
DOC_MAPK_gen_1	22	31	PF00069	0.541
DOC_MAPK_MEF2A_6	139	147	PF00069	0.560
DOC_MAPK_MEF2A_6	24	33	PF00069	0.517
DOC_MAPK_MEF2A_6	67	75	PF00069	0.317
DOC_PP1_RVXF_1	15	21	PF00149	0.476
DOC_PP2B_LxvP_1	499	502	PF13499	0.368
DOC_PP2B_LxvP_1	510	513	PF13499	0.456
DOC_USP7_MATH_1	290	294	PF00917	0.537
DOC_USP7_MATH_1	304	308	PF00917	0.330
DOC_USP7_MATH_1	69	73	PF00917	0.428
DOC_USP7_MATH_1	74	78	PF00917	0.413
DOC_USP7_UBL2_3	486	490	PF12436	0.466
DOC_USP7_UBL2_3	9	13	PF12436	0.563
DOC_WW_Pin1_4	261	266	PF00397	0.353
DOC_WW_Pin1_4	413	418	PF00397	0.383
DOC_WW_Pin1_4	505	510	PF00397	0.504
LIG_14-3-3_CanoR_1	179	183	PF00244	0.466
LIG_14-3-3_CanoR_1	22	27	PF00244	0.528
LIG_14-3-3_CanoR_1	306	316	PF00244	0.434
LIG_14-3-3_CanoR_1	355	360	PF00244	0.464
LIG_14-3-3_CanoR_1	427	436	PF00244	0.425
LIG_14-3-3_CanoR_1	451	461	PF00244	0.348
LIG_BIR_II_1	1	5	PF00653	0.673
LIG_BRCT_BRCA1_1	161	165	PF00533	0.357
LIG_BRCT_BRCA1_1	299	303	PF00533	0.337
LIG_BRCT_BRCA1_1	418	422	PF00533	0.403
LIG_deltaCOP1_diTrp_1	185	192	PF00928	0.436
LIG_DLG_GKlike_1	22	29	PF00625	0.427
LIG_FHA_1	222	228	PF00498	0.438
LIG_FHA_1	262	268	PF00498	0.387
LIG_FHA_1	274	280	PF00498	0.409
LIG_FHA_1	335	341	PF00498	0.443
LIG_FHA_1	483	489	PF00498	0.523
LIG_FHA_1	74	80	PF00498	0.380
LIG_FHA_1	96	102	PF00498	0.566
LIG_FHA_2	170	176	PF00498	0.433
LIG_FHA_2	45	51	PF00498	0.603
LIG_FHA_2	55	61	PF00498	0.423
LIG_LIR_Gen_1	164	174	PF02991	0.486
LIG_LIR_Gen_1	191	202	PF02991	0.254
LIG_LIR_Gen_1	253	263	PF02991	0.490
LIG_LIR_Gen_1	460	471	PF02991	0.441
LIG_LIR_Gen_1	493	504	PF02991	0.427
LIG_LIR_Nem_3	164	169	PF02991	0.422
LIG_LIR_Nem_3	191	197	PF02991	0.428
LIG_LIR_Nem_3	253	258	PF02991	0.510
LIG_LIR_Nem_3	342	347	PF02991	0.426
LIG_LIR_Nem_3	36	41	PF02991	0.528
LIG_LIR_Nem_3	460	466	PF02991	0.437
LIG_LIR_Nem_3	493	499	PF02991	0.430
LIG_MLH1_MIPbox_1	418	422	PF16413	0.355
LIG_NRBOX	30	36	PF00104	0.358
LIG_PCNA_PIPBox_1	381	390	PF02747	0.252
LIG_PDZ_Class_1	543	548	PF00595	0.521
LIG_Pex14_1	188	192	PF04695	0.419
LIG_Pex14_2	219	223	PF04695	0.395
LIG_PTB_Apo_2	311	318	PF02174	0.450
LIG_PTB_Phospho_1	311	317	PF10480	0.452
LIG_REV1ctd_RIR_1	419	430	PF16727	0.422
LIG_SH2_CRK	156	160	PF00017	0.445
LIG_SH2_CRK	317	321	PF00017	0.395
LIG_SH2_CRK	357	361	PF00017	0.286
LIG_SH2_NCK_1	317	321	PF00017	0.444
LIG_SH2_NCK_1	357	361	PF00017	0.431
LIG_SH2_PTP2	388	391	PF00017	0.434
LIG_SH2_STAT3	432	435	PF00017	0.333
LIG_SH2_STAT5	194	197	PF00017	0.248
LIG_SH2_STAT5	357	360	PF00017	0.438
LIG_SH2_STAT5	388	391	PF00017	0.468
LIG_SH3_3	1	7	PF00018	0.438
LIG_SH3_3	187	193	PF00018	0.505
LIG_SH3_3	84	90	PF00018	0.307
LIG_TRAF2_1	102	105	PF00917	0.472
LIG_TRFH_1	463	467	PF08558	0.438
LIG_TYR_ITIM	461	466	PF00017	0.456
LIG_UBA3_1	153	160	PF00899	0.284
MOD_CDC14_SPxK_1	508	511	PF00782	0.488
MOD_CDK_SPxK_1	505	511	PF00069	0.489
MOD_CDK_SPxxK_3	413	420	PF00069	0.381
MOD_CK1_1	288	294	PF00069	0.491
MOD_CK1_1	307	313	PF00069	0.250
MOD_CK1_1	398	404	PF00069	0.419
MOD_CK1_1	416	422	PF00069	0.435
MOD_CK1_1	445	451	PF00069	0.469
MOD_CK2_1	532	538	PF00069	0.477
MOD_CK2_1	54	60	PF00069	0.477
MOD_Cter_Amidation	11	14	PF01082	0.607
MOD_DYRK1A_RPxSP_1	261	265	PF00069	0.430
MOD_GlcNHglycan	1	4	PF01048	0.582
MOD_GlcNHglycan	161	164	PF01048	0.372
MOD_GlcNHglycan	287	290	PF01048	0.415
MOD_GlcNHglycan	397	400	PF01048	0.443
MOD_GlcNHglycan	444	447	PF01048	0.394
MOD_GlcNHglycan	505	508	PF01048	0.418
MOD_GSK3_1	134	141	PF00069	0.391
MOD_GSK3_1	161	168	PF00069	0.369
MOD_GSK3_1	207	214	PF00069	0.481
MOD_GSK3_1	304	311	PF00069	0.410
MOD_GSK3_1	390	397	PF00069	0.575
MOD_GSK3_1	398	405	PF00069	0.427
MOD_GSK3_1	44	51	PF00069	0.639
MOD_GSK3_1	453	460	PF00069	0.449
MOD_GSK3_1	69	76	PF00069	0.451
MOD_LATS_1	11	17	PF00433	0.430
MOD_LATS_1	118	124	PF00433	0.437
MOD_LATS_1	205	211	PF00433	0.286
MOD_N-GLC_1	188	193	PF02516	0.470
MOD_N-GLC_1	335	340	PF02516	0.442
MOD_N-GLC_1	391	396	PF02516	0.408
MOD_N-GLC_1	453	458	PF02516	0.468
MOD_N-GLC_1	532	537	PF02516	0.519
MOD_N-GLC_1	69	74	PF02516	0.427
MOD_N-GLC_1	93	98	PF02516	0.638
MOD_NEK2_1	165	170	PF00069	0.427
MOD_NEK2_1	178	183	PF00069	0.343
MOD_NEK2_1	230	235	PF00069	0.463
MOD_NEK2_1	33	38	PF00069	0.459
MOD_NEK2_1	334	339	PF00069	0.412
MOD_NEK2_1	44	49	PF00069	0.549
MOD_NEK2_1	453	458	PF00069	0.338
MOD_NEK2_1	503	508	PF00069	0.591
MOD_NEK2_1	516	521	PF00069	0.307
MOD_NEK2_1	79	84	PF00069	0.444
MOD_NEK2_2	122	127	PF00069	0.269
MOD_NEK2_2	374	379	PF00069	0.244
MOD_PIKK_1	427	433	PF00454	0.500
MOD_PKA_1	13	19	PF00069	0.483
MOD_PKA_1	22	28	PF00069	0.440
MOD_PKA_1	426	432	PF00069	0.549
MOD_PKA_2	13	19	PF00069	0.579
MOD_PKA_2	138	144	PF00069	0.520
MOD_PKA_2	178	184	PF00069	0.407
MOD_PKA_2	305	311	PF00069	0.436
MOD_PKA_2	426	432	PF00069	0.541
MOD_PKA_2	48	54	PF00069	0.585
MOD_Plk_1	188	194	PF00069	0.374
MOD_Plk_1	335	341	PF00069	0.441
MOD_Plk_1	374	380	PF00069	0.377
MOD_Plk_1	532	538	PF00069	0.499
MOD_Plk_1	69	75	PF00069	0.429
MOD_Plk_4	161	167	PF00069	0.419
MOD_Plk_4	178	184	PF00069	0.338
MOD_Plk_4	335	341	PF00069	0.437
MOD_Plk_4	34	40	PF00069	0.484
MOD_Plk_4	355	361	PF00069	0.279
MOD_Plk_4	516	522	PF00069	0.312
MOD_Plk_4	532	538	PF00069	0.271
MOD_Plk_4	75	81	PF00069	0.402
MOD_Plk_4	95	101	PF00069	0.355
MOD_ProDKin_1	261	267	PF00069	0.359
MOD_ProDKin_1	413	419	PF00069	0.381
MOD_ProDKin_1	505	511	PF00069	0.509
TRG_DiLeu_BaEn_2	225	231	PF01217	0.393
TRG_ENDOCYTIC_2	156	159	PF00928	0.451
TRG_ENDOCYTIC_2	194	197	PF00928	0.388
TRG_ENDOCYTIC_2	317	320	PF00928	0.386
TRG_ENDOCYTIC_2	357	360	PF00928	0.359
TRG_ENDOCYTIC_2	463	466	PF00928	0.425
TRG_NLS_MonoCore_2	423	428	PF00514	0.384
TRG_NLS_MonoExtN_4	424	429	PF00514	0.509
TRG_Pf-PMV_PEXEL_1	237	241	PF00026	0.440

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I082	Leptomonas seymouri	41%	98%
A0A3S5H7X9	Leishmania donovani	80%	100%
A4HBB4	Leishmania braziliensis	57%	100%
A4IAG2	Leishmania infantum	80%	100%
C9ZLT1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	20%	100%
C9ZNB1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	21%	100%
Q4Q2E9	Leishmania major	78%	100%