FCP1 homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NLI interacting factor-like phosphatase, putative

Species:

Leishmania mexicana

UniProt:

E9B5I5_LEIMU

TriTrypDb:

LmxM.33.3920

Length:

586

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B5I5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5I5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004721	phosphoprotein phosphatase activity	3	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.547
CLV_C14_Caspase3-7	140	144	PF00656	0.615
CLV_C14_Caspase3-7	165	169	PF00656	0.593
CLV_C14_Caspase3-7	284	288	PF00656	0.553
CLV_NRD_NRD_1	202	204	PF00675	0.601
CLV_NRD_NRD_1	210	212	PF00675	0.610
CLV_NRD_NRD_1	256	258	PF00675	0.586
CLV_NRD_NRD_1	259	261	PF00675	0.568
CLV_NRD_NRD_1	263	265	PF00675	0.539
CLV_NRD_NRD_1	27	29	PF00675	0.496
CLV_NRD_NRD_1	271	273	PF00675	0.496
CLV_NRD_NRD_1	293	295	PF00675	0.501
CLV_NRD_NRD_1	361	363	PF00675	0.299
CLV_NRD_NRD_1	373	375	PF00675	0.299
CLV_NRD_NRD_1	93	95	PF00675	0.623
CLV_PCSK_FUR_1	371	375	PF00082	0.299
CLV_PCSK_KEX2_1	202	204	PF00082	0.606
CLV_PCSK_KEX2_1	209	211	PF00082	0.617
CLV_PCSK_KEX2_1	256	258	PF00082	0.620
CLV_PCSK_KEX2_1	263	265	PF00082	0.523
CLV_PCSK_KEX2_1	27	29	PF00082	0.496
CLV_PCSK_KEX2_1	271	273	PF00082	0.458
CLV_PCSK_KEX2_1	293	295	PF00082	0.501
CLV_PCSK_KEX2_1	361	363	PF00082	0.299
CLV_PCSK_KEX2_1	373	375	PF00082	0.299
CLV_PCSK_KEX2_1	93	95	PF00082	0.623
CLV_PCSK_SKI1_1	211	215	PF00082	0.600
CLV_PCSK_SKI1_1	384	388	PF00082	0.205
CLV_PCSK_SKI1_1	433	437	PF00082	0.374
CLV_PCSK_SKI1_1	438	442	PF00082	0.306
CLV_Separin_Metazoa	325	329	PF03568	0.358
DEG_SPOP_SBC_1	230	234	PF00917	0.592
DOC_CYCLIN_RxL_1	430	437	PF00134	0.334
DOC_CYCLIN_RxL_1	538	548	PF00134	0.402
DOC_CYCLIN_yCln2_LP_2	274	277	PF00134	0.418
DOC_MAPK_MEF2A_6	328	337	PF00069	0.299
DOC_PP2B_LxvP_1	274	277	PF13499	0.453
DOC_PP4_FxxP_1	58	61	PF00568	0.600
DOC_USP7_MATH_1	213	217	PF00917	0.596
DOC_USP7_MATH_1	228	232	PF00917	0.597
DOC_USP7_MATH_1	408	412	PF00917	0.452
DOC_USP7_MATH_1	425	429	PF00917	0.207
DOC_USP7_MATH_1	487	491	PF00917	0.670
DOC_USP7_MATH_1	565	569	PF00917	0.555
DOC_USP7_MATH_1	573	577	PF00917	0.404
DOC_USP7_MATH_1	84	88	PF00917	0.654
DOC_USP7_MATH_1	98	102	PF00917	0.503
DOC_WW_Pin1_4	469	474	PF00397	0.649
DOC_WW_Pin1_4	545	550	PF00397	0.381
DOC_WW_Pin1_4	61	66	PF00397	0.620
LIG_14-3-3_CanoR_1	227	237	PF00244	0.634
LIG_14-3-3_CanoR_1	377	386	PF00244	0.276
LIG_14-3-3_CanoR_1	448	453	PF00244	0.455
LIG_14-3-3_CanoR_1	70	78	PF00244	0.541
LIG_14-3-3_CanoR_1	97	107	PF00244	0.578
LIG_ActinCP_TwfCPI_2	58	67	PF01115	0.623
LIG_BIR_II_1	1	5	PF00653	0.514
LIG_Clathr_ClatBox_1	396	400	PF01394	0.358
LIG_eIF4E_1	146	152	PF01652	0.509
LIG_FHA_1	100	106	PF00498	0.523
LIG_FHA_1	129	135	PF00498	0.500
LIG_FHA_1	232	238	PF00498	0.594
LIG_FHA_1	447	453	PF00498	0.418
LIG_FHA_1	483	489	PF00498	0.641
LIG_FHA_1	546	552	PF00498	0.456
LIG_FHA_1	561	567	PF00498	0.478
LIG_FHA_1	72	78	PF00498	0.551
LIG_FHA_2	241	247	PF00498	0.469
LIG_GBD_Chelix_1	301	309	PF00786	0.299
LIG_Integrin_isoDGR_2	291	293	PF01839	0.403
LIG_LIR_Apic_2	270	276	PF02991	0.472
LIG_LIR_Apic_2	344	350	PF02991	0.358
LIG_LIR_Apic_2	417	422	PF02991	0.358
LIG_LIR_Apic_2	55	61	PF02991	0.604
LIG_LIR_Gen_1	147	156	PF02991	0.480
LIG_LIR_Gen_1	434	443	PF02991	0.229
LIG_LIR_Nem_3	143	149	PF02991	0.578
LIG_LIR_Nem_3	434	439	PF02991	0.229
LIG_LIR_Nem_3	576	580	PF02991	0.381
LIG_MYND_1	549	553	PF01753	0.445
LIG_NRBOX	411	417	PF00104	0.358
LIG_Pex14_2	179	183	PF04695	0.620
LIG_Pex14_2	299	303	PF04695	0.299
LIG_SH2_CRK	149	153	PF00017	0.542
LIG_SH2_CRK	314	318	PF00017	0.289
LIG_SH2_CRK	547	551	PF00017	0.451
LIG_SH2_CRK	577	581	PF00017	0.384
LIG_SH2_GRB2like	133	136	PF00017	0.541
LIG_SH2_GRB2like	347	350	PF00017	0.299
LIG_SH2_NCK_1	149	153	PF00017	0.693
LIG_SH2_PTP2	347	350	PF00017	0.358
LIG_SH2_SRC	347	350	PF00017	0.299
LIG_SH2_STAT5	128	131	PF00017	0.545
LIG_SH2_STAT5	133	136	PF00017	0.483
LIG_SH2_STAT5	347	350	PF00017	0.299
LIG_SH2_STAT5	419	422	PF00017	0.299
LIG_SH2_STAT5	547	550	PF00017	0.442
LIG_SH3_1	547	553	PF00018	0.475
LIG_SH3_2	92	97	PF14604	0.601
LIG_SH3_3	33	39	PF00018	0.514
LIG_SH3_3	547	553	PF00018	0.441
LIG_SH3_3	579	585	PF00018	0.471
LIG_SH3_3	89	95	PF00018	0.601
LIG_SUMO_SIM_anti_2	426	434	PF11976	0.355
LIG_SUMO_SIM_anti_2	495	500	PF11976	0.437
LIG_SUMO_SIM_par_1	394	400	PF11976	0.299
LIG_SUMO_SIM_par_1	426	434	PF11976	0.297
LIG_TRAF2_1	23	26	PF00917	0.501
LIG_TRAF2_1	459	462	PF00917	0.605
LIG_TRAF2_2	45	50	PF00917	0.517
LIG_UBA3_1	429	433	PF00899	0.358
MOD_CDC14_SPxK_1	64	67	PF00782	0.617
MOD_CDK_SPK_2	469	474	PF00069	0.649
MOD_CDK_SPxK_1	61	67	PF00069	0.621
MOD_CDK_SPxxK_3	469	476	PF00069	0.523
MOD_CK1_1	124	130	PF00069	0.533
MOD_CK1_1	144	150	PF00069	0.639
MOD_CK1_1	163	169	PF00069	0.562
MOD_CK1_1	218	224	PF00069	0.603
MOD_CK1_1	231	237	PF00069	0.627
MOD_CK1_1	279	285	PF00069	0.435
MOD_CK1_1	447	453	PF00069	0.467
MOD_CK1_1	568	574	PF00069	0.519
MOD_CK1_1	576	582	PF00069	0.378
MOD_CK1_1	99	105	PF00069	0.502
MOD_CK2_1	139	145	PF00069	0.554
MOD_CK2_1	240	246	PF00069	0.472
MOD_Cter_Amidation	291	294	PF01082	0.520
MOD_Cter_Amidation	359	362	PF01082	0.299
MOD_GlcNHglycan	1	4	PF01048	0.518
MOD_GlcNHglycan	137	142	PF01048	0.602
MOD_GlcNHglycan	278	281	PF01048	0.405
MOD_GlcNHglycan	404	407	PF01048	0.358
MOD_GlcNHglycan	490	493	PF01048	0.609
MOD_GSK3_1	119	126	PF00069	0.581
MOD_GSK3_1	137	144	PF00069	0.466
MOD_GSK3_1	160	167	PF00069	0.726
MOD_GSK3_1	201	208	PF00069	0.646
MOD_GSK3_1	213	220	PF00069	0.593
MOD_GSK3_1	226	233	PF00069	0.589
MOD_GSK3_1	235	242	PF00069	0.762
MOD_GSK3_1	279	286	PF00069	0.442
MOD_GSK3_1	444	451	PF00069	0.496
MOD_GSK3_1	478	485	PF00069	0.597
MOD_GSK3_1	488	495	PF00069	0.426
MOD_GSK3_1	50	57	PF00069	0.780
MOD_GSK3_1	565	572	PF00069	0.450
MOD_GSK3_1	61	68	PF00069	0.626
MOD_N-GLC_1	8	13	PF02516	0.503
MOD_N-GLC_2	380	382	PF02516	0.299
MOD_NEK2_1	240	245	PF00069	0.504
MOD_NEK2_1	305	310	PF00069	0.299
MOD_NEK2_1	326	331	PF00069	0.358
MOD_NEK2_1	51	56	PF00069	0.612
MOD_NEK2_1	69	74	PF00069	0.579
MOD_NEK2_1	96	101	PF00069	0.621
MOD_NEK2_2	536	541	PF00069	0.419
MOD_NEK2_2	65	70	PF00069	0.629
MOD_PIKK_1	99	105	PF00454	0.520
MOD_PK_1	448	454	PF00069	0.406
MOD_PKA_1	202	208	PF00069	0.593
MOD_PKA_1	256	262	PF00069	0.606
MOD_PKA_2	201	207	PF00069	0.602
MOD_PKA_2	226	232	PF00069	0.634
MOD_PKA_2	256	262	PF00069	0.628
MOD_PKA_2	444	450	PF00069	0.564
MOD_PKA_2	467	473	PF00069	0.527
MOD_PKA_2	483	489	PF00069	0.520
MOD_PKA_2	69	75	PF00069	0.626
MOD_PKA_2	84	90	PF00069	0.570
MOD_PKA_2	96	102	PF00069	0.509
MOD_Plk_1	240	246	PF00069	0.473
MOD_Plk_1	305	311	PF00069	0.299
MOD_Plk_1	425	431	PF00069	0.299
MOD_Plk_1	8	14	PF00069	0.502
MOD_Plk_2-3	164	170	PF00069	0.667
MOD_Plk_4	129	135	PF00069	0.506
MOD_Plk_4	232	238	PF00069	0.594
MOD_Plk_4	305	311	PF00069	0.299
MOD_Plk_4	425	431	PF00069	0.358
MOD_ProDKin_1	469	475	PF00069	0.649
MOD_ProDKin_1	545	551	PF00069	0.390
MOD_ProDKin_1	61	67	PF00069	0.621
MOD_SUMO_for_1	23	26	PF00179	0.501
TRG_DiLeu_BaEn_1	270	275	PF01217	0.538
TRG_DiLeu_BaLyEn_6	547	552	PF01217	0.443
TRG_ENDOCYTIC_2	149	152	PF00928	0.627
TRG_ENDOCYTIC_2	314	317	PF00928	0.289
TRG_ENDOCYTIC_2	577	580	PF00928	0.379
TRG_ER_diArg_1	201	203	PF00400	0.614
TRG_ER_diArg_1	209	211	PF00400	0.627
TRG_ER_diArg_1	271	273	PF00400	0.507
TRG_ER_diArg_1	371	374	PF00400	0.206
TRG_ER_diArg_1	473	476	PF00400	0.524
TRG_ER_diArg_1	92	94	PF00400	0.628
TRG_NES_CRM1_1	295	307	PF08389	0.358
TRG_NES_CRM1_1	325	336	PF08389	0.299
TRG_NES_CRM1_1	388	400	PF08389	0.358
TRG_NLS_MonoExtC_3	259	264	PF00514	0.601
TRG_NLS_MonoExtN_4	257	264	PF00514	0.602
TRG_Pf-PMV_PEXEL_1	433	437	PF00026	0.334

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCT0	Leptomonas seymouri	55%	100%
A0A3S7X8G2	Leishmania donovani	89%	100%
A4HBB3	Leishmania braziliensis	76%	100%
A4IAG1	Leishmania infantum	89%	100%
Q4Q2F0	Leishmania major	88%	100%