Protein-serine/threonine kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative

Species:

Leishmania mexicana

UniProt:

E9B5I3_LEIMU

TriTrypDb:

LmxM.33.3900

Length:

489

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005759	mitochondrial matrix	5	7
GO:0031974	membrane-enclosed lumen	2	7
GO:0043233	organelle lumen	3	7
GO:0070013	intracellular organelle lumen	4	7
GO:0110165	cellular anatomical entity	1	7
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9B5I3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5I3

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0044237	cellular metabolic process	2	7
GO:0006109	regulation of carbohydrate metabolic process	5	1
GO:0006468	protein phosphorylation	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0010675	obsolete regulation of cellular carbohydrate metabolic process	5	1
GO:0010906	regulation of glucose metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0019538	protein metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0062012	regulation of small molecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004672	protein kinase activity	3	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	153	157	PF00656	0.608
CLV_C14_Caspase3-7	304	308	PF00656	0.354
CLV_C14_Caspase3-7	41	45	PF00656	0.309
CLV_C14_Caspase3-7	65	69	PF00656	0.292
CLV_NRD_NRD_1	10	12	PF00675	0.570
CLV_NRD_NRD_1	136	138	PF00675	0.436
CLV_NRD_NRD_1	257	259	PF00675	0.315
CLV_NRD_NRD_1	75	77	PF00675	0.427
CLV_PCSK_KEX2_1	10	12	PF00082	0.570
CLV_PCSK_KEX2_1	256	258	PF00082	0.313
CLV_PCSK_KEX2_1	322	324	PF00082	0.384
CLV_PCSK_KEX2_1	73	75	PF00082	0.318
CLV_PCSK_PC1ET2_1	322	324	PF00082	0.384
CLV_PCSK_PC1ET2_1	73	75	PF00082	0.318
CLV_PCSK_PC7_1	253	259	PF00082	0.316
CLV_PCSK_SKI1_1	322	326	PF00082	0.385
CLV_PCSK_SKI1_1	372	376	PF00082	0.304
DEG_APCC_DBOX_1	226	234	PF00400	0.402
DEG_Nend_UBRbox_3	1	3	PF02207	0.471
DEG_SPOP_SBC_1	175	179	PF00917	0.629
DEG_SPOP_SBC_1	334	338	PF00917	0.445
DEG_SPOP_SBC_1	483	487	PF00917	0.537
DOC_CKS1_1	26	31	PF01111	0.379
DOC_CYCLIN_RxL_1	15	28	PF00134	0.403
DOC_CYCLIN_RxL_1	185	194	PF00134	0.608
DOC_CYCLIN_yCln2_LP_2	341	347	PF00134	0.505
DOC_MAPK_FxFP_2	131	134	PF00069	0.428
DOC_MAPK_gen_1	212	221	PF00069	0.488
DOC_MAPK_gen_1	224	232	PF00069	0.354
DOC_MAPK_gen_1	384	393	PF00069	0.304
DOC_MAPK_gen_1	472	482	PF00069	0.367
DOC_MAPK_MEF2A_6	212	221	PF00069	0.488
DOC_MAPK_MEF2A_6	224	232	PF00069	0.354
DOC_MAPK_MEF2A_6	384	393	PF00069	0.304
DOC_MAPK_MEF2A_6	475	482	PF00069	0.443
DOC_MAPK_NFAT4_5	214	222	PF00069	0.465
DOC_PP1_RVXF_1	186	193	PF00149	0.545
DOC_PP1_RVXF_1	255	262	PF00149	0.336
DOC_PP1_RVXF_1	468	474	PF00149	0.304
DOC_PP1_RVXF_1	80	86	PF00149	0.403
DOC_PP2B_LxvP_1	23	26	PF13499	0.398
DOC_PP2B_LxvP_1	30	33	PF13499	0.355
DOC_PP2B_PxIxI_1	386	392	PF00149	0.304
DOC_PP4_FxxP_1	131	134	PF00568	0.556
DOC_USP7_MATH_1	173	177	PF00917	0.595
DOC_USP7_MATH_1	241	245	PF00917	0.430
DOC_USP7_UBL2_3	419	423	PF12436	0.304
DOC_USP7_UBL2_3	73	77	PF12436	0.449
DOC_WW_Pin1_4	126	131	PF00397	0.537
DOC_WW_Pin1_4	25	30	PF00397	0.376
DOC_WW_Pin1_4	336	341	PF00397	0.422
DOC_WW_Pin1_4	484	489	PF00397	0.457
LIG_14-3-3_CanoR_1	10	19	PF00244	0.419
LIG_14-3-3_CanoR_1	137	145	PF00244	0.540
LIG_14-3-3_CanoR_1	212	218	PF00244	0.468
LIG_14-3-3_CanoR_1	227	233	PF00244	0.328
LIG_14-3-3_CanoR_1	358	364	PF00244	0.326
LIG_14-3-3_CanoR_1	394	403	PF00244	0.369
LIG_14-3-3_CanoR_1	61	67	PF00244	0.433
LIG_Actin_WH2_2	360	378	PF00022	0.369
LIG_APCC_ABBA_1	314	319	PF00400	0.489
LIG_BRCT_BRCA1_1	127	131	PF00533	0.415
LIG_deltaCOP1_diTrp_1	398	406	PF00928	0.304
LIG_FHA_1	214	220	PF00498	0.409
LIG_FHA_1	275	281	PF00498	0.412
LIG_FHA_1	336	342	PF00498	0.465
LIG_FHA_1	380	386	PF00498	0.304
LIG_FHA_1	443	449	PF00498	0.304
LIG_FHA_1	460	466	PF00498	0.304
LIG_FHA_2	137	143	PF00498	0.604
LIG_FHA_2	197	203	PF00498	0.513
LIG_FHA_2	26	32	PF00498	0.373
LIG_FHA_2	425	431	PF00498	0.335
LIG_GBD_Chelix_1	47	55	PF00786	0.371
LIG_LIR_Apic_2	128	134	PF02991	0.417
LIG_LIR_Gen_1	300	306	PF02991	0.346
LIG_LIR_Gen_1	398	407	PF02991	0.304
LIG_LIR_Gen_1	458	465	PF02991	0.382
LIG_LIR_Gen_1	60	71	PF02991	0.377
LIG_LIR_Nem_3	184	190	PF02991	0.649
LIG_LIR_Nem_3	300	305	PF02991	0.370
LIG_LIR_Nem_3	368	374	PF02991	0.369
LIG_LIR_Nem_3	398	404	PF02991	0.304
LIG_LIR_Nem_3	458	463	PF02991	0.369
LIG_LIR_Nem_3	60	66	PF02991	0.359
LIG_MYND_1	130	134	PF01753	0.545
LIG_Pex14_1	250	254	PF04695	0.344
LIG_Pex14_1	85	89	PF04695	0.384
LIG_Pex14_2	4	8	PF04695	0.602
LIG_Pex14_2	418	422	PF04695	0.304
LIG_SH2_CRK	460	464	PF00017	0.284
LIG_SH2_NCK_1	146	150	PF00017	0.593
LIG_SH2_SRC	146	149	PF00017	0.559
LIG_SH2_STAP1	432	436	PF00017	0.304
LIG_SH2_STAT5	22	25	PF00017	0.383
LIG_SH2_STAT5	369	372	PF00017	0.304
LIG_SH2_STAT5	89	92	PF00017	0.403
LIG_SH2_STAT5	96	99	PF00017	0.320
LIG_SH3_3	222	228	PF00018	0.340
LIG_SH3_3	23	29	PF00018	0.390
LIG_SH3_3	438	444	PF00018	0.325
LIG_SH3_3	468	474	PF00018	0.304
LIG_SH3_3	477	483	PF00018	0.391
LIG_SUMO_SIM_anti_2	231	237	PF11976	0.417
LIG_SUMO_SIM_anti_2	388	393	PF11976	0.314
LIG_SUMO_SIM_par_1	297	304	PF11976	0.365
LIG_SUMO_SIM_par_1	310	315	PF11976	0.370
LIG_UBA3_1	132	138	PF00899	0.431
LIG_UBA3_1	219	224	PF00899	0.322
LIG_WRC_WIRS_1	63	68	PF05994	0.446
MOD_CK1_1	14	20	PF00069	0.345
MOD_CK1_1	154	160	PF00069	0.665
MOD_CK1_1	176	182	PF00069	0.658
MOD_CK1_1	310	316	PF00069	0.370
MOD_CK1_1	335	341	PF00069	0.411
MOD_CK2_1	196	202	PF00069	0.528
MOD_CK2_1	424	430	PF00069	0.284
MOD_GlcNHglycan	171	174	PF01048	0.584
MOD_GlcNHglycan	181	184	PF01048	0.604
MOD_GSK3_1	113	120	PF00069	0.468
MOD_GSK3_1	136	143	PF00069	0.585
MOD_GSK3_1	148	155	PF00069	0.530
MOD_GSK3_1	169	176	PF00069	0.583
MOD_GSK3_1	177	184	PF00069	0.609
MOD_GSK3_1	329	336	PF00069	0.403
MOD_GSK3_1	350	357	PF00069	0.573
MOD_GSK3_1	482	489	PF00069	0.450
MOD_GSK3_1	62	69	PF00069	0.283
MOD_N-GLC_1	114	119	PF02516	0.348
MOD_N-GLC_1	167	172	PF02516	0.516
MOD_N-GLC_1	307	312	PF02516	0.368
MOD_N-GLC_2	377	379	PF02516	0.369
MOD_N-GLC_2	95	97	PF02516	0.354
MOD_NEK2_1	269	274	PF00069	0.440
MOD_NEK2_1	333	338	PF00069	0.383
MOD_NEK2_1	4	9	PF00069	0.657
MOD_NEK2_1	424	429	PF00069	0.313
MOD_NEK2_1	66	71	PF00069	0.298
MOD_NEK2_2	183	188	PF00069	0.545
MOD_NEK2_2	379	384	PF00069	0.369
MOD_PIKK_1	274	280	PF00454	0.487
MOD_PKA_2	136	142	PF00069	0.544
MOD_PKA_2	228	234	PF00069	0.422
MOD_PKA_2	350	356	PF00069	0.376
MOD_PKA_2	57	63	PF00069	0.340
MOD_Plk_1	117	123	PF00069	0.399
MOD_Plk_1	140	146	PF00069	0.570
MOD_Plk_1	465	471	PF00069	0.477
MOD_Plk_4	140	146	PF00069	0.512
MOD_Plk_4	228	234	PF00069	0.482
MOD_Plk_4	301	307	PF00069	0.422
MOD_Plk_4	329	335	PF00069	0.334
MOD_Plk_4	365	371	PF00069	0.358
MOD_Plk_4	66	72	PF00069	0.502
MOD_Plk_4	85	91	PF00069	0.366
MOD_ProDKin_1	126	132	PF00069	0.542
MOD_ProDKin_1	25	31	PF00069	0.378
MOD_ProDKin_1	336	342	PF00069	0.424
MOD_SUMO_rev_2	315	324	PF00179	0.429
TRG_DiLeu_BaEn_3	319	325	PF01217	0.368
TRG_DiLeu_BaLyEn_6	215	220	PF01217	0.360
TRG_ENDOCYTIC_2	22	25	PF00928	0.386
TRG_ENDOCYTIC_2	449	452	PF00928	0.304
TRG_ENDOCYTIC_2	460	463	PF00928	0.304
TRG_ENDOCYTIC_2	63	66	PF00928	0.372
TRG_ER_diArg_1	10	12	PF00400	0.630
TRG_ER_diArg_1	226	229	PF00400	0.395
TRG_ER_diArg_1	256	258	PF00400	0.339
TRG_ER_diArg_1	469	472	PF00400	0.304
TRG_NLS_MonoExtC_3	72	77	PF00514	0.384
TRG_Pf-PMV_PEXEL_1	102	106	PF00026	0.454
TRG_Pf-PMV_PEXEL_1	262	266	PF00026	0.343

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P768	Leptomonas seymouri	55%	100%
A0A3Q8III9	Leishmania donovani	90%	98%
A4HBB1	Leishmania braziliensis	81%	100%
A4IAF9	Leishmania infantum	90%	98%
Q4Q2F2	Leishmania major	91%	100%