Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B5I2_LEIMU

TriTrypDb:

LmxM.33.3890

Length:

305

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0020022	acidocalcisome	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9B5I2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5I2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	237	243	PF00089	0.413
CLV_NRD_NRD_1	122	124	PF00675	0.580
CLV_PCSK_KEX2_1	122	124	PF00082	0.580
CLV_PCSK_KEX2_1	83	85	PF00082	0.574
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.589
CLV_PCSK_SKI1_1	134	138	PF00082	0.575
CLV_PCSK_SKI1_1	14	18	PF00082	0.330
CLV_PCSK_SKI1_1	22	26	PF00082	0.302
DEG_APCC_DBOX_1	278	286	PF00400	0.320
DOC_MAPK_gen_1	83	90	PF00069	0.418
DOC_PP4_FxxP_1	62	65	PF00568	0.230
DOC_USP7_MATH_1	216	220	PF00917	0.231
DOC_USP7_MATH_1	291	295	PF00917	0.449
DOC_USP7_MATH_1	65	69	PF00917	0.362
DOC_WW_Pin1_4	232	237	PF00397	0.378
DOC_WW_Pin1_4	249	254	PF00397	0.462
LIG_14-3-3_CanoR_1	122	129	PF00244	0.397
LIG_14-3-3_CanoR_1	159	163	PF00244	0.368
LIG_14-3-3_CanoR_1	190	195	PF00244	0.302
LIG_14-3-3_CanoR_1	22	27	PF00244	0.474
LIG_14-3-3_CanoR_1	240	244	PF00244	0.305
LIG_14-3-3_CanoR_1	257	266	PF00244	0.341
LIG_CaM_IQ_9	271	286	PF13499	0.321
LIG_Clathr_ClatBox_1	146	150	PF01394	0.340
LIG_FHA_1	107	113	PF00498	0.415
LIG_FHA_1	141	147	PF00498	0.379
LIG_FHA_1	159	165	PF00498	0.398
LIG_FHA_1	209	215	PF00498	0.391
LIG_FHA_1	23	29	PF00498	0.337
LIG_FHA_1	290	296	PF00498	0.394
LIG_FHA_2	77	83	PF00498	0.259
LIG_GBD_Chelix_1	73	81	PF00786	0.515
LIG_LIR_Apic_2	59	65	PF02991	0.278
LIG_LIR_Gen_1	156	164	PF02991	0.370
LIG_LIR_Gen_1	25	34	PF02991	0.286
LIG_LIR_Gen_1	57	65	PF02991	0.410
LIG_LIR_Nem_3	143	147	PF02991	0.382
LIG_LIR_Nem_3	156	160	PF02991	0.300
LIG_LIR_Nem_3	174	180	PF02991	0.285
LIG_LIR_Nem_3	199	204	PF02991	0.323
LIG_LIR_Nem_3	25	29	PF02991	0.286
LIG_LIR_Nem_3	252	258	PF02991	0.349
LIG_LYPXL_yS_3	144	147	PF13949	0.411
LIG_PCNA_yPIPBox_3	14	27	PF02747	0.544
LIG_Pex14_2	26	30	PF04695	0.284
LIG_PTB_Apo_2	151	158	PF02174	0.327
LIG_PTB_Phospho_1	151	157	PF10480	0.332
LIG_SH2_CRK	180	184	PF00017	0.202
LIG_SH2_GRB2like	231	234	PF00017	0.418
LIG_SH2_NCK_1	157	161	PF00017	0.322
LIG_SH2_STAP1	131	135	PF00017	0.280
LIG_SH2_STAP1	180	184	PF00017	0.228
LIG_SH2_STAT5	10	13	PF00017	0.604
LIG_SH2_STAT5	177	180	PF00017	0.394
LIG_SH2_STAT5	222	225	PF00017	0.396
LIG_SUMO_SIM_anti_2	31	36	PF11976	0.353
LIG_SUMO_SIM_par_1	270	277	PF11976	0.404
LIG_SUMO_SIM_par_1	36	43	PF11976	0.180
LIG_TYR_ITIM	155	160	PF00017	0.465
LIG_TYR_ITIM	178	183	PF00017	0.229
LIG_WRC_WIRS_1	23	28	PF05994	0.303
MOD_CK1_1	124	130	PF00069	0.546
MOD_CK1_1	168	174	PF00069	0.547
MOD_CK1_1	182	188	PF00069	0.437
MOD_CK1_1	273	279	PF00069	0.506
MOD_CK1_1	294	300	PF00069	0.354
MOD_CK1_1	66	72	PF00069	0.519
MOD_CK2_1	274	280	PF00069	0.489
MOD_CK2_1	65	71	PF00069	0.429
MOD_CK2_1	76	82	PF00069	0.295
MOD_GlcNHglycan	214	217	PF01048	0.556
MOD_GSK3_1	101	108	PF00069	0.259
MOD_GSK3_1	164	171	PF00069	0.483
MOD_GSK3_1	178	185	PF00069	0.336
MOD_GSK3_1	208	215	PF00069	0.418
MOD_GSK3_1	216	223	PF00069	0.426
MOD_GSK3_1	245	252	PF00069	0.598
MOD_GSK3_1	270	277	PF00069	0.490
MOD_GSK3_1	290	297	PF00069	0.303
MOD_GSK3_1	72	79	PF00069	0.545
MOD_LATS_1	163	169	PF00433	0.261
MOD_N-GLC_1	171	176	PF02516	0.574
MOD_N-GLC_1	232	237	PF02516	0.490
MOD_N-GLC_1	289	294	PF02516	0.558
MOD_NEK2_1	101	106	PF00069	0.338
MOD_NEK2_1	140	145	PF00069	0.420
MOD_NEK2_1	178	183	PF00069	0.372
MOD_NEK2_1	274	279	PF00069	0.453
MOD_NEK2_1	28	33	PF00069	0.307
MOD_NEK2_1	39	44	PF00069	0.276
MOD_PIKK_1	225	231	PF00454	0.398
MOD_PIKK_1	259	265	PF00454	0.492
MOD_PKA_2	121	127	PF00069	0.410
MOD_PKA_2	158	164	PF00069	0.428
MOD_PKA_2	189	195	PF00069	0.367
MOD_PKA_2	212	218	PF00069	0.519
MOD_PKA_2	239	245	PF00069	0.367
MOD_Plk_1	14	20	PF00069	0.462
MOD_Plk_1	171	177	PF00069	0.528
MOD_Plk_4	101	107	PF00069	0.378
MOD_Plk_4	14	20	PF00069	0.555
MOD_Plk_4	179	185	PF00069	0.380
MOD_Plk_4	196	202	PF00069	0.344
MOD_Plk_4	22	28	PF00069	0.188
MOD_Plk_4	76	82	PF00069	0.519
MOD_ProDKin_1	232	238	PF00069	0.471
MOD_ProDKin_1	249	255	PF00069	0.578
TRG_DiLeu_BaLyEn_6	142	147	PF01217	0.284
TRG_ENDOCYTIC_2	144	147	PF00928	0.479
TRG_ENDOCYTIC_2	157	160	PF00928	0.347
TRG_ENDOCYTIC_2	180	183	PF00928	0.535
TRG_ER_diArg_1	121	123	PF00400	0.432

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5I4	Leptomonas seymouri	58%	100%
A0A0S4JKH0	Bodo saltans	26%	100%
A0A1X0PA82	Trypanosomatidae	36%	100%
A0A3S7X8F5	Leishmania donovani	89%	100%
A0A422NSU6	Trypanosoma rangeli	32%	100%
A4HBB0	Leishmania braziliensis	74%	100%
A4IAF8	Leishmania infantum	89%	100%
C9ZLT6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
Q4Q2F3	Leishmania major	88%	100%
V5B695	Trypanosoma cruzi	33%	100%