J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B5I0_LEIMU

TriTrypDb:

LmxM.33.3870

Length:

781

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9B5I0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5I0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	382	386	PF00656	0.604
CLV_MEL_PAP_1	629	635	PF00089	0.350
CLV_NRD_NRD_1	121	123	PF00675	0.412
CLV_NRD_NRD_1	172	174	PF00675	0.511
CLV_NRD_NRD_1	400	402	PF00675	0.381
CLV_NRD_NRD_1	687	689	PF00675	0.515
CLV_NRD_NRD_1	694	696	PF00675	0.443
CLV_NRD_NRD_1	725	727	PF00675	0.314
CLV_NRD_NRD_1	747	749	PF00675	0.210
CLV_PCSK_KEX2_1	121	123	PF00082	0.412
CLV_PCSK_KEX2_1	400	402	PF00082	0.346
CLV_PCSK_KEX2_1	657	659	PF00082	0.451
CLV_PCSK_KEX2_1	687	689	PF00082	0.518
CLV_PCSK_KEX2_1	694	696	PF00082	0.385
CLV_PCSK_KEX2_1	724	726	PF00082	0.316
CLV_PCSK_KEX2_1	747	749	PF00082	0.210
CLV_PCSK_PC1ET2_1	657	659	PF00082	0.420
CLV_PCSK_SKI1_1	264	268	PF00082	0.381
CLV_PCSK_SKI1_1	367	371	PF00082	0.371
CLV_PCSK_SKI1_1	39	43	PF00082	0.565
CLV_PCSK_SKI1_1	442	446	PF00082	0.358
CLV_PCSK_SKI1_1	694	698	PF00082	0.432
CLV_PCSK_SKI1_1	748	752	PF00082	0.354
CLV_Separin_Metazoa	553	557	PF03568	0.578
DEG_Nend_Nbox_1	1	3	PF02207	0.457
DEG_SPOP_SBC_1	112	116	PF00917	0.605
DEG_SPOP_SBC_1	203	207	PF00917	0.691
DEG_SPOP_SBC_1	480	484	PF00917	0.540
DEG_SPOP_SBC_1	538	542	PF00917	0.463
DOC_CKS1_1	420	425	PF01111	0.539
DOC_CKS1_1	64	69	PF01111	0.583
DOC_CYCLIN_RxL_1	504	514	PF00134	0.568
DOC_CYCLIN_yCln2_LP_2	140	146	PF00134	0.685
DOC_CYCLIN_yCln2_LP_2	188	194	PF00134	0.733
DOC_CYCLIN_yCln2_LP_2	444	450	PF00134	0.580
DOC_MAPK_DCC_7	77	85	PF00069	0.598
DOC_MAPK_gen_1	245	253	PF00069	0.472
DOC_MAPK_gen_1	657	663	PF00069	0.509
DOC_MAPK_gen_1	71	80	PF00069	0.573
DOC_MAPK_gen_1	724	734	PF00069	0.506
DOC_MAPK_MEF2A_6	245	253	PF00069	0.596
DOC_MAPK_MEF2A_6	71	80	PF00069	0.610
DOC_MAPK_MEF2A_6	725	734	PF00069	0.483
DOC_MAPK_NFAT4_5	73	81	PF00069	0.604
DOC_PP2B_LxvP_1	140	143	PF13499	0.689
DOC_PP2B_LxvP_1	188	191	PF13499	0.649
DOC_PP2B_LxvP_1	319	322	PF13499	0.532
DOC_PP2B_LxvP_1	370	373	PF13499	0.566
DOC_PP2B_LxvP_1	444	447	PF13499	0.662
DOC_PP2B_LxvP_1	555	558	PF13499	0.582
DOC_PP2B_LxvP_1	60	63	PF13499	0.610
DOC_PP2B_LxvP_1	78	81	PF13499	0.551
DOC_PP4_FxxP_1	64	67	PF00568	0.581
DOC_USP7_MATH_1	103	107	PF00917	0.650
DOC_USP7_MATH_1	152	156	PF00917	0.679
DOC_USP7_MATH_1	159	163	PF00917	0.668
DOC_USP7_MATH_1	203	207	PF00917	0.655
DOC_USP7_MATH_1	386	390	PF00917	0.524
DOC_USP7_MATH_1	487	491	PF00917	0.484
DOC_USP7_MATH_1	537	541	PF00917	0.580
DOC_USP7_MATH_1	611	615	PF00917	0.554
DOC_USP7_MATH_1	678	682	PF00917	0.776
DOC_USP7_MATH_1	686	690	PF00917	0.658
DOC_USP7_MATH_1	742	746	PF00917	0.483
DOC_WW_Pin1_4	129	134	PF00397	0.740
DOC_WW_Pin1_4	172	177	PF00397	0.704
DOC_WW_Pin1_4	23	28	PF00397	0.193
DOC_WW_Pin1_4	419	424	PF00397	0.576
DOC_WW_Pin1_4	509	514	PF00397	0.564
DOC_WW_Pin1_4	58	63	PF00397	0.576
DOC_WW_Pin1_4	673	678	PF00397	0.635
DOC_WW_Pin1_4	9	14	PF00397	0.359
LIG_14-3-3_CanoR_1	104	112	PF00244	0.608
LIG_14-3-3_CanoR_1	121	130	PF00244	0.729
LIG_14-3-3_CanoR_1	283	289	PF00244	0.589
LIG_14-3-3_CanoR_1	644	652	PF00244	0.603
LIG_14-3-3_CanoR_1	658	662	PF00244	0.621
LIG_14-3-3_CanoR_1	729	733	PF00244	0.561
LIG_14-3-3_CanoR_1	747	754	PF00244	0.395
LIG_Actin_WH2_2	497	512	PF00022	0.528
LIG_APCC_ABBA_1	732	737	PF00400	0.483
LIG_BRCT_BRCA1_1	365	369	PF00533	0.690
LIG_BRCT_BRCA1_1	60	64	PF00533	0.613
LIG_BRCT_BRCA1_1	678	682	PF00533	0.599
LIG_eIF4E_1	10	16	PF01652	0.362
LIG_eIF4E_1	515	521	PF01652	0.557
LIG_EVH1_1	452	456	PF00568	0.579
LIG_EVH1_2	375	379	PF00568	0.531
LIG_FHA_1	213	219	PF00498	0.662
LIG_FHA_1	234	240	PF00498	0.756
LIG_FHA_1	481	487	PF00498	0.538
LIG_FHA_1	559	565	PF00498	0.639
LIG_FHA_1	729	735	PF00498	0.483
LIG_FHA_2	173	179	PF00498	0.682
LIG_FHA_2	358	364	PF00498	0.623
LIG_FHA_2	380	386	PF00498	0.606
LIG_FHA_2	64	70	PF00498	0.582
LIG_FHA_2	695	701	PF00498	0.683
LIG_FHA_2	705	711	PF00498	0.528
LIG_GBD_Chelix_1	330	338	PF00786	0.376
LIG_LIR_Apic_2	61	67	PF02991	0.578
LIG_LIR_Gen_1	287	293	PF02991	0.589
LIG_LIR_Gen_1	313	322	PF02991	0.565
LIG_LIR_Gen_1	457	466	PF02991	0.576
LIG_LIR_Gen_1	495	505	PF02991	0.558
LIG_LIR_Gen_1	608	616	PF02991	0.576
LIG_LIR_Gen_1	707	714	PF02991	0.485
LIG_LIR_Gen_1	752	761	PF02991	0.527
LIG_LIR_Nem_3	124	130	PF02991	0.672
LIG_LIR_Nem_3	287	291	PF02991	0.579
LIG_LIR_Nem_3	313	319	PF02991	0.562
LIG_LIR_Nem_3	366	372	PF02991	0.692
LIG_LIR_Nem_3	457	461	PF02991	0.623
LIG_LIR_Nem_3	495	500	PF02991	0.571
LIG_LIR_Nem_3	707	712	PF02991	0.485
LIG_LIR_Nem_3	752	757	PF02991	0.473
LIG_LYPXL_yS_3	127	130	PF13949	0.630
LIG_PCNA_PIPBox_1	702	711	PF02747	0.509
LIG_PCNA_yPIPBox_3	329	339	PF02747	0.572
LIG_PCNA_yPIPBox_3	627	637	PF02747	0.551
LIG_Pex14_2	524	528	PF04695	0.521
LIG_Rb_pABgroove_1	631	639	PF01858	0.552
LIG_SH2_CRK	10	14	PF00017	0.404
LIG_SH2_CRK	288	292	PF00017	0.598
LIG_SH2_CRK	709	713	PF00017	0.450
LIG_SH2_CRK	727	731	PF00017	0.532
LIG_SH2_CRK	761	765	PF00017	0.463
LIG_SH2_GRB2like	497	500	PF00017	0.561
LIG_SH2_NCK_1	344	348	PF00017	0.536
LIG_SH2_NCK_1	647	651	PF00017	0.542
LIG_SH2_PTP2	248	251	PF00017	0.582
LIG_SH2_SRC	248	251	PF00017	0.582
LIG_SH2_SRC	497	500	PF00017	0.561
LIG_SH2_SRC	515	518	PF00017	0.555
LIG_SH2_STAP1	344	348	PF00017	0.607
LIG_SH2_STAT5	14	17	PF00017	0.399
LIG_SH2_STAT5	248	251	PF00017	0.541
LIG_SH2_STAT5	252	255	PF00017	0.518
LIG_SH2_STAT5	448	451	PF00017	0.533
LIG_SH2_STAT5	479	482	PF00017	0.515
LIG_SH2_STAT5	497	500	PF00017	0.591
LIG_SH2_STAT5	569	572	PF00017	0.550
LIG_SH3_3	21	27	PF00018	0.192
LIG_SH3_3	370	376	PF00018	0.642
LIG_SH3_3	450	456	PF00018	0.585
LIG_SH3_3	56	62	PF00018	0.576
LIG_SUMO_SIM_anti_2	82	87	PF11976	0.605
LIG_SUMO_SIM_par_1	581	588	PF11976	0.440
LIG_SUMO_SIM_par_1	82	87	PF11976	0.605
LIG_TRAF2_1	270	273	PF00917	0.552
LIG_TRFH_1	192	196	PF08558	0.660
LIG_WRC_WIRS_1	390	395	PF05994	0.564
LIG_WRC_WIRS_1	525	530	PF05994	0.527
LIG_WRC_WIRS_1	664	669	PF05994	0.623
MOD_CDK_SPK_2	172	177	PF00069	0.704
MOD_CDK_SPxxK_3	129	136	PF00069	0.639
MOD_CK1_1	212	218	PF00069	0.583
MOD_CK1_1	241	247	PF00069	0.641
MOD_CK1_1	257	263	PF00069	0.524
MOD_CK1_1	315	321	PF00069	0.652
MOD_CK1_1	389	395	PF00069	0.553
MOD_CK1_1	457	463	PF00069	0.507
MOD_CK1_1	490	496	PF00069	0.612
MOD_CK1_1	614	620	PF00069	0.507
MOD_CK1_1	645	651	PF00069	0.472
MOD_CK1_1	666	672	PF00069	0.741
MOD_CK1_1	676	682	PF00069	0.653
MOD_CK1_1	704	710	PF00069	0.541
MOD_CK1_1	762	768	PF00069	0.468
MOD_CK1_1	97	103	PF00069	0.683
MOD_CK2_1	172	178	PF00069	0.682
MOD_CK2_1	362	368	PF00069	0.587
MOD_CK2_1	448	454	PF00069	0.589
MOD_CK2_1	63	69	PF00069	0.581
MOD_CK2_1	716	722	PF00069	0.456
MOD_CK2_1	746	752	PF00069	0.415
MOD_GlcNHglycan	105	108	PF01048	0.503
MOD_GlcNHglycan	148	151	PF01048	0.549
MOD_GlcNHglycan	154	157	PF01048	0.511
MOD_GlcNHglycan	461	464	PF01048	0.307
MOD_GlcNHglycan	492	495	PF01048	0.390
MOD_GlcNHglycan	500	503	PF01048	0.301
MOD_GlcNHglycan	647	650	PF01048	0.315
MOD_GlcNHglycan	668	671	PF01048	0.478
MOD_GlcNHglycan	688	691	PF01048	0.593
MOD_GlcNHglycan	748	751	PF01048	0.190
MOD_GSK3_1	204	211	PF00069	0.620
MOD_GSK3_1	253	260	PF00069	0.602
MOD_GSK3_1	357	364	PF00069	0.685
MOD_GSK3_1	385	392	PF00069	0.504
MOD_GSK3_1	410	417	PF00069	0.623
MOD_GSK3_1	712	719	PF00069	0.544
MOD_GSK3_1	742	749	PF00069	0.441
MOD_GSK3_1	90	97	PF00069	0.741
MOD_LATS_1	119	125	PF00433	0.640
MOD_N-GLC_1	152	157	PF02516	0.438
MOD_N-GLC_1	498	503	PF02516	0.362
MOD_N-GLC_1	716	721	PF02516	0.283
MOD_NEK2_1	165	170	PF00069	0.672
MOD_NEK2_1	204	209	PF00069	0.670
MOD_NEK2_1	233	238	PF00069	0.727
MOD_NEK2_1	253	258	PF00069	0.558
MOD_NEK2_1	350	355	PF00069	0.595
MOD_NEK2_1	361	366	PF00069	0.659
MOD_NEK2_1	378	383	PF00069	0.600
MOD_NEK2_1	481	486	PF00069	0.568
MOD_NEK2_1	492	497	PF00069	0.503
MOD_NEK2_1	498	503	PF00069	0.466
MOD_NEK2_1	55	60	PF00069	0.683
MOD_NEK2_1	570	575	PF00069	0.493
MOD_NEK2_1	712	717	PF00069	0.483
MOD_NEK2_1	764	769	PF00069	0.483
MOD_NEK2_1	84	89	PF00069	0.766
MOD_NEK2_1	90	95	PF00069	0.711
MOD_PIKK_1	570	576	PF00454	0.531
MOD_PIKK_1	764	770	PF00454	0.483
MOD_PK_1	546	552	PF00069	0.565
MOD_PK_1	657	663	PF00069	0.587
MOD_PKA_1	121	127	PF00069	0.597
MOD_PKA_1	657	663	PF00069	0.639
MOD_PKA_1	694	700	PF00069	0.629
MOD_PKA_2	121	127	PF00069	0.668
MOD_PKA_2	614	620	PF00069	0.558
MOD_PKA_2	645	651	PF00069	0.600
MOD_PKA_2	657	663	PF00069	0.619
MOD_PKA_2	686	692	PF00069	0.753
MOD_PKA_2	694	700	PF00069	0.618
MOD_PKA_2	728	734	PF00069	0.551
MOD_PKA_2	746	752	PF00069	0.406
MOD_PKA_2	91	97	PF00069	0.748
MOD_PKA_2	98	104	PF00069	0.682
MOD_Plk_1	159	165	PF00069	0.702
MOD_Plk_1	213	219	PF00069	0.612
MOD_Plk_1	272	278	PF00069	0.552
MOD_Plk_1	312	318	PF00069	0.615
MOD_Plk_1	558	564	PF00069	0.580
MOD_Plk_2-3	454	460	PF00069	0.580
MOD_Plk_4	214	220	PF00069	0.724
MOD_Plk_4	238	244	PF00069	0.706
MOD_Plk_4	254	260	PF00069	0.505
MOD_Plk_4	414	420	PF00069	0.537
MOD_Plk_4	481	487	PF00069	0.506
MOD_Plk_4	493	499	PF00069	0.484
MOD_Plk_4	55	61	PF00069	0.586
MOD_Plk_4	759	765	PF00069	0.506
MOD_Plk_4	79	85	PF00069	0.646
MOD_ProDKin_1	129	135	PF00069	0.741
MOD_ProDKin_1	172	178	PF00069	0.703
MOD_ProDKin_1	23	29	PF00069	0.193
MOD_ProDKin_1	419	425	PF00069	0.571
MOD_ProDKin_1	509	515	PF00069	0.561
MOD_ProDKin_1	58	64	PF00069	0.578
MOD_ProDKin_1	673	679	PF00069	0.636
MOD_ProDKin_1	9	15	PF00069	0.359
MOD_SUMO_rev_2	269	275	PF00179	0.552
MOD_SUMO_rev_2	434	441	PF00179	0.567
TRG_DiLeu_BaEn_1	559	564	PF01217	0.573
TRG_DiLeu_BaEn_1	752	757	PF01217	0.517
TRG_DiLeu_BaEn_4	272	278	PF01217	0.569
TRG_DiLeu_BaLyEn_6	373	378	PF01217	0.607
TRG_DiLeu_BaLyEn_6	50	55	PF01217	0.618
TRG_ENDOCYTIC_2	127	130	PF00928	0.673
TRG_ENDOCYTIC_2	248	251	PF00928	0.571
TRG_ENDOCYTIC_2	288	291	PF00928	0.594
TRG_ENDOCYTIC_2	307	310	PF00928	0.465
TRG_ENDOCYTIC_2	497	500	PF00928	0.568
TRG_ENDOCYTIC_2	709	712	PF00928	0.485
TRG_ENDOCYTIC_2	727	730	PF00928	0.463
TRG_ENDOCYTIC_2	761	764	PF00928	0.463
TRG_ER_diArg_1	121	123	PF00400	0.613
TRG_ER_diArg_1	245	248	PF00400	0.660
TRG_ER_diArg_1	400	402	PF00400	0.585
TRG_ER_diArg_1	603	606	PF00400	0.529
TRG_ER_diArg_1	644	647	PF00400	0.588
TRG_ER_diArg_1	686	688	PF00400	0.614
TRG_ER_diArg_1	694	696	PF00400	0.585
TRG_ER_diArg_1	723	726	PF00400	0.506
TRG_Pf-PMV_PEXEL_1	121	125	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	163	167	PF00026	0.433
TRG_Pf-PMV_PEXEL_1	308	313	PF00026	0.406
TRG_Pf-PMV_PEXEL_1	341	346	PF00026	0.353

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD42	Leptomonas seymouri	43%	100%
A0A0S4KK52	Bodo saltans	22%	78%
A0A3S7X8I0	Leishmania donovani	82%	100%
A4HBA8	Leishmania braziliensis	68%	100%
A4IAF6	Leishmania infantum	82%	100%
Q4Q2F5	Leishmania major	82%	100%