Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B5H7_LEIMU

TriTrypDb:

LmxM.33.3840

Length:

249

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B5H7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5H7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	63	67	PF00656	0.292
CLV_PCSK_SKI1_1	93	97	PF00082	0.593
DOC_PP2B_LxvP_1	185	188	PF13499	0.497
DOC_PP4_FxxP_1	152	155	PF00568	0.480
DOC_USP7_MATH_1	126	130	PF00917	0.637
DOC_USP7_MATH_1	131	135	PF00917	0.605
DOC_USP7_MATH_1	144	148	PF00917	0.657
DOC_USP7_MATH_1	188	192	PF00917	0.498
DOC_USP7_MATH_1	25	29	PF00917	0.370
DOC_WW_Pin1_4	136	141	PF00397	0.693
DOC_WW_Pin1_4	4	9	PF00397	0.711
LIG_14-3-3_CanoR_1	179	185	PF00244	0.473
LIG_BIR_II_1	1	5	PF00653	0.647
LIG_BRCT_BRCA1_1	155	159	PF00533	0.521
LIG_BRCT_BRCA1_1	190	194	PF00533	0.377
LIG_FHA_1	27	33	PF00498	0.524
LIG_FHA_1	41	47	PF00498	0.447
LIG_FHA_2	112	118	PF00498	0.481
LIG_FHA_2	211	217	PF00498	0.527
LIG_FHA_2	230	236	PF00498	0.530
LIG_FHA_2	58	64	PF00498	0.495
LIG_LIR_Gen_1	156	167	PF02991	0.480
LIG_LIR_Gen_1	183	190	PF02991	0.436
LIG_LIR_Gen_1	60	67	PF02991	0.508
LIG_LIR_Nem_3	156	162	PF02991	0.438
LIG_LIR_Nem_3	17	22	PF02991	0.480
LIG_LIR_Nem_3	183	187	PF02991	0.402
LIG_LIR_Nem_3	191	196	PF02991	0.370
LIG_LIR_Nem_3	222	226	PF02991	0.363
LIG_LIR_Nem_3	60	64	PF02991	0.505
LIG_MLH1_MIPbox_1	190	194	PF16413	0.483
LIG_NRBOX	108	114	PF00104	0.458
LIG_NRBOX	206	212	PF00104	0.445
LIG_SH2_STAT5	22	25	PF00017	0.361
LIG_SH2_STAT5	80	83	PF00017	0.638
LIG_SH3_3	138	144	PF00018	0.605
LIG_SUMO_SIM_anti_2	28	36	PF11976	0.501
LIG_TRAF2_1	166	169	PF00917	0.477
LIG_TRAF2_1	8	11	PF00917	0.660
MOD_CK1_1	108	114	PF00069	0.483
MOD_CK1_1	125	131	PF00069	0.736
MOD_CK1_1	134	140	PF00069	0.643
MOD_CK1_1	142	148	PF00069	0.572
MOD_CK1_1	2	8	PF00069	0.616
MOD_CK2_1	111	117	PF00069	0.482
MOD_CK2_1	163	169	PF00069	0.406
MOD_CK2_1	229	235	PF00069	0.499
MOD_CK2_1	4	10	PF00069	0.749
MOD_CMANNOS	181	184	PF00535	0.360
MOD_GlcNHglycan	124	127	PF01048	0.630
MOD_GlcNHglycan	141	144	PF01048	0.676
MOD_GlcNHglycan	165	168	PF01048	0.322
MOD_GlcNHglycan	4	7	PF01048	0.710
MOD_GlcNHglycan	74	77	PF01048	0.539
MOD_GSK3_1	104	111	PF00069	0.495
MOD_GSK3_1	122	129	PF00069	0.593
MOD_GSK3_1	131	138	PF00069	0.549
MOD_GSK3_1	153	160	PF00069	0.509
MOD_GSK3_1	74	81	PF00069	0.605
MOD_N-GLC_1	57	62	PF02516	0.513
MOD_N-GLC_2	176	178	PF02516	0.439
MOD_NEK2_1	105	110	PF00069	0.487
MOD_NEK2_1	157	162	PF00069	0.496
MOD_NEK2_1	210	215	PF00069	0.519
MOD_NEK2_1	78	83	PF00069	0.616
MOD_PIKK_1	150	156	PF00454	0.415
MOD_Plk_1	188	194	PF00069	0.525
MOD_Plk_1	57	63	PF00069	0.517
MOD_Plk_1	9	15	PF00069	0.424
MOD_Plk_4	108	114	PF00069	0.386
MOD_Plk_4	153	159	PF00069	0.388
MOD_Plk_4	180	186	PF00069	0.498
MOD_Plk_4	57	63	PF00069	0.530
MOD_ProDKin_1	136	142	PF00069	0.691
MOD_ProDKin_1	4	10	PF00069	0.708
MOD_SUMO_rev_2	90	95	PF00179	0.594
TRG_DiLeu_BaEn_1	91	96	PF01217	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE51	Leptomonas seymouri	54%	94%
A0A0S4KKN8	Bodo saltans	27%	88%
A0A1X0ND66	Trypanosomatidae	34%	100%
A0A3Q8IEP6	Leishmania donovani	79%	96%
A0A422NSY2	Trypanosoma rangeli	37%	100%
A4HBA5	Leishmania braziliensis	69%	100%
A4IAF3	Leishmania infantum	79%	96%
C9ZLU1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
Q4Q2F8	Leishmania major	83%	100%