TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR repeat, putative

Species:

Leishmania mexicana

UniProt:

E9B5H5_LEIMU

TriTrypDb:

LmxM.33.3820

Length:

289

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B5H5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5H5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	125	129	PF00656	0.544
CLV_NRD_NRD_1	200	202	PF00675	0.314
CLV_NRD_NRD_1	234	236	PF00675	0.389
CLV_NRD_NRD_1	98	100	PF00675	0.386
CLV_PCSK_KEX2_1	200	202	PF00082	0.314
CLV_PCSK_SKI1_1	99	103	PF00082	0.416
DOC_USP7_MATH_1	109	113	PF00917	0.425
DOC_USP7_MATH_1	127	131	PF00917	0.643
DOC_USP7_MATH_1	132	136	PF00917	0.605
DOC_USP7_MATH_1	61	65	PF00917	0.671
DOC_USP7_UBL2_3	173	177	PF12436	0.533
DOC_USP7_UBL2_3	236	240	PF12436	0.379
DOC_WW_Pin1_4	120	125	PF00397	0.595
DOC_WW_Pin1_4	18	23	PF00397	0.591
DOC_WW_Pin1_4	31	36	PF00397	0.685
LIG_14-3-3_CanoR_1	113	120	PF00244	0.464
LIG_Actin_WH2_2	65	81	PF00022	0.509
LIG_BIR_III_4	229	233	PF00653	0.407
LIG_BRCT_BRCA1_1	283	287	PF00533	0.379
LIG_Clathr_ClatBox_1	171	175	PF01394	0.438
LIG_FHA_1	158	164	PF00498	0.282
LIG_FHA_2	123	129	PF00498	0.706
LIG_FHA_2	136	142	PF00498	0.735
LIG_FHA_2	143	149	PF00498	0.756
LIG_LIR_Gen_1	219	228	PF02991	0.407
LIG_LIR_Gen_1	23	32	PF02991	0.454
LIG_LIR_Nem_3	203	208	PF02991	0.243
LIG_LIR_Nem_3	212	218	PF02991	0.336
LIG_LIR_Nem_3	219	224	PF02991	0.421
LIG_LIR_Nem_3	23	29	PF02991	0.458
LIG_NRP_CendR_1	286	289	PF00754	0.454
LIG_Pex14_1	211	215	PF04695	0.312
LIG_Pex14_2	39	43	PF04695	0.442
LIG_PTB_Apo_2	163	170	PF02174	0.259
LIG_SH2_CRK	26	30	PF00017	0.571
LIG_SH2_STAP1	157	161	PF00017	0.360
LIG_SH2_STAP1	283	287	PF00017	0.379
LIG_SH2_STAT3	206	209	PF00017	0.424
LIG_SH2_STAT5	157	160	PF00017	0.304
LIG_SH2_STAT5	164	167	PF00017	0.258
LIG_SH2_STAT5	194	197	PF00017	0.326
LIG_SH2_STAT5	198	201	PF00017	0.273
LIG_SH3_3	103	109	PF00018	0.341
LIG_SH3_3	121	127	PF00018	0.491
LIG_SUMO_SIM_par_1	67	74	PF11976	0.522
LIG_TRAF2_1	144	147	PF00917	0.448
LIG_UBA3_1	171	177	PF00899	0.382
LIG_UBA3_1	250	255	PF00899	0.330
MOD_CDC14_SPxK_1	21	24	PF00782	0.512
MOD_CDK_SPxK_1	18	24	PF00069	0.509
MOD_CK1_1	112	118	PF00069	0.577
MOD_CK1_1	135	141	PF00069	0.643
MOD_CK2_1	135	141	PF00069	0.681
MOD_CK2_1	142	148	PF00069	0.653
MOD_CK2_1	61	67	PF00069	0.684
MOD_GlcNHglycan	128	132	PF01048	0.570
MOD_GlcNHglycan	212	215	PF01048	0.430
MOD_GlcNHglycan	64	67	PF01048	0.479
MOD_GSK3_1	114	121	PF00069	0.590
MOD_GSK3_1	133	140	PF00069	0.591
MOD_GSK3_1	151	158	PF00069	0.423
MOD_GSK3_1	16	23	PF00069	0.554
MOD_GSK3_1	277	284	PF00069	0.396
MOD_GSK3_1	89	96	PF00069	0.384
MOD_NEK2_2	281	286	PF00069	0.375
MOD_PKA_2	112	118	PF00069	0.598
MOD_Plk_1	155	161	PF00069	0.339
MOD_Plk_1	190	196	PF00069	0.451
MOD_Plk_2-3	217	223	PF00069	0.330
MOD_Plk_4	190	196	PF00069	0.516
MOD_Plk_4	93	99	PF00069	0.433
MOD_ProDKin_1	120	126	PF00069	0.596
MOD_ProDKin_1	18	24	PF00069	0.592
MOD_ProDKin_1	31	37	PF00069	0.685
MOD_SUMO_for_1	176	179	PF00179	0.451
TRG_DiLeu_BaEn_3	245	251	PF01217	0.340
TRG_DiLeu_BaEn_4	73	79	PF01217	0.552
TRG_ENDOCYTIC_2	205	208	PF00928	0.287
TRG_ENDOCYTIC_2	221	224	PF00928	0.335
TRG_ENDOCYTIC_2	26	29	PF00928	0.574
TRG_ER_diArg_1	199	201	PF00400	0.324
TRG_Pf-PMV_PEXEL_1	249	253	PF00026	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILM5	Leptomonas seymouri	59%	100%
A0A0S4KMF2	Bodo saltans	50%	100%
A0A1X0PA31	Trypanosomatidae	55%	100%
A0A3Q8IHU2	Leishmania donovani	87%	100%
A0A422NSX9	Trypanosoma rangeli	56%	100%
A4HBA3	Leishmania braziliensis	77%	99%
A4IAF1	Leishmania infantum	87%	100%
C9ZLU3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
Q3ZBR5	Bos taurus	30%	99%
Q4Q2G0	Leishmania major	86%	100%
Q99614	Homo sapiens	31%	99%