Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B5H3_LEIMU

TriTrypDb:

LmxM.33.3810

Length:

197

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9B5H3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5H3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	139	141	PF00675	0.580
CLV_PCSK_KEX2_1	139	141	PF00082	0.579
CLV_PCSK_KEX2_1	39	41	PF00082	0.369
CLV_PCSK_PC1ET2_1	39	41	PF00082	0.416
CLV_PCSK_SKI1_1	74	78	PF00082	0.573
DOC_MAPK_gen_1	9	17	PF00069	0.601
DOC_PP1_RVXF_1	124	130	PF00149	0.421
DOC_PP1_RVXF_1	180	187	PF00149	0.474
LIG_14-3-3_CanoR_1	11	16	PF00244	0.521
LIG_14-3-3_CterR_2	194	197	PF00244	0.454
LIG_APCC_ABBAyCdc20_2	182	188	PF00400	0.363
LIG_BIR_II_1	1	5	PF00653	0.543
LIG_FHA_1	10	16	PF00498	0.499
LIG_FHA_1	51	57	PF00498	0.186
LIG_GBD_Chelix_1	56	64	PF00786	0.243
LIG_LIR_Gen_1	168	177	PF02991	0.441
LIG_LIR_Gen_1	2	10	PF02991	0.530
LIG_LIR_Nem_3	130	134	PF02991	0.454
LIG_LIR_Nem_3	2	8	PF02991	0.618
LIG_LIR_Nem_3	35	41	PF02991	0.605
LIG_LYPXL_S_1	68	72	PF13949	0.404
LIG_LYPXL_yS_3	100	103	PF13949	0.368
LIG_LYPXL_yS_3	69	72	PF13949	0.318
LIG_SH2_CRK	5	9	PF00017	0.542
LIG_SH2_STAT5	71	74	PF00017	0.381
LIG_SH2_STAT5	75	78	PF00017	0.376
LIG_SH3_3	31	37	PF00018	0.555
LIG_SUMO_SIM_par_1	12	18	PF11976	0.570
LIG_TYR_ITIM	67	72	PF00017	0.379
LIG_UBA3_1	159	163	PF00899	0.493
LIG_WRC_WIRS_1	20	25	PF05994	0.444
LIG_WW_3	123	127	PF00397	0.358
MOD_CK1_1	32	38	PF00069	0.504
MOD_GlcNHglycan	112	115	PF01048	0.519
MOD_GlcNHglycan	167	170	PF01048	0.498
MOD_GlcNHglycan	31	34	PF01048	0.422
MOD_N-GLC_1	118	123	PF02516	0.487
MOD_NEK2_1	1	6	PF00069	0.426
MOD_NEK2_1	10	15	PF00069	0.375
MOD_NEK2_1	29	34	PF00069	0.472
MOD_PIKK_1	118	124	PF00454	0.530
MOD_PKA_2	10	16	PF00069	0.433
MOD_Plk_1	118	124	PF00069	0.651
MOD_Plk_1	152	158	PF00069	0.467
MOD_Plk_4	51	57	PF00069	0.311
MOD_SUMO_for_1	162	165	PF00179	0.503
MOD_SUMO_for_1	45	48	PF00179	0.463
TRG_DiLeu_BaEn_1	180	185	PF01217	0.565
TRG_DiLeu_BaLyEn_6	62	67	PF01217	0.347
TRG_ENDOCYTIC_2	100	103	PF00928	0.457
TRG_ENDOCYTIC_2	170	173	PF00928	0.579
TRG_ENDOCYTIC_2	5	8	PF00928	0.515
TRG_ENDOCYTIC_2	69	72	PF00928	0.383
TRG_ER_diArg_1	138	140	PF00400	0.343
TRG_ER_diArg_1	88	91	PF00400	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6S8	Leptomonas seymouri	60%	100%
A0A0S4KIP5	Bodo saltans	36%	99%
A0A1X0PAY8	Trypanosomatidae	47%	100%
A0A3S7X8G4	Leishmania donovani	95%	100%
A4HBA1	Leishmania braziliensis	84%	100%
A4IAE9	Leishmania infantum	95%	100%
C9ZLU5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
Q4Q2G2	Leishmania major	93%	100%