Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B5H2_LEIMU

TriTrypDb:

LmxM.33.3800

Length:

355

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B5H2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B5H2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	145	149	PF00656	0.392
CLV_C14_Caspase3-7	31	35	PF00656	0.433
CLV_MEL_PAP_1	66	72	PF00089	0.389
CLV_NRD_NRD_1	146	148	PF00675	0.536
CLV_NRD_NRD_1	315	317	PF00675	0.391
CLV_NRD_NRD_1	4	6	PF00675	0.617
CLV_PCSK_FUR_1	2	6	PF00082	0.629
CLV_PCSK_KEX2_1	146	148	PF00082	0.396
CLV_PCSK_KEX2_1	302	304	PF00082	0.499
CLV_PCSK_KEX2_1	32	34	PF00082	0.449
CLV_PCSK_KEX2_1	4	6	PF00082	0.542
CLV_PCSK_KEX2_1	59	61	PF00082	0.315
CLV_PCSK_PC1ET2_1	302	304	PF00082	0.427
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.449
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.324
CLV_PCSK_SKI1_1	118	122	PF00082	0.446
CLV_PCSK_SKI1_1	205	209	PF00082	0.421
CLV_PCSK_SKI1_1	278	282	PF00082	0.375
CLV_PCSK_SKI1_1	302	306	PF00082	0.531
CLV_PCSK_SKI1_1	349	353	PF00082	0.439
DEG_Nend_UBRbox_1	1	4	PF02207	0.505
DOC_CYCLIN_RxL_1	202	211	PF00134	0.374
DOC_CYCLIN_yCln2_LP_2	315	321	PF00134	0.480
DOC_MAPK_gen_1	152	162	PF00069	0.409
DOC_MAPK_gen_1	316	327	PF00069	0.524
DOC_MAPK_gen_1	32	39	PF00069	0.537
DOC_MAPK_HePTP_8	29	41	PF00069	0.431
DOC_MAPK_MEF2A_6	194	203	PF00069	0.329
DOC_MAPK_MEF2A_6	32	41	PF00069	0.438
DOC_MAPK_RevD_3	17	33	PF00069	0.338
DOC_PP2B_LxvP_1	207	210	PF13499	0.477
DOC_PP2B_LxvP_1	54	57	PF13499	0.325
DOC_PP4_FxxP_1	76	79	PF00568	0.488
DOC_USP7_MATH_1	3	7	PF00917	0.612
DOC_USP7_MATH_1	345	349	PF00917	0.370
DOC_USP7_MATH_1	55	59	PF00917	0.408
DOC_USP7_MATH_1	88	92	PF00917	0.664
DOC_WW_Pin1_4	125	130	PF00397	0.381
DOC_WW_Pin1_4	75	80	PF00397	0.449
LIG_14-3-3_CanoR_1	155	161	PF00244	0.416
LIG_14-3-3_CanoR_1	2	12	PF00244	0.480
LIG_14-3-3_CanoR_1	320	327	PF00244	0.476
LIG_14-3-3_CanoR_1	60	70	PF00244	0.350
LIG_14-3-3_CanoR_1	87	94	PF00244	0.493
LIG_APCC_ABBA_1	246	251	PF00400	0.292
LIG_BRCT_BRCA1_1	5	9	PF00533	0.437
LIG_BRCT_BRCA1_1	57	61	PF00533	0.444
LIG_FHA_1	13	19	PF00498	0.343
LIG_FHA_1	157	163	PF00498	0.406
LIG_FHA_1	214	220	PF00498	0.441
LIG_FHA_1	25	31	PF00498	0.406
LIG_FHA_1	279	285	PF00498	0.378
LIG_FHA_1	333	339	PF00498	0.377
LIG_FHA_1	49	55	PF00498	0.323
LIG_FHA_1	61	67	PF00498	0.357
LIG_FHA_2	26	32	PF00498	0.412
LIG_FHA_2	269	275	PF00498	0.447
LIG_FHA_2	338	344	PF00498	0.417
LIG_LIR_Apic_2	328	332	PF02991	0.504
LIG_LIR_Apic_2	74	79	PF02991	0.418
LIG_LIR_Gen_1	14	24	PF02991	0.334
LIG_LIR_Gen_1	178	188	PF02991	0.259
LIG_LIR_Gen_1	271	280	PF02991	0.287
LIG_LIR_Gen_1	307	318	PF02991	0.341
LIG_LIR_Nem_3	109	115	PF02991	0.330
LIG_LIR_Nem_3	128	134	PF02991	0.369
LIG_LIR_Nem_3	14	19	PF02991	0.338
LIG_LIR_Nem_3	178	183	PF02991	0.248
LIG_LIR_Nem_3	271	276	PF02991	0.291
LIG_LIR_Nem_3	307	313	PF02991	0.333
LIG_LIR_Nem_3	348	353	PF02991	0.412
LIG_LIR_Nem_3	6	12	PF02991	0.403
LIG_PDZ_Class_2	350	355	PF00595	0.302
LIG_Pex14_2	76	80	PF04695	0.493
LIG_SH2_CRK	180	184	PF00017	0.535
LIG_SH2_STAT5	12	15	PF00017	0.362
LIG_SH2_STAT5	165	168	PF00017	0.373
LIG_SH2_STAT5	310	313	PF00017	0.432
LIG_SH2_STAT5	42	45	PF00017	0.388
LIG_SH3_3	250	256	PF00018	0.372
LIG_SUMO_SIM_par_1	51	58	PF11976	0.312
LIG_TRAF2_1	139	142	PF00917	0.448
LIG_TRAF2_1	321	324	PF00917	0.359
LIG_WRC_WIRS_1	102	107	PF05994	0.453
MOD_CDC14_SPxK_1	78	81	PF00782	0.392
MOD_CDK_SPxK_1	75	81	PF00069	0.388
MOD_CK1_1	104	110	PF00069	0.461
MOD_CK1_1	136	142	PF00069	0.434
MOD_CK1_1	272	278	PF00069	0.372
MOD_CK1_1	65	71	PF00069	0.344
MOD_CK1_1	75	81	PF00069	0.403
MOD_CK2_1	136	142	PF00069	0.432
MOD_CK2_1	25	31	PF00069	0.416
MOD_CK2_1	268	274	PF00069	0.425
MOD_CK2_1	337	343	PF00069	0.424
MOD_DYRK1A_RPxSP_1	125	129	PF00069	0.372
MOD_GlcNHglycan	90	93	PF01048	0.648
MOD_GSK3_1	268	275	PF00069	0.527
MOD_GSK3_1	333	340	PF00069	0.371
MOD_GSK3_1	61	68	PF00069	0.482
MOD_GSK3_1	71	78	PF00069	0.504
MOD_N-GLC_1	221	226	PF02516	0.586
MOD_NEK2_1	106	111	PF00069	0.387
MOD_NEK2_1	220	225	PF00069	0.665
MOD_NEK2_1	304	309	PF00069	0.467
MOD_NEK2_1	311	316	PF00069	0.361
MOD_NEK2_1	61	66	PF00069	0.384
MOD_NEK2_1	72	77	PF00069	0.395
MOD_NEK2_2	3	8	PF00069	0.480
MOD_PIKK_1	107	113	PF00454	0.452
MOD_PIKK_1	178	184	PF00454	0.357
MOD_PKA_2	3	9	PF00069	0.590
MOD_PKA_2	319	325	PF00069	0.478
MOD_PKA_2	86	92	PF00069	0.531
MOD_PKB_1	171	179	PF00069	0.402
MOD_Plk_1	173	179	PF00069	0.471
MOD_Plk_4	101	107	PF00069	0.423
MOD_Plk_4	156	162	PF00069	0.478
MOD_Plk_4	25	31	PF00069	0.406
MOD_Plk_4	49	55	PF00069	0.362
MOD_Plk_4	62	68	PF00069	0.480
MOD_ProDKin_1	125	131	PF00069	0.382
MOD_ProDKin_1	75	81	PF00069	0.460
MOD_SUMO_rev_2	296	304	PF00179	0.444
TRG_DiLeu_BaEn_1	300	305	PF01217	0.389
TRG_DiLeu_LyEn_5	300	305	PF01217	0.480
TRG_ENDOCYTIC_2	16	19	PF00928	0.351
TRG_ENDOCYTIC_2	180	183	PF00928	0.414
TRG_ENDOCYTIC_2	310	313	PF00928	0.429
TRG_ER_diArg_1	1	4	PF00400	0.655
TRG_ER_diArg_1	169	172	PF00400	0.446
TRG_Pf-PMV_PEXEL_1	302	306	PF00026	0.393

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P771	Leptomonas seymouri	58%	95%
A0A0S4KPS3	Bodo saltans	31%	100%
A0A1X0PA34	Trypanosomatidae	41%	100%
A0A3S7X8E4	Leishmania donovani	92%	100%
A0A422NT02	Trypanosoma rangeli	40%	100%
A4HBA0	Leishmania braziliensis	82%	100%
A4IAE8	Leishmania infantum	92%	100%
C9ZLU6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
Q4Q2G3	Leishmania major	92%	100%
V5DMU4	Trypanosoma cruzi	41%	100%